citicoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	664	987-78-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

citicoline
cytidine choline diphosphate
cytidine diphosphate choline
cytidine diphosphocholine
cytidine diphosphorylcholine
cytidoline
difosfocin
emicholine
choline cytidine diphosphate
citicholine
citidoline
corenalin
cyscholin
citicoline sodium

Donor of choline in biosynthesis of choline-containing phosphoglycerides.

Molecular weight: 488.33
Formula: C14H26N4O11P2
CLOGP: -6.41
LIPINSKI: 1
HAC: 15
HDO: 4
TPSA: 213.50
ALOGS: -1.83
ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Blood triglycerides increased	79.56	59.06	19	254	14140	34942518
Blood cholesterol increased	72.54	59.06	19	254	20524	34936134
Hyperglycaemia	60.26	59.06	19	254	39461	34917197

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Blood triglycerides increased	77.64	52.86	20	569	21020	79722779
Apraxia	64.22	52.86	12	577	2855	79740944
Perseveration	55.35	52.86	8	581	389	79743410
Neuroleptic malignant syndrome	54.25	52.86	16	573	27543	79716256
Drug interaction	54.17	52.86	35	554	415148	79328651

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N06BX06	NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Other psychostimulants and nootropics
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018697	Nootropic Agents
CHEBI has role	CHEBI:35471	psychotropic drugs
CHEBI has role	CHEBI:63726	neuroprotective agents
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:75772	S. cerevisiae metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.08	acidic
pKa2	11.57	acidic
pKa3	13.08	acidic
pKa4	4.04	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4029346	VUID
N0000180302	NUI
D00057	KEGG_DRUG
33818-15-4	SECONDARY_CAS_RN
1099914	RXNORM
4029346	VANDF
C0010725	UMLSCUI
CHEBI:16436	CHEBI
CHEMBL1256994	ChEMBL_ID
CHEMBL1231700	ChEMBL_ID
DB12153	DRUGBANK_ID
2290	INN_ID
536BQ2JVC7	UNII
13804	PUBCHEM_CID
22451	MMSL
d05961	MMSL
004171	NDDF
009636	NDDF
1163164009	SNOMEDCT_US
1163165005	SNOMEDCT_US
698027009	SNOMEDCT_US
D003566	MESH_DESCRIPTOR_UI
CDC	PDB_CHEM_ID

Pharmaceutical products:

None