epimestrol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
estrogens 1026 7004-98-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • epimestrol
  • stimovul
A synthetic steroid with estrogenic activity.
  • Molecular weight: 302.41
  • Formula: C19H26O3
  • CLOGP: 3.79
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 49.69
  • ALOGS: -4.32
  • ROTB: 1

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.344 Moderate 0.78
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.618 Moderate 0.78
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 43.954 10^-6 cm/s Moderate 0.78
dh-clint Dog hepatocyte intrinsic clearance 38.107 uL/min/10^6 cells Moderate 0.78
dppb Dog plasma protein binding (% unbound) 1.680 % Moderate 0.78
fcs-ppb Fetal calf serum protein binding (% unbound) 4.980 % Moderate 0.78
herg hERG pIC50 4.760 pIC50 Moderate 0.78
hh-clint Human hepatocyte intrinsic clearance 20.701 uL/min/10^6 cells Moderate 0.78
hlm-clint Human liver microsomal intrinsic clearance 23.174 uL/min/mg protein Moderate 0.78
hppb Human plasma protein binding (% unbound) 1.850 % Moderate 0.78
kinase-safety-class ACVR2B,BRAF,BTK,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,NTRK2,PDK1,PDK2,PDK4,PIK3CA,PRKDC,TEK,TGFBR1,ZAP70 19
kinase-selectivity-class AXL,EIF2AK3,GRK2,MAP2K6 4
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.117 Moderate 0.78
mh-clint Mouse hepatocyte intrinsic clearance 129.122 Moderate 0.78
mppb Mouse plasma protein binding (% unbound) 2.350 Moderate 0.78
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 4.178 Moderate 0.78
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 3.740 % Moderate 0.78
rh-clint Rat hepatocyte intrinsic clearance 105.925 uL/min/10^6 cells Moderate 0.78
rh-fuinc Rat hepatocyte fraction unbound in incubation 27.960 % Moderate 0.78
rppb Rat plasma protein binding (% unbound) 2.870 % Moderate 0.78
solubility-dd Solubility at pH 7.4 in DMSO 17.620 uM Moderate 0.78

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G03GB03 GENITO URINARY SYSTEM AND SEX HORMONES
SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
GONADOTROPINS AND OTHER OVULATION STIMULANTS
Ovulation stimulants, synthetic
MeSH PA D004967 Estrogens
MeSH PA D006728 Hormones

Related Drugs by ATC class:

G03GB Ovulation stimulants, synthetic 2 drugs
clomifenecyclofenil

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D04021 KEGG_DRUG
C0014561 UMLSCUI
CHEBI:34738 CHEBI
CHEMBL2106236 ChEMBL_ID
DB13386 DRUGBANK_ID
D004836 MESH_DESCRIPTOR_UI
244809 PUBCHEM_CID
2739 INN_ID
7IVE3SDZ38 UNII

Pharmaceutical products:

None