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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
cycloguanil 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
754
516-21-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
cycloguanil
cycloguanil embonate
cycloguanil pamoate
the active metabolite of proguanil; antifolate drug
Molecular weight: 251.72
Formula: C11H14ClN5
CLOGP: 1.07
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 80
ALOGS: -3.01
ROTB: 1
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
P01BB02
ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Biguanides
MeSH PA
D000890
Anti-Infective Agents
MeSH PA
D000962
Antimalarials
MeSH PA
D000977
Antiparasitic Agents
MeSH PA
D000981
Antiprotozoal Agents
MeSH PA
D004791
Enzyme Inhibitors
MeSH PA
D005493
Folic Acid Antagonists
Showing 1 to 7 of 7 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
11.2
Basic
pKa2
4.66
Basic
pKa3
3.37
Basic
Showing 1 to 3 of 3 entries
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Dihydrofolate reductase
Enzyme
P00374
DYR_HUMAN
Ki
7.25
CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase
Enzyme
DRTS_PLAFK
INHIBITOR
Ki
8.96
CHEMBL
CHEMBL
Dihydrofolate reductase
Enzyme
DYR_PNECA
Ki
7.63
CHEMBL
Dihydrofolate reductase
Enzyme
DYR_RAT
IC50
6.96
CHEMBL
Dihydrofolate reductase
Enzyme
DYR_ECOLI
Ki
5.99
CHEMBL
Dihydrofolate reductase
Enzyme
DYR_LACCA
Ki
4.76
CHEMBL
Dihydrofolate reductase
Enzyme
DYR_CHICK
Ki
6.95
CHEMBL
Dihydrofolate reductase
Enzyme
B0BL08_ECOLX
Ki
5.99
CHEMBL
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External reference:
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ID
Source
1CY
PDB_CHEM_ID
002945
NDDF
002946
NDDF
10027
IUPHAR_LIGAND_ID
1527
INN_ID
26RM326WVN
UNII
28223003
SNOMEDCT_US
609-78-9
SECONDARY_CAS_RN
9049
PUBCHEM_CID
C0056751
UMLSCUI
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Pharmaceutical products:
None
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cycloguanil