cycrimine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
763 77-39-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cycrimine
  • cycrimine hydrochloride
  • pagitane
  • cycrimine HCl
  • Molecular weight: 287.45
  • Formula: C19H29NO
  • CLOGP: 4.59
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 23.47
  • ALOGS: -4.50
  • ROTB: 5
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.166 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.057 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 31.550 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 10.023 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 22.260 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 39.510 % High 1
herg hERG pIC50 5.232 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.838 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 12.417 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 27.270 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K7,MAPK10,MAPK12,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,SIK3,TEK,TGFBR1 34
kinase-selectivity-class AXL,EIF2AK3,EPHB4,GRK2,PDK4,STK33 6
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.531 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.342 High 1
mh-clint Mouse hepatocyte intrinsic clearance 56.754 High 1
mppb Mouse plasma protein binding (% unbound) 25.400 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.016 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 39.400 % High 1
rat-kpuu-brain Rat brain Kpuu 0.495 % High 1
rh-clint Rat hepatocyte intrinsic clearance 164.437 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 48.270 % High 1
rppb Rat plasma protein binding (% unbound) 30.780 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 712.853 uM High 1

Approvals:

DateAgencyCompanyOrphan
None FDA LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:66956 antidyskinesia agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Parkinson's disease indication 49049000 DOID:14330




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST WOMBAT-PK CHEMBL

External reference:

IDSource
126-02-3 SECONDARY_CAS_RN
22037 RXNORM
C0056835 UMLSCUI
CHEBI:59692 CHEBI
CHEMBL1201227 ChEMBL_ID
CHEMBL1200828 ChEMBL_ID
DB00942 DRUGBANK_ID
C012262 MESH_SUPPLEMENTAL_RECORD_UI
2911 PUBCHEM_CID
289 INN_ID
543567RFQQ UNII
001642 NDDF
004665 NDDF
71108007 SNOMEDCT_US
543567RFQQ INXIGHT DRUGS

Pharmaceutical products:

None