denopamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
dopaminergic agents dopamine derivatives used as cardiac stimulant/antihypertensives/diuretics	806	71771-90-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

denopamine
kalgut
carguto

Molecular weight: 317.39
Formula: C18H23NO4
CLOGP: 1.47
LIPINSKI: 0
HAC: 5
HDO: 3
TPSA: 70.95
ALOGS: -3.76
ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D000322	Adrenergic Agonists
MeSH PA	D000318	Adrenergic beta-Agonists
MeSH PA	D002316	Cardiotonic Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D020011	Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.17	acidic
pKa2	8.43	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN	AGONIST	Ki	5.80		IUPHAR	SCIENTIFIC LITERATURE
Solute carrier family 22 member 1	Transporter	O15245	S22A1_HUMAN		IC50	4.33		CHEMBL

External reference:

ID	Source
D02614	KEGG_DRUG
C0075749	UMLSCUI
CHEBI:135359	CHEBI
CHEMBL493682	ChEMBL_ID
C037293	MESH_SUPPLEMENTAL_RECORD_UI
5311064	PUBCHEM_CID
534	IUPHAR_LIGAND_ID
5460	INN_ID
V5F60UPD8P	UNII
008205	NDDF

Pharmaceutical products:

None