denopamine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
dopaminergic agents dopamine derivatives used as cardiac stimulant/antihypertensives/diuretics 806 71771-90-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • denopamine
  • kalgut
  • carguto
  • Molecular weight: 317.39
  • Formula: C18H23NO4
  • CLOGP: 1.67
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 70.95
  • ALOGS: -3.76
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D020011 Protective Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.17 acidic
pKa2 8.43 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR AGONIST Ki 5.80 IUPHAR SCIENTIFIC LITERATURE
Solute carrier family 22 member 1 Transporter IC50 4.33 CHEMBL

External reference:

IDSource
D02614 KEGG_DRUG
008205 NDDF
CHEMBL493682 ChEMBL_ID
V5F60UPD8P UNII
5460 INN_ID
CHEBI:135359 CHEBI
534 IUPHAR_LIGAND_ID
5311064 PUBCHEM_CID
C037293 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None