clozapine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 722 5786-21-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clozapine
  • asaleptin
  • azaleptine
  • clozapin
  • clozaril
  • fazaclo
  • klozapol
  • leponex
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
  • Molecular weight: 326.83
  • Formula: C18H19ClN4
  • CLOGP: 3.56
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 30.87
  • ALOGS: -3.25
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O
0.30 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 45.90 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 55 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.60 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Sept. 26, 1989 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
White blood cell count increased 4231.98 48.44 1036 15072 6042 2335935
Neutrophil count increased 4085.50 48.44 804 15304 1201 2340776
Granulocytopenia 3702.67 48.44 692 15416 621 2341356
Hospitalisation 2971.17 48.44 920 15188 13933 2328044
Death 2960.99 48.44 1454 14654 80014 2261963
Neutropenia 2778.83 48.44 957 15151 20591 2321386
Schizophrenia 2136.88 48.44 440 15668 919 2341058
White blood cell count decreased 2106.21 48.44 747 15361 17461 2324516
Antipsychotic drug level increased 1883.98 48.44 344 15764 225 2341752
Neutrophil count decreased 1643.94 48.44 485 15623 6082 2335895
Psychotic disorder 1637.70 48.44 449 15659 4230 2337747
Agranulocytosis 1381.28 48.44 369 15739 3113 2338864
Salivary hypersecretion 1355.44 48.44 297 15811 928 2341049
Leukopenia 1277.56 48.44 445 15663 9751 2332226
Pneumonia 1270.14 48.44 704 15404 48592 2293385
Tachycardia 1198.37 48.44 482 15626 15927 2326050
Haemoglobin decreased 1181.73 48.44 491 15617 17660 2324317
Mental impairment 1171.46 48.44 301 15807 2139 2339838
Sedation 1066.69 48.44 299 15809 3063 2338914
C-reactive protein increased 959.30 48.44 318 15790 5937 2336040
Platelet count increased 928.95 48.44 246 15862 1991 2339986
Lower respiratory tract infection 925.59 48.44 299 15809 5125 2336852
Malaise 925.15 48.44 600 15508 54985 2286992
Differential white blood cell count abnormal 918.91 48.44 158 15950 27 2341950
Pyrexia 847.58 48.44 561 15547 53147 2288830
Somnolence 764.23 48.44 393 15715 23092 2318885
Urinary tract infection 736.51 48.44 416 15692 29526 2312451
Mental disorder 733.05 48.44 233 15875 3774 2338203
Myocarditis 726.37 48.44 179 15929 1044 2340933
Fall 725.48 48.44 485 15623 46614 2295363
Electrocardiogram QT prolonged 690.52 48.44 264 15844 7550 2334427
Constipation 686.34 48.44 356 15752 21273 2320704
Treatment noncompliance 655.42 48.44 232 15876 5302 2336675
Overdose 623.79 48.44 325 15783 19582 2322395
Neuroleptic malignant syndrome 618.55 48.44 176 15932 1904 2340073
Chronic obstructive pulmonary disease 603.37 48.44 233 15875 6844 2335133
Antipsychotic drug level above therapeutic 585.75 48.44 108 16000 79 2341898
Hallucination, auditory 538.88 48.44 160 15948 2032 2339945
Leukocytosis 520.61 48.44 175 15933 3401 2338576
Infection 518.27 48.44 278 15830 17751 2324226
Confusional state 489.00 48.44 297 15811 24047 2317930
Drug interaction 461.53 48.44 306 15802 28857 2313120
Drug level increased 456.09 48.44 149 15959 2638 2339339
Sinus tachycardia 449.73 48.44 154 15954 3171 2338806
Delusion 448.41 48.44 137 15971 1928 2340049
Catatonia 447.52 48.44 113 15995 737 2341240
Toxicity to various agents 395.03 48.44 291 15817 32463 2309514
Neutrophilia 394.44 48.44 93 16015 434 2341543
Agitation 390.84 48.44 196 15912 10855 2331122
Diabetes mellitus 381.93 48.44 171 15937 7324 2334653
Breast cancer 367.22 48.44 179 15929 9316 2332661
Platelet count decreased 364.44 48.44 211 15897 15602 2326375
Vomiting 363.35 48.44 389 15719 71213 2270764
Pneumonia aspiration 361.21 48.44 135 15973 3607 2338370
Seizure 353.98 48.44 243 15865 24223 2317754
Eosinophil count increased 350.76 48.44 99 16009 1035 2340942
Lung neoplasm malignant 350.29 48.44 125 15983 2917 2339060
Sepsis 349.08 48.44 217 15891 18271 2323706
Lymphocyte count decreased 345.43 48.44 127 15981 3236 2338741
Loss of consciousness 343.57 48.44 216 15892 18551 2323426
Suicide attempt 340.86 48.44 180 15928 11102 2330875
Anaemia 329.70 48.44 268 15840 34524 2307453
Hypotension 326.78 48.44 259 15849 32177 2309800
Orthostatic hypotension 326.58 48.44 117 15991 2762 2339215
Blood creatine phosphokinase increased 316.43 48.44 134 15974 5002 2336975
Neoplasm malignant 314.19 48.44 133 15975 4960 2337017
Urinary incontinence 313.56 48.44 126 15982 4107 2337870
Body temperature increased 311.88 48.44 116 15992 3055 2338922
Weight increased 306.94 48.44 215 15893 22122 2319855
Psychiatric decompensation 306.39 48.44 65 16043 164 2341813
Paranoia 306.09 48.44 103 16005 2004 2339973
Delirium 294.52 48.44 128 15980 5095 2336882
Myocardial infarction 287.11 48.44 194 15914 18819 2323158
Heart rate increased 282.12 48.44 158 15950 10947 2331030
Aggression 282.02 48.44 121 15987 4665 2337312
Generalised tonic-clonic seizure 281.38 48.44 125 15983 5247 2336730
Haematocrit decreased 280.50 48.44 117 15991 4201 2337776
Abnormal behaviour 279.36 48.44 120 15988 4640 2337337
General physical health deterioration 277.03 48.44 170 15938 13969 2328008
Blood alkaline phosphatase increased 276.04 48.44 131 15977 6414 2335563
Myoclonus 274.44 48.44 99 16009 2384 2339593
Circulatory collapse 272.99 48.44 110 15998 3610 2338367
Intestinal obstruction 271.87 48.44 115 15993 4278 2337699
Troponin increased 270.85 48.44 80 16028 994 2340983
Cardiac arrest 268.52 48.44 170 15938 14760 2327217
Respiratory failure 268.48 48.44 164 15944 13364 2328613
Parkinson's disease 266.77 48.44 83 16025 1243 2340734
Blood glucose increased 264.59 48.44 157 15951 12133 2329844
Pre-existing disease 258.62 48.44 49 16059 49 2341928
Schizoaffective disorder 256.91 48.44 57 16051 190 2341787
Aspiration 254.87 48.44 83 16025 1451 2340526
Alanine aminotransferase increased 252.88 48.44 160 15948 13872 2328105
Dyskinesia 252.62 48.44 112 15996 4677 2337300
Red blood cell count decreased 248.53 48.44 107 16001 4159 2337818
Choking 246.58 48.44 81 16027 1457 2340520
Antipsychotic drug level decreased 246.13 48.44 43 16065 12 2341965
Eosinophilia 242.96 48.44 95 16013 2875 2339102
Intentional self-injury 242.02 48.44 104 16004 4023 2337954
Product use in unapproved indication 238.26 48.44 142 15966 11058 2330919
Pericardial effusion 235.00 48.44 101 16007 3908 2338069
Suicidal ideation 234.37 48.44 140 15968 10947 2331030
Pulmonary embolism 234.28 48.44 168 15940 17915 2324062
Electroencephalogram abnormal 232.37 48.44 67 16041 760 2341217
Obesity 230.66 48.44 77 16031 1459 2340518
Antipsychotic drug level below therapeutic 230.59 48.44 43 16065 36 2341941
Dystonia 229.49 48.44 84 16024 2110 2339867
Dyspnoea 226.90 48.44 322 15786 78411 2263566
Monocyte count increased 226.62 48.44 60 16048 482 2341495
General physical condition abnormal 222.63 48.44 62 16046 614 2341363
Thrombocytopenia 221.32 48.44 166 15942 18965 2323012
Anosognosia 218.96 48.44 41 16067 36 2341941
Liver function test abnormal 216.21 48.44 116 15992 7374 2334603
Depressed level of consciousness 200.72 48.44 111 15997 7493 2334484
Gamma-glutamyltransferase increased 197.48 48.44 99 16009 5463 2336514
Eosinophil count decreased 197.13 48.44 46 16062 203 2341774
Drug ineffective 193.72 48.44 344 15764 101280 2240697
Hallucination 190.89 48.44 110 15998 8038 2333939
Mean cell haemoglobin decreased 187.25 48.44 45 16063 231 2341746
Faecaloma 187.10 48.44 58 16050 857 2341120
Dizziness 186.87 48.44 252 15856 58413 2283564
Intentional overdose 186.39 48.44 122 15986 11199 2330778
Coma 185.26 48.44 112 15996 8944 2333033
Lethargy 183.84 48.44 110 15998 8620 2333357
Extrapyramidal disorder 181.17 48.44 72 16036 2275 2339702
Psychiatric symptom 180.48 48.44 56 16052 830 2341147
Type 2 diabetes mellitus 175.28 48.44 69 16039 2125 2339852
Mean cell volume decreased 174.53 48.44 42 16066 217 2341760
Electrocardiogram abnormal 172.71 48.44 60 16048 1288 2340689
Dementia 171.90 48.44 72 16036 2609 2339368
Dysarthria 171.84 48.44 94 16014 6208 2335769
Epilepsy 168.89 48.44 84 16024 4555 2337422
Sopor 168.49 48.44 80 16028 3915 2338062
Anxiety 167.02 48.44 170 15938 29189 2312788
Cardiomyopathy 162.12 48.44 70 16038 2737 2339240
Therapy cessation 159.93 48.44 84 16024 5109 2336868
Unresponsive to stimuli 159.13 48.44 82 16026 4794 2337183
Cardiac disorder 157.95 48.44 96 16012 7737 2334240
Pericarditis 157.49 48.44 58 16050 1482 2340495
Obsessive-compulsive disorder 156.43 48.44 47 16061 621 2341356
Metabolic disorder 155.66 48.44 46 16062 572 2341405
Disorientation 154.52 48.44 88 16020 6284 2335693
Refusal of treatment by patient 153.39 48.44 54 16054 1207 2340770
Disturbance in social behaviour 148.79 48.44 35 16073 161 2341816
Muscle rigidity 147.72 48.44 58 16050 1773 2340204
Terminal state 145.58 48.44 45 16063 658 2341319
Mental status changes 143.22 48.44 80 16028 5502 2336475
Completed suicide 140.46 48.44 133 15975 20901 2321076
Blood prolactin abnormal 140.18 48.44 30 16078 80 2341897
Drooling 139.67 48.44 44 16064 687 2341290
Pleurothotonus 138.17 48.44 35 16073 231 2341746
Tardive dyskinesia 137.55 48.44 54 16054 1650 2340327
Asthma 137.06 48.44 101 16007 11213 2330764
Abdominal pain 136.63 48.44 165 15943 34209 2307768
Pleural effusion 136.51 48.44 102 16006 11566 2330411
Hepatic steatosis 134.44 48.44 64 16044 3149 2338828
Condition aggravated 132.84 48.44 157 15951 31822 2310155
Red cell distribution width increased 130.80 48.44 40 16068 563 2341414
Enuresis 130.39 48.44 36 16072 344 2341633
Sudden death 129.54 48.44 53 16055 1807 2340170
Dysphagia 128.09 48.44 102 16006 12703 2329274
Blood albumin decreased 127.93 48.44 52 16056 1743 2340234
Diarrhoea 126.82 48.44 257 15851 83307 2258670
Ileus 124.88 48.44 54 16054 2118 2339859
Cerebrovascular accident 122.27 48.44 121 15987 20065 2321912
Chest pain 121.60 48.44 141 15967 27996 2313981
Medication error 120.66 48.44 74 16034 6057 2335920
Haemoglobin increased 120.33 48.44 35 16073 410 2341567
Blood prolactin increased 119.58 48.44 43 16065 1024 2340953
Accidental exposure to product 119.32 48.44 83 16025 8414 2333563
Hypophagia 118.33 48.44 63 16045 3937 2338040
Abdominal distension 117.31 48.44 89 16019 10322 2331655
Ankle fracture 116.28 48.44 52 16056 2213 2339764
Lymphocyte count increased 116.10 48.44 35 16073 468 2341509
Weight decreased 115.67 48.44 138 15970 28233 2313744
Tremor 114.44 48.44 118 15990 20543 2321434
Cardio-respiratory arrest 113.82 48.44 83 16025 9063 2332914
Red blood cell sedimentation rate increased 112.71 48.44 50 16058 2087 2339890
Electrocardiogram T wave abnormal 112.68 48.44 32 16076 342 2341635
Blood creatinine increased 112.01 48.44 87 16021 10446 2331531
Hypertension 111.40 48.44 133 15975 27228 2314749
Gait disturbance 111.11 48.44 121 15987 22424 2319553
Mean cell haemoglobin concentration decreased 110.50 48.44 28 16080 185 2341792
Blood urea decreased 110.13 48.44 31 16077 320 2341657
Mean cell volume increased 109.18 48.44 31 16077 331 2341646
Sexual dysfunction 107.25 48.44 30 16078 302 2341675
Cardiometabolic syndrome 106.73 48.44 28 16080 216 2341761
Psychotic symptom 106.61 48.44 27 16081 178 2341799
Renal impairment 106.53 48.44 83 16025 10009 2331968
Mutism 106.19 48.44 29 16079 265 2341712
Troponin T increased 105.96 48.44 27 16081 183 2341794
Syncope 103.75 48.44 102 16006 16773 2325204
Respiratory tract infection 101.32 48.44 57 16051 3972 2338005
Impaired self-care 101.27 48.44 29 16079 320 2341657
Respiratory disorder 98.94 48.44 56 16052 3948 2338029
Refusal of examination 97.10 48.44 18 16090 14 2341963
Asthenia 97.00 48.44 165 15943 46761 2295216
Monocyte count decreased 95.76 48.44 26 16082 232 2341745
Blood sodium decreased 95.01 48.44 50 16058 3050 2338927
Posture abnormal 94.90 48.44 29 16079 407 2341570
Personality change 94.58 48.44 35 16073 906 2341071
Surgery 94.35 48.44 61 16047 5474 2336503
Gastrointestinal hypomotility 93.74 48.44 26 16082 253 2341724
Cognitive disorder 93.44 48.44 60 16048 5321 2336656
Viral infection 93.44 48.44 57 16051 4619 2337358
Urinary retention 92.54 48.44 52 16056 3615 2338362
Hyperprolactinaemia 91.95 48.44 32 16076 690 2341287
Dehydration 91.75 48.44 109 15999 22186 2319791
Parkinsonism 91.73 48.44 39 16069 1466 2340511
Cardiac failure 91.41 48.44 82 16026 12012 2329965
Electrocardiogram T wave inversion 91.35 48.44 31 16077 618 2341359
Head injury 90.55 48.44 53 16055 3981 2337996
Renal failure 90.53 48.44 96 16012 17253 2324724
Hypothermia 90.51 48.44 43 16065 2105 2339872
Gastrointestinal carcinoma 89.98 48.44 26 16082 297 2341680
Ileus paralytic 88.90 48.44 32 16076 764 2341213
Overweight 88.88 48.44 28 16080 437 2341540
Mania 88.24 48.44 44 16064 2396 2339581
Blood urea increased 87.94 48.44 50 16058 3555 2338422
Akathisia 87.74 48.44 39 16069 1635 2340342
Urosepsis 87.60 48.44 41 16067 1940 2340037
Altered state of consciousness 87.40 48.44 51 16057 3809 2338168
Blood triglycerides increased 85.73 48.44 42 16066 2201 2339776
Exposure during pregnancy 85.68 48.44 112 15996 25107 2316870
Septic shock 85.46 48.44 63 16045 6991 2334986
Hip fracture 85.45 48.44 54 16054 4658 2337319
Glomerular filtration rate decreased 85.44 48.44 37 16071 1456 2340521
Wrong product administered 84.85 48.44 36 16072 1346 2340631
Blood pressure decreased 84.79 48.44 70 16038 9166 2332811
Aspartate aminotransferase increased 84.61 48.44 80 16028 12532 2329445
Neutrophil percentage increased 84.49 48.44 26 16082 374 2341603
Normal newborn 83.61 48.44 35 16073 1265 2340712
Borderline personality disorder 82.52 48.44 20 16088 107 2341870
Depression 82.03 48.44 116 15992 28016 2313961
Product use issue 81.27 48.44 77 16031 12092 2329885
Hepatitis C 79.68 48.44 35 16073 1426 2340551
Myocardial ischaemia 79.48 48.44 40 16068 2222 2339755
Speech disorder 78.91 48.44 58 16050 6406 2335571
Cellulitis 78.81 48.44 67 16041 9134 2332843
Lung cancer metastatic 78.08 48.44 26 16082 488 2341489
Influenza like illness 77.76 48.44 75 16033 12039 2329938
Acute kidney injury 77.65 48.44 113 15995 28009 2313968
Unevaluable event 76.67 48.44 65 16043 8826 2333151
Oxygen saturation decreased 74.91 48.44 60 16048 7526 2334451
Restlessness 74.61 48.44 49 16059 4514 2337463
Oculogyric crisis 74.47 48.44 23 16085 335 2341642
Incontinence 73.41 48.44 33 16075 1421 2340556
Iron deficiency anaemia 73.40 48.44 37 16071 2062 2339915
Arrhythmia 73.38 48.44 54 16054 5974 2336003
Ovarian cancer 73.37 48.44 32 16076 1281 2340696
Bipolar disorder 73.26 48.44 32 16076 1286 2340691
Appendicitis 73.24 48.44 31 16077 1152 2340825
Miosis 72.23 48.44 31 16077 1193 2340784
Pulmonary oedema 72.20 48.44 58 16050 7305 2334672
Abdominal tenderness 70.07 48.44 29 16079 1018 2340959
Depressed mood 68.83 48.44 49 16059 5149 2336828
Bundle branch block right 68.81 48.44 27 16081 823 2341154
Body mass index increased 68.59 48.44 18 16090 139 2341838
Gestational diabetes 68.50 48.44 31 16077 1356 2340621
Cholelithiasis 68.43 48.44 51 16057 5752 2336225
Maternal exposure during pregnancy 68.39 48.44 77 16031 14786 2327191
Red blood cell count increased 67.99 48.44 21 16087 306 2341671
Lower limb fracture 67.88 48.44 35 16073 2046 2339931
Subileus 67.71 48.44 24 16084 547 2341430
Respiratory depression 66.50 48.44 35 16073 2135 2339842
Sedation complication 66.45 48.44 18 16090 159 2341818
Hyperhidrosis 66.08 48.44 77 16031 15345 2326632
Oropharyngeal pain 65.93 48.44 67 16041 11451 2330526
Protein total decreased 65.91 48.44 26 16082 804 2341173
Blood disorder 65.63 48.44 27 16081 933 2341044
Respiratory arrest 65.59 48.44 51 16057 6127 2335850
Megacolon 65.42 48.44 20 16088 281 2341696
Left ventricular dysfunction 65.34 48.44 29 16079 1211 2340766
No adverse event 64.97 48.44 61 16047 9467 2332510
Blood pressure increased 64.89 48.44 80 16028 16906 2325071
Pyelonephritis 64.10 48.44 34 16074 2107 2339870
Self-injurious ideation 63.82 48.44 23 16085 551 2341426
Dysphemia 63.80 48.44 22 16086 461 2341516
Multiple organ dysfunction syndrome 62.09 48.44 54 16054 7587 2334390
Affective disorder 61.79 48.44 25 16083 827 2341150
Drug abuse 61.74 48.44 66 16042 11960 2330017
Neutrophil count abnormal 61.54 48.44 21 16087 426 2341551
Hypothyroidism 61.29 48.44 43 16065 4414 2337563
Negativism 61.26 48.44 16 16092 121 2341856
Non-Hodgkin's lymphoma 60.07 48.44 25 16083 890 2341087
Gastrointestinal sounds abnormal 60.05 48.44 22 16086 553 2341424
Tachypnoea 60.04 48.44 33 16075 2196 2339781
Tubulointerstitial nephritis 59.96 48.44 34 16074 2404 2339573
Haematemesis 59.93 48.44 41 16067 4041 2337936
Intestinal dilatation 59.81 48.44 18 16090 239 2341738
Persecutory delusion 59.36 48.44 21 16087 476 2341501
Thinking abnormal 58.59 48.44 31 16077 1911 2340066
Breast cancer metastatic 58.46 48.44 32 16076 2112 2339865
Eye movement disorder 58.24 48.44 26 16082 1101 2340876
Encephalopathy 58.10 48.44 42 16066 4519 2337458
Hypercholesterolaemia 57.98 48.44 29 16079 1589 2340388
Parotid gland enlargement 57.93 48.44 16 16092 153 2341824
Polydipsia 57.89 48.44 22 16086 614 2341363
Fatigue 57.45 48.44 193 15915 84680 2257297
Product dose omission 57.03 48.44 117 15991 38140 2303837
Social avoidant behaviour 56.95 48.44 21 16087 538 2341439
Stress 56.31 48.44 49 16059 6889 2335088
Cough 56.27 48.44 107 16001 33010 2308967
Living in residential institution 56.25 48.44 16 16092 172 2341805
Lymphoma 55.60 48.44 30 16078 1924 2340053
Hallucinations, mixed 55.26 48.44 21 16087 586 2341391
Caesarean section 55.25 48.44 39 16069 4042 2337935
Parotitis 55.08 48.44 17 16091 247 2341730
Brain neoplasm 54.89 48.44 23 16085 833 2341144
Incorrect dose administered 54.76 48.44 56 16052 9639 2332338
Suicidal behaviour 54.66 48.44 20 16088 501 2341476
Hepatic enzyme increased 54.25 48.44 56 16052 9746 2332231
Rhabdomyolysis 53.71 48.44 47 16061 6657 2335320
Respiratory distress 53.71 48.44 42 16066 5087 2336890
Body mass index decreased 53.62 48.44 12 16096 42 2341935
Thrombocytosis 53.13 48.44 23 16085 904 2341073
Emphysema 52.79 48.44 24 16084 1061 2340916
Intestinal ischaemia 52.66 48.44 24 16084 1067 2340910
Anal incontinence 52.65 48.44 28 16080 1744 2340233
Full blood count abnormal 51.97 48.44 17 16091 301 2341676
Cholecystitis 51.77 48.44 30 16078 2210 2339767
Hyperthermia 51.69 48.44 26 16082 1442 2340535
Glucose tolerance impaired 51.68 48.44 20 16088 587 2341390
Accidental overdose 51.56 48.44 37 16071 3935 2338042
Acute psychosis 51.44 48.44 19 16089 489 2341488
Pallor 51.21 48.44 36 16072 3706 2338271
Hallucination, visual 51.17 48.44 33 16075 2946 2339031
Insurance issue 51.13 48.44 18 16090 402 2341575
Huntington's disease 50.19 48.44 11 16097 34 2341943
Mobility decreased 49.96 48.44 51 16057 8759 2333218
White blood cell disorder 49.71 48.44 17 16091 347 2341630
Echocardiogram abnormal 49.58 48.44 15 16093 203 2341774
Personality disorder 49.40 48.44 17 16091 354 2341623
Small intestinal obstruction 49.37 48.44 29 16079 2191 2339786
Stupor 49.17 48.44 20 16088 671 2341306
Blood chloride decreased 48.75 48.44 20 16088 686 2341291
Tricuspid valve incompetence 48.73 48.44 26 16082 1630 2340347

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
White blood cell count increased 7208.25 38.35 1936 23585 5376 1715884
Neutrophil count increased 6621.18 38.35 1479 24042 1114 1720146
Granulocytopenia 4651.28 38.35 1017 24504 586 1720674
Schizophrenia 4021.97 38.35 945 24576 1101 1720159
Hospitalisation 3865.08 38.35 1368 24153 11332 1709928
Neutropenia 3792.09 38.35 1485 24036 16775 1704485
Death 3694.70 38.35 2400 23121 85043 1636217
White blood cell count decreased 2938.48 38.35 1130 24391 12019 1709241
Differential white blood cell count abnormal 2662.87 38.35 538 24983 38 1721222
Neutrophil count decreased 2638.74 38.35 857 24664 5224 1716036
Psychotic disorder 2411.70 38.35 766 24755 4290 1716970
Myocarditis 2409.92 38.35 618 24903 1285 1719975
Agranulocytosis 2375.46 38.35 699 24822 2877 1718383
Tachycardia 2323.76 38.35 944 24577 11684 1709576
Antipsychotic drug level increased 2223.76 38.35 479 25042 218 1721042
Mental impairment 2060.71 38.35 550 24971 1423 1719837
Salivary hypersecretion 2027.85 38.35 511 25010 954 1720306
Malaise 1839.40 38.35 1049 24472 28516 1692744
Lower respiratory tract infection 1596.01 38.35 525 24996 3326 1717934
Leukopenia 1563.93 38.35 636 24885 7844 1713416
C-reactive protein increased 1546.26 38.35 571 24950 5314 1715946
Haemoglobin decreased 1535.92 38.35 776 24745 16338 1704922
Pneumonia 1379.50 38.35 1035 24486 45147 1676113
Sedation 1368.08 38.35 454 25067 2963 1718297
Neuroleptic malignant syndrome 1351.73 38.35 441 25080 2707 1718553
Pyrexia 1255.75 38.35 981 24540 45419 1675841
Blood creatine phosphokinase increased 1148.57 38.35 518 25003 8338 1712922
Mental disorder 1059.29 38.35 358 25163 2485 1718775
Eosinophil count increased 1044.23 38.35 300 25221 1101 1720159
Constipation 976.51 38.35 550 24971 14450 1706810
Fall 943.29 38.35 669 24852 26545 1694715
Platelet count decreased 942.77 38.35 556 24965 15967 1705293
Treatment noncompliance 940.04 38.35 385 25136 4816 1716444
Platelet count increased 927.90 38.35 283 25238 1338 1719922
Seizure 848.49 38.35 562 24959 19879 1701381
Troponin increased 831.86 38.35 248 25273 1067 1720193
Somnolence 812.48 38.35 508 25013 16231 1705029
Leukocytosis 807.60 38.35 310 25211 3223 1718037
Sinus tachycardia 773.44 38.35 275 25246 2257 1719003
Hallucination, auditory 766.38 38.35 261 25260 1856 1719404
Pneumonia aspiration 765.43 38.35 334 25187 4932 1716328
Urinary tract infection 736.05 38.35 400 25121 9753 1711507
Electrocardiogram QT prolonged 720.12 38.35 325 25196 5220 1716040
Confusional state 708.46 38.35 511 25010 20767 1700493
Antipsychotic drug level below therapeutic 705.39 38.35 148 25373 41 1721219
Heart rate increased 679.40 38.35 328 25193 6182 1715078
Neutrophilia 654.61 38.35 172 25349 405 1720855
Agitation 654.29 38.35 381 25140 10645 1710615
Vomiting 646.06 38.35 620 24901 37695 1683565
Overdose 641.58 38.35 438 25083 16263 1704997
Circulatory collapse 637.50 38.35 260 25261 3207 1718053
Antipsychotic drug level decreased 616.79 38.35 128 25393 27 1721233
Infection 611.48 38.35 380 25141 11980 1709280
Antipsychotic drug level above therapeutic 607.52 38.35 134 25387 82 1721178
Lung neoplasm malignant 596.80 38.35 242 25279 2937 1718323
Aggression 558.24 38.35 309 25212 7806 1713454
Eosinophilia 552.58 38.35 236 25285 3291 1717969
Catatonia 547.00 38.35 164 25357 721 1720539
Weight increased 543.59 38.35 342 25179 11015 1710245
Body temperature increased 541.26 38.35 215 25306 2462 1718798
Delusion 535.62 38.35 203 25318 2028 1719232
Monocyte count increased 533.13 38.35 146 25375 426 1720834
Abnormal behaviour 530.24 38.35 275 25246 6067 1715193
Cardiomyopathy 528.59 38.35 213 25308 2539 1718721
Sepsis 505.26 38.35 403 25118 19035 1702225
Cardiac disorder 499.38 38.35 282 25239 7409 1713851
Faecaloma 492.47 38.35 144 25377 569 1720691
Red blood cell count decreased 487.69 38.35 219 25302 3467 1717793
Myocardial infarction 457.60 38.35 440 25081 26734 1694526
Diabetes mellitus 455.76 38.35 256 25265 6652 1714608
Paranoia 440.27 38.35 175 25346 2006 1719254
Neoplasm malignant 435.49 38.35 213 25308 4126 1717134
Obsessive-compulsive disorder 428.97 38.35 134 25387 694 1720566
General physical health deterioration 428.86 38.35 312 25209 12806 1708454
Obesity 425.73 38.35 142 25379 937 1720323
Drug interaction 424.75 38.35 428 25093 27530 1693730
Chest pain 424.12 38.35 368 25153 19546 1701714
Intestinal obstruction 421.78 38.35 195 25326 3312 1717948
Lymphocyte count decreased 421.62 38.35 170 25351 2028 1719232
Drug level increased 419.04 38.35 181 25340 2596 1718664
Delirium 414.87 38.35 234 25287 6128 1715132
Parkinson's disease 412.65 38.35 157 25364 1585 1719675
Alanine aminotransferase increased 403.54 38.35 293 25228 11985 1709275
Hepatitis C 391.84 38.35 173 25348 2623 1718637
Haematocrit decreased 390.99 38.35 197 25324 4076 1717184
Chronic obstructive pulmonary disease 388.26 38.35 219 25302 5734 1715526
Myoclonus 384.09 38.35 161 25360 2134 1719126
Hypotension 380.72 38.35 415 25106 29239 1692021
Left ventricular dysfunction 375.16 38.35 133 25388 1078 1720182
Electrocardiogram abnormal 371.15 38.35 132 25389 1081 1720179
Pericarditis 369.28 38.35 140 25381 1398 1719862
Loss of consciousness 355.75 38.35 294 25227 14581 1706679
Generalised tonic-clonic seizure 351.13 38.35 180 25341 3866 1717394
Aspiration 346.15 38.35 141 25380 1729 1719531
Lymphocyte count increased 343.14 38.35 100 25421 389 1720871
Pericardial effusion 338.86 38.35 166 25355 3224 1718036
Cardiac arrest 336.16 38.35 293 25228 15637 1705623
Therapy cessation 335.74 38.35 161 25360 2978 1718282
Dyspnoea 327.36 38.35 512 25009 51547 1669713
Anxiety 322.41 38.35 283 25238 15244 1706016
General physical condition abnormal 322.38 38.35 104 25417 608 1720652
Orthostatic hypotension 319.19 38.35 160 25361 3271 1717989
Ejection fraction decreased 318.07 38.35 140 25381 2105 1719155
Influenza like illness 316.44 38.35 193 25328 5860 1715400
Dysphagia 314.45 38.35 234 25287 9934 1711326
Toxicity to various agents 311.45 38.35 371 25150 28770 1692490
Extrapyramidal disorder 310.39 38.35 140 25381 2237 1719023
Gamma-glutamyltransferase increased 304.13 38.35 177 25344 4921 1716339
Drooling 300.24 38.35 101 25420 686 1720574
Left ventricular hypertrophy 296.26 38.35 102 25419 750 1720510
Thrombocytopenia 289.30 38.35 307 25214 20942 1700318
Blood triglycerides increased 289.15 38.35 137 25384 2463 1718797
Viral infection 287.60 38.35 141 25380 2742 1718518
Psychiatric decompensation 285.94 38.35 77 25444 206 1721054
Blood glucose increased 275.71 38.35 220 25301 10364 1710896
Mean cell haemoglobin decreased 274.56 38.35 69 25452 125 1721135
Unresponsive to stimuli 274.21 38.35 160 25361 4469 1716791
Haemoglobin increased 274.02 38.35 87 25434 479 1720781
Muscle rigidity 270.72 38.35 118 25403 1730 1719530
Dysarthria 270.55 38.35 166 25355 5093 1716167
Mean cell volume decreased 269.25 38.35 68 25453 127 1721133
Hallucination 268.29 38.35 195 25326 7975 1713285
Suicide attempt 267.31 38.35 187 25334 7194 1714066
Eosinophil count decreased 258.37 38.35 66 25455 132 1721128
Blood cholesterol increased 254.93 38.35 132 25389 2894 1718366
Sudden death 252.73 38.35 130 25391 2810 1718450
Hyperhidrosis 251.90 38.35 224 25297 12264 1708996
Urinary incontinence 249.79 38.35 126 25395 2610 1718650
Type 2 diabetes mellitus 249.60 38.35 112 25409 1766 1719494
Choking 243.97 38.35 93 25428 943 1720317
Completed suicide 242.23 38.35 247 25274 16065 1705195
Gastrointestinal hypomotility 237.67 38.35 65 25456 188 1721072
Pulmonary embolism 237.47 38.35 221 25300 12838 1708422
Suicidal ideation 230.25 38.35 181 25340 8337 1712923
Ileus paralytic 228.41 38.35 87 25434 880 1720380
Pre-existing disease 225.43 38.35 51 25470 41 1721219
Abdominal pain 225.07 38.35 271 25250 21219 1700041
Intentional self-injury 223.43 38.35 116 25405 2557 1718703
Dizziness 222.50 38.35 343 25178 34018 1687242
Schizoaffective disorder 217.70 38.35 59 25462 163 1721097
Weight decreased 217.44 38.35 274 25247 22479 1698781
Hypertension 216.43 38.35 253 25268 19195 1702065
Drug ineffective 214.62 38.35 480 25041 63321 1657939
Liver function test abnormal 214.14 38.35 148 25373 5578 1715682
Psychiatric symptom 213.98 38.35 79 25442 727 1720533
Disorientation 213.14 38.35 145 25376 5324 1715936
Lethargy 210.15 38.35 160 25361 7024 1714236
Thinking abnormal 209.32 38.35 89 25432 1223 1720037
Epilepsy 208.80 38.35 127 25394 3832 1717428
Blood pressure increased 199.36 38.35 184 25337 10569 1710691
Terminal state 195.01 38.35 74 25447 740 1720520
Dyskinesia 194.99 38.35 120 25401 3699 1717561
Coma 191.26 38.35 152 25369 7110 1714150
Red blood cell sedimentation rate increased 190.62 38.35 79 25442 1014 1720246
Dehydration 188.62 38.35 225 25296 17433 1703827
Blood alkaline phosphatase increased 186.58 38.35 131 25390 5064 1716196
Depressed level of consciousness 184.44 38.35 143 25378 6449 1714811
Cardiomegaly 182.85 38.35 97 25424 2237 1719023
Bundle branch block right 182.74 38.35 80 25441 1185 1720075
Tremor 182.54 38.35 192 25329 12939 1708321
Enuresis 181.27 38.35 59 25462 356 1720904
Body mass index increased 179.73 38.35 46 25475 93 1721167
Troponin T increased 179.34 38.35 54 25467 241 1721019
Lymphoma 178.73 38.35 92 25429 1990 1719270
Anaemia 178.00 38.35 285 25236 29172 1692088
Congestive cardiomyopathy 177.77 38.35 77 25444 1110 1720150
Echocardiogram abnormal 176.85 38.35 49 25472 151 1721109
Psychotic symptom 176.07 38.35 50 25471 173 1721087
Overweight 174.69 38.35 53 25468 244 1721016
Ventricular hypokinesia 171.10 38.35 65 25456 652 1720608
Aspartate aminotransferase increased 170.81 38.35 169 25352 10587 1710673
Tardive dyskinesia 170.14 38.35 74 25447 1078 1720182
Myocardial ischaemia 167.26 38.35 102 25419 3091 1718169
Syncope 167.07 38.35 190 25331 13979 1707281
Restlessness 162.27 38.35 112 25409 4209 1717051
Akathisia 160.05 38.35 74 25447 1254 1720006
Ileus 159.37 38.35 90 25431 2356 1718904
Rhabdomyolysis 159.20 38.35 165 25356 10925 1710335
Mean cell volume increased 158.38 38.35 48 25473 220 1721040
Condition aggravated 156.57 38.35 225 25296 20925 1700335
Coma scale abnormal 156.39 38.35 58 25463 541 1720719
Gait disturbance 156.36 38.35 174 25347 12496 1708764
Mitral valve incompetence 155.78 38.35 82 25439 1860 1719400
Abdominal distension 155.12 38.35 128 25393 6316 1714944
Parkinsonism 154.82 38.35 73 25448 1296 1719964
Respiratory failure 153.48 38.35 184 25337 14321 1706939
Respiratory tract infection 152.43 38.35 88 25433 2405 1718855
Intentional overdose 151.41 38.35 136 25385 7534 1713726
Megacolon 150.59 38.35 48 25473 268 1720992
Arrhythmia 147.95 38.35 121 25400 5895 1715365
Cardiac failure 146.87 38.35 168 25353 12434 1708826
Appendicitis 144.71 38.35 66 25455 1082 1720178
Diarrhoea 143.94 38.35 371 25150 53481 1667779
Speech disorder 138.95 38.35 104 25417 4444 1716816
Polydipsia 137.88 38.35 56 25465 680 1720580
Blood creatinine increased 134.74 38.35 169 25352 13777 1707483
Mental status changes 134.51 38.35 115 25406 5960 1715300
Hypophagia 134.51 38.35 92 25429 3405 1717855
Colitis ischaemic 134.27 38.35 58 25463 830 1720430
Dystonia 133.63 38.35 75 25446 1939 1719321
Arteriosclerosis coronary artery 132.49 38.35 73 25448 1819 1719441
Pulmonary oedema 132.40 38.35 118 25403 6468 1714792
Pleural effusion 130.95 38.35 149 25372 10961 1710299
Dementia 130.84 38.35 75 25446 2021 1719239
Cerebrovascular accident 130.62 38.35 189 25332 17677 1703583
Refusal of treatment by patient 129.76 38.35 62 25459 1135 1720125
Small intestinal obstruction 129.33 38.35 71 25450 1756 1719504
Hepatitis C virus test positive 129.31 38.35 35 25486 96 1721164
Oropharyngeal pain 129.29 38.35 102 25419 4716 1716544
Apathy 128.05 38.35 63 25458 1233 1720027
Persecutory delusion 127.26 38.35 46 25475 396 1720864
Blood sodium decreased 126.85 38.35 76 25445 2228 1719032
Red cell distribution width increased 126.83 38.35 45 25476 365 1720895
Cough 125.91 38.35 193 25328 19004 1702256
Gastrointestinal necrosis 125.69 38.35 50 25471 573 1720687
Non-Hodgkin's lymphoma 124.40 38.35 56 25465 889 1720371
Tricuspid valve incompetence 124.40 38.35 61 25460 1185 1720075
Intestinal dilatation 124.35 38.35 40 25481 231 1721029
Respiratory disorder 123.85 38.35 84 25437 3065 1718195
Left atrial dilatation 123.37 38.35 39 25482 211 1721049
Oesophageal carcinoma 122.73 38.35 51 25470 659 1720601
Ankle fracture 120.49 38.35 49 25472 597 1720663
Lung cancer metastatic 119.54 38.35 47 25474 521 1720739
Medication error 117.88 38.35 96 25425 4647 1716613
Eating disorder 117.74 38.35 59 25462 1203 1720057
Cognitive disorder 116.90 38.35 92 25429 4238 1717022
Blood prolactin increased 116.82 38.35 44 25477 430 1720830
Electroencephalogram abnormal 116.08 38.35 48 25473 612 1720648
Anosognosia 115.47 38.35 28 25493 40 1721220
Bundle branch block left 115.24 38.35 51 25470 776 1720484
Mania 113.91 38.35 69 25452 2064 1719196
Alcohol abuse 113.81 38.35 46 25475 551 1720709
Troponin I increased 113.79 38.35 39 25482 282 1720978
Pulmonary congestion 113.77 38.35 65 25456 1740 1719520
Lower limb fracture 113.50 38.35 50 25471 752 1720508
Refusal of examination 113.30 38.35 24 25497 8 1721252
Red blood cell count increased 112.73 38.35 37 25484 230 1721030
Blood test abnormal 112.73 38.35 52 25469 876 1720384
Electrocardiogram T wave abnormal 109.93 38.35 36 25485 222 1721038
Cardiometabolic syndrome 108.02 38.35 37 25484 267 1720993
Dilatation ventricular 107.98 38.35 44 25477 539 1720721
Blood disorder 107.22 38.35 45 25476 597 1720663
Cellulitis 107.05 38.35 104 25417 6364 1714896
Pallor 106.42 38.35 79 25442 3332 1717928
Lymphocytosis 106.01 38.35 40 25481 393 1720867
Blood urea increased 105.95 38.35 90 25431 4621 1716639
Sleep apnoea syndrome 105.65 38.35 66 25455 2088 1719172
Head injury 105.63 38.35 75 25446 2949 1718311
Depression 104.27 38.35 164 25357 16505 1704755
Gastroenteritis 102.58 38.35 64 25457 2020 1719240
Renal failure 102.51 38.35 180 25341 19837 1701423
Product use in unapproved indication 102.04 38.35 121 25400 9301 1711959
Fatigue 101.41 38.35 315 25206 50466 1670794
Waist circumference increased 100.67 38.35 29 25492 107 1721153
Blood urea decreased 100.33 38.35 32 25489 179 1721081
Impaired self-care 100.24 38.35 31 25490 154 1721106
Palpitations 98.85 38.35 102 25419 6712 1714548
Electrocardiogram T wave inversion 96.02 38.35 38 25483 429 1720831
Brain injury 95.59 38.35 48 25473 983 1720277
Empyema 95.47 38.35 38 25483 436 1720824
Incorrect dose administered 95.23 38.35 104 25417 7305 1713955
Appendicitis perforated 95.07 38.35 35 25486 319 1720941
Hepatic steatosis 94.70 38.35 66 25455 2518 1718742
Mean cell haemoglobin concentration decreased 92.82 38.35 27 25494 104 1721156
Blood creatinine decreased 92.12 38.35 36 25485 392 1720868
Intestinal ischaemia 91.72 38.35 47 25474 1006 1720254
Nasopharyngitis 91.42 38.35 118 25403 9892 1711368
Gastrointestinal carcinoma 91.19 38.35 33 25488 285 1720975
Bipolar disorder 90.38 38.35 42 25479 720 1720540
Splenomegaly 89.24 38.35 59 25462 2061 1719199
Haematemesis 89.10 38.35 79 25442 4298 1716962
Asthma 89.03 38.35 83 25438 4821 1716439
Influenza 88.74 38.35 96 25425 6671 1714589
Hyperlipidaemia 86.55 38.35 59 25462 2170 1719090
Cardio-respiratory arrest 85.57 38.35 110 25411 9183 1712077
Full blood count abnormal 85.05 38.35 29 25492 206 1721054
Disinhibition 85.02 38.35 32 25489 312 1720948
Surgery 84.18 38.35 64 25457 2799 1718461
Lung disorder 84.12 38.35 82 25439 5037 1716223
Asthenia 83.44 38.35 230 25291 34440 1686820
Upper respiratory tract infection 81.57 38.35 73 25448 4020 1717240
Nausea 81.24 38.35 294 25227 50902 1670358
Hyperthermia 80.89 38.35 51 25470 1640 1719620
Withdrawal syndrome 80.49 38.35 57 25464 2231 1719029
Conduction disorder 80.49 38.35 32 25489 366 1720894
QRS axis abnormal 80.02 38.35 27 25494 185 1721075
Psychiatric evaluation 80.00 38.35 17 25504 6 1721254
Product dose omission 79.74 38.35 173 25348 22267 1698993
Oculogyric crisis 79.62 38.35 31 25490 334 1720926
Blood pressure fluctuation 79.35 38.35 46 25475 1266 1719994
Social avoidant behaviour 78.22 38.35 36 25485 603 1720657
Obsessive thoughts 76.95 38.35 26 25495 179 1721081
Hyponatraemia 75.84 38.35 102 25419 8898 1712362
Incontinence 75.74 38.35 41 25480 985 1720275
Monocyte count decreased 75.43 38.35 24 25497 133 1721127
Aortic dilatation 75.15 38.35 25 25496 163 1721097
Blood albumin decreased 74.59 38.35 48 25473 1600 1719660
Systolic dysfunction 74.26 38.35 24 25497 141 1721119
Pulmonary valve incompetence 73.83 38.35 24 25497 144 1721116
Electrocardiogram ST segment elevation 73.57 38.35 39 25482 897 1720363
Acute psychosis 72.10 38.35 31 25490 438 1720822
Blood sodium increased 72.10 38.35 31 25490 438 1720822
Drug abuse 71.20 38.35 124 25397 13565 1707695
Appendicectomy 71.00 38.35 26 25495 233 1721027
Acute kidney injury 70.78 38.35 218 25303 34726 1686534
Multiple organ dysfunction syndrome 70.75 38.35 100 25421 9142 1712118
Glucose tolerance impaired 70.74 38.35 30 25491 409 1720851
Volvulus 70.52 38.35 26 25495 238 1721022
Chronic lymphocytic leukaemia 70.27 38.35 37 25484 839 1720421
Posture abnormal 70.11 38.35 29 25492 370 1720890
Autism spectrum disorder 69.75 38.35 28 25493 329 1720931
Testis cancer 69.30 38.35 26 25495 251 1721009
Pancreatitis 69.20 38.35 87 25434 7100 1714160
Hypersplenism 69.17 38.35 20 25501 75 1721185
Road traffic accident 69.17 38.35 63 25458 3550 1717710
Substance abuse 68.29 38.35 38 25483 965 1720295
Metabolic acidosis 67.97 38.35 75 25446 5327 1715933
Glomerular filtration rate decreased 67.34 38.35 43 25478 1414 1719846
Ventricular hypertrophy 66.58 38.35 35 25486 791 1720469
Respiratory arrest 66.54 38.35 77 25444 5762 1715498
Faecal vomiting 66.40 38.35 19 25502 68 1721192
Dementia with Lewy bodies 66.28 38.35 20 25501 90 1721170
Chest discomfort 66.26 38.35 86 25435 7245 1714015
Disturbance in attention 66.17 38.35 66 25455 4168 1717092
Diastolic dysfunction 66.02 38.35 30 25491 487 1720773
Globulins decreased 65.88 38.35 17 25504 36 1721224
Unevaluable event 65.81 38.35 78 25443 5988 1715272
Hypoxia 65.23 38.35 77 25444 5886 1715374
Gastritis 64.91 38.35 57 25464 3060 1718200
Polydipsia psychogenic 64.66 38.35 17 25504 40 1721220
Urinary retention 64.62 38.35 73 25448 5322 1715938
Depressed mood 64.51 38.35 56 25465 2960 1718300
Brain neoplasm 64.35 38.35 32 25489 641 1720619
Accidental exposure to product 64.22 38.35 64 25457 4037 1717223
Mean cell haemoglobin concentration increased 64.08 38.35 17 25504 42 1721218
Increased appetite 63.97 38.35 36 25485 935 1720325
Dyslipidaemia 63.79 38.35 34 25487 791 1720469
Muscle twitching 63.64 38.35 45 25476 1757 1719503
Pharyngitis 63.52 38.35 38 25483 1110 1720150
Hallucination, visual 63.41 38.35 52 25469 2540 1718720
Bradykinesia 62.94 38.35 29 25492 487 1720773
Intestinal pseudo-obstruction 62.81 38.35 22 25499 171 1721089
Suspiciousness 62.70 38.35 19 25502 87 1721173
Emotional distress 61.96 38.35 45 25476 1833 1719427
Protein total decreased 61.50 38.35 31 25490 640 1720620
Monocytosis 61.39 38.35 20 25501 121 1721139
Tachypnoea 61.27 38.35 49 25472 2309 1718951
Septic shock 60.97 38.35 87 25434 8022 1713238
Blunted affect 60.76 38.35 18 25503 75 1721185
Body temperature decreased 60.44 38.35 36 25485 1043 1720217
Myocardial necrosis marker increased 60.36 38.35 25 25496 320 1720940
Product use issue 60.14 38.35 89 25432 8482 1712778
Movement disorder 59.66 38.35 42 25479 1628 1719632
Endotracheal intubation 59.49 38.35 27 25494 437 1720823
Anion gap increased 59.22 38.35 23 25498 246 1721014
Blood pressure decreased 58.91 38.35 83 25438 7563 1713697
Blood lactate dehydrogenase increased 58.75 38.35 58 25463 3617 1717643
Cholelithiasis 58.27 38.35 54 25467 3111 1718149
Cardiotoxicity 58.10 38.35 32 25489 796 1720464
Hypersomnia 58.04 38.35 42 25479 1701 1719559
Hypothermia 57.94 38.35 42 25479 1706 1719554
Sleep disorder 57.43 38.35 60 25461 4003 1717257
Disease recurrence 57.37 38.35 49 25472 2533 1718727
Drug level decreased 57.24 38.35 34 25487 980 1720280
Renal impairment 56.95 38.35 106 25415 12208 1709052
Hodgkin's disease 56.91 38.35 31 25490 754 1720506
High density lipoprotein decreased 56.24 38.35 29 25492 629 1720631
Waxy flexibility 55.99 38.35 15 25506 39 1721221
Basophil count increased 55.72 38.35 17 25504 80 1721180
Emphysema 55.54 38.35 36 25485 1215 1720045
Blood count abnormal 55.22 38.35 38 25483 1419 1719841
Therapeutic product effect variable 54.55 38.35 18 25503 114 1721146
Stress 54.40 38.35 48 25473 2593 1718667
Deep vein thrombosis 54.38 38.35 92 25429 9828 1711432
Stupor 54.19 38.35 28 25493 610 1720650
Mutism 54.06 38.35 20 25501 185 1721075
Intestinal perforation 53.88 38.35 39 25482 1580 1719680
Insomnia 53.86 38.35 122 25399 16154 1705106
Respiratory distress 53.79 38.35 65 25456 5092 1716168
Mean cell haemoglobin increased 53.77 38.35 18 25503 120 1721140
Chronic hepatitis C 53.75 38.35 16 25505 68 1721192
Huntington's disease 53.70 38.35 15 25506 48 1721212
Injury 53.52 38.35 50 25471 2910 1718350
Gastrointestinal disorder 53.07 38.35 62 25459 4686 1716574
Total cholesterol/HDL ratio increased 52.65 38.35 13 25508 21 1721239
Dysphemia 52.56 38.35 23 25498 340 1720920
Heart rate irregular 52.34 38.35 39 25482 1653 1719607
Euphoric mood 52.09 38.35 30 25491 815 1720445
Gastrointestinal haemorrhage 51.79 38.35 111 25410 14156 1707104
Left ventricular failure 51.74 38.35 28 25493 672 1720588
Living in residential institution 51.61 38.35 17 25504 107 1721153
Heat stroke 51.49 38.35 20 25501 214 1721046
Intellectual disability 51.24 38.35 19 25502 177 1721083
Laparotomy 51.16 38.35 16 25505 83 1721177
Blood lactate dehydrogenase decreased 50.73 38.35 15 25506 62 1721198
Abdominal compartment syndrome 50.69 38.35 17 25504 114 1721146
Mechanical ventilation 50.59 38.35 22 25499 320 1720940
Metabolic disorder 49.99 38.35 25 25496 507 1720753
Cyanosis 49.96 38.35 46 25475 2628 1718632
Incoherent 49.80 38.35 29 25492 805 1720455
Hepatic enzyme increased 49.71 38.35 71 25450 6550 1714710
Throat cancer 49.70 38.35 19 25502 194 1721066
C-reactive protein decreased 49.62 38.35 15 25506 68 1721192
Hyperpyrexia 49.32 38.35 26 25495 591 1720669
Sudden cardiac death 49.10 38.35 29 25492 827 1720433
Lymphocyte percentage increased 48.92 38.35 15 25506 72 1721188
Productive cough 48.92 38.35 52 25469 3539 1717721
Blood bilirubin increased 48.71 38.35 68 25453 6142 1715118
Musculoskeletal stiffness 48.58 38.35 66 25455 5810 1715450
Hypogammaglobulinaemia 48.46 38.35 26 25495 613 1720647
Parkinson's disease psychosis 48.25 38.35 10 25511 2 1721258
Alcohol poisoning 47.94 38.35 24 25497 488 1720772
Myocardial fibrosis 47.79 38.35 17 25504 139 1721121
Asphyxia 47.67 38.35 31 25490 1052 1720208
Chronic kidney disease 47.63 38.35 56 25465 4261 1716999
Therapeutic response decreased 47.34 38.35 63 25458 5437 1715823
Respiratory rate increased 47.29 38.35 33 25488 1261 1719999
B-cell lymphoma 47.20 38.35 28 25493 805 1720455
No adverse event 47.15 38.35 61 25460 5121 1716139
Peritonitis 47.10 38.35 45 25476 2694 1718566
Illusion 46.72 38.35 18 25503 188 1721072
Communication disorder 46.62 38.35 22 25499 391 1720869
Metastases to central nervous system 46.43 38.35 35 25486 1510 1719750
Cardiopulmonary failure 45.75 38.35 28 25493 853 1720407
Suicidal behaviour 45.72 38.35 21 25500 350 1720910
Diabetic ketoacidosis 45.54 38.35 48 25473 3235 1718025
Irritability 45.53 38.35 62 25459 5470 1715790
Drug withdrawal syndrome 45.51 38.35 56 25465 4469 1716791
Body temperature fluctuation 44.96 38.35 16 25505 131 1721129
White blood cell disorder 44.93 38.35 19 25502 257 1721003
Transient ischaemic attack 44.53 38.35 57 25464 4734 1716526
Ill-defined disorder 44.47 38.35 37 25484 1844 1719416
Lymphocyte morphology abnormal 44.33 38.35 16 25505 137 1721123
Drug level changed 44.33 38.35 16 25505 137 1721123
Eosinophilic colitis 44.30 38.35 13 25508 52 1721208
Myoglobin blood increased 44.09 38.35 22 25499 444 1720816
Blood potassium decreased 43.89 38.35 40 25481 2255 1719005
Lung abscess 43.87 38.35 22 25499 449 1720811
Psychotic behaviour 43.73 38.35 16 25505 143 1721117
Urosepsis 43.63 38.35 33 25488 1431 1719829
Ventricular extrasystoles 43.54 38.35 37 25484 1899 1719361
Sexual dysfunction 43.39 38.35 36 25485 1787 1719473
Balance disorder 43.16 38.35 62 25459 5750 1715510
Leukaemia 43.08 38.35 26 25495 772 1720488
Blood bicarbonate decreased 43.04 38.35 21 25500 403 1720857
Altered state of consciousness 43.03 38.35 48 25473 3449 1717811
Monocyte percentage increased 43.00 38.35 15 25506 115 1721145
Affective disorder 42.96 38.35 25 25496 693 1720567
Necrotising colitis 42.87 38.35 18 25503 239 1721021
Neutrophil percentage increased 42.80 38.35 18 25503 240 1721020
Gastrooesophageal reflux disease 42.74 38.35 55 25466 4592 1716668
Sopor 42.48 38.35 37 25484 1964 1719296
Electrocardiogram change 42.48 38.35 17 25504 198 1721062
Cogwheel rigidity 42.48 38.35 17 25504 198 1721062
Chest X-ray abnormal 42.45 38.35 24 25497 629 1720631
Drug level above therapeutic 42.21 38.35 22 25499 488 1720772
Hypercholesterolaemia 42.18 38.35 30 25491 1182 1720078
Drowning 42.15 38.35 16 25505 160 1721100
Accident 42.10 38.35 26 25495 805 1720455
Tonsillitis 42.05 38.35 22 25499 492 1720768
Lymphopenia 41.97 38.35 37 25484 1996 1719264
Exercise tolerance decreased 41.94 38.35 23 25498 567 1720693
Aortic valve incompetence 41.64 38.35 25 25496 735 1720525
Regurgitation 41.12 38.35 16 25505 172 1721088
Tobacco interaction 41.10 38.35 9 25512 5 1721255
Accidental overdose 41.02 38.35 51 25470 4113 1717147
Imprisonment 40.71 38.35 15 25506 137 1721123
Rebound psychosis 40.18 38.35 10 25511 17 1721243
Hypothyroidism 40.17 38.35 40 25481 2520 1718740
Inflammation 40.15 38.35 46 25475 3404 1717856
Petit mal epilepsy 39.99 38.35 22 25499 546 1720714
Gastric dilatation 39.62 38.35 14 25507 112 1721148
Type 1 diabetes mellitus 39.55 38.35 25 25496 807 1720453
Cholecystitis 39.28 38.35 32 25489 1548 1719712
Priapism 39.27 38.35 31 25490 1433 1719827
Decubitus ulcer 38.82 38.35 27 25494 1026 1720234
Hip fracture 38.78 38.35 33 25488 1697 1719563
Liver disorder 38.78 38.35 58 25463 5578 1715682
Blood calcium decreased 38.76 38.35 30 25491 1347 1719913
Wrong product administered 38.75 38.35 28 25493 1131 1720129
Cardiac septal hypertrophy 38.74 38.35 11 25510 38 1721222
Delusional disorder, unspecified type 38.67 38.35 14 25507 121 1721139
Anal incontinence 38.60 38.35 28 25493 1138 1720122
Polyserositis 38.57 38.35 12 25509 61 1721199
Lung consolidation 38.52 38.35 22 25499 588 1720672
Oxygen saturation decreased 38.47 38.35 58 25463 5617 1715643

Pharmacologic Action:

SourceCodeDescription
ATC N05AH02 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
CHEBI has role CHEBI:48279 serotonergic antagonist
CHEBI has role CHEBI:48561 dopaminergic antagonist
CHEBI has role CHEBI:37887 adrenergic antagonist
CHEBI has role CHEBI:37956 histamine antagonist
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:65259 GABA antagonist
CHEBI has role CHEBI:65191 second generation antipsychotic
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018756 GABA Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Treatment-Resistant Schizophrenia indication
Suicidal Behavior in Schizophrenia indication
Suicidal Behavior in Schizoaffective Disorder indication
Bipolar disorder in remission off-label use 85248005
Bipolar affective disorder, current episode manic off-label use 191618007
Sinus tachycardia contraindication 11092001
Constipation contraindication 14760008 DOID:2089
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Alcohol-induced psychosis contraindication 42344001 DOID:252
Fecal impaction contraindication 44635007
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Drug-induced neutropenia contraindication 47318007
Myocarditis contraindication 50920009 DOID:820
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Cerebrovascular disease contraindication 62914000 DOID:6713
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Decreased respiratory function contraindication 80954004
Leukopenia contraindication 84828003 DOID:615
Tardive dyskinesia contraindication 102449007
Deep venous thrombosis contraindication 128053003
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Primary dilated cardiomyopathy contraindication 195021004
Cerebrovascular accident contraindication 230690007
Pulmonary thromboembolism contraindication 233935004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Syncope contraindication 271594007
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Eosinophil count raised contraindication 386789004
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Obesity contraindication 414916001 DOID:9970
Central nervous system depression contraindication 418072004
Gastrointestinal hypomotility contraindication 421807004
Uncontrolled Epilepsy contraindication
Substance Overdose contraindication
Neoplastic Myeloproliferative Disorders contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 4.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 6.86 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.30 WOMBAT-PK CHEMBL
Muscarinic acetylcholine receptor M3 GPCR Ki 7.59 WOMBAT-PK
Histamine H1 receptor GPCR Ki 9.20 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 6.59 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 8.26 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR ANTAGONIST Ki 7.70 IUPHAR
5-hydroxytryptamine receptor 1F GPCR AGONIST Ki 6.90 IUPHAR
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 6.40 IUPHAR
5-hydroxytryptamine receptor 1D GPCR AGONIST Ki 6.40 IUPHAR
5-hydroxytryptamine receptor 1B GPCR AGONIST Ki 6.20 IUPHAR
D(3) dopamine receptor GPCR ANTAGONIST Ki 6.59 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.42 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 7.78 WOMBAT-PK
D(1A) dopamine receptor GPCR Ki 6.89 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 7.98 WOMBAT-PK
5-hydroxytryptamine receptor 3A Ion channel Ki 7.28 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 8.54 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.36 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 7.79 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR EC50 7.22 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 7.30 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR IC50 8.18 WOMBAT-PK
Histamine H4 receptor GPCR Ki 8.23 WOMBAT-PK
Histamine H2 receptor GPCR Ki 6.82 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 8.10 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 7.95 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR Ki 8.05 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.60 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 7.15 WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 5.20 WOMBAT-PK
UDP-glucuronosyltransferase 1-4 Enzyme app Km 4.21 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Ki 5.83 WOMBAT-PK
Adenosine receptor A3 GPCR IC50 6.81 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 8.20 CHEMBL
5-hydroxytryptamine receptor 5A GPCR Ki 6 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 5.41 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.78 PDSP
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
D(4) dopamine receptor GPCR ANTAGONIST Ki 7.52 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 8.44 DRUG MATRIX
Transporter Transporter Ki 6.41 CHEMBL
Histamine H1 receptor GPCR Ki 8.42 CHEMBL
Transporter Transporter Ki 6.16 CHEMBL
Dopamine receptor GPCR IC50 6.74 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 8.20 CHEMBL
D(1A) dopamine receptor GPCR Ki 6.38 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 4.59 CHEMBL
D(4) dopamine receptor GPCR Ki 8.05 CHEMBL
Muscarinic acetylcholine receptor GPCR Ki 7.60 CHEMBL
D(2) dopamine receptor GPCR IC50 6.54 CHEMBL
D(2) dopamine receptor GPCR Ki 6.16 CHEMBL
D(3) dopamine receptor GPCR Ki 6.79 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 8.74 CHEMBL
Dopamine receptor GPCR Ki 6.49 CHEMBL
5-hydroxytryptamine receptor 3A Ion channel Ki 7.49 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 7.24 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 6.80 CHEMBL
Serotonin 3 (5-HT3) receptor Ion channel Ki 7.28 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 8.68 CHEMBL
Adenylate cyclase Enzyme IC50 6.85 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 7.34 CHEMBL
D(3) dopamine receptor GPCR Ki 6.33 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 7.66 CHEMBL
Serotonin 1 (5-HT1) receptor GPCR Ki 6.68 CHEMBL
5-hydroxytryptamine receptor 1B GPCR IC50 5.60 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 7.41 CHEMBL
D(1A) dopamine receptor GPCR Ki 7.37 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 7.72 CHEMBL
Histamine H1 receptor GPCR Ki 8.54 CHEMBL
D(2) dopamine receptor GPCR Ki 6.60 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR IC50 7.55 CHEMBL
5-hydroxytryptamine receptor 2A GPCR IC50 8.52 CHEMBL
D(2) dopamine receptor GPCR Ki 7.47 CHEMBL
D(1A) dopamine receptor GPCR Ki 6.38 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 8.10 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.70 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.22 CHEMBL
5-hydroxytryptamine receptor 5A Unclassified ANTAGONIST Ki 5.30 IUPHAR
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7.40 IUPHAR
Histamine H4 receptor GPCR ANTAGONIST Ki 5.70 IUPHAR
Histamine H4 receptor GPCR ANTAGONIST Ki 5.50 IUPHAR
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 8.40 IUPHAR
Histamine H3 receptor GPCR ANTAGONIST Ki 5.80 IUPHAR

External reference:

IDSource
D003024 MESH_DESCRIPTOR_UI
4019488 VUID
N0000147608 NUI
C0009079 UMLSCUI
D00283 KEGG_DRUG
96221003 SNOMEDCT_US
4019488 VANDF
2626 RXNORM
11496 MMSL
d00199 MMSL
003526 NDDF
387568001 SNOMEDCT_US
4484 MMSL
4036908 VANDF
4037056 VANDF
4037345 VANDF
CHEMBL42 ChEMBL_ID
DB00363 DRUGBANK_ID
CHEMBL538973 ChEMBL_ID
J60AR2IKIC UNII
2612 INN_ID
CHEBI:3766 CHEBI
38 IUPHAR_LIGAND_ID
135398737 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3010 TABLET, ORALLY DISINTEGRATING 100 mg ORAL NDA authorized generic 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3011 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL NDA authorized generic 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3012 TABLET, ORALLY DISINTEGRATING 25 mg ORAL NDA authorized generic 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3086 TABLET, ORALLY DISINTEGRATING 150 mg ORAL NDA authorized generic 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3087 TABLET, ORALLY DISINTEGRATING 200 mg ORAL NDA authorized generic 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4359 TABLET 25 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4404 TABLET 50 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-4405 TABLET 200 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5416 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5417 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5419 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-7772 TABLET 100 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0825 TABLET 25 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0860 TABLET 100 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0972 TABLET 50 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-0973 TABLET 200 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3813 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3815 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0781-5989 TABLET 25 mg ORAL NDA 19 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 0781-5992 TABLET 100 mg ORAL NDA 19 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 16729-141 TABLET 25 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 16729-142 TABLET 100 mg ORAL ANDA 18 sections
FazaClo HUMAN PRESCRIPTION DRUG LABEL 1 18860-101 TABLET, ORALLY DISINTEGRATING 12.50 mg ORAL NDA 18 sections
FazaClo HUMAN PRESCRIPTION DRUG LABEL 1 18860-102 TABLET, ORALLY DISINTEGRATING 25 mg ORAL NDA 18 sections
FazaClo HUMAN PRESCRIPTION DRUG LABEL 1 18860-104 TABLET, ORALLY DISINTEGRATING 100 mg ORAL NDA 18 sections
FazaClo HUMAN PRESCRIPTION DRUG LABEL 1 18860-105 TABLET, ORALLY DISINTEGRATING 150 mg ORAL NDA 18 sections
FazaClo HUMAN PRESCRIPTION DRUG LABEL 1 18860-106 TABLET, ORALLY DISINTEGRATING 200 mg ORAL NDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 51079-212 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 51079-288 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 18 sections
Clozapine HUMAN PRESCRIPTION DRUG LABEL 1 51079-749 TABLET 200 mg ORAL ANDA 18 sections