(S)-nitrendipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
calcium channel blockers, nifedipine derivatives	6	80873-62-7

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

(S)-nitrendipine
(-)-Nitrendipine

Molecular weight: 360.37
Formula: C18H20N2O6
CLOGP: 3.73
LIPINSKI: 0
HAC: 8
HDO: 1
TPSA: 110.45
ALOGS: -4.41
ROTB: 7

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.37	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Voltage-dependent L-type calcium channel subunit alpha-1D	Ion channel	Q01668	CAC1D_HUMAN	GATING INHIBITOR	IC50	8.40		IUPHAR	IUPHAR
Voltage-dependent L-type calcium channel subunit alpha-1C	Ion channel	Q13936	CAC1C_HUMAN	BLOCKER				SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Intermediate conductance calcium-activated potassium channel protein 4	Ion channel	O15554	KCNN4_HUMAN	BLOCKER	IC50	7.60		IUPHAR
Voltage-dependent L-type calcium channel subunit alpha-1F	Ion channel	O60840	CAC1F_HUMAN	GATING INHIBITOR	IC50	6		IUPHAR
Voltage-dependent L-type calcium channel subunit alpha-1C	Ion channel		CAC1C_RAT	GATING INHIBITOR	IC50	6		IUPHAR
Voltage-dependent L-type calcium channel subunit alpha-1S	Ion channel		CAC1S_RAT	GATING INHIBITOR	IC50	6		IUPHAR

External reference:

ID	Source
CHEBI:135522	CHEBI
CHEMBL251230	ChEMBL_ID
157702	PUBCHEM_CID
I3TBK07DB4	UNII

Pharmaceutical products:

None