clometacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-inflammatory, indometacin derivatives	698	25803-14-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

clometacin
clometacine
clometazin
clomethacin
duperan
mindolic acid

Molecular weight: 357.79
Formula: C19H16ClNO4
CLOGP: 4.47
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 68.53
ALOGS: -4.97
ROTB: 5

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Hosey CM, Chan R, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000700	Analgesics
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.92	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin-H2 D-isomerase	Enzyme		PTGDS_MOUSE		IC50	6.70		CHEMBL

External reference:

ID	Source
C0055922	UMLSCUI
CHEBI:135512	CHEBI
CHEMBL13376	ChEMBL_ID
C017136	MESH_SUPPLEMENTAL_RECORD_UI
33176	PUBCHEM_CID
3041	INN_ID
L9M34YK25C	UNII

Pharmaceutical products:

None