algestone acetophenide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 797 24356-94-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • deladroxone
  • alphasone acetophenide
  • dihydroxyprogesterone acetophenide
  • droxone
  • algestone acetophenide
A progesterone that has been used in ESTRUS SYNCHRONIZATION and has been evaluated as an injectable contraceptive in combination with estradiol enanthate. It is also applied topically as an anti-inflammatory and in the treatment of ACNE.
  • Molecular weight: 448.60
  • Formula: C29H36O4
  • CLOGP: 5.32
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 52.60
  • ALOGS: -6.10
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lupus nephritis 35.96 35.07 4 3 3004 79741377

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D003270 Contraceptive Agents
MeSH PA D003271 Contraceptive Agents, Female
MeSH PA D000080066 Contraceptive Agents, Hormonal
MeSH PA D003280 Contraceptives, Oral, Synthetic
MeSH PA D006728 Hormones
MeSH PA D011372 Progestins
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:49326 synthetic oral contraceptives

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02809 KEGG_DRUG
CHEBI:49327 CHEBI
CHEMBL3989742 ChEMBL_ID
CHEMBL2105993 ChEMBL_ID
DB15775 DRUGBANK_ID
32887 MMSL
006143 NDDF
C0002039 UMLSCUI
D000463 MESH_DESCRIPTOR_UI
102011 PUBCHEM_CID
OL7KC2O3OT UNII

Pharmaceutical products:

None