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cysteine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 769 | 52-90-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -2.495 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.486 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 17.906 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 0.553 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 86.850 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 74.950 | % | High | 1 |
| herg | hERG pIC50 | 5.158 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 2.239 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 4.603 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 92.060 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BMX,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHUK,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT1,FLT3,GRK2,GRK3,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 68 | |||
| kinase-selectivity-class | ACVR2B,AXL,BMX,BRAF,CDK9,EIF2AK3,EPHB4,GRK2,MAP2K6,MAP3K14,MAPK7,PIK3CB,PIK3CD,PIK3CG,PRKDC,STK33,TEK,TGFBR1 | 18 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 5.212 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 1.858 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 96.950 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 3.673 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 84.060 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 4.365 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 91.130 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 96.140 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 570.164 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 22, 1986 | FDA | HOSPIRA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:78675 | fundamental metabolite |
| CHEBI has role | CHEBI:64577 | flour treatment agent |
| CHEBI has role | CHEBI:77703 | EC 4.3.1.3 (histidine ammonia-lyase) inhibitor |
| CHEBI has role | CHEBI:77746 | human metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Bronchiectasis | indication | 12295008 | DOID:9563 |
| Amyloidosis | indication | 17602002 | DOID:9120 |
| Bronchitis | indication | 32398004 | DOID:6132 |
| General anesthesia | indication | 50697003 | |
| Poisoning by acetaminophen | indication | 70273001 | |
| Cystic fibrosis of the lung | indication | 86555001 | |
| Thick Bronchial Secretions | indication | ||
| Contrast Media-Induced Nephrotoxicity Prevention | indication | ||
| Atelectasis due to Mucous Obstruction | indication | ||
| Meconium ileus | off-label use | 206523001 | |
| Bronchial Studies | off-label use | ||
| Bronchospasm | contraindication | 4386001 | |
| Classical phenylketonuria | contraindication | 7573000 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Esophageal varices | contraindication | 28670008 | |
| Gastrointestinal ulcer | contraindication | 40845000 | |
| Low blood pressure | contraindication | 45007003 | |
| Gastrointestinal hemorrhage | contraindication | 74474003 | |
| Decreased respiratory function | contraindication | 80954004 | |
| Acute exacerbation of asthma | contraindication | 708038006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.82 | acidic |
| pKa2 | 10.19 | acidic |
| pKa3 | 8.8 | Basic |
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 500MG/10ML (50MG/ML) | ELCYS | EXELA PHARMA | N210660 | April 16, 2019 | RX | SOLUTION | INTRAVENOUS | 10478453 | Jan. 15, 2039 | METHOD OF USING L-CYSTEINE IN AN ADMIXTURE FOR TREATING PATIENTS NEEDING PARENTERAL NUTRITION |
| 500MG/10ML (50MG/ML) | ELCYS | EXELA PHARMA | N210660 | April 16, 2019 | RX | SOLUTION | INTRAVENOUS | 10583155 | Jan. 15, 2039 | METHOD OF USING L-CYSTEINE IN AN ADMIXTURE FOR TREATING PATIENTS NEEDING PARENTERAL NUTRITION |
| 500MG/10ML (50MG/ML) | ELCYS | EXELA PHARMA | N210660 | April 16, 2019 | RX | SOLUTION | INTRAVENOUS | 11510942 | Jan. 15, 2039 | METHOD OF USING L-CYSTEINE IN AN ADMIXTURE FOR TREATING PATIENTS NEEDING PARENTERAL NUTRITION |
| 500MG/10ML (50MG/ML) | ELCYS | EXELA PHARMA | N210660 | April 16, 2019 | RX | SOLUTION | INTRAVENOUS | 11969439 | Jan. 15, 2039 | METHOD OF USING L-CYSTEINE IN AN ADMIXTURE FOR TREATING PATIENTS NEEDING PARENTERAL NUTRITION |
| 500MG/10ML (50MG/ML) | NOURESS | BAXTER HLTHCARE CORP | N212535 | Dec. 13, 2019 | DISCN | SOLUTION | INTRAVENOUS | 10478453 | Jan. 15, 2039 | METHOD OF USING L-CYSTEINE IN AN ADMIXTURE FOR TREATING PATIENTS NEEDING PARENTERAL NUTRITION |
| 500MG/10ML (50MG/ML) | NOURESS | BAXTER HLTHCARE CORP | N212535 | Dec. 13, 2019 | DISCN | SOLUTION | INTRAVENOUS | 10583155 | Jan. 15, 2039 | METHOD OF USING L-CYSTEINE IN AN ADMIXTURE FOR TREATING PATIENTS NEEDING PARENTERAL NUTRITION |
| 500MG/10ML (50MG/ML) | NOURESS | BAXTER HLTHCARE CORP | N212535 | Dec. 13, 2019 | DISCN | SOLUTION | INTRAVENOUS | 11510942 | Jan. 15, 2039 | METHOD OF USING L-CYSTEINE IN AN ADMIXTURE FOR TREATING PATIENTS NEEDING PARENTERAL NUTRITION |
| 500MG/10ML (50MG/ML) | NOURESS | BAXTER HLTHCARE CORP | N212535 | Dec. 13, 2019 | DISCN | SOLUTION | INTRAVENOUS | 10543186 | March 15, 2039 | METHOD OF INTRAVENOUSLY ADMINISTERING A DILUTED CYSTEINE HYDROCHLORIDE SOLUTION TO A NEONATE IN NEED THEREOF |
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cystine/glutamate transporter | Transporter | Ki | 4.23 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4031437 | VUID |
| N0000184609 | NUI |
| D00026 | KEGG_DRUG |
| 7048-04-6 | SECONDARY_CAS_RN |
| 221086 | RXNORM |
| C0010654 | UMLSCUI |
| CHEBI:15356 | CHEBI |
| BTC | PDB_CHEM_ID |
| CHEMBL863 | ChEMBL_ID |
| 5862 | PUBCHEM_CID |
| DB00151 | DRUGBANK_ID |
| CHEMBL1200630 | ChEMBL_ID |
| D003545 | MESH_DESCRIPTOR_UI |
| 6162 | INN_ID |
| K848JZ4886 | UNII |
| 11233 | MMSL |
| 4524 | MMSL |
| 7452 | MMSL |
| d04181 | MMSL |
| 000934 | NDDF |
| 004536 | NDDF |
| 108949008 | SNOMEDCT_US |
| 5932006 | SNOMEDCT_US |
| 4782 | IUPHAR_LIGAND_ID |
| 4018687 | VANDF |
| 4019702 | VANDF |
| 4031437 | VANDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| TrophAmine | HUMAN PRESCRIPTION DRUG LABEL | 20 | 0264-1933 | SOLUTION | 0.02 g | INTRAVENOUS | NDA | 23 sections |
| Premasol - sulfite-free (Amino Acid) | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0338-1130 | INJECTION, SOLUTION | 0.02 g | INTRAVENOUS | ANDA | 15 sections |
| Premasol - sulfite-free (Amino Acid) | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0338-1131 | INJECTION, SOLUTION | 0.01 g | INTRAVENOUS | ANDA | 15 sections |
| CYSTEINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0338-9645 | INJECTION | 34.50 mg | INTRAVENOUS | NDA | 19 sections |
| ELCYS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51754-1007 | INJECTION, SOLUTION | 10 mg | INTRAVENOUS | NDA | 20 sections |
| ELCYS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51754-1008 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | NDA | 20 sections |
| ELCYS | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51754-1008 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | NDA | 20 sections |
| Nouress | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76014-006 | INJECTION | 34.50 mg | Intravenous | NDA | 19 sections |