cyclofenil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
753 2624-43-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyclofenil
  • cyclofenyl
  • cyclopenil
  • cyclophenil
  • cyclophenyl
  • ondogyne
  • fertodur
A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE.
  • Molecular weight: 364.44
  • Formula: C23H24O4
  • CLOGP: 5.12
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 52.60
  • ALOGS: -5.66
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.14 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 51
kinase-selectivity-class GRK2 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03GB01 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Ovulation stimulants, synthetic
MeSH PA D005300 Fertility Agents, Female
MeSH PA D012102 Reproductive Control Agents

Related Drugs by ATC class:

G03GB Ovulation stimulants, synthetic 2 drugs
clomifeneepimestrol

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Estrogen receptor Nuclear hormone receptor EC50 7.58 CHEMBL

External reference:

IDSource
N0000166610 NUI
D01281 KEGG_DRUG
2983 RXNORM
C0010560 UMLSCUI
CHEBI:31446 CHEBI
CHEMBL141305 ChEMBL_ID
DB13472 DRUGBANK_ID
D003506 MESH_DESCRIPTOR_UI
2898 PUBCHEM_CID
2258 INN_ID
J468V64WZ1 UNII
003955 NDDF
325778008 SNOMEDCT_US
418997003 SNOMEDCT_US

Pharmaceutical products:

None