Stem definition | Drug id | CAS RN |
---|---|---|
663 | 59729-33-8 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
20 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.03 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 12 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.64 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 12 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 4.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.20 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 33 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 17, 1998 | FDA | FOREST LABS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1408.42 | 9.54 | 1977 | 193726 | 143696 | 63149623 |
Toxicity to various agents | 1232.52 | 9.54 | 2494 | 193209 | 244756 | 63048563 |
Drug abuse | 1066.27 | 9.54 | 1214 | 194489 | 71304 | 63222015 |
Electrocardiogram QT prolonged | 687.47 | 9.54 | 882 | 194821 | 58648 | 63234671 |
Serotonin syndrome | 598.14 | 9.54 | 579 | 195124 | 28103 | 63265216 |
Overdose | 523.94 | 9.54 | 1120 | 194583 | 113958 | 63179361 |
Drug interaction | 523.41 | 9.54 | 1724 | 193979 | 227407 | 63065912 |
Pemphigus | 508.87 | 9.54 | 12 | 195691 | 183714 | 63109605 |
Systemic lupus erythematosus | 464.56 | 9.54 | 51 | 195652 | 208867 | 63084452 |
Intentional overdose | 460.83 | 9.54 | 823 | 194880 | 73329 | 63219990 |
Hand deformity | 459.69 | 9.54 | 6 | 195697 | 159451 | 63133868 |
Synovitis | 446.70 | 9.54 | 34 | 195669 | 186884 | 63106435 |
Suicide attempt | 400.33 | 9.54 | 693 | 195010 | 60225 | 63233094 |
Drug ineffective | 389.25 | 9.54 | 1782 | 193921 | 1042983 | 62250336 |
Glossodynia | 356.70 | 9.54 | 61 | 195642 | 178815 | 63114504 |
Sopor | 352.72 | 9.54 | 387 | 195316 | 21777 | 63271542 |
Anti-cyclic citrullinated peptide antibody positive | 332.18 | 9.54 | 5 | 195698 | 116207 | 63177112 |
Suicidal ideation | 330.57 | 9.54 | 647 | 195056 | 61774 | 63231545 |
Agitation | 307.51 | 9.54 | 612 | 195091 | 59145 | 63234174 |
Arthropathy | 299.65 | 9.54 | 176 | 195527 | 234616 | 63058703 |
Pericarditis | 295.24 | 9.54 | 31 | 195672 | 131548 | 63161771 |
Drug intolerance | 293.74 | 9.54 | 311 | 195392 | 308350 | 62984969 |
Alopecia | 290.09 | 9.54 | 369 | 195334 | 337167 | 62956152 |
Hyponatraemia | 289.86 | 9.54 | 880 | 194823 | 111020 | 63182299 |
Treatment failure | 288.70 | 9.54 | 126 | 195577 | 198917 | 63094402 |
Torsade de pointes | 271.69 | 9.54 | 266 | 195437 | 13085 | 63280234 |
Intentional self-injury | 257.02 | 9.54 | 355 | 195348 | 25332 | 63267987 |
Wound | 251.97 | 9.54 | 94 | 195609 | 163169 | 63130150 |
Helicobacter infection | 249.59 | 9.54 | 8 | 195695 | 92777 | 63200542 |
Temperature regulation disorder | 249.16 | 9.54 | 182 | 195521 | 5950 | 63287369 |
Duodenal ulcer perforation | 240.18 | 9.54 | 6 | 195697 | 87203 | 63206116 |
Rheumatoid factor positive | 235.59 | 9.54 | 5 | 195698 | 84401 | 63208918 |
Therapeutic product effect decreased | 235.08 | 9.54 | 153 | 195550 | 193034 | 63100285 |
Respiratory arrest | 228.42 | 9.54 | 382 | 195321 | 32263 | 63261056 |
Infusion related reaction | 228.34 | 9.54 | 252 | 195451 | 245269 | 63048050 |
Anxiety | 220.33 | 9.54 | 1282 | 194421 | 216259 | 63077060 |
Cardio-respiratory arrest | 215.59 | 9.54 | 532 | 195171 | 59427 | 63233892 |
Tremor | 210.08 | 9.54 | 886 | 194817 | 131353 | 63161966 |
Discomfort | 207.11 | 9.54 | 130 | 195573 | 167244 | 63126075 |
Poisoning | 198.78 | 9.54 | 228 | 195475 | 13472 | 63279847 |
Abdominal discomfort | 194.29 | 9.54 | 439 | 195264 | 320446 | 62972873 |
Contraindicated product administered | 194.10 | 9.54 | 231 | 195472 | 217417 | 63075902 |
Hyperhidrosis | 186.66 | 9.54 | 742 | 194961 | 107094 | 63186225 |
Off label use | 181.29 | 9.54 | 1277 | 194426 | 673185 | 62620134 |
Joint swelling | 175.15 | 9.54 | 478 | 195225 | 327188 | 62966131 |
Muscle injury | 174.44 | 9.54 | 6 | 195697 | 65339 | 63227980 |
Rash | 170.36 | 9.54 | 1023 | 194680 | 559848 | 62733471 |
Swelling | 167.25 | 9.54 | 376 | 195327 | 275002 | 63018317 |
Folliculitis | 164.50 | 9.54 | 14 | 195689 | 70303 | 63223016 |
Food allergy | 159.14 | 9.54 | 186 | 195517 | 11215 | 63282104 |
Somnolence | 158.65 | 9.54 | 1018 | 194685 | 177667 | 63115652 |
Panic attack | 158.47 | 9.54 | 263 | 195440 | 22068 | 63271251 |
Cardiac arrest | 157.11 | 9.54 | 633 | 195070 | 91912 | 63201407 |
Infection | 147.35 | 9.54 | 303 | 195400 | 228870 | 63064449 |
Sleep disorder due to general medical condition, insomnia type | 146.07 | 9.54 | 3 | 195700 | 52214 | 63241105 |
Foetal exposure during pregnancy | 137.16 | 9.54 | 304 | 195399 | 31658 | 63261661 |
Fall | 137.13 | 9.54 | 1827 | 193876 | 390507 | 62902812 |
Disturbance in attention | 129.03 | 9.54 | 331 | 195372 | 37858 | 63255461 |
Maternal exposure during pregnancy | 128.30 | 9.54 | 307 | 195396 | 219755 | 63073564 |
Coeliac disease | 128.21 | 9.54 | 177 | 195526 | 12620 | 63280699 |
Accidental overdose | 123.80 | 9.54 | 242 | 195461 | 23067 | 63270252 |
Blister | 121.94 | 9.54 | 132 | 195571 | 129682 | 63163637 |
Seizure | 121.60 | 9.54 | 762 | 194941 | 131872 | 63161447 |
Depression | 120.91 | 9.54 | 1026 | 194677 | 195466 | 63097853 |
Impaired healing | 120.91 | 9.54 | 84 | 195619 | 102458 | 63190861 |
Myoclonus | 119.52 | 9.54 | 192 | 195511 | 15676 | 63277643 |
Irritable bowel syndrome | 118.08 | 9.54 | 53 | 195650 | 82359 | 63210960 |
Akathisia | 117.43 | 9.54 | 143 | 195560 | 9003 | 63284316 |
Product use issue | 116.74 | 9.54 | 323 | 195380 | 220197 | 63073122 |
Mydriasis | 116.24 | 9.54 | 163 | 195540 | 11793 | 63281526 |
Irritability | 115.78 | 9.54 | 283 | 195420 | 31411 | 63261908 |
Electrocardiogram QRS complex prolonged | 112.84 | 9.54 | 114 | 195589 | 5824 | 63287495 |
Restlessness | 110.81 | 9.54 | 266 | 195437 | 29187 | 63264132 |
Withdrawal syndrome | 107.89 | 9.54 | 209 | 195494 | 19788 | 63273531 |
Unresponsive to stimuli | 106.99 | 9.54 | 286 | 195417 | 33530 | 63259789 |
Bruxism | 106.95 | 9.54 | 88 | 195615 | 3437 | 63289882 |
Drug withdrawal syndrome | 102.74 | 9.54 | 246 | 195457 | 26948 | 63266371 |
Ill-defined disorder | 96.34 | 9.54 | 67 | 195636 | 81688 | 63211631 |
Nightmare | 95.59 | 9.54 | 194 | 195509 | 19000 | 63274319 |
Peripheral swelling | 94.31 | 9.54 | 460 | 195243 | 265482 | 63027837 |
Immunodeficiency | 94.17 | 9.54 | 199 | 195504 | 20055 | 63273264 |
Anorgasmia | 93.94 | 9.54 | 43 | 195660 | 560 | 63292759 |
Aggression | 92.49 | 9.54 | 216 | 195487 | 23282 | 63270037 |
Small for dates baby | 92.18 | 9.54 | 83 | 195620 | 3668 | 63289651 |
Loss of consciousness | 92.17 | 9.54 | 652 | 195051 | 117469 | 63175850 |
Stomatitis | 92.02 | 9.54 | 180 | 195523 | 138545 | 63154774 |
Sinusitis | 91.84 | 9.54 | 373 | 195330 | 226280 | 63067039 |
Hepatic enzyme increased | 90.37 | 9.54 | 320 | 195383 | 202008 | 63091311 |
Long QT syndrome | 89.47 | 9.54 | 77 | 195626 | 3202 | 63290117 |
Psoriatic arthropathy | 89.38 | 9.54 | 90 | 195613 | 91430 | 63201889 |
Muscle twitching | 86.57 | 9.54 | 189 | 195514 | 19479 | 63273840 |
Accidental death | 85.65 | 9.54 | 61 | 195642 | 1915 | 63291404 |
Rheumatic fever | 85.20 | 9.54 | 15 | 195688 | 43096 | 63250223 |
C-reactive protein increased | 82.77 | 9.54 | 102 | 195601 | 94605 | 63198714 |
Febrile neutropenia | 82.69 | 9.54 | 149 | 195554 | 118300 | 63175019 |
Muscle rigidity | 81.00 | 9.54 | 135 | 195568 | 11365 | 63281954 |
Galactorrhoea | 77.55 | 9.54 | 79 | 195624 | 4076 | 63289243 |
Intentional product use issue | 75.61 | 9.54 | 177 | 195526 | 127715 | 63165604 |
Rash erythematous | 75.50 | 9.54 | 295 | 195408 | 42215 | 63251104 |
Hallucination | 75.39 | 9.54 | 352 | 195351 | 54465 | 63238854 |
Blood cholesterol increased | 73.36 | 9.54 | 110 | 195593 | 93922 | 63199397 |
Intentional product misuse | 72.94 | 9.54 | 376 | 195327 | 60541 | 63232778 |
Exposure via ingestion | 72.73 | 9.54 | 65 | 195638 | 2844 | 63290475 |
Arthralgia | 72.55 | 9.54 | 1278 | 194425 | 568432 | 62724887 |
Fibromyalgia | 71.98 | 9.54 | 85 | 195618 | 80335 | 63212984 |
C-reactive protein abnormal | 70.29 | 9.54 | 27 | 195676 | 46069 | 63247250 |
Disorientation | 69.43 | 9.54 | 273 | 195430 | 39179 | 63254140 |
Alcoholism | 67.24 | 9.54 | 51 | 195652 | 1767 | 63291552 |
Respiratory disorder neonatal | 67.17 | 9.54 | 44 | 195659 | 1201 | 63292118 |
Hyperreflexia | 66.98 | 9.54 | 87 | 195616 | 5847 | 63287472 |
Mania | 66.40 | 9.54 | 129 | 195574 | 12238 | 63281081 |
Hip arthroplasty | 66.14 | 9.54 | 32 | 195671 | 47614 | 63245705 |
Dyskinesia | 64.25 | 9.54 | 231 | 195472 | 31771 | 63261548 |
Dizziness | 63.37 | 9.54 | 1754 | 193949 | 428171 | 62865148 |
Haematemesis | 63.17 | 9.54 | 222 | 195481 | 30190 | 63263129 |
Extrapyramidal disorder | 62.31 | 9.54 | 131 | 195572 | 13153 | 63280166 |
Self-injurious ideation | 61.75 | 9.54 | 57 | 195646 | 2602 | 63290717 |
Confusional state | 61.45 | 9.54 | 1047 | 194656 | 235333 | 63057986 |
Memory impairment | 61.22 | 9.54 | 539 | 195164 | 103719 | 63189600 |
Pain | 60.39 | 9.54 | 1781 | 193922 | 738847 | 62554472 |
Product prescribing error | 59.96 | 9.54 | 198 | 195505 | 26091 | 63267228 |
Knee arthroplasty | 59.25 | 9.54 | 48 | 195655 | 54158 | 63239161 |
Depressed level of consciousness | 57.68 | 9.54 | 358 | 195345 | 61720 | 63231599 |
Malignant neoplasm progression | 57.58 | 9.54 | 103 | 195600 | 82018 | 63211301 |
Psychomotor hyperactivity | 56.97 | 9.54 | 111 | 195592 | 10552 | 63282767 |
Hypersensitivity | 56.87 | 9.54 | 602 | 195101 | 292083 | 63001236 |
Depressed mood | 55.94 | 9.54 | 259 | 195444 | 39932 | 63253387 |
Coma scale abnormal | 55.76 | 9.54 | 74 | 195629 | 5079 | 63288240 |
Yawning | 55.44 | 9.54 | 37 | 195666 | 1043 | 63292276 |
Crying | 55.21 | 9.54 | 178 | 195525 | 23165 | 63270154 |
Interstitial lung disease | 54.80 | 9.54 | 66 | 195637 | 61842 | 63231477 |
Labelled drug-drug interaction issue | 54.79 | 9.54 | 37 | 195666 | 1064 | 63292255 |
Bradycardia | 54.67 | 9.54 | 400 | 195303 | 72827 | 63220492 |
Generalised tonic-clonic seizure | 53.68 | 9.54 | 204 | 195499 | 28812 | 63264507 |
Bradyphrenia | 53.31 | 9.54 | 85 | 195618 | 6895 | 63286424 |
Myocardial stunning | 53.02 | 9.54 | 20 | 195683 | 153 | 63293166 |
Obsessive-compulsive disorder | 52.97 | 9.54 | 64 | 195639 | 3996 | 63289323 |
Parkinsonism | 52.56 | 9.54 | 106 | 195597 | 10333 | 63282986 |
Ventricular septal defect | 52.27 | 9.54 | 66 | 195637 | 4312 | 63289007 |
Inappropriate antidiuretic hormone secretion | 51.17 | 9.54 | 133 | 195570 | 15329 | 63277990 |
Neonatal hypoxia | 51.13 | 9.54 | 29 | 195674 | 606 | 63292713 |
Antidepressant drug level above therapeutic | 49.37 | 9.54 | 25 | 195678 | 412 | 63292907 |
Ventricular tachycardia | 48.75 | 9.54 | 154 | 195549 | 19825 | 63273494 |
Therapeutic product effect incomplete | 48.62 | 9.54 | 209 | 195494 | 124847 | 63168472 |
Nasopharyngitis | 48.56 | 9.54 | 525 | 195178 | 253732 | 63039587 |
Pyrexia | 48.46 | 9.54 | 1093 | 194610 | 469385 | 62823934 |
Loss of libido | 48.04 | 9.54 | 37 | 195666 | 1312 | 63292007 |
Syncope | 47.39 | 9.54 | 562 | 195141 | 116823 | 63176496 |
Pulseless electrical activity | 47.33 | 9.54 | 84 | 195619 | 7437 | 63285882 |
Lethargy | 47.12 | 9.54 | 315 | 195388 | 55692 | 63237627 |
Neutropenia | 46.40 | 9.54 | 332 | 195371 | 174673 | 63118646 |
Product use in unapproved indication | 46.39 | 9.54 | 342 | 195361 | 178738 | 63114581 |
Musculoskeletal stiffness | 46.20 | 9.54 | 356 | 195347 | 184262 | 63109057 |
Psychotic disorder | 46.11 | 9.54 | 179 | 195524 | 25533 | 63267786 |
Disease progression | 46.00 | 9.54 | 208 | 195495 | 122550 | 63170769 |
Illness anxiety disorder | 45.65 | 9.54 | 17 | 195686 | 125 | 63293194 |
Pancytopenia | 45.48 | 9.54 | 150 | 195553 | 96783 | 63196536 |
Macular degeneration | 44.98 | 9.54 | 10 | 195693 | 24366 | 63268953 |
Atrial septal defect | 44.32 | 9.54 | 78 | 195625 | 6860 | 63286459 |
Anger | 44.19 | 9.54 | 110 | 195593 | 12346 | 63280973 |
Medication error | 43.95 | 9.54 | 294 | 195409 | 51990 | 63241329 |
Hyperprolactinaemia | 43.74 | 9.54 | 57 | 195646 | 3843 | 63289476 |
Bradykinesia | 43.56 | 9.54 | 66 | 195637 | 5122 | 63288197 |
Drug withdrawal syndrome neonatal | 43.34 | 9.54 | 42 | 195661 | 2039 | 63291280 |
Mood swings | 43.02 | 9.54 | 139 | 195564 | 18109 | 63275210 |
Condition aggravated | 42.95 | 9.54 | 929 | 194774 | 401288 | 62892031 |
Lower respiratory tract infection | 42.81 | 9.54 | 236 | 195467 | 132071 | 63161248 |
Nicotine dependence | 42.79 | 9.54 | 27 | 195676 | 690 | 63292629 |
Pneumonia | 42.65 | 9.54 | 1077 | 194626 | 455690 | 62837629 |
Bursitis | 42.52 | 9.54 | 226 | 195477 | 36815 | 63256504 |
Alcohol abuse | 42.25 | 9.54 | 42 | 195661 | 2104 | 63291215 |
Mobility decreased | 42.06 | 9.54 | 211 | 195492 | 120948 | 63172371 |
Drug dependence | 41.93 | 9.54 | 168 | 195535 | 24315 | 63269004 |
Reversible cerebral vasoconstriction syndrome | 41.56 | 9.54 | 46 | 195657 | 2612 | 63290707 |
Myelosuppression | 41.25 | 9.54 | 11 | 195692 | 23692 | 63269627 |
Septic shock | 41.16 | 9.54 | 90 | 195613 | 66539 | 63226780 |
Impulsive behaviour | 40.83 | 9.54 | 36 | 195667 | 1547 | 63291772 |
Abnormal behaviour | 40.76 | 9.54 | 152 | 195551 | 21274 | 63272045 |
Rib deformity | 40.67 | 9.54 | 19 | 195684 | 260 | 63293059 |
Posturing | 40.62 | 9.54 | 23 | 195680 | 479 | 63292840 |
Hypoglycaemia | 40.29 | 9.54 | 320 | 195383 | 59745 | 63233574 |
Ventricular arrhythmia | 39.93 | 9.54 | 54 | 195649 | 3774 | 63289545 |
Obsessive thoughts | 39.70 | 9.54 | 24 | 195679 | 567 | 63292752 |
Concussion | 38.61 | 9.54 | 87 | 195616 | 9157 | 63284162 |
Cerebral vasoconstriction | 38.42 | 9.54 | 31 | 195672 | 1177 | 63292142 |
Libido decreased | 37.97 | 9.54 | 44 | 195659 | 2628 | 63290691 |
Thinking abnormal | 37.77 | 9.54 | 94 | 195609 | 10549 | 63282770 |
Gastrointestinal disorder | 37.75 | 9.54 | 243 | 195460 | 130996 | 63162323 |
Abnormal dreams | 37.44 | 9.54 | 93 | 195610 | 10423 | 63282896 |
Hypokinesia | 37.34 | 9.54 | 111 | 195592 | 13825 | 63279494 |
Drug tolerance decreased | 36.98 | 9.54 | 5 | 195698 | 17468 | 63275851 |
Calcium deficiency | 36.31 | 9.54 | 29 | 195674 | 1085 | 63292234 |
Catatonia | 36.24 | 9.54 | 56 | 195647 | 4421 | 63288898 |
Apathy | 35.88 | 9.54 | 82 | 195621 | 8712 | 63284607 |
Angle closure glaucoma | 35.73 | 9.54 | 39 | 195664 | 2180 | 63291139 |
Mucosal inflammation | 35.53 | 9.54 | 56 | 195647 | 46872 | 63246447 |
Suicidal behaviour | 35.08 | 9.54 | 42 | 195661 | 2597 | 63290722 |
Speech disorder | 35.08 | 9.54 | 230 | 195473 | 40399 | 63252920 |
Insomnia | 34.72 | 9.54 | 889 | 194814 | 214363 | 63078956 |
Hepatic function abnormal | 34.59 | 9.54 | 38 | 195665 | 37104 | 63256215 |
Ductus arteriosus premature closure | 34.43 | 9.54 | 18 | 195685 | 318 | 63293001 |
Liver disorder | 34.43 | 9.54 | 71 | 195632 | 53616 | 63239703 |
Ventricular fibrillation | 34.19 | 9.54 | 97 | 195606 | 11770 | 63281549 |
Cytomegalovirus infection | 34.12 | 9.54 | 11 | 195692 | 20941 | 63272378 |
Hostility | 33.86 | 9.54 | 35 | 195668 | 1837 | 63291482 |
Clonus | 33.42 | 9.54 | 55 | 195648 | 4581 | 63288738 |
Congenital thrombocytopenia | 33.10 | 9.54 | 11 | 195692 | 55 | 63293264 |
Coma | 32.86 | 9.54 | 323 | 195380 | 64041 | 63229278 |
Alcohol use | 32.54 | 9.54 | 36 | 195667 | 2043 | 63291276 |
Hallucination, auditory | 32.35 | 9.54 | 100 | 195603 | 12724 | 63280595 |
Dystonia | 32.34 | 9.54 | 105 | 195598 | 13714 | 63279605 |
Rabbit syndrome | 31.80 | 9.54 | 17 | 195686 | 315 | 63293004 |
Premature delivery | 31.64 | 9.54 | 28 | 195675 | 30253 | 63263066 |
Tenosynovitis | 31.57 | 9.54 | 3 | 195700 | 13792 | 63279527 |
Hypokalaemia | 31.52 | 9.54 | 472 | 195231 | 103332 | 63189987 |
Fluid retention | 31.19 | 9.54 | 301 | 195402 | 59385 | 63233934 |
Carcinoid heart disease | 31.18 | 9.54 | 9 | 195694 | 25 | 63293294 |
Tearfulness | 31.05 | 9.54 | 50 | 195653 | 4089 | 63289230 |
Panic reaction | 30.74 | 9.54 | 50 | 195653 | 4124 | 63289195 |
Dementia | 30.63 | 9.54 | 127 | 195576 | 18667 | 63274652 |
Brain injury | 30.22 | 9.54 | 67 | 195636 | 6976 | 63286343 |
Red blood cell sedimentation rate increased | 30.08 | 9.54 | 56 | 195647 | 43926 | 63249393 |
Physical assault | 30.03 | 9.54 | 24 | 195679 | 899 | 63292420 |
Adverse event | 30.02 | 9.54 | 107 | 195596 | 67452 | 63225867 |
Negative thoughts | 29.93 | 9.54 | 24 | 195679 | 903 | 63292416 |
Bipolar I disorder | 29.93 | 9.54 | 33 | 195670 | 1866 | 63291453 |
Photosensitivity reaction | 29.89 | 9.54 | 108 | 195595 | 14886 | 63278433 |
Injection site pain | 29.84 | 9.54 | 256 | 195447 | 129544 | 63163775 |
Rheumatoid arthritis | 29.80 | 9.54 | 577 | 195126 | 253242 | 63040077 |
Rheumatoid nodule | 29.78 | 9.54 | 8 | 195695 | 17147 | 63276172 |
Labelled drug-drug interaction medication error | 29.74 | 9.54 | 100 | 195603 | 13299 | 63280020 |
Arthritis | 29.71 | 9.54 | 222 | 195481 | 115699 | 63177620 |
Flat affect | 29.70 | 9.54 | 29 | 195674 | 1421 | 63291898 |
Mental disorder | 29.65 | 9.54 | 158 | 195545 | 25761 | 63267558 |
Nervousness | 29.62 | 9.54 | 180 | 195523 | 30799 | 63262520 |
Drug eruption | 29.42 | 9.54 | 27 | 195676 | 28667 | 63264652 |
Cholecystitis chronic | 29.18 | 9.54 | 84 | 195619 | 10277 | 63283042 |
Stiff person syndrome | 29.02 | 9.54 | 16 | 195687 | 316 | 63293003 |
Amnesia | 28.89 | 9.54 | 280 | 195423 | 55305 | 63238014 |
Sputum purulent | 28.60 | 9.54 | 25 | 195678 | 1062 | 63292257 |
Homicidal ideation | 28.58 | 9.54 | 31 | 195672 | 1721 | 63291598 |
Emotional distress | 28.55 | 9.54 | 185 | 195518 | 32364 | 63260955 |
Maternal drugs affecting foetus | 28.53 | 9.54 | 55 | 195648 | 5187 | 63288132 |
Type 2 diabetes mellitus | 28.48 | 9.54 | 101 | 195602 | 63767 | 63229552 |
Restless legs syndrome | 28.47 | 9.54 | 123 | 195580 | 18408 | 63274911 |
Paranoia | 28.47 | 9.54 | 90 | 195613 | 11589 | 63281730 |
Orthostatic intolerance | 28.46 | 9.54 | 26 | 195677 | 1171 | 63292148 |
Toxicologic test abnormal | 28.39 | 9.54 | 21 | 195682 | 700 | 63292619 |
Alcohol poisoning | 27.94 | 9.54 | 32 | 195671 | 1887 | 63291432 |
Potentiating drug interaction | 27.86 | 9.54 | 49 | 195654 | 4307 | 63289012 |
Hypotonia | 27.83 | 9.54 | 77 | 195626 | 9208 | 63284111 |
Therapy non-responder | 27.60 | 9.54 | 130 | 195573 | 75771 | 63217548 |
Selective eating disorder | 27.58 | 9.54 | 33 | 195670 | 2039 | 63291280 |
Skin ulcer | 27.54 | 9.54 | 57 | 195646 | 42988 | 63250331 |
Hyperkinesia | 27.53 | 9.54 | 30 | 195673 | 1674 | 63291645 |
Congenital pulmonary valve atresia | 27.52 | 9.54 | 10 | 195693 | 68 | 63293251 |
Cognitive disorder | 27.47 | 9.54 | 278 | 195425 | 55537 | 63237782 |
Poor feeding infant | 27.40 | 9.54 | 16 | 195687 | 354 | 63292965 |
Secondary immunodeficiency | 27.10 | 9.54 | 27 | 195676 | 1356 | 63291963 |
Tachycardia | 26.99 | 9.54 | 513 | 195190 | 117643 | 63175676 |
Post viral fatigue syndrome | 26.95 | 9.54 | 15 | 195688 | 302 | 63293017 |
Stress | 26.84 | 9.54 | 321 | 195382 | 66846 | 63226473 |
Hypochloraemia | 26.75 | 9.54 | 32 | 195671 | 1977 | 63291342 |
Drug resistance | 26.73 | 9.54 | 19 | 195684 | 22914 | 63270405 |
Platelet count decreased | 26.26 | 9.54 | 230 | 195473 | 115892 | 63177427 |
Histrionic personality disorder | 26.15 | 9.54 | 9 | 195694 | 51 | 63293268 |
Pneumocystis jirovecii pneumonia | 25.63 | 9.54 | 10 | 195693 | 16904 | 63276415 |
Palmar-plantar erythrodysaesthesia syndrome | 25.63 | 9.54 | 20 | 195683 | 22995 | 63270324 |
Major depression | 25.54 | 9.54 | 68 | 195635 | 7950 | 63285369 |
Disturbance in sexual arousal | 25.52 | 9.54 | 11 | 195692 | 123 | 63293196 |
Polyhydramnios | 25.17 | 9.54 | 33 | 195670 | 2238 | 63291081 |
Vertigo | 25.17 | 9.54 | 289 | 195414 | 59598 | 63233721 |
Liver function test increased | 24.98 | 9.54 | 39 | 195664 | 32772 | 63260547 |
Adrenal insufficiency | 24.91 | 9.54 | 12 | 195691 | 17903 | 63275416 |
Sedation complication | 24.85 | 9.54 | 6 | 195697 | 13816 | 63279503 |
Autoimmune disorder | 24.67 | 9.54 | 11 | 195692 | 17166 | 63276153 |
Pupillary reflex impaired | 24.66 | 9.54 | 31 | 195672 | 2016 | 63291303 |
Urinary retention | 24.63 | 9.54 | 169 | 195534 | 30132 | 63263187 |
Gestational diabetes | 24.55 | 9.54 | 69 | 195634 | 8327 | 63284992 |
Injection site reaction | 24.49 | 9.54 | 95 | 195608 | 58429 | 63234890 |
Sinus tachycardia | 24.48 | 9.54 | 143 | 195560 | 24125 | 63269194 |
Hallucination, visual | 24.41 | 9.54 | 121 | 195582 | 19177 | 63274142 |
Dyspnoea | 24.37 | 9.54 | 1733 | 193970 | 659580 | 62633739 |
Dissociation | 24.32 | 9.54 | 37 | 195666 | 2882 | 63290437 |
Optic ischaemic neuropathy | 24.21 | 9.54 | 24 | 195679 | 1198 | 63292121 |
Cystoid macular oedema | 24.18 | 9.54 | 27 | 195676 | 1548 | 63291771 |
Foetal chromosome abnormality | 24.11 | 9.54 | 7 | 195696 | 20 | 63293299 |
Libido increased | 24.07 | 9.54 | 25 | 195678 | 1320 | 63291999 |
Constipation | 23.69 | 9.54 | 882 | 194821 | 224061 | 63069258 |
Mutism | 23.43 | 9.54 | 27 | 195676 | 1603 | 63291716 |
Dermatillomania | 23.26 | 9.54 | 11 | 195692 | 155 | 63293164 |
Personality change | 23.09 | 9.54 | 60 | 195643 | 6913 | 63286406 |
Hepatotoxicity | 22.90 | 9.54 | 50 | 195653 | 36991 | 63256328 |
CFTR gene mutation | 22.87 | 9.54 | 10 | 195693 | 116 | 63293203 |
Neuropathy, ataxia, retinitis pigmentosa syndrome | 22.86 | 9.54 | 8 | 195695 | 48 | 63293271 |
Neuropathy peripheral | 22.77 | 9.54 | 232 | 195471 | 113435 | 63179884 |
Product dose omission issue | 22.75 | 9.54 | 549 | 195154 | 233764 | 63059555 |
Melaena | 22.73 | 9.54 | 166 | 195537 | 30199 | 63263120 |
Foetal death | 22.67 | 9.54 | 80 | 195623 | 10900 | 63282419 |
Hypocoagulable state | 22.62 | 9.54 | 23 | 195680 | 1184 | 63292135 |
Pruritus | 22.60 | 9.54 | 898 | 194805 | 360555 | 62932764 |
Goitre | 22.59 | 9.54 | 54 | 195649 | 5907 | 63287412 |
Bronchomalacia | 22.56 | 9.54 | 12 | 195691 | 220 | 63293099 |
Abnormal weight gain | 22.50 | 9.54 | 28 | 195675 | 1802 | 63291517 |
Postmortem blood drug level increased | 22.46 | 9.54 | 17 | 195686 | 587 | 63292732 |
Pruritus allergic | 22.39 | 9.54 | 26 | 195677 | 1556 | 63291763 |
Cataract | 22.38 | 9.54 | 95 | 195608 | 56958 | 63236361 |
Sebaceous gland infection | 22.24 | 9.54 | 11 | 195692 | 172 | 63293147 |
Basal ganglion degeneration | 22.16 | 9.54 | 15 | 195688 | 433 | 63292886 |
Dysarthria | 22.12 | 9.54 | 215 | 195488 | 42496 | 63250823 |
Hypercholesterolaemia | 21.96 | 9.54 | 20 | 195683 | 21314 | 63272005 |
Tachyphrenia | 21.87 | 9.54 | 24 | 195679 | 1350 | 63291969 |
Infantile apnoea | 21.80 | 9.54 | 21 | 195682 | 1012 | 63292307 |
Adrenergic syndrome | 21.57 | 9.54 | 7 | 195696 | 32 | 63293287 |
Therapeutic response decreased | 21.43 | 9.54 | 107 | 195596 | 61418 | 63231901 |
Talipes | 21.28 | 9.54 | 25 | 195678 | 1515 | 63291804 |
Pulmonary fibrosis | 21.26 | 9.54 | 58 | 195645 | 39751 | 63253568 |
Post-traumatic neck syndrome | 21.25 | 9.54 | 29 | 195674 | 2045 | 63291274 |
Bone marrow failure | 21.19 | 9.54 | 36 | 195667 | 29254 | 63264065 |
Diaphragmatic rupture | 21.19 | 9.54 | 12 | 195691 | 250 | 63293069 |
Feeling abnormal | 21.09 | 9.54 | 603 | 195100 | 147789 | 63145530 |
Neoplasm progression | 21.05 | 9.54 | 51 | 195652 | 36377 | 63256942 |
Mental impairment | 21.04 | 9.54 | 93 | 195610 | 14058 | 63279261 |
Red blood cell sedimentation rate abnormal | 21.02 | 9.54 | 18 | 195685 | 19764 | 63273555 |
Depression suicidal | 21 | 9.54 | 27 | 195676 | 1796 | 63291523 |
Hypoxic-ischaemic encephalopathy | 20.95 | 9.54 | 43 | 195660 | 4244 | 63289075 |
Substance abuse | 20.93 | 9.54 | 46 | 195657 | 4761 | 63288558 |
Vascular access site thrombosis | 20.90 | 9.54 | 7 | 195696 | 36 | 63293283 |
Asthma | 20.89 | 9.54 | 528 | 195175 | 127033 | 63166286 |
Hospitalisation | 20.83 | 9.54 | 165 | 195538 | 84916 | 63208403 |
Respiratory disorder | 20.82 | 9.54 | 57 | 195646 | 39025 | 63254294 |
Neonatal respiratory depression | 20.79 | 9.54 | 8 | 195695 | 65 | 63293254 |
Thrombocytopenia | 20.79 | 9.54 | 334 | 195369 | 150823 | 63142496 |
Alcohol interaction | 20.73 | 9.54 | 31 | 195672 | 2378 | 63290941 |
Facial paralysis | 20.66 | 9.54 | 92 | 195611 | 13949 | 63279370 |
Iris coloboma | 20.29 | 9.54 | 7 | 195696 | 40 | 63293279 |
Acute myeloid leukaemia | 20.26 | 9.54 | 14 | 195689 | 17133 | 63276186 |
Hypotonia neonatal | 20.24 | 9.54 | 22 | 195681 | 1224 | 63292095 |
Activation syndrome | 20.23 | 9.54 | 11 | 195692 | 211 | 63293108 |
Substance abuser | 20.21 | 9.54 | 6 | 195697 | 19 | 63293300 |
Product administration error | 20.07 | 9.54 | 128 | 195575 | 22269 | 63271050 |
Fear | 20.05 | 9.54 | 99 | 195604 | 15667 | 63277652 |
Injection site erythema | 20.04 | 9.54 | 162 | 195541 | 83012 | 63210307 |
Product substitution issue | 20.02 | 9.54 | 100 | 195603 | 15896 | 63277423 |
Female sexual arousal disorder | 20.00 | 9.54 | 7 | 195696 | 42 | 63293277 |
Joint range of motion decreased | 19.86 | 9.54 | 44 | 195659 | 32384 | 63260935 |
Hypertonia | 19.77 | 9.54 | 44 | 195659 | 4593 | 63288726 |
Epilepsy | 19.71 | 9.54 | 147 | 195556 | 26918 | 63266401 |
Anticholinergic syndrome | 19.57 | 9.54 | 30 | 195673 | 2352 | 63290967 |
Social problem | 19.53 | 9.54 | 18 | 195685 | 820 | 63292499 |
Bradycardia neonatal | 19.43 | 9.54 | 19 | 195684 | 933 | 63292386 |
Drug hypersensitivity | 19.38 | 9.54 | 772 | 194931 | 309915 | 62983404 |
Pulmonary valve stenosis congenital | 19.37 | 9.54 | 10 | 195693 | 172 | 63293147 |
CYP3A4 polymorphism | 19.34 | 9.54 | 8 | 195695 | 80 | 63293239 |
Agonal rhythm | 19.33 | 9.54 | 6 | 195697 | 23 | 63293296 |
Infected dermal cyst | 19.29 | 9.54 | 14 | 195689 | 453 | 63292866 |
Cytokine release syndrome | 19.28 | 9.54 | 10 | 195693 | 14304 | 63279015 |
Neuroleptic malignant syndrome | 19.28 | 9.54 | 81 | 195622 | 11975 | 63281344 |
Orgasm abnormal | 19.26 | 9.54 | 8 | 195695 | 81 | 63293238 |
Atonic urinary bladder | 19.17 | 9.54 | 8 | 195695 | 82 | 63293237 |
Acquired epileptic aphasia | 19.14 | 9.54 | 4 | 195699 | 0 | 63293319 |
Antidepressant drug level increased | 19.11 | 9.54 | 12 | 195691 | 304 | 63293015 |
Haematotoxicity | 19.11 | 9.54 | 3 | 195700 | 9373 | 63283946 |
Cardiac failure | 19.09 | 9.54 | 179 | 195524 | 88963 | 63204356 |
Cerebrospinal fluid retention | 19.00 | 9.54 | 8 | 195695 | 84 | 63293235 |
Neuroglycopenia | 18.99 | 9.54 | 14 | 195689 | 464 | 63292855 |
Osmotic demyelination syndrome | 18.97 | 9.54 | 16 | 195687 | 647 | 63292672 |
Self esteem decreased | 18.76 | 9.54 | 16 | 195687 | 657 | 63292662 |
Gait inability | 18.50 | 9.54 | 92 | 195611 | 52867 | 63240452 |
Panniculitis | 18.50 | 9.54 | 6 | 195697 | 11379 | 63281940 |
Skin swelling | 18.47 | 9.54 | 36 | 195667 | 3423 | 63289896 |
Caput succedaneum | 18.46 | 9.54 | 5 | 195698 | 10 | 63293309 |
Liver injury | 18.46 | 9.54 | 110 | 195593 | 60410 | 63232909 |
Lip swelling | 18.43 | 9.54 | 161 | 195542 | 30902 | 63262417 |
Vascular access site infection | 18.40 | 9.54 | 7 | 195696 | 55 | 63293264 |
Pregnancy | 18.38 | 9.54 | 184 | 195519 | 36652 | 63256667 |
Social avoidant behaviour | 18.33 | 9.54 | 33 | 195670 | 2955 | 63290364 |
Muscle tightness | 18.29 | 9.54 | 79 | 195624 | 11821 | 63281498 |
Delirium | 18.24 | 9.54 | 237 | 195466 | 50304 | 63243015 |
Respiratory tract infection | 18.23 | 9.54 | 66 | 195637 | 41417 | 63251902 |
Multiple sclerosis relapse | 18.20 | 9.54 | 229 | 195474 | 48249 | 63245070 |
Metastases to liver | 18.09 | 9.54 | 28 | 195675 | 23611 | 63269708 |
Sternal fracture | 17.97 | 9.54 | 28 | 195675 | 2226 | 63291093 |
Cardiac failure congestive | 17.96 | 9.54 | 190 | 195513 | 92243 | 63201076 |
Hypersomnia | 17.96 | 9.54 | 106 | 195597 | 17949 | 63275370 |
Amputation stump pain | 17.89 | 9.54 | 6 | 195697 | 31 | 63293288 |
Head injury | 17.85 | 9.54 | 145 | 195558 | 27251 | 63266068 |
Meningitis streptococcal | 17.79 | 9.54 | 9 | 195694 | 148 | 63293171 |
Retinal coloboma | 17.73 | 9.54 | 6 | 195697 | 32 | 63293287 |
Mood altered | 17.64 | 9.54 | 91 | 195612 | 14652 | 63278667 |
Tissue infiltration | 17.63 | 9.54 | 15 | 195688 | 614 | 63292705 |
Hypertonic bladder | 17.55 | 9.54 | 36 | 195667 | 3552 | 63289767 |
Panic disorder | 17.34 | 9.54 | 30 | 195673 | 2603 | 63290716 |
Areflexia | 17.32 | 9.54 | 33 | 195670 | 3085 | 63290234 |
Cholecystectomy | 17.28 | 9.54 | 72 | 195631 | 10605 | 63282714 |
Chronic sinusitis | 17.26 | 9.54 | 9 | 195694 | 12834 | 63280485 |
Lipoedema | 17.23 | 9.54 | 11 | 195692 | 287 | 63293032 |
Meconium in amniotic fluid | 17.20 | 9.54 | 11 | 195692 | 288 | 63293031 |
Transplant rejection | 16.96 | 9.54 | 6 | 195697 | 10774 | 63282545 |
Soft tissue injury | 16.77 | 9.54 | 23 | 195680 | 1629 | 63291690 |
Cardiac steatosis | 16.74 | 9.54 | 6 | 195697 | 39 | 63293280 |
Cushingoid | 16.66 | 9.54 | 3 | 195700 | 8482 | 63284837 |
Bone erosion | 16.64 | 9.54 | 18 | 195685 | 17699 | 63275620 |
Herpes zoster | 16.64 | 9.54 | 168 | 195535 | 82294 | 63211025 |
Differential white blood cell count abnormal | 16.63 | 9.54 | 16 | 195687 | 770 | 63292549 |
Aspartate aminotransferase increased | 16.57 | 9.54 | 188 | 195515 | 90089 | 63203230 |
Pyelonephritis chronic | 16.55 | 9.54 | 10 | 195693 | 236 | 63293083 |
Decerebrate posture | 16.53 | 9.54 | 8 | 195695 | 119 | 63293200 |
Fibrous histiocytoma | 16.46 | 9.54 | 14 | 195689 | 573 | 63292746 |
Circulatory collapse | 16.46 | 9.54 | 120 | 195583 | 21818 | 63271501 |
Kinematic imbalances due to suboccipital strain | 16.38 | 9.54 | 4 | 195699 | 4 | 63293315 |
Psychiatric symptom | 16.34 | 9.54 | 44 | 195659 | 5179 | 63288140 |
Rhabdomyolysis | 16.24 | 9.54 | 207 | 195496 | 43744 | 63249575 |
Frequent bowel movements | 16.18 | 9.54 | 124 | 195579 | 22898 | 63270421 |
Pulmonary valve disease | 16.14 | 9.54 | 5 | 195698 | 19 | 63293300 |
Psoriasis | 16.07 | 9.54 | 366 | 195337 | 86591 | 63206728 |
Akinesia | 15.90 | 9.54 | 22 | 195681 | 1571 | 63291748 |
Urethral haemorrhage | 15.90 | 9.54 | 6 | 195697 | 46 | 63293273 |
Aspiration | 15.89 | 9.54 | 71 | 195632 | 10780 | 63282539 |
Loss of personal independence in daily activities | 15.81 | 9.54 | 208 | 195495 | 97082 | 63196237 |
Leukopenia | 15.78 | 9.54 | 157 | 195546 | 77133 | 63216186 |
Hyporeflexia | 15.76 | 9.54 | 24 | 195679 | 1871 | 63291448 |
Morbid thoughts | 15.73 | 9.54 | 14 | 195689 | 609 | 63292710 |
Non-cardiogenic pulmonary oedema | 15.69 | 9.54 | 15 | 195688 | 716 | 63292603 |
Sleep terror | 15.68 | 9.54 | 29 | 195674 | 2651 | 63290668 |
Delusion | 15.67 | 9.54 | 76 | 195627 | 11941 | 63281378 |
Postmortem blood drug level | 15.63 | 9.54 | 8 | 195695 | 135 | 63293184 |
Polymenorrhagia | 15.57 | 9.54 | 6 | 195697 | 49 | 63293270 |
Initial insomnia | 15.52 | 9.54 | 48 | 195655 | 6109 | 63287210 |
Respiratory alkalosis | 15.52 | 9.54 | 29 | 195674 | 2672 | 63290647 |
Adjustment disorder with depressed mood | 15.52 | 9.54 | 6 | 195697 | 10198 | 63283121 |
Live birth | 15.51 | 9.54 | 35 | 195668 | 25595 | 63267724 |
Hippocampal sclerosis | 15.51 | 9.54 | 7 | 195696 | 88 | 63293231 |
Ocular hyperaemia | 15.50 | 9.54 | 34 | 195669 | 25110 | 63268209 |
Suspected suicide | 15.45 | 9.54 | 50 | 195653 | 6518 | 63286801 |
Hallucinations, mixed | 15.43 | 9.54 | 41 | 195662 | 4788 | 63288531 |
Pulmonary toxicity | 15.33 | 9.54 | 5 | 195698 | 9450 | 63283869 |
Hypercalcaemia | 15.32 | 9.54 | 41 | 195662 | 28281 | 63265038 |
Mental status changes | 15.27 | 9.54 | 188 | 195515 | 39411 | 63253908 |
Urticaria | 15.13 | 9.54 | 392 | 195311 | 165410 | 63127909 |
Dysponesis | 15.12 | 9.54 | 4 | 195699 | 7 | 63293312 |
Tardive dyskinesia | 15.09 | 9.54 | 59 | 195644 | 8443 | 63284876 |
Metastases to bone | 15.06 | 9.54 | 26 | 195677 | 20993 | 63272326 |
Female orgasmic disorder | 14.97 | 9.54 | 6 | 195697 | 55 | 63293264 |
Enterocolitis | 14.96 | 9.54 | 3 | 195700 | 7855 | 63285464 |
Uterine enlargement | 14.95 | 9.54 | 19 | 195684 | 1249 | 63292070 |
Neutrophil count decreased | 14.94 | 9.54 | 107 | 195596 | 56299 | 63237020 |
Bipolar II disorder | 14.89 | 9.54 | 11 | 195692 | 366 | 63292953 |
Creatinine renal clearance decreased | 14.84 | 9.54 | 17 | 195686 | 16291 | 63277028 |
Respiratory rate increased | 14.80 | 9.54 | 82 | 195621 | 13566 | 63279753 |
Thrombotic microangiopathy | 14.80 | 9.54 | 7 | 195696 | 10554 | 63282765 |
Accommodation disorder | 14.78 | 9.54 | 11 | 195692 | 370 | 63292949 |
Injection site swelling | 14.76 | 9.54 | 86 | 195617 | 47486 | 63245833 |
Upper respiratory tract infection | 14.75 | 9.54 | 344 | 195359 | 81703 | 63211616 |
Vertigo CNS origin | 14.73 | 9.54 | 5 | 195698 | 27 | 63293292 |
Bronchial hyperreactivity | 14.66 | 9.54 | 22 | 195681 | 1693 | 63291626 |
Swollen tongue | 14.65 | 9.54 | 168 | 195535 | 34632 | 63258687 |
Tension | 14.53 | 9.54 | 31 | 195672 | 3144 | 63290175 |
Pancreatitis | 14.47 | 9.54 | 222 | 195481 | 48833 | 63244486 |
Blood bilirubin increased | 14.47 | 9.54 | 62 | 195641 | 37078 | 63256241 |
Acute kidney injury | 14.44 | 9.54 | 664 | 195039 | 262751 | 63030568 |
Dissociative amnesia | 14.43 | 9.54 | 5 | 195698 | 29 | 63293290 |
Borderline personality disorder | 14.38 | 9.54 | 15 | 195688 | 796 | 63292523 |
Urine abnormality | 14.37 | 9.54 | 51 | 195652 | 6968 | 63286351 |
Multiple sclerosis | 14.29 | 9.54 | 126 | 195577 | 24246 | 63269073 |
Dysaesthesia | 14.29 | 9.54 | 38 | 195665 | 4440 | 63288879 |
Polydipsia | 14.28 | 9.54 | 33 | 195670 | 3531 | 63289788 |
Balance disorder | 14.28 | 9.54 | 351 | 195352 | 84071 | 63209248 |
Blood creatine phosphokinase increased | 14.23 | 9.54 | 150 | 195553 | 30280 | 63263039 |
Conversion disorder | 14.19 | 9.54 | 22 | 195681 | 1742 | 63291577 |
Neutrophil count abnormal | 14.12 | 9.54 | 29 | 195674 | 2863 | 63290456 |
Increased appetite | 14.10 | 9.54 | 63 | 195640 | 9567 | 63283752 |
Antisocial behaviour | 14.09 | 9.54 | 11 | 195692 | 398 | 63292921 |
Palpitations | 14.07 | 9.54 | 451 | 195252 | 112319 | 63181000 |
Blood pressure decreased | 14.06 | 9.54 | 280 | 195423 | 64742 | 63228577 |
Alanine aminotransferase increased | 14.03 | 9.54 | 230 | 195473 | 103540 | 63189779 |
Therapy interrupted | 14.02 | 9.54 | 52 | 195651 | 32403 | 63260916 |
Ureteric dilatation | 14.02 | 9.54 | 5 | 195698 | 32 | 63293287 |
Incoherent | 14.01 | 9.54 | 38 | 195665 | 4492 | 63288827 |
Localised infection | 13.99 | 9.54 | 47 | 195656 | 30163 | 63263156 |
Throat irritation | 13.97 | 9.54 | 64 | 195639 | 37583 | 63255736 |
Ejection fraction decreased | 13.93 | 9.54 | 30 | 195673 | 22302 | 63271017 |
Peripheral circulatory failure | 13.85 | 9.54 | 16 | 195687 | 952 | 63292367 |
Pupil fixed | 13.77 | 9.54 | 22 | 195681 | 1787 | 63291532 |
Injection site pruritus | 13.76 | 9.54 | 82 | 195621 | 45034 | 63248285 |
Amniorrhexis | 13.76 | 9.54 | 5 | 195698 | 34 | 63293285 |
Visual field defect | 13.71 | 9.54 | 48 | 195655 | 6513 | 63286806 |
Parotid gland enlargement | 13.68 | 9.54 | 15 | 195688 | 843 | 63292476 |
Blood ethanol increased | 13.63 | 9.54 | 7 | 195696 | 119 | 63293200 |
Peritoneal perforation | 13.63 | 9.54 | 7 | 195696 | 119 | 63293200 |
Tension headache | 13.60 | 9.54 | 41 | 195662 | 5145 | 63288174 |
Hypertension | 13.57 | 9.54 | 713 | 194990 | 278590 | 63014729 |
Sciatica | 13.55 | 9.54 | 57 | 195646 | 34267 | 63259052 |
Hepatic steatosis | 13.54 | 9.54 | 142 | 195561 | 28627 | 63264692 |
Gallbladder disorder | 13.53 | 9.54 | 102 | 195601 | 18740 | 63274579 |
Adjusted calcium decreased | 13.50 | 9.54 | 8 | 195695 | 182 | 63293137 |
Anaesthesia | 13.49 | 9.54 | 11 | 195692 | 424 | 63292895 |
Reversible airways obstruction | 13.48 | 9.54 | 22 | 195681 | 1820 | 63291499 |
Toxic epidermal necrolysis | 13.46 | 9.54 | 37 | 195666 | 25297 | 63268022 |
Trismus | 13.46 | 9.54 | 34 | 195669 | 3851 | 63289468 |
Pseudomonas infection | 13.46 | 9.54 | 9 | 195694 | 11204 | 63282115 |
Activated partial thromboplastin time abnormal | 13.42 | 9.54 | 7 | 195696 | 123 | 63293196 |
Periventricular leukomalacia | 13.37 | 9.54 | 7 | 195696 | 124 | 63293195 |
Lung disorder | 13.34 | 9.54 | 125 | 195578 | 62136 | 63231183 |
Osteoarthritis | 13.33 | 9.54 | 210 | 195493 | 95133 | 63198186 |
Disinhibition | 13.32 | 9.54 | 15 | 195688 | 868 | 63292451 |
Drug dose titration not performed | 13.27 | 9.54 | 12 | 195691 | 533 | 63292786 |
Bronchopulmonary aspergillosis | 13.26 | 9.54 | 5 | 195698 | 8630 | 63284689 |
Impaired self-care | 13.23 | 9.54 | 22 | 195681 | 1848 | 63291471 |
Pneumonia viral | 13.18 | 9.54 | 4 | 195699 | 7918 | 63285401 |
Lower limb fracture | 13.15 | 9.54 | 35 | 195668 | 24186 | 63269133 |
Hypervigilance | 13.14 | 9.54 | 10 | 195693 | 348 | 63292971 |
Hyponatraemic syndrome | 13.09 | 9.54 | 12 | 195691 | 543 | 63292776 |
Hepatic cytolysis | 13.03 | 9.54 | 17 | 195686 | 15390 | 63277929 |
Miosis | 13.03 | 9.54 | 51 | 195652 | 7302 | 63286017 |
Cytopenia | 13.02 | 9.54 | 10 | 195693 | 11591 | 63281728 |
Renal impairment | 12.90 | 9.54 | 193 | 195510 | 88162 | 63205157 |
Antipsychotic drug level above therapeutic | 12.89 | 9.54 | 16 | 195687 | 1027 | 63292292 |
Tinnitus | 12.83 | 9.54 | 167 | 195536 | 35461 | 63257858 |
Reflexes abnormal | 12.80 | 9.54 | 13 | 195690 | 668 | 63292651 |
Pleural effusion | 12.80 | 9.54 | 206 | 195497 | 93004 | 63200315 |
Sensory disturbance | 12.79 | 9.54 | 79 | 195624 | 13593 | 63279726 |
Pickwickian syndrome | 12.78 | 9.54 | 10 | 195693 | 363 | 63292956 |
Indifference | 12.75 | 9.54 | 7 | 195696 | 137 | 63293182 |
Post procedural haematuria | 12.65 | 9.54 | 5 | 195698 | 44 | 63293275 |
Congestive hepatopathy | 12.64 | 9.54 | 28 | 195675 | 2914 | 63290405 |
Muscle tension dysphonia | 12.62 | 9.54 | 8 | 195695 | 206 | 63293113 |
Drug ineffective for unapproved indication | 12.58 | 9.54 | 58 | 195645 | 34005 | 63259314 |
Cerebral ventricular rupture | 12.56 | 9.54 | 8 | 195695 | 208 | 63293111 |
Gastrointestinal sounds abnormal | 12.55 | 9.54 | 34 | 195669 | 4017 | 63289302 |
Hyperacusis | 12.53 | 9.54 | 23 | 195680 | 2090 | 63291229 |
Anosmia | 12.50 | 9.54 | 48 | 195655 | 6812 | 63286507 |
Foot deformity | 12.45 | 9.54 | 44 | 195659 | 27809 | 63265510 |
Blood creatinine increased | 12.44 | 9.54 | 193 | 195510 | 87651 | 63205668 |
Hip surgery | 12.44 | 9.54 | 30 | 195673 | 3301 | 63290018 |
Pneumonitis | 12.41 | 9.54 | 61 | 195642 | 35161 | 63258158 |
Burns second degree | 12.33 | 9.54 | 22 | 195681 | 1956 | 63291363 |
Tic | 12.29 | 9.54 | 19 | 195684 | 1501 | 63291818 |
Anti-neuronal antibody positive | 12.29 | 9.54 | 3 | 195700 | 3 | 63293316 |
Bisexuality | 12.29 | 9.54 | 3 | 195700 | 3 | 63293316 |
Electrolyte substitution therapy | 12.29 | 9.54 | 3 | 195700 | 3 | 63293316 |
Onychogryphosis | 12.29 | 9.54 | 3 | 195700 | 3 | 63293316 |
Cervix haematoma uterine | 12.29 | 9.54 | 3 | 195700 | 3 | 63293316 |
Menopause | 12.26 | 9.54 | 27 | 195676 | 2798 | 63290521 |
Pruritus genital | 12.25 | 9.54 | 26 | 195677 | 2628 | 63290691 |
Respiratory acidosis | 12.24 | 9.54 | 47 | 195656 | 6668 | 63286651 |
Neutrophil Pelger-Huet anomaly present | 12.24 | 9.54 | 6 | 195697 | 92 | 63293227 |
Poor quality sleep | 12.18 | 9.54 | 104 | 195599 | 19831 | 63273488 |
Psychogenic seizure | 12.10 | 9.54 | 20 | 195683 | 1672 | 63291647 |
Catarrh | 12.02 | 9.54 | 19 | 195684 | 1530 | 63291789 |
Aphasia | 12.01 | 9.54 | 155 | 195548 | 32845 | 63260474 |
Congenital tricuspid valve incompetence | 12.01 | 9.54 | 6 | 195697 | 96 | 63293223 |
Disability | 11.99 | 9.54 | 24 | 195679 | 18323 | 63274996 |
Exostosis | 11.99 | 9.54 | 23 | 195680 | 17839 | 63275480 |
Microphthalmos | 11.98 | 9.54 | 7 | 195696 | 155 | 63293164 |
Sexual inhibition | 11.88 | 9.54 | 4 | 195699 | 21 | 63293298 |
Immune thrombocytopenia | 11.83 | 9.54 | 64 | 195639 | 10492 | 63282827 |
COVID-19 | 11.81 | 9.54 | 262 | 195441 | 112841 | 63180478 |
Crepitations | 11.78 | 9.54 | 5 | 195698 | 8035 | 63285284 |
Nasal obstruction | 11.76 | 9.54 | 20 | 195683 | 1711 | 63291608 |
Biliary dyskinesia | 11.75 | 9.54 | 26 | 195677 | 2703 | 63290616 |
Marital problem | 11.75 | 9.54 | 7 | 195696 | 161 | 63293158 |
Product administered to patient of inappropriate age | 11.74 | 9.54 | 29 | 195674 | 3239 | 63290080 |
Osteonecrosis of jaw | 11.71 | 9.54 | 62 | 195641 | 35061 | 63258258 |
Multiple organ dysfunction syndrome | 11.70 | 9.54 | 115 | 195588 | 56637 | 63236682 |
Drug abuser | 11.64 | 9.54 | 27 | 195676 | 2896 | 63290423 |
Cardiospasm | 11.62 | 9.54 | 21 | 195682 | 1886 | 63291433 |
Atrial tachycardia | 11.58 | 9.54 | 34 | 195669 | 4206 | 63289113 |
Nodal arrhythmia | 11.52 | 9.54 | 16 | 195687 | 1147 | 63292172 |
Agitation neonatal | 11.49 | 9.54 | 11 | 195692 | 526 | 63292793 |
Post-traumatic stress disorder | 11.48 | 9.54 | 39 | 195664 | 5212 | 63288107 |
Rhinitis | 11.48 | 9.54 | 67 | 195636 | 11299 | 63282020 |
Atrophic vulvovaginitis | 11.45 | 9.54 | 20 | 195683 | 1748 | 63291571 |
Sunburn | 11.38 | 9.54 | 26 | 195677 | 2762 | 63290557 |
Periodic limb movement disorder | 11.38 | 9.54 | 8 | 195695 | 246 | 63293073 |
White blood cell count decreased | 11.37 | 9.54 | 334 | 195369 | 138770 | 63154549 |
Vascular encephalopathy | 11.32 | 9.54 | 10 | 195693 | 431 | 63292888 |
Hyperventilation | 11.31 | 9.54 | 43 | 195660 | 6073 | 63287246 |
Diastolic hypertension | 11.29 | 9.54 | 4 | 195699 | 25 | 63293294 |
Choanal atresia | 11.29 | 9.54 | 4 | 195699 | 25 | 63293294 |
Apgar score low | 11.29 | 9.54 | 13 | 195690 | 771 | 63292548 |
Noninfective encephalitis | 11.26 | 9.54 | 10 | 195693 | 434 | 63292885 |
Acidosis | 11.20 | 9.54 | 66 | 195637 | 11167 | 63282152 |
Analgesic drug level above therapeutic | 11.19 | 9.54 | 7 | 195696 | 176 | 63293143 |
Accidental exposure to product | 11.14 | 9.54 | 45 | 195658 | 27360 | 63265959 |
Hypocalcaemia | 11.13 | 9.54 | 55 | 195648 | 31658 | 63261661 |
Blunted affect | 11.13 | 9.54 | 8 | 195695 | 255 | 63293064 |
Renal disorder | 11.11 | 9.54 | 58 | 195645 | 32916 | 63260403 |
Phobia | 11.08 | 9.54 | 9 | 195694 | 345 | 63292974 |
Congenital megacolon | 11.08 | 9.54 | 3 | 195700 | 6 | 63293313 |
Polyarthritis | 11.07 | 9.54 | 9 | 195694 | 10137 | 63283182 |
Maternal exposure timing unspecified | 11.06 | 9.54 | 4 | 195699 | 7083 | 63286236 |
Regressive behaviour | 11.05 | 9.54 | 7 | 195696 | 180 | 63293139 |
Caesarean section | 11.01 | 9.54 | 90 | 195613 | 16942 | 63276377 |
Pleurisy | 10.98 | 9.54 | 6 | 195697 | 8334 | 63284985 |
Facial bones fracture | 10.94 | 9.54 | 32 | 195671 | 3950 | 63289369 |
Palmoplantar keratoderma | 10.85 | 9.54 | 21 | 195682 | 1986 | 63291333 |
Narcolepsy | 10.82 | 9.54 | 17 | 195686 | 1361 | 63291958 |
Vaginal haemorrhage | 10.82 | 9.54 | 131 | 195572 | 27356 | 63265963 |
Upper gastrointestinal haemorrhage | 10.81 | 9.54 | 97 | 195606 | 18755 | 63274564 |
Sexually inappropriate behaviour | 10.81 | 9.54 | 6 | 195697 | 120 | 63293199 |
Systolic hypertension | 10.79 | 9.54 | 10 | 195693 | 459 | 63292860 |
Drug level above therapeutic | 10.79 | 9.54 | 36 | 195667 | 4769 | 63288550 |
Drug screen positive | 10.78 | 9.54 | 30 | 195673 | 3599 | 63289720 |
Pulmonary valve incompetence | 10.78 | 9.54 | 17 | 195686 | 1366 | 63291953 |
Teratogenicity | 10.75 | 9.54 | 8 | 195695 | 269 | 63293050 |
No adverse event | 10.74 | 9.54 | 79 | 195624 | 41326 | 63251993 |
Incision site haemorrhage | 10.70 | 9.54 | 11 | 195692 | 574 | 63292745 |
Joint destruction | 10.69 | 9.54 | 3 | 195700 | 6249 | 63287070 |
Urinary incontinence | 10.67 | 9.54 | 148 | 195555 | 31866 | 63261453 |
Merycism | 10.65 | 9.54 | 8 | 195695 | 273 | 63293046 |
Carcinoid syndrome | 10.64 | 9.54 | 6 | 195697 | 124 | 63293195 |
Heterophoria | 10.56 | 9.54 | 4 | 195699 | 31 | 63293288 |
Pulmonary arterial hypertension | 10.54 | 9.54 | 35 | 195668 | 22542 | 63270777 |
Gastroenteritis bacterial | 10.52 | 9.54 | 9 | 195694 | 371 | 63292948 |
Oedema | 10.52 | 9.54 | 225 | 195478 | 97397 | 63195922 |
Breath sounds abnormal | 10.47 | 9.54 | 11 | 195692 | 10962 | 63282357 |
Gastrointestinal procedural complication | 10.41 | 9.54 | 7 | 195696 | 200 | 63293119 |
Musculoskeletal chest pain | 10.37 | 9.54 | 105 | 195598 | 20978 | 63272341 |
Throat clearing | 10.37 | 9.54 | 23 | 195680 | 2396 | 63290923 |
Neonatal sinus tachycardia | 10.34 | 9.54 | 4 | 195699 | 33 | 63293286 |
Umbilical artery vascular resistance increased | 10.34 | 9.54 | 4 | 195699 | 33 | 63293286 |
Unintentional medical device removal | 10.34 | 9.54 | 3 | 195700 | 6112 | 63287207 |
Irregular sleep wake rhythm disorder | 10.28 | 9.54 | 7 | 195696 | 204 | 63293115 |
Respiratory depression | 10.27 | 9.54 | 75 | 195628 | 13640 | 63279679 |
Angiodermatitis | 10.24 | 9.54 | 5 | 195698 | 76 | 63293243 |
Oral neoplasm benign | 10.22 | 9.54 | 3 | 195700 | 9 | 63293310 |
Steroid dependence | 10.21 | 9.54 | 19 | 195684 | 1745 | 63291574 |
Agoraphobia | 10.20 | 9.54 | 9 | 195694 | 387 | 63292932 |
Hepatorenal syndrome | 10.19 | 9.54 | 20 | 195683 | 1912 | 63291407 |
Myocardial depression | 10.17 | 9.54 | 10 | 195693 | 494 | 63292825 |
Tendonitis | 10.16 | 9.54 | 29 | 195674 | 19586 | 63273733 |
Airway remodelling | 10.12 | 9.54 | 5 | 195698 | 78 | 63293241 |
Chronic spontaneous urticaria | 10.11 | 9.54 | 15 | 195688 | 1142 | 63292177 |
Nystagmus | 10.11 | 9.54 | 42 | 195661 | 6178 | 63287141 |
Intra-abdominal haemorrhage | 10.05 | 9.54 | 23 | 195680 | 2446 | 63290873 |
Pancreatic injury | 10.04 | 9.54 | 4 | 195699 | 36 | 63293283 |
Dermatochalasis | 9.99 | 9.54 | 3 | 195700 | 10 | 63293309 |
Antisocial personality disorder | 9.99 | 9.54 | 3 | 195700 | 10 | 63293309 |
Right ventricular failure | 9.98 | 9.54 | 24 | 195679 | 17164 | 63276155 |
Violence-related symptom | 9.97 | 9.54 | 9 | 195694 | 399 | 63292920 |
Corneal reflex decreased | 9.95 | 9.54 | 6 | 195697 | 141 | 63293178 |
Anaemia | 9.95 | 9.54 | 774 | 194929 | 292656 | 63000663 |
Contraindicated product prescribed | 9.93 | 9.54 | 16 | 195687 | 1309 | 63292010 |
Sudden cardiac death | 9.92 | 9.54 | 21 | 195682 | 2119 | 63291200 |
Hypopnoea | 9.90 | 9.54 | 30 | 195673 | 3776 | 63289543 |
Dysphemia | 9.89 | 9.54 | 24 | 195679 | 2651 | 63290668 |
Hypersexuality | 9.88 | 9.54 | 10 | 195693 | 512 | 63292807 |
Joint stiffness | 9.87 | 9.54 | 82 | 195621 | 41787 | 63251532 |
Tuberculosis | 9.87 | 9.54 | 12 | 195691 | 11199 | 63282120 |
Therapy partial responder | 9.82 | 9.54 | 11 | 195692 | 10647 | 63282672 |
Oromandibular dystonia | 9.80 | 9.54 | 10 | 195693 | 517 | 63292802 |
Myocardial fibrosis | 9.80 | 9.54 | 12 | 195691 | 760 | 63292559 |
Joint ankylosis | 9.78 | 9.54 | 14 | 195689 | 1032 | 63292287 |
Ceruloplasmin decreased | 9.77 | 9.54 | 3 | 195700 | 11 | 63293308 |
Glaucoma | 9.75 | 9.54 | 28 | 195675 | 18877 | 63274442 |
Neonatal infection | 9.73 | 9.54 | 6 | 195697 | 147 | 63293172 |
Tubulointerstitial nephritis | 9.73 | 9.54 | 99 | 195604 | 19804 | 63273515 |
Drug level increased | 9.68 | 9.54 | 110 | 195593 | 22626 | 63270693 |
Fear of injection | 9.66 | 9.54 | 5 | 195698 | 7159 | 63286160 |
Micturition disorder | 9.63 | 9.54 | 23 | 195680 | 2515 | 63290804 |
Affective disorder | 9.60 | 9.54 | 41 | 195662 | 6105 | 63287214 |
Q fever | 9.59 | 9.54 | 6 | 195697 | 151 | 63293168 |
CSF white blood cell count increased | 9.59 | 9.54 | 4 | 195699 | 41 | 63293278 |
Rectal haemorrhage | 9.57 | 9.54 | 208 | 195495 | 48822 | 63244497 |
Prescribed underdose | 9.57 | 9.54 | 53 | 195650 | 29636 | 63263683 |
Congenital lymphoedema | 9.56 | 9.54 | 3 | 195700 | 12 | 63293307 |
Blood copper decreased | 9.56 | 9.54 | 3 | 195700 | 12 | 63293307 |
Blood osmolarity decreased | 9.54 | 9.54 | 13 | 195690 | 915 | 63292404 |
Oral candidiasis | 9.54 | 9.54 | 37 | 195666 | 22761 | 63270558 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1016.16 | 10.74 | 1273 | 91177 | 96895 | 34767586 |
Toxicity to various agents | 893.28 | 10.74 | 1762 | 90688 | 198600 | 34665881 |
Serotonin syndrome | 526.00 | 10.74 | 430 | 92020 | 19503 | 34844978 |
Drug abuse | 459.86 | 10.74 | 888 | 91562 | 98208 | 34766273 |
Suicidal ideation | 452.68 | 10.74 | 546 | 91904 | 39842 | 34824639 |
Intentional overdose | 297.39 | 10.74 | 464 | 91986 | 43210 | 34821271 |
Overdose | 289.96 | 10.74 | 701 | 91749 | 90358 | 34774123 |
Suicide attempt | 276.71 | 10.74 | 423 | 92027 | 38693 | 34825788 |
Paranoia | 248.50 | 10.74 | 226 | 92224 | 11842 | 34852639 |
Foetal exposure during pregnancy | 233.62 | 10.74 | 386 | 92064 | 37715 | 34826766 |
Drug interaction | 218.20 | 10.74 | 1174 | 91276 | 224772 | 34639709 |
Tearfulness | 215.93 | 10.74 | 116 | 92334 | 2551 | 34861930 |
Anxiety | 213.03 | 10.74 | 662 | 91788 | 98766 | 34765715 |
Disinhibition | 200.57 | 10.74 | 118 | 92332 | 3108 | 34861373 |
Psychiatric decompensation | 200.06 | 10.74 | 114 | 92336 | 2823 | 34861658 |
Depression suicidal | 197.35 | 10.74 | 107 | 92343 | 2398 | 34862083 |
Depressive symptom | 192.14 | 10.74 | 110 | 92340 | 2749 | 34861732 |
Obsessive-compulsive disorder | 187.94 | 10.74 | 139 | 92311 | 5425 | 34859056 |
Antipsychotic drug level below therapeutic | 181.97 | 10.74 | 102 | 92348 | 2445 | 34862036 |
Electrocardiogram QT prolonged | 167.99 | 10.74 | 349 | 92101 | 40603 | 34823878 |
Respiratory disorder neonatal | 160.94 | 10.74 | 81 | 92369 | 1549 | 34862932 |
Therapeutic product effect variable | 153.12 | 10.74 | 90 | 92360 | 2366 | 34862115 |
Intentional self-injury | 152.21 | 10.74 | 185 | 92265 | 13586 | 34850895 |
Off label use | 150.93 | 10.74 | 586 | 91864 | 418938 | 34445543 |
Akathisia | 147.95 | 10.74 | 142 | 92308 | 7967 | 34856514 |
Psychomotor skills impaired | 146.55 | 10.74 | 104 | 92346 | 3802 | 34860679 |
Drug withdrawal syndrome neonatal | 139.58 | 10.74 | 98 | 92352 | 3521 | 34860960 |
Aggression | 135.81 | 10.74 | 311 | 92139 | 38653 | 34825828 |
Agitation neonatal | 130.82 | 10.74 | 62 | 92388 | 1034 | 34863447 |
Euphoric mood | 130.77 | 10.74 | 113 | 92337 | 5528 | 34858953 |
Poisoning | 129.88 | 10.74 | 161 | 92289 | 12065 | 34852416 |
Psychotic disorder | 125.38 | 10.74 | 229 | 92221 | 24223 | 34840258 |
Irritability | 122.53 | 10.74 | 228 | 92222 | 24462 | 34840019 |
Increased appetite | 122.32 | 10.74 | 123 | 92327 | 7306 | 34857175 |
Depression | 120.86 | 10.74 | 543 | 91907 | 96555 | 34767926 |
Febrile neutropenia | 120.07 | 10.74 | 111 | 92339 | 136738 | 34727743 |
Loss of libido | 119.67 | 10.74 | 78 | 92372 | 2474 | 34862007 |
Agitation | 118.94 | 10.74 | 378 | 92072 | 57021 | 34807460 |
Depressed mood | 113.40 | 10.74 | 192 | 92258 | 19125 | 34845356 |
Respiratory arrest | 111.49 | 10.74 | 236 | 92214 | 27807 | 34836674 |
Pyrexia | 109.04 | 10.74 | 482 | 91968 | 332531 | 34531950 |
Restlessness | 106.62 | 10.74 | 219 | 92231 | 25263 | 34839218 |
Confusional state | 106.52 | 10.74 | 699 | 91751 | 143461 | 34721020 |
Small for dates baby | 104.11 | 10.74 | 85 | 92365 | 3842 | 34860639 |
Hypertonia neonatal | 103.84 | 10.74 | 41 | 92409 | 426 | 34864055 |
Neonatal respiratory distress syndrome | 100.03 | 10.74 | 84 | 92366 | 3950 | 34860531 |
Atrial septal defect | 92.78 | 10.74 | 106 | 92344 | 7286 | 34857195 |
Disturbance in attention | 92.51 | 10.74 | 209 | 92241 | 25736 | 34838745 |
Sexual dysfunction | 90.53 | 10.74 | 97 | 92353 | 6206 | 34858275 |
Intrusive thoughts | 89.25 | 10.74 | 33 | 92417 | 282 | 34864199 |
Orgasmic sensation decreased | 86.53 | 10.74 | 23 | 92427 | 52 | 34864429 |
Tremor | 82.67 | 10.74 | 434 | 92016 | 82153 | 34782328 |
Erectile dysfunction | 80.08 | 10.74 | 172 | 92278 | 20465 | 34844016 |
Pneumonia | 76.93 | 10.74 | 603 | 91847 | 362024 | 34502457 |
Psychomotor retardation | 76.38 | 10.74 | 69 | 92381 | 3581 | 34860900 |
Homicidal ideation | 73.10 | 10.74 | 59 | 92391 | 2623 | 34861858 |
Acute kidney injury | 72.42 | 10.74 | 491 | 91959 | 304497 | 34559984 |
Anger | 69.58 | 10.74 | 118 | 92332 | 11766 | 34852715 |
Asphyxia | 69.38 | 10.74 | 88 | 92362 | 6747 | 34857734 |
Neonatal hypoxia | 67.60 | 10.74 | 29 | 92421 | 378 | 34864103 |
Cardio-respiratory arrest | 67.12 | 10.74 | 307 | 92143 | 54966 | 34809515 |
Temperature regulation disorder | 66.93 | 10.74 | 35 | 92415 | 727 | 34863754 |
Malignant neoplasm progression | 66.45 | 10.74 | 81 | 92369 | 87965 | 34776516 |
Interstitial lung disease | 65.90 | 10.74 | 46 | 92404 | 65236 | 34799245 |
Maternal drugs affecting foetus | 62.27 | 10.74 | 64 | 92386 | 3901 | 34860580 |
Sepsis | 61.93 | 10.74 | 229 | 92221 | 166332 | 34698149 |
Sedation | 60.68 | 10.74 | 156 | 92294 | 20850 | 34843631 |
Libido decreased | 60.05 | 10.74 | 68 | 92382 | 4628 | 34859853 |
Tachyphrenia | 60.02 | 10.74 | 39 | 92411 | 1230 | 34863251 |
Diarrhoea | 58.68 | 10.74 | 705 | 91745 | 389207 | 34475274 |
Neonatal seizure | 58.59 | 10.74 | 28 | 92422 | 476 | 34864005 |
Hepatic function abnormal | 58.55 | 10.74 | 22 | 92428 | 44341 | 34820140 |
Fall | 58.51 | 10.74 | 805 | 91645 | 202080 | 34662401 |
Genital hypoaesthesia | 57.46 | 10.74 | 22 | 92428 | 209 | 34864272 |
Accidental death | 56.52 | 10.74 | 49 | 92401 | 2407 | 34862074 |
Septic shock | 56.43 | 10.74 | 64 | 92386 | 71770 | 34792711 |
Sopor | 56.39 | 10.74 | 109 | 92341 | 12027 | 34852454 |
Hallucination | 55.95 | 10.74 | 277 | 92173 | 51221 | 34813260 |
Cryptorchism | 55.84 | 10.74 | 45 | 92405 | 1996 | 34862485 |
Panic attack | 55.67 | 10.74 | 94 | 92356 | 9338 | 34855143 |
Obesity | 55.42 | 10.74 | 112 | 92338 | 12766 | 34851715 |
Multiple organ dysfunction syndrome | 55.11 | 10.74 | 73 | 92377 | 76493 | 34787988 |
Prescribed overdose | 54.92 | 10.74 | 100 | 92350 | 10547 | 34853934 |
Somnambulism | 54.53 | 10.74 | 53 | 92397 | 3019 | 34861462 |
Muscle rigidity | 54.52 | 10.74 | 99 | 92351 | 10419 | 34854062 |
Bradycardia neonatal | 53.68 | 10.74 | 33 | 92417 | 943 | 34863538 |
Mental impairment | 53.31 | 10.74 | 97 | 92353 | 10225 | 34854256 |
Hallucination, auditory | 52.91 | 10.74 | 105 | 92345 | 11812 | 34852669 |
Exposure during pregnancy | 52.68 | 10.74 | 89 | 92361 | 8845 | 34855636 |
Intentional product misuse | 52.18 | 10.74 | 249 | 92201 | 45362 | 34819119 |
Homicide | 51.97 | 10.74 | 32 | 92418 | 917 | 34863564 |
Disease progression | 51.21 | 10.74 | 133 | 92317 | 107944 | 34756537 |
Cytomegalovirus infection | 51.01 | 10.74 | 5 | 92445 | 26130 | 34838351 |
Platelet count decreased | 50.33 | 10.74 | 156 | 92294 | 119561 | 34744920 |
Rhinitis perennial | 50.07 | 10.74 | 22 | 92428 | 305 | 34864176 |
Withdrawal syndrome | 49.69 | 10.74 | 105 | 92345 | 12350 | 34852131 |
Mood swings | 49.66 | 10.74 | 81 | 92369 | 7820 | 34856661 |
Somnolence | 49.57 | 10.74 | 480 | 91970 | 110636 | 34753845 |
Hallucination, visual | 49.21 | 10.74 | 130 | 92320 | 17661 | 34846820 |
Hypospadias | 49.06 | 10.74 | 51 | 92399 | 3150 | 34861331 |
Disturbance in sexual arousal | 47.50 | 10.74 | 17 | 92433 | 131 | 34864350 |
Drug screen positive | 46.90 | 10.74 | 55 | 92395 | 3888 | 34860593 |
Poverty of speech | 46.53 | 10.74 | 19 | 92431 | 217 | 34864264 |
Cardiac failure | 45.79 | 10.74 | 109 | 92341 | 91139 | 34773342 |
Derealisation | 45.64 | 10.74 | 25 | 92425 | 572 | 34863909 |
Logorrhoea | 45.23 | 10.74 | 43 | 92407 | 2383 | 34862098 |
Muscle twitching | 44.83 | 10.74 | 90 | 92360 | 10208 | 34854273 |
Coma scale abnormal | 44.53 | 10.74 | 54 | 92396 | 3954 | 34860527 |
COVID-19 | 44.43 | 10.74 | 86 | 92364 | 77464 | 34787017 |
Hypoglycaemia neonatal | 43.89 | 10.74 | 38 | 92412 | 1863 | 34862618 |
Mydriasis | 43.88 | 10.74 | 73 | 92377 | 7164 | 34857317 |
Parathyroid gland enlargement | 42.84 | 10.74 | 16 | 92434 | 141 | 34864340 |
Cardiac arrest | 42.69 | 10.74 | 415 | 92035 | 95744 | 34768737 |
Drug reaction with eosinophilia and systemic symptoms | 42.52 | 10.74 | 17 | 92433 | 32995 | 34831486 |
Hypomania | 42.44 | 10.74 | 41 | 92409 | 2318 | 34862163 |
Neutropenia | 41.95 | 10.74 | 243 | 92207 | 156535 | 34707946 |
Upper respiratory fungal infection | 41.33 | 10.74 | 16 | 92434 | 157 | 34864324 |
Myoclonus | 41.13 | 10.74 | 108 | 92342 | 14617 | 34849864 |
Renal failure | 40.73 | 10.74 | 192 | 92258 | 130365 | 34734116 |
Mucosal inflammation | 40.60 | 10.74 | 26 | 92424 | 38596 | 34825885 |
Haemangioma congenital | 40.45 | 10.74 | 22 | 92428 | 496 | 34863985 |
Leukaemia | 40.13 | 10.74 | 55 | 92395 | 4548 | 34859933 |
Infantile apnoea | 39.35 | 10.74 | 27 | 92423 | 934 | 34863547 |
Depressed level of consciousness | 38.69 | 10.74 | 219 | 92231 | 42622 | 34821859 |
Hyperreflexia | 38.60 | 10.74 | 45 | 92405 | 3161 | 34861320 |
Cytokine release syndrome | 38.42 | 10.74 | 7 | 92443 | 22870 | 34841611 |
Congenital ureteropelvic junction obstruction | 38.25 | 10.74 | 12 | 92438 | 58 | 34864423 |
Dyslipidaemia | 38.20 | 10.74 | 70 | 92380 | 7418 | 34857063 |
Premature ejaculation | 38.03 | 10.74 | 14 | 92436 | 118 | 34864363 |
Drug ineffective | 37.89 | 10.74 | 920 | 91530 | 455831 | 34408650 |
Stomatitis | 37.81 | 10.74 | 34 | 92416 | 42480 | 34822001 |
Hanging | 37.72 | 10.74 | 15 | 92435 | 159 | 34864322 |
Alcohol use | 37.68 | 10.74 | 45 | 92405 | 3243 | 34861238 |
Atrial fibrillation | 37.59 | 10.74 | 181 | 92269 | 122212 | 34742269 |
Drug withdrawal syndrome | 36.90 | 10.74 | 126 | 92324 | 19708 | 34844773 |
Vasoplegia syndrome | 36.72 | 10.74 | 34 | 92416 | 1822 | 34862659 |
Ventricular septal defect | 36.69 | 10.74 | 49 | 92401 | 3952 | 34860529 |
Anaemia | 36.48 | 10.74 | 418 | 92032 | 232917 | 34631564 |
Amnesia | 36.38 | 10.74 | 153 | 92297 | 26410 | 34838071 |
Prescription drug used without a prescription | 36.07 | 10.74 | 36 | 92414 | 2118 | 34862363 |
Neuropathy peripheral | 36.05 | 10.74 | 107 | 92343 | 83156 | 34781325 |
Pleural effusion | 35.88 | 10.74 | 104 | 92346 | 81442 | 34783039 |
Oedema peripheral | 35.74 | 10.74 | 179 | 92271 | 119633 | 34744848 |
Disorientation | 35.67 | 10.74 | 178 | 92272 | 33010 | 34831471 |
Mania | 35.44 | 10.74 | 78 | 92372 | 9433 | 34855048 |
Dyskinesia | 35.42 | 10.74 | 135 | 92315 | 22278 | 34842203 |
Congenital hepatomegaly | 35.29 | 10.74 | 9 | 92441 | 16 | 34864465 |
Hyperhidrosis | 35.23 | 10.74 | 330 | 92120 | 75362 | 34789119 |
Inappropriate antidiuretic hormone secretion | 35.08 | 10.74 | 93 | 92357 | 12660 | 34851821 |
Forced expiratory volume | 34.96 | 10.74 | 13 | 92437 | 113 | 34864368 |
Anorgasmia | 34.91 | 10.74 | 24 | 92426 | 833 | 34863648 |
Respiratory failure | 34.85 | 10.74 | 158 | 92292 | 108414 | 34756067 |
Thrombocytopenia | 34.78 | 10.74 | 256 | 92194 | 155991 | 34708490 |
Rheumatoid arthritis | 34.70 | 10.74 | 30 | 92420 | 38208 | 34826273 |
Loss of consciousness | 34.37 | 10.74 | 352 | 92098 | 82315 | 34782166 |
Mental disorder | 34.09 | 10.74 | 103 | 92347 | 15106 | 34849375 |
Adjustment disorder | 33.96 | 10.74 | 27 | 92423 | 1174 | 34863307 |
Negative thoughts | 33.25 | 10.74 | 21 | 92429 | 630 | 34863851 |
Hyperventilation | 32.94 | 10.74 | 39 | 92411 | 2785 | 34861696 |
Pneumonitis | 32.71 | 10.74 | 25 | 92425 | 33853 | 34830628 |
Renal impairment | 32.49 | 10.74 | 134 | 92316 | 94379 | 34770102 |
Drug resistance | 32.34 | 10.74 | 14 | 92436 | 25913 | 34838568 |
Bipolar disorder | 32.23 | 10.74 | 44 | 92406 | 3625 | 34860856 |
Electrocardiogram QRS complex prolonged | 31.89 | 10.74 | 51 | 92399 | 4843 | 34859638 |
Unresponsive to stimuli | 31.88 | 10.74 | 151 | 92299 | 27418 | 34837063 |
Circulatory collapse | 31.84 | 10.74 | 125 | 92325 | 20913 | 34843568 |
Apgar score low | 31.67 | 10.74 | 23 | 92427 | 872 | 34863609 |
Newborn persistent pulmonary hypertension | 31.25 | 10.74 | 12 | 92438 | 115 | 34864366 |
Gun shot wound | 31.13 | 10.74 | 25 | 92425 | 1103 | 34863378 |
Pancytopenia | 30.82 | 10.74 | 138 | 92312 | 95019 | 34769462 |
Tardive dyskinesia | 30.65 | 10.74 | 55 | 92395 | 5735 | 34858746 |
Product use in unapproved indication | 30.41 | 10.74 | 184 | 92266 | 117315 | 34747166 |
Limb deformity | 29.99 | 10.74 | 19 | 92431 | 573 | 34863908 |
Nightmare | 29.98 | 10.74 | 95 | 92355 | 14296 | 34850185 |
Failure to suspend medication | 29.83 | 10.74 | 17 | 92433 | 421 | 34864060 |
Optic nerve hypoplasia | 29.63 | 10.74 | 6 | 92444 | 0 | 34864481 |
Weight increased | 29.59 | 10.74 | 376 | 92074 | 92657 | 34771824 |
Apathy | 29.48 | 10.74 | 60 | 92390 | 6872 | 34857609 |
Patent ductus arteriosus | 29.12 | 10.74 | 40 | 92410 | 3314 | 34861167 |
Toxicologic test abnormal | 28.56 | 10.74 | 18 | 92432 | 538 | 34863943 |
Selective eating disorder | 28.46 | 10.74 | 29 | 92421 | 1749 | 34862732 |
C-reactive protein increased | 28.43 | 10.74 | 63 | 92387 | 54035 | 34810446 |
Drug hypersensitivity | 28.41 | 10.74 | 113 | 92337 | 80416 | 34784065 |
Psychomotor hyperactivity | 28.34 | 10.74 | 72 | 92378 | 9550 | 34854931 |
Myelosuppression | 28.15 | 10.74 | 8 | 92442 | 19257 | 34845224 |
Foot deformity | 27.82 | 10.74 | 46 | 92404 | 4491 | 34859990 |
Spontaneous penile erection | 27.69 | 10.74 | 13 | 92437 | 212 | 34864269 |
Pregnancy | 27.61 | 10.74 | 14 | 92436 | 272 | 34864209 |
Hyperbilirubinaemia neonatal | 27.45 | 10.74 | 20 | 92430 | 762 | 34863719 |
Hypotonia neonatal | 27.31 | 10.74 | 25 | 92425 | 1320 | 34863161 |
Impaired work ability | 27.15 | 10.74 | 58 | 92392 | 6872 | 34857609 |
Torsade de pointes | 26.72 | 10.74 | 59 | 92391 | 7150 | 34857331 |
Prostate cancer | 26.33 | 10.74 | 40 | 92410 | 39609 | 34824872 |
Sexual relationship change | 26.28 | 10.74 | 7 | 92443 | 16 | 34864465 |
Hypertonia | 25.97 | 10.74 | 43 | 92407 | 4203 | 34860278 |
Infection | 25.88 | 10.74 | 138 | 92312 | 90777 | 34773704 |
Tremor neonatal | 25.77 | 10.74 | 15 | 92435 | 387 | 34864094 |
Eosinophilia | 25.76 | 10.74 | 19 | 92431 | 26203 | 34838278 |
Pneumocystis jirovecii pneumonia | 25.63 | 10.74 | 10 | 92440 | 19700 | 34844781 |
Radiologically isolated syndrome | 25.48 | 10.74 | 6 | 92444 | 6 | 34864475 |
Impulsive behaviour | 25.45 | 10.74 | 30 | 92420 | 2132 | 34862349 |
Disseminated intravascular coagulation | 25.33 | 10.74 | 13 | 92437 | 21803 | 34842678 |
Decreased appetite | 25.23 | 10.74 | 300 | 92150 | 166092 | 34698389 |
Finnegan score increased | 24.92 | 10.74 | 7 | 92443 | 21 | 34864460 |
Intentional product misuse to child | 24.69 | 10.74 | 5 | 92445 | 0 | 34864481 |
Congenital hypercoagulation | 24.69 | 10.74 | 5 | 92445 | 0 | 34864481 |
Synovitis | 24.29 | 10.74 | 4 | 92446 | 14062 | 34850419 |
Oedema | 24.26 | 10.74 | 53 | 92397 | 45688 | 34818793 |
Clonus | 24.18 | 10.74 | 33 | 92417 | 2717 | 34861764 |
Haemophagocytic lymphohistiocytosis | 24.00 | 10.74 | 3 | 92447 | 12970 | 34851511 |
Infusion related reaction | 23.82 | 10.74 | 67 | 92383 | 52990 | 34811491 |
Schizoaffective disorder | 23.75 | 10.74 | 23 | 92427 | 1304 | 34863177 |
Heat stroke | 23.73 | 10.74 | 20 | 92430 | 945 | 34863536 |
Neonatal pneumonia | 23.68 | 10.74 | 10 | 92440 | 125 | 34864356 |
Congenital pulmonary hypertension | 23.65 | 10.74 | 9 | 92441 | 84 | 34864397 |
Seizure | 23.56 | 10.74 | 399 | 92051 | 104458 | 34760023 |
Bronchopulmonary aspergillosis | 23.53 | 10.74 | 5 | 92445 | 14654 | 34849827 |
Panic reaction | 23.51 | 10.74 | 24 | 92426 | 1451 | 34863030 |
Antipsychotic drug level increased | 23.45 | 10.74 | 39 | 92411 | 3826 | 34860655 |
Tumour lysis syndrome | 23.29 | 10.74 | 8 | 92442 | 17051 | 34847430 |
Delusion | 23.27 | 10.74 | 80 | 92370 | 12555 | 34851926 |
Kinematic imbalances due to suboccipital strain | 23.07 | 10.74 | 6 | 92444 | 12 | 34864469 |
Parkinsonism | 23.05 | 10.74 | 60 | 92390 | 8078 | 34856403 |
Dissociation | 22.91 | 10.74 | 25 | 92425 | 1633 | 34862848 |
Conduction disorder | 22.75 | 10.74 | 28 | 92422 | 2082 | 34862399 |
Thrombosis | 22.44 | 10.74 | 64 | 92386 | 50394 | 34814087 |
Bladder trabeculation | 22.35 | 10.74 | 5 | 92445 | 3 | 34864478 |
Dreamy state | 22.15 | 10.74 | 6 | 92444 | 15 | 34864466 |
Neonatal disorder | 22.07 | 10.74 | 18 | 92432 | 812 | 34863669 |
Myocardial fibrosis | 21.90 | 10.74 | 21 | 92429 | 1176 | 34863305 |
Congenital hydronephrosis | 21.85 | 10.74 | 17 | 92433 | 716 | 34863765 |
Myocardial infarction | 21.69 | 10.74 | 210 | 92240 | 120875 | 34743606 |
Tic | 21.69 | 10.74 | 27 | 92423 | 2031 | 34862450 |
Feeling abnormal | 21.57 | 10.74 | 259 | 92191 | 62976 | 34801505 |
Mental status changes | 21.33 | 10.74 | 173 | 92277 | 37910 | 34826571 |
Lactic acidosis | 21.29 | 10.74 | 37 | 92413 | 34735 | 34829746 |
Major depression | 21.16 | 10.74 | 41 | 92409 | 4531 | 34859950 |
Joint swelling | 21.14 | 10.74 | 84 | 92366 | 59806 | 34804675 |
Infant irritability | 21.06 | 10.74 | 7 | 92443 | 42 | 34864439 |
Maternal exposure during breast feeding | 20.88 | 10.74 | 23 | 92427 | 1518 | 34862963 |
Toxic epidermal necrolysis | 20.86 | 10.74 | 16 | 92434 | 21630 | 34842851 |
Interstitial granulomatous dermatitis | 20.82 | 10.74 | 10 | 92440 | 172 | 34864309 |
Gender dysphoria | 20.78 | 10.74 | 7 | 92443 | 44 | 34864437 |
Constipation | 20.74 | 10.74 | 247 | 92203 | 136735 | 34727746 |
Drug dependence | 20.68 | 10.74 | 122 | 92328 | 24095 | 34840386 |
Dyspnoea | 20.55 | 10.74 | 802 | 91648 | 375980 | 34488501 |
Agoraphobia | 20.51 | 10.74 | 11 | 92439 | 241 | 34864240 |
Postmortem blood drug level increased | 20.43 | 10.74 | 11 | 92439 | 243 | 34864238 |
Epistaxis | 20.38 | 10.74 | 82 | 92368 | 58169 | 34806312 |
Substance abuse | 20.28 | 10.74 | 55 | 92395 | 7586 | 34856895 |
Thinking abnormal | 20.28 | 10.74 | 48 | 92402 | 6089 | 34858392 |
Blood alcohol increased | 20.12 | 10.74 | 17 | 92433 | 806 | 34863675 |
Bacterial infection | 20.06 | 10.74 | 10 | 92440 | 17053 | 34847428 |
Sexually inappropriate behaviour | 20.06 | 10.74 | 14 | 92436 | 498 | 34863983 |
Pulmonary oedema | 20.03 | 10.74 | 203 | 92247 | 47326 | 34817155 |
Brain oedema | 20.02 | 10.74 | 81 | 92369 | 13740 | 34850741 |
Hyponatraemic syndrome | 19.88 | 10.74 | 10 | 92440 | 191 | 34864290 |
Pilonidal cyst congenital | 19.84 | 10.74 | 6 | 92444 | 25 | 34864456 |
Congenital central nervous system anomaly | 19.80 | 10.74 | 15 | 92435 | 607 | 34863874 |
Peripheral swelling | 19.72 | 10.74 | 120 | 92330 | 76421 | 34788060 |
Suicidal behaviour | 19.69 | 10.74 | 22 | 92428 | 1475 | 34863006 |
Hyperbilirubinaemia | 19.61 | 10.74 | 10 | 92440 | 16833 | 34847648 |
Victim of chemical submission | 19.44 | 10.74 | 7 | 92443 | 55 | 34864426 |
Cough | 19.34 | 10.74 | 280 | 92170 | 149860 | 34714621 |
Persistent foetal circulation | 19.21 | 10.74 | 12 | 92438 | 353 | 34864128 |
Wrong product administered | 19.04 | 10.74 | 43 | 92407 | 5291 | 34859190 |
Choanal atresia | 18.90 | 10.74 | 5 | 92445 | 11 | 34864470 |
Anhidrosis | 18.88 | 10.74 | 8 | 92442 | 101 | 34864380 |
Parkinson's disease | 18.86 | 10.74 | 21 | 92429 | 1403 | 34863078 |
Medication error | 18.84 | 10.74 | 124 | 92326 | 25441 | 34839040 |
Osmolar gap abnormal | 18.79 | 10.74 | 6 | 92444 | 31 | 34864450 |
Decreased interest | 18.79 | 10.74 | 27 | 92423 | 2333 | 34862148 |
Bradyphrenia | 18.62 | 10.74 | 40 | 92410 | 4758 | 34859723 |
Intestinal congestion | 18.60 | 10.74 | 5 | 92445 | 12 | 34864469 |
Poor quality sleep | 18.59 | 10.74 | 56 | 92394 | 8200 | 34856281 |
Dysphemia | 18.56 | 10.74 | 22 | 92428 | 1573 | 34862908 |
Bladder cancer | 18.46 | 10.74 | 10 | 92440 | 16268 | 34848213 |
Neuroleptic malignant syndrome | 18.43 | 10.74 | 95 | 92355 | 17839 | 34846642 |
Hypercalcaemia | 18.29 | 10.74 | 9 | 92441 | 15459 | 34849022 |
Blood bilirubin increased | 18.21 | 10.74 | 47 | 92403 | 38249 | 34826232 |
Accidental overdose | 18.20 | 10.74 | 103 | 92347 | 20037 | 34844444 |
Diffuse large B-cell lymphoma stage II | 18.19 | 10.74 | 6 | 92444 | 35 | 34864446 |
Duodenal ulcer perforation | 18.15 | 10.74 | 22 | 92428 | 1610 | 34862871 |
Hospitalisation | 18.12 | 10.74 | 83 | 92367 | 56819 | 34807662 |
Tachycardia | 18.10 | 10.74 | 320 | 92130 | 84452 | 34780029 |
Insomnia | 18.03 | 10.74 | 380 | 92070 | 103527 | 34760954 |
Bone marrow failure | 18.03 | 10.74 | 31 | 92419 | 29222 | 34835259 |
Rash | 18 | 10.74 | 450 | 92000 | 222302 | 34642179 |
Salivary hypersecretion | 17.94 | 10.74 | 57 | 92393 | 8587 | 34855894 |
Haematuria | 17.81 | 10.74 | 70 | 92380 | 49996 | 34814485 |
Neonatal infection | 17.75 | 10.74 | 12 | 92438 | 405 | 34864076 |
Abnormal behaviour | 17.73 | 10.74 | 120 | 92330 | 24849 | 34839632 |
Cardiogenic shock | 17.53 | 10.74 | 27 | 92423 | 26591 | 34837890 |
Leukopenia | 17.48 | 10.74 | 248 | 92202 | 62608 | 34801873 |
Colitis | 17.44 | 10.74 | 47 | 92403 | 37703 | 34826778 |
Exposure via ingestion | 17.43 | 10.74 | 25 | 92425 | 2156 | 34862325 |
Self-medication | 17.38 | 10.74 | 28 | 92422 | 2675 | 34861806 |
Coordination abnormal | 17.35 | 10.74 | 52 | 92398 | 7592 | 34856889 |
Influenza | 17.32 | 10.74 | 70 | 92380 | 49596 | 34814885 |
Cytopenia | 17.31 | 10.74 | 6 | 92444 | 12717 | 34851764 |
Ascites | 17.29 | 10.74 | 64 | 92386 | 46507 | 34817974 |
Abdominal distension | 17.08 | 10.74 | 88 | 92362 | 58404 | 34806077 |
Arthropathy | 17.05 | 10.74 | 28 | 92422 | 26879 | 34837602 |
COVID-19 pneumonia | 17.05 | 10.74 | 12 | 92438 | 16955 | 34847526 |
Libido disorder | 17.01 | 10.74 | 10 | 92440 | 263 | 34864218 |
Hyponatraemia | 16.90 | 10.74 | 310 | 92140 | 82381 | 34782100 |
Hepatitis C virus test positive | 16.90 | 10.74 | 11 | 92439 | 348 | 34864133 |
Liver disorder | 16.87 | 10.74 | 39 | 92411 | 32958 | 34831523 |
Lymphoma | 16.84 | 10.74 | 6 | 92444 | 12501 | 34851980 |
Economic problem | 16.84 | 10.74 | 19 | 92431 | 1288 | 34863193 |
Alcoholism | 16.77 | 10.74 | 29 | 92421 | 2936 | 34861545 |
Urticaria | 16.48 | 10.74 | 97 | 92353 | 62280 | 34802201 |
Drug-induced liver injury | 16.48 | 10.74 | 32 | 92418 | 28800 | 34835681 |
Incontinence | 16.45 | 10.74 | 43 | 92407 | 5804 | 34858677 |
Bronchopulmonary aspergillosis allergic | 16.44 | 10.74 | 16 | 92434 | 913 | 34863568 |
Wrong patient received product | 16.40 | 10.74 | 27 | 92423 | 2627 | 34861854 |
Dyspnoea exertional | 16.38 | 10.74 | 59 | 92391 | 43220 | 34821261 |
Nasopharyngitis | 16.34 | 10.74 | 113 | 92337 | 69855 | 34794626 |
Myelodysplastic syndrome | 16.32 | 10.74 | 16 | 92434 | 19192 | 34845289 |
Rectourethral fistula | 16.32 | 10.74 | 5 | 92445 | 22 | 34864459 |
Opiates positive | 16.30 | 10.74 | 13 | 92437 | 568 | 34863913 |
Osteonecrosis of jaw | 16.27 | 10.74 | 14 | 92436 | 17875 | 34846606 |
Xanthoma | 16.20 | 10.74 | 7 | 92443 | 93 | 34864388 |
Slow response to stimuli | 16.18 | 10.74 | 15 | 92435 | 805 | 34863676 |
Spermatozoa morphology abnormal | 16.10 | 10.74 | 4 | 92446 | 6 | 34864475 |
Blood catecholamines decreased | 16.10 | 10.74 | 4 | 92446 | 6 | 34864475 |
Congenital pneumonia | 16.06 | 10.74 | 7 | 92443 | 95 | 34864386 |
White blood cell count decreased | 16.06 | 10.74 | 168 | 92282 | 95277 | 34769204 |
Rhinorrhoea | 16 | 10.74 | 27 | 92423 | 25641 | 34838840 |
Facial spasm | 15.89 | 10.74 | 9 | 92441 | 220 | 34864261 |
Generalised tonic-clonic seizure | 15.78 | 10.74 | 103 | 92347 | 21071 | 34843410 |
Acute myeloid leukaemia | 15.78 | 10.74 | 15 | 92435 | 18255 | 34846226 |
Bronchial disorder | 15.74 | 10.74 | 19 | 92431 | 1384 | 34863097 |
Cyanosis neonatal | 15.69 | 10.74 | 10 | 92440 | 305 | 34864176 |
Morbid thoughts | 15.57 | 10.74 | 9 | 92441 | 229 | 34864252 |
Hand deformity | 15.55 | 10.74 | 32 | 92418 | 3693 | 34860788 |
Arachnoid cyst | 15.50 | 10.74 | 9 | 92441 | 231 | 34864250 |
Pneumonia bacterial | 15.47 | 10.74 | 6 | 92444 | 11866 | 34852615 |
Positive end-expiratory pressure | 15.38 | 10.74 | 4 | 92446 | 8 | 34864473 |
Physical assault | 15.36 | 10.74 | 17 | 92433 | 1128 | 34863353 |
Hydrocele | 15.35 | 10.74 | 23 | 92427 | 2064 | 34862417 |
Oesophageal carcinoma | 15.30 | 10.74 | 3 | 92447 | 9301 | 34855180 |
Urinary retention | 15.29 | 10.74 | 155 | 92295 | 36133 | 34828348 |
Hypertrophic cardiomyopathy | 15.21 | 10.74 | 17 | 92433 | 1140 | 34863341 |
Anomaly of external ear congenital | 15.20 | 10.74 | 7 | 92443 | 109 | 34864372 |
Acute stress disorder | 15.18 | 10.74 | 8 | 92442 | 169 | 34864312 |
Poor feeding infant | 15.03 | 10.74 | 12 | 92438 | 525 | 34863956 |
Eye haematoma | 14.97 | 10.74 | 6 | 92444 | 65 | 34864416 |
Floppy infant | 14.92 | 10.74 | 7 | 92443 | 114 | 34864367 |
Pruritus | 14.89 | 10.74 | 275 | 92175 | 141706 | 34722775 |
Abnormal dreams | 14.85 | 10.74 | 49 | 92401 | 7529 | 34856952 |
Tendon disorder | 14.82 | 10.74 | 27 | 92423 | 2848 | 34861633 |
Gas poisoning | 14.81 | 10.74 | 3 | 92447 | 0 | 34864481 |
Holoprosencephaly | 14.81 | 10.74 | 3 | 92447 | 0 | 34864481 |
Visual snow syndrome | 14.81 | 10.74 | 3 | 92447 | 0 | 34864481 |
Genital anaesthesia | 14.77 | 10.74 | 4 | 92446 | 10 | 34864471 |
Hypertrophic scar | 14.77 | 10.74 | 4 | 92446 | 10 | 34864471 |
Syncope | 14.76 | 10.74 | 331 | 92119 | 91120 | 34773361 |
Oesophageal perforation | 14.72 | 10.74 | 17 | 92433 | 1182 | 34863299 |
Caesarean section | 14.72 | 10.74 | 23 | 92427 | 2141 | 34862340 |
Muscle mass | 14.71 | 10.74 | 9 | 92441 | 255 | 34864226 |
Gastrointestinal mucosal exfoliation | 14.70 | 10.74 | 7 | 92443 | 118 | 34864363 |
JC virus CSF test positive | 14.70 | 10.74 | 7 | 92443 | 118 | 34864363 |
Periventricular leukomalacia | 14.66 | 10.74 | 6 | 92444 | 69 | 34864412 |
Radicular pain | 14.50 | 10.74 | 6 | 92444 | 71 | 34864410 |
Self-injurious ideation | 14.50 | 10.74 | 20 | 92430 | 1664 | 34862817 |
Pneumonitis chemical | 14.49 | 10.74 | 8 | 92442 | 186 | 34864295 |
Resting tremor | 14.48 | 10.74 | 13 | 92437 | 669 | 34863812 |
Blood creatinine increased | 14.47 | 10.74 | 171 | 92279 | 94805 | 34769676 |
Psychiatric symptom | 14.46 | 10.74 | 30 | 92420 | 3483 | 34860998 |
Priapism | 14.33 | 10.74 | 37 | 92413 | 4957 | 34859524 |
Thrombotic stroke | 14.31 | 10.74 | 9 | 92441 | 268 | 34864213 |
Opisthotonus | 14.29 | 10.74 | 11 | 92439 | 456 | 34864025 |
Granulocytopenia | 14.27 | 10.74 | 44 | 92406 | 6523 | 34857958 |
Appendicitis | 14.20 | 10.74 | 11 | 92439 | 14796 | 34849685 |
Angioedema | 14.11 | 10.74 | 51 | 92399 | 37323 | 34827158 |
Vestibular disorder | 14.10 | 10.74 | 16 | 92434 | 1091 | 34863390 |
Testicular atrophy | 14.01 | 10.74 | 12 | 92438 | 580 | 34863901 |
Acute myocardial infarction | 13.95 | 10.74 | 84 | 92366 | 53635 | 34810846 |
Head circumference abnormal | 13.92 | 10.74 | 5 | 92445 | 39 | 34864442 |
Iron binding capacity total increased | 13.92 | 10.74 | 5 | 92445 | 39 | 34864442 |
Hepatic failure | 13.79 | 10.74 | 46 | 92404 | 34485 | 34829996 |
Infantile vomiting | 13.70 | 10.74 | 5 | 92445 | 41 | 34864440 |
Hepatic cytolysis | 13.61 | 10.74 | 11 | 92439 | 14485 | 34849996 |
Ventricular flutter | 13.48 | 10.74 | 6 | 92444 | 86 | 34864395 |
Erythema | 13.46 | 10.74 | 160 | 92290 | 88620 | 34775861 |
Dysarthria | 13.45 | 10.74 | 146 | 92304 | 34636 | 34829845 |
Cardiac failure congestive | 13.43 | 10.74 | 148 | 92302 | 83122 | 34781359 |
Lacrimation increased | 13.40 | 10.74 | 3 | 92447 | 8479 | 34856002 |
Oesophageal atresia | 13.38 | 10.74 | 11 | 92439 | 502 | 34863979 |
Arthralgia | 13.32 | 10.74 | 345 | 92105 | 169696 | 34694785 |
Tension | 13.27 | 10.74 | 22 | 92428 | 2153 | 34862328 |
Drug dispensed to wrong patient | 13.17 | 10.74 | 11 | 92439 | 513 | 34863968 |
Congenital hydrocephalus | 13.11 | 10.74 | 6 | 92444 | 92 | 34864389 |
Micropenis | 13.11 | 10.74 | 5 | 92445 | 47 | 34864434 |
Jaundice | 13.06 | 10.74 | 42 | 92408 | 31840 | 34832641 |
Activation syndrome | 13.05 | 10.74 | 6 | 92444 | 93 | 34864388 |
Teratogenicity | 13.01 | 10.74 | 5 | 92445 | 48 | 34864433 |
Pleurothotonus | 13.01 | 10.74 | 16 | 92434 | 1189 | 34863292 |
Product use issue | 12.91 | 10.74 | 106 | 92344 | 63110 | 34801371 |
Toxic skin eruption | 12.90 | 10.74 | 7 | 92443 | 11378 | 34853103 |
Accidental poisoning | 12.86 | 10.74 | 13 | 92437 | 777 | 34863704 |
Myositis | 12.85 | 10.74 | 8 | 92442 | 12062 | 34852419 |
Thrombotic microangiopathy | 12.85 | 10.74 | 6 | 92444 | 10624 | 34853857 |
Staphylococcal sepsis | 12.79 | 10.74 | 5 | 92445 | 9839 | 34854642 |
Carbon monoxide poisoning | 12.72 | 10.74 | 6 | 92444 | 99 | 34864382 |
Rash maculo-papular | 12.71 | 10.74 | 36 | 92414 | 28415 | 34836066 |
Brugada syndrome | 12.71 | 10.74 | 13 | 92437 | 788 | 34863693 |
Osteoporosis | 12.68 | 10.74 | 9 | 92441 | 12659 | 34851822 |
Persistent depressive disorder | 12.61 | 10.74 | 9 | 92441 | 332 | 34864149 |
Mood altered | 12.59 | 10.74 | 52 | 92398 | 8900 | 34855581 |
Haematospermia | 12.56 | 10.74 | 9 | 92441 | 334 | 34864147 |
Open reduction of fracture | 12.56 | 10.74 | 6 | 92444 | 102 | 34864379 |
Angle closure glaucoma | 12.48 | 10.74 | 14 | 92436 | 943 | 34863538 |
Blood urea increased | 12.44 | 10.74 | 40 | 92410 | 30324 | 34834157 |
Hyperuricaemia | 12.40 | 10.74 | 3 | 92447 | 8040 | 34856441 |
Neoplasm progression | 12.35 | 10.74 | 27 | 92423 | 23273 | 34841208 |
Haemoglobin decreased | 12.33 | 10.74 | 235 | 92215 | 120537 | 34743944 |
Renal disorder | 12.32 | 10.74 | 31 | 92419 | 25449 | 34839032 |
Bronchitis | 12.32 | 10.74 | 63 | 92387 | 41900 | 34822581 |
Semen volume decreased | 12.26 | 10.74 | 9 | 92441 | 347 | 34864134 |
Coagulation factor increased | 12.25 | 10.74 | 5 | 92445 | 57 | 34864424 |
Dystonia | 12.24 | 10.74 | 59 | 92391 | 10786 | 34853695 |
Venoocclusive liver disease | 12.22 | 10.74 | 3 | 92447 | 7963 | 34856518 |
Emotional disorder | 12.15 | 10.74 | 38 | 92412 | 5678 | 34858803 |
Contraindicated product administered | 12.14 | 10.74 | 24 | 92426 | 21457 | 34843024 |
Social avoidant behaviour | 12.13 | 10.74 | 26 | 92424 | 3088 | 34861393 |
Dissociative disorder | 12.11 | 10.74 | 10 | 92440 | 459 | 34864022 |
Drug abuser | 12.08 | 10.74 | 30 | 92420 | 3924 | 34860557 |
Bacteraemia | 12.05 | 10.74 | 21 | 92429 | 19696 | 34844785 |
Pulmonary embolism | 12.03 | 10.74 | 166 | 92284 | 89580 | 34774901 |
Respiratory distress | 11.97 | 10.74 | 51 | 92399 | 35614 | 34828867 |
Pulmonary valve stenosis | 11.97 | 10.74 | 9 | 92441 | 360 | 34864121 |
Male orgasmic disorder | 11.95 | 10.74 | 6 | 92444 | 114 | 34864367 |
Wrong dose | 11.90 | 10.74 | 11 | 92439 | 588 | 34863893 |
Intentional product use issue | 11.89 | 10.74 | 101 | 92349 | 59715 | 34804766 |
Crystalluria | 11.89 | 10.74 | 10 | 92440 | 471 | 34864010 |
Personality disorder | 11.79 | 10.74 | 15 | 92435 | 1153 | 34863328 |
Hypoalbuminaemia | 11.73 | 10.74 | 9 | 92441 | 12165 | 34852316 |
Coagulation factor VII level decreased | 11.72 | 10.74 | 6 | 92444 | 119 | 34864362 |
Personality change | 11.70 | 10.74 | 35 | 92415 | 5104 | 34859377 |
Klebsiella infection | 11.64 | 10.74 | 4 | 92446 | 8527 | 34855954 |
Adjusted calcium increased | 11.63 | 10.74 | 4 | 92446 | 27 | 34864454 |
Adrenal insufficiency | 11.59 | 10.74 | 12 | 92438 | 14035 | 34850446 |
Pulmonary artery stenosis congenital | 11.54 | 10.74 | 10 | 92440 | 491 | 34863990 |
Alcoholic psychosis | 11.53 | 10.74 | 3 | 92447 | 6 | 34864475 |
Liver function test increased | 11.40 | 10.74 | 13 | 92437 | 14552 | 34849929 |
CSF white blood cell count positive | 11.39 | 10.74 | 4 | 92446 | 29 | 34864452 |
Application site hypersensitivity | 11.37 | 10.74 | 6 | 92444 | 127 | 34864354 |
Sleep disorder due to a general medical condition | 11.36 | 10.74 | 35 | 92415 | 5186 | 34859295 |
Lymphocyte count decreased | 11.35 | 10.74 | 27 | 92423 | 22595 | 34841886 |
Bradykinesia | 11.33 | 10.74 | 29 | 92421 | 3864 | 34860617 |
Oliguria | 11.32 | 10.74 | 4 | 92446 | 8376 | 34856105 |
Hepatic enzyme increased | 11.29 | 10.74 | 59 | 92391 | 39021 | 34825460 |
Memory impairment | 11.28 | 10.74 | 169 | 92281 | 43149 | 34821332 |
Graft versus host disease | 11.26 | 10.74 | 7 | 92443 | 10562 | 34853919 |
Blood pressure fluctuation | 11.24 | 10.74 | 32 | 92418 | 25217 | 34839264 |
Transaminases increased | 11.22 | 10.74 | 35 | 92415 | 26788 | 34837693 |
Pericardial effusion | 11.17 | 10.74 | 31 | 92419 | 24631 | 34839850 |
Kidney transplant rejection | 11.16 | 10.74 | 3 | 92447 | 7494 | 34856987 |
Antidepressant drug level increased | 11.16 | 10.74 | 6 | 92444 | 132 | 34864349 |
Product administered to patient of inappropriate age | 11.16 | 10.74 | 26 | 92424 | 3265 | 34861216 |
Antipsychotic drug level above therapeutic | 11.15 | 10.74 | 15 | 92435 | 1218 | 34863263 |
Treatment failure | 11.11 | 10.74 | 75 | 92375 | 46622 | 34817859 |
Dysphoria | 11.09 | 10.74 | 21 | 92429 | 2281 | 34862200 |
HIV peripheral neuropathy | 11.05 | 10.74 | 4 | 92446 | 32 | 34864449 |
Infertility | 11.02 | 10.74 | 7 | 92443 | 212 | 34864269 |
Diabetic foetopathy | 11.02 | 10.74 | 7 | 92443 | 212 | 34864269 |
Product dose omission issue | 11.00 | 10.74 | 237 | 92213 | 119474 | 34745007 |
Reduced facial expression | 11.00 | 10.74 | 14 | 92436 | 1077 | 34863404 |
Alcohol interaction | 10.98 | 10.74 | 24 | 92426 | 2889 | 34861592 |
Anaphylactic reaction | 10.96 | 10.74 | 46 | 92404 | 32255 | 34832226 |
Chronic kidney disease | 10.93 | 10.74 | 64 | 92386 | 41146 | 34823335 |
Dissociative amnesia | 10.91 | 10.74 | 5 | 92445 | 77 | 34864404 |
Cognitive disorder | 10.89 | 10.74 | 120 | 92330 | 28573 | 34835908 |
Yawning | 10.86 | 10.74 | 10 | 92440 | 532 | 34863949 |
Application site reaction | 10.85 | 10.74 | 9 | 92441 | 416 | 34864065 |
Poor personal hygiene | 10.82 | 10.74 | 8 | 92442 | 312 | 34864169 |
Incoherent | 10.79 | 10.74 | 31 | 92419 | 4421 | 34860060 |
Therapy partial responder | 10.77 | 10.74 | 6 | 92444 | 9610 | 34854871 |
Product storage error | 10.76 | 10.74 | 4 | 92446 | 8118 | 34856363 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 2255.12 | 9.72 | 3183 | 232892 | 242584 | 79265729 |
Toxicity to various agents | 1944.58 | 9.72 | 4018 | 232057 | 417522 | 79090791 |
Drug abuse | 1382.90 | 9.72 | 2034 | 234041 | 160657 | 79347656 |
Serotonin syndrome | 1019.05 | 9.72 | 934 | 235141 | 44093 | 79464220 |
Electrocardiogram QT prolonged | 741.14 | 9.72 | 1112 | 234963 | 89274 | 79419039 |
Overdose | 715.84 | 9.72 | 1642 | 234433 | 182564 | 79325749 |
Drug interaction | 629.43 | 9.72 | 2663 | 233412 | 412520 | 79095793 |
Intentional overdose | 625.60 | 9.72 | 1124 | 234951 | 104836 | 79403477 |
Suicidal ideation | 616.94 | 9.72 | 933 | 235142 | 75407 | 79432906 |
Suicide attempt | 478.29 | 9.72 | 871 | 235204 | 82061 | 79426252 |
Respiratory arrest | 355.57 | 9.72 | 623 | 235452 | 56927 | 79451386 |
Sopor | 355.25 | 9.72 | 463 | 235612 | 32547 | 79475766 |
Synovitis | 330.27 | 9.72 | 32 | 236043 | 150702 | 79357611 |
Anxiety | 325.11 | 9.72 | 1527 | 234548 | 246985 | 79261328 |
Intentional self-injury | 324.69 | 9.72 | 439 | 235636 | 31980 | 79476333 |
Agitation | 322.81 | 9.72 | 829 | 235246 | 98886 | 79409427 |
Poisoning | 322.38 | 9.72 | 386 | 235689 | 24886 | 79483427 |
Off label use | 282.59 | 9.72 | 1557 | 234518 | 905658 | 78602655 |
Cardio-respiratory arrest | 280.62 | 9.72 | 831 | 235244 | 107679 | 79400634 |
Drug ineffective | 272.17 | 9.72 | 1981 | 234094 | 1078932 | 78429381 |
Torsade de pointes | 271.37 | 9.72 | 310 | 235765 | 19002 | 79489311 |
Hand deformity | 256.90 | 9.72 | 12 | 236063 | 103907 | 79404406 |
Tremor | 241.52 | 9.72 | 1071 | 235004 | 169012 | 79339301 |
Temperature regulation disorder | 224.23 | 9.72 | 165 | 235910 | 5688 | 79502625 |
Hyponatraemia | 221.65 | 9.72 | 1078 | 234997 | 176770 | 79331543 |
Pemphigus | 221.15 | 9.72 | 20 | 236055 | 99562 | 79408751 |
Paranoia | 214.44 | 9.72 | 276 | 235799 | 19156 | 79489157 |
Systemic lupus erythematosus | 204.51 | 9.72 | 53 | 236022 | 121096 | 79387217 |
Febrile neutropenia | 197.19 | 9.72 | 236 | 235839 | 230763 | 79277550 |
Hyperhidrosis | 195.06 | 9.72 | 927 | 235148 | 150565 | 79357748 |
Arthropathy | 188.15 | 9.72 | 149 | 235926 | 176962 | 79331351 |
Depression suicidal | 186.03 | 9.72 | 125 | 235950 | 3717 | 79504596 |
Treatment failure | 180.38 | 9.72 | 144 | 235931 | 170342 | 79337971 |
Cardiac arrest | 180.32 | 9.72 | 994 | 235081 | 171102 | 79337211 |
Aggression | 178.83 | 9.72 | 437 | 235638 | 50521 | 79457792 |
Pericarditis | 175.17 | 9.72 | 46 | 236029 | 104190 | 79404123 |
Restlessness | 173.15 | 9.72 | 408 | 235667 | 46084 | 79462229 |
Helicobacter infection | 172.43 | 9.72 | 8 | 236067 | 69696 | 79438617 |
Tearfulness | 172.12 | 9.72 | 143 | 235932 | 5902 | 79502411 |
Depression | 169.58 | 9.72 | 1161 | 234914 | 215629 | 79292684 |
Disturbance in attention | 169.15 | 9.72 | 427 | 235648 | 50374 | 79457939 |
Drug intolerance | 168.53 | 9.72 | 329 | 235746 | 263790 | 79244523 |
Panic attack | 166.50 | 9.72 | 275 | 235800 | 23941 | 79484372 |
Somnolence | 166.18 | 9.72 | 1244 | 234831 | 237737 | 79270576 |
Therapeutic product effect decreased | 161.64 | 9.72 | 148 | 235927 | 163715 | 79344598 |
Psychiatric decompensation | 161.54 | 9.72 | 116 | 235959 | 3847 | 79504466 |
Loss of libido | 161.18 | 9.72 | 100 | 235975 | 2585 | 79505728 |
Fall | 159.20 | 9.72 | 2170 | 233905 | 485459 | 79022854 |
Food allergy | 157.59 | 9.72 | 177 | 235898 | 10647 | 79497666 |
Irritability | 155.32 | 9.72 | 363 | 235712 | 40781 | 79467532 |
Infusion related reaction | 151.95 | 9.72 | 281 | 235794 | 229956 | 79278357 |
Rheumatoid factor positive | 150.90 | 9.72 | 6 | 236069 | 59833 | 79448480 |
Depressive symptom | 146.70 | 9.72 | 134 | 235941 | 6289 | 79502024 |
Electrocardiogram QRS complex prolonged | 143.98 | 9.72 | 169 | 235906 | 10664 | 79497649 |
Coeliac disease | 142.50 | 9.72 | 172 | 235903 | 11179 | 79497134 |
Withdrawal syndrome | 142.15 | 9.72 | 272 | 235803 | 26582 | 79481731 |
Confusional state | 140.84 | 9.72 | 1500 | 234575 | 316497 | 79191816 |
Psychotic disorder | 137.83 | 9.72 | 348 | 235727 | 41054 | 79467259 |
Glossodynia | 137.29 | 9.72 | 67 | 236008 | 103270 | 79405043 |
Mydriasis | 134.49 | 9.72 | 210 | 235865 | 17433 | 79490880 |
Alopecia | 132.67 | 9.72 | 306 | 235769 | 231049 | 79277264 |
Pyrexia | 131.08 | 9.72 | 1331 | 234744 | 677378 | 78830935 |
Infection | 129.69 | 9.72 | 331 | 235744 | 241381 | 79266932 |
Accidental overdose | 128.96 | 9.72 | 330 | 235745 | 39251 | 79469062 |
Akathisia | 127.38 | 9.72 | 176 | 235899 | 13083 | 79495230 |
Psychomotor skills impaired | 126.98 | 9.72 | 113 | 235962 | 5124 | 79503189 |
Myoclonus | 124.67 | 9.72 | 262 | 235813 | 27398 | 79480915 |
Interstitial lung disease | 124.32 | 9.72 | 91 | 235984 | 112509 | 79395804 |
Joint swelling | 124.16 | 9.72 | 438 | 235637 | 288208 | 79220105 |
Accidental death | 123.20 | 9.72 | 102 | 235973 | 4189 | 79504124 |
Loss of consciousness | 122.82 | 9.72 | 885 | 235190 | 167058 | 79341255 |
Muscle twitching | 122.77 | 9.72 | 244 | 235831 | 24520 | 79483793 |
Muscle injury | 122.01 | 9.72 | 5 | 236070 | 48556 | 79459757 |
Malignant neoplasm progression | 121.33 | 9.72 | 134 | 235941 | 135856 | 79372457 |
Muscle rigidity | 121.15 | 9.72 | 214 | 235861 | 19668 | 79488645 |
Depressed mood | 120.26 | 9.72 | 366 | 235709 | 48114 | 79460199 |
Intentional product misuse | 120.01 | 9.72 | 579 | 235496 | 94586 | 79413727 |
Seizure | 119.56 | 9.72 | 962 | 235113 | 187872 | 79320441 |
Nightmare | 117.77 | 9.72 | 246 | 235829 | 25615 | 79482698 |
Anorgasmia | 116.28 | 9.72 | 62 | 236013 | 1192 | 79507121 |
Duodenal ulcer perforation | 115.55 | 9.72 | 27 | 236048 | 66184 | 79442129 |
Unresponsive to stimuli | 114.71 | 9.72 | 395 | 235680 | 55393 | 79452920 |
Pneumonia | 109.91 | 9.72 | 1339 | 234736 | 658907 | 78849406 |
Hyperreflexia | 106.80 | 9.72 | 128 | 235947 | 8257 | 79500056 |
Wound | 106.39 | 9.72 | 112 | 235963 | 116067 | 79392246 |
Sleep disorder due to general medical condition, insomnia type | 104.57 | 9.72 | 6 | 236069 | 43550 | 79464763 |
Septic shock | 103.09 | 9.72 | 127 | 235948 | 122674 | 79385639 |
Stomatitis | 102.30 | 9.72 | 173 | 235902 | 146584 | 79361729 |
Obsessive-compulsive disorder | 102.21 | 9.72 | 106 | 235969 | 5821 | 79502492 |
Hallucination | 101.92 | 9.72 | 513 | 235562 | 85232 | 79423081 |
Drug withdrawal syndrome | 101.47 | 9.72 | 278 | 235797 | 34440 | 79473873 |
Neutropenia | 99.07 | 9.72 | 476 | 235599 | 287234 | 79221079 |
Coma scale abnormal | 98.49 | 9.72 | 125 | 235950 | 8553 | 79499760 |
Mania | 96.70 | 9.72 | 185 | 235890 | 18075 | 79490238 |
Bruxism | 95.89 | 9.72 | 86 | 235989 | 3940 | 79504373 |
Rash | 95.41 | 9.72 | 1175 | 234900 | 577183 | 78931130 |
Product use in unapproved indication | 94.71 | 9.72 | 400 | 235675 | 249959 | 79258354 |
Hepatic function abnormal | 94.70 | 9.72 | 49 | 236026 | 73058 | 79435255 |
C-reactive protein increased | 91.88 | 9.72 | 150 | 235925 | 128877 | 79379436 |
Disinhibition | 87.90 | 9.72 | 68 | 236007 | 2530 | 79505783 |
Libido decreased | 87.90 | 9.72 | 93 | 235982 | 5228 | 79503085 |
Acute kidney injury | 87.62 | 9.72 | 1050 | 235025 | 518354 | 78989959 |
Orgasmic sensation decreased | 86.10 | 9.72 | 22 | 236053 | 33 | 79508280 |
Folliculitis | 84.75 | 9.72 | 29 | 236046 | 55351 | 79452962 |
Homicidal ideation | 84.63 | 9.72 | 75 | 236000 | 3382 | 79504931 |
Cytomegalovirus infection | 83.72 | 9.72 | 13 | 236062 | 42631 | 79465682 |
Exposure via ingestion | 82.94 | 9.72 | 89 | 235986 | 5085 | 79503228 |
Discomfort | 81.33 | 9.72 | 155 | 235920 | 125462 | 79382851 |
Disease progression | 81.08 | 9.72 | 277 | 235798 | 184085 | 79324228 |
Immunodeficiency | 81.00 | 9.72 | 191 | 235884 | 21577 | 79486736 |
Anger | 77.85 | 9.72 | 163 | 235912 | 16999 | 79491314 |
Mucosal inflammation | 77.22 | 9.72 | 66 | 236009 | 75514 | 79432799 |
Blister | 76.85 | 9.72 | 148 | 235927 | 119328 | 79388985 |
Pancytopenia | 76.34 | 9.72 | 244 | 235831 | 165501 | 79342812 |
Disorientation | 76.30 | 9.72 | 378 | 235697 | 62398 | 79445915 |
Erectile dysfunction | 75.73 | 9.72 | 147 | 235928 | 14517 | 79493796 |
Peripheral swelling | 75.31 | 9.72 | 478 | 235597 | 269139 | 79239174 |
Abdominal discomfort | 74.48 | 9.72 | 436 | 235639 | 250291 | 79258022 |
Dyskinesia | 74.42 | 9.72 | 296 | 235779 | 44477 | 79463836 |
Depressed level of consciousness | 72.75 | 9.72 | 513 | 235562 | 96139 | 79412174 |
Long QT syndrome | 72.74 | 9.72 | 89 | 235986 | 5866 | 79502447 |
Mood swings | 72.42 | 9.72 | 173 | 235902 | 19707 | 79488606 |
Alcoholism | 72.29 | 9.72 | 71 | 236004 | 3652 | 79504661 |
Platelet count decreased | 71.77 | 9.72 | 314 | 235761 | 194350 | 79313963 |
Psychomotor retardation | 71.65 | 9.72 | 90 | 235985 | 6094 | 79502219 |
C-reactive protein abnormal | 71.17 | 9.72 | 27 | 236048 | 48340 | 79459973 |
Contraindicated product administered | 70.42 | 9.72 | 235 | 235840 | 157303 | 79351010 |
Inappropriate antidiuretic hormone secretion | 70.33 | 9.72 | 204 | 235871 | 26109 | 79482204 |
Galactorrhoea | 69.81 | 9.72 | 69 | 236006 | 3577 | 79504736 |
Intrusive thoughts | 69.45 | 9.72 | 33 | 236042 | 491 | 79507822 |
Tachyphrenia | 69.41 | 9.72 | 54 | 236021 | 2026 | 79506287 |
Impulsive behaviour | 69.17 | 9.72 | 62 | 236013 | 2838 | 79505475 |
Myelosuppression | 67.27 | 9.72 | 18 | 236057 | 40278 | 79468035 |
Psychomotor hyperactivity | 67.27 | 9.72 | 152 | 235923 | 16697 | 79491616 |
Disturbance in sexual arousal | 67.18 | 9.72 | 26 | 236049 | 225 | 79508088 |
Multiple organ dysfunction syndrome | 65.73 | 9.72 | 163 | 235912 | 120083 | 79388230 |
Bradyphrenia | 65.44 | 9.72 | 115 | 235960 | 10525 | 79497788 |
Generalised tonic-clonic seizure | 64.89 | 9.72 | 280 | 235795 | 43630 | 79464683 |
Irritable bowel syndrome | 64.02 | 9.72 | 54 | 236021 | 62187 | 79446126 |
Thrombocytopenia | 63.42 | 9.72 | 492 | 235583 | 264767 | 79243546 |
Swelling | 62.16 | 9.72 | 381 | 235694 | 216330 | 79291983 |
Sexual dysfunction | 61.40 | 9.72 | 94 | 235981 | 7669 | 79500644 |
Cardiac failure | 61.27 | 9.72 | 243 | 235832 | 154599 | 79353714 |
Fibromyalgia | 61.20 | 9.72 | 60 | 236015 | 64280 | 79444033 |
Intentional product use issue | 58.75 | 9.72 | 241 | 235834 | 151871 | 79356442 |
Impaired healing | 58.64 | 9.72 | 106 | 235969 | 87549 | 79420764 |
Cytokine release syndrome | 58.38 | 9.72 | 17 | 236058 | 35981 | 79472332 |
Sepsis | 58.37 | 9.72 | 513 | 235562 | 268915 | 79239398 |
Psoriatic arthropathy | 58.06 | 9.72 | 88 | 235987 | 77911 | 79430402 |
Self-injurious ideation | 57.30 | 9.72 | 62 | 236013 | 3576 | 79504737 |
Hallucination, auditory | 56.82 | 9.72 | 162 | 235913 | 20531 | 79487782 |
Hallucination, visual | 56.51 | 9.72 | 219 | 235856 | 32510 | 79475803 |
Memory impairment | 56.03 | 9.72 | 541 | 235534 | 111193 | 79397120 |
Alcohol use | 55.48 | 9.72 | 70 | 236005 | 4761 | 79503552 |
Drug dependence | 54.99 | 9.72 | 253 | 235822 | 40516 | 79467797 |
Sinusitis | 54.88 | 9.72 | 346 | 235729 | 195155 | 79313158 |
Parkinsonism | 54.77 | 9.72 | 139 | 235936 | 16445 | 79491868 |
Ill-defined disorder | 54.36 | 9.72 | 69 | 236006 | 65806 | 79442507 |
Homicide | 53.65 | 9.72 | 37 | 236038 | 1149 | 79507164 |
Drug resistance | 53.63 | 9.72 | 29 | 236046 | 42184 | 79466129 |
Dizziness | 52.85 | 9.72 | 1980 | 234095 | 524461 | 78983852 |
Drug screen positive | 51.64 | 9.72 | 76 | 235999 | 5987 | 79502326 |
Clonus | 51.55 | 9.72 | 81 | 235994 | 6759 | 79501554 |
Haematemesis | 51.44 | 9.72 | 297 | 235778 | 51967 | 79456346 |
Amnesia | 51.18 | 9.72 | 341 | 235734 | 62716 | 79445597 |
Yawning | 51.18 | 9.72 | 38 | 236037 | 1328 | 79506985 |
Medication error | 50.87 | 9.72 | 363 | 235712 | 68279 | 79440034 |
Thinking abnormal | 50.63 | 9.72 | 117 | 235958 | 13044 | 79495269 |
Myocardial stunning | 50.51 | 9.72 | 20 | 236055 | 185 | 79508128 |
Negative thoughts | 50.37 | 9.72 | 38 | 236037 | 1361 | 79506952 |
Renal impairment | 50.30 | 9.72 | 268 | 235807 | 157515 | 79350798 |
Arthralgia | 50.16 | 9.72 | 1299 | 234776 | 570504 | 78937809 |
Liver disorder | 49.86 | 9.72 | 86 | 235989 | 72331 | 79435982 |
Mental disorder | 49.67 | 9.72 | 204 | 235871 | 31098 | 79477215 |
Haemophagocytic lymphohistiocytosis | 49.52 | 9.72 | 4 | 236071 | 21833 | 79486480 |
Mental impairment | 49.36 | 9.72 | 146 | 235929 | 18890 | 79489423 |
Maternal exposure during pregnancy | 49.24 | 9.72 | 222 | 235853 | 136316 | 79371997 |
Insomnia | 49.05 | 9.72 | 1008 | 235067 | 244162 | 79264151 |
Lethargy | 48.63 | 9.72 | 409 | 235666 | 80883 | 79427430 |
Product use issue | 48.36 | 9.72 | 393 | 235682 | 209429 | 79298884 |
Hepatic enzyme increased | 48.31 | 9.72 | 329 | 235746 | 182281 | 79326032 |
Bradykinesia | 48.26 | 9.72 | 86 | 235989 | 7957 | 79500356 |
Pneumocystis jirovecii pneumonia | 48.07 | 9.72 | 18 | 236057 | 32490 | 79475823 |
Abnormal dreams | 47.86 | 9.72 | 105 | 235970 | 11307 | 79497006 |
Antipsychotic drug level below therapeutic | 47.65 | 9.72 | 35 | 236040 | 1203 | 79507110 |
Genital hypoaesthesia | 47.40 | 9.72 | 19 | 236056 | 182 | 79508131 |
Bursitis | 47.28 | 9.72 | 221 | 235854 | 35623 | 79472690 |
Cerebral vasoconstriction | 46.55 | 9.72 | 37 | 236038 | 1433 | 79506880 |
Knee arthroplasty | 46.37 | 9.72 | 36 | 236039 | 43212 | 79465101 |
Rhinitis perennial | 46.02 | 9.72 | 22 | 236053 | 332 | 79507981 |
Asphyxia | 45.98 | 9.72 | 105 | 235970 | 11615 | 79496698 |
Labelled drug-drug interaction issue | 45.67 | 9.72 | 36 | 236039 | 1377 | 79506936 |
Physical assault | 45.64 | 9.72 | 38 | 236037 | 1573 | 79506740 |
Nasopharyngitis | 45.12 | 9.72 | 507 | 235568 | 253374 | 79254939 |
Lower respiratory tract infection | 44.88 | 9.72 | 213 | 235862 | 129007 | 79379306 |
Sedation | 44.78 | 9.72 | 285 | 235790 | 51610 | 79456703 |
Toxicologic test abnormal | 44.72 | 9.72 | 35 | 236040 | 1325 | 79506988 |
Increased appetite | 44.45 | 9.72 | 105 | 235970 | 11873 | 79496440 |
Alcohol abuse | 43.92 | 9.72 | 66 | 236009 | 5297 | 79503016 |
Anaemia | 43.64 | 9.72 | 994 | 235081 | 444021 | 79064292 |
Rheumatic fever | 43.54 | 9.72 | 15 | 236060 | 28510 | 79479803 |
Pleural effusion | 42.89 | 9.72 | 253 | 235822 | 145009 | 79363304 |
Dyspnoea | 42.76 | 9.72 | 2088 | 233987 | 854937 | 78653376 |
Drug reaction with eosinophilia and systemic symptoms | 42.69 | 9.72 | 78 | 235997 | 64166 | 79444147 |
Dissociation | 42.62 | 9.72 | 56 | 236019 | 3965 | 79504348 |
Blood cholesterol increased | 41.57 | 9.72 | 119 | 235956 | 83601 | 79424712 |
Premature ejaculation | 40.65 | 9.72 | 13 | 236062 | 59 | 79508254 |
Abnormal behaviour | 40.54 | 9.72 | 214 | 235861 | 36207 | 79472106 |
Panic reaction | 40.49 | 9.72 | 59 | 236016 | 4606 | 79503707 |
Coma | 40.43 | 9.72 | 466 | 235609 | 100183 | 79408130 |
Major depression | 40.39 | 9.72 | 85 | 235990 | 8895 | 79499418 |
Cardiac failure congestive | 39.96 | 9.72 | 252 | 235823 | 142150 | 79366163 |
Bone marrow failure | 39.66 | 9.72 | 56 | 236019 | 51051 | 79457262 |
Reversible cerebral vasoconstriction syndrome | 39.48 | 9.72 | 47 | 236028 | 3010 | 79505303 |
Concussion | 39.36 | 9.72 | 87 | 235988 | 9416 | 79498897 |
Hip arthroplasty | 39.32 | 9.72 | 29 | 236046 | 35727 | 79472586 |
Syncope | 39.30 | 9.72 | 748 | 235327 | 178701 | 79329612 |
Neuropathy peripheral | 39.17 | 9.72 | 251 | 235824 | 141054 | 79367259 |
Bronchopulmonary aspergillosis | 39.07 | 9.72 | 9 | 236066 | 22285 | 79486028 |
Nicotine dependence | 39.03 | 9.72 | 28 | 236047 | 927 | 79507386 |
Atrial fibrillation | 38.88 | 9.72 | 386 | 235689 | 197500 | 79310813 |
Angle closure glaucoma | 38.84 | 9.72 | 46 | 236029 | 2930 | 79505383 |
Bradycardia | 38.38 | 9.72 | 589 | 235486 | 134968 | 79373345 |
Rib deformity | 38.10 | 9.72 | 17 | 236058 | 217 | 79508096 |
Antidepressant drug level above therapeutic | 37.63 | 9.72 | 24 | 236051 | 652 | 79507661 |
Hyperprolactinaemia | 37.52 | 9.72 | 57 | 236018 | 4619 | 79503694 |
Suicidal behaviour | 37.21 | 9.72 | 47 | 236028 | 3200 | 79505113 |
Ascites | 37.08 | 9.72 | 108 | 235967 | 75454 | 79432859 |
Renal failure | 37.03 | 9.72 | 398 | 235677 | 200570 | 79307743 |
Euphoric mood | 36.95 | 9.72 | 75 | 236000 | 7651 | 79500662 |
Diarrhoea | 36.84 | 9.72 | 2183 | 233892 | 878306 | 78630007 |
Somnambulism | 36.70 | 9.72 | 63 | 236012 | 5658 | 79502655 |
Rash erythematous | 36.34 | 9.72 | 294 | 235781 | 57475 | 79450838 |
Urinary retention | 36.06 | 9.72 | 289 | 235786 | 56341 | 79451972 |
Tachycardia | 35.90 | 9.72 | 732 | 235343 | 177036 | 79331277 |
Substance abuse | 35.57 | 9.72 | 89 | 235986 | 10437 | 79497876 |
Adrenal insufficiency | 35.56 | 9.72 | 20 | 236055 | 28467 | 79479846 |
Hypertonia | 35.53 | 9.72 | 71 | 236004 | 7161 | 79501152 |
Acute myeloid leukaemia | 35.34 | 9.72 | 24 | 236051 | 30861 | 79477452 |
Haematotoxicity | 34.76 | 9.72 | 3 | 236072 | 15516 | 79492797 |
Logorrhoea | 34.73 | 9.72 | 53 | 236022 | 4312 | 79504001 |
Pneumonitis | 34.44 | 9.72 | 81 | 235994 | 60779 | 79447534 |
Apathy | 34.09 | 9.72 | 100 | 235975 | 12877 | 79495436 |
Crying | 34.09 | 9.72 | 147 | 235928 | 22896 | 79485417 |
Catatonia | 33.86 | 9.72 | 78 | 235997 | 8678 | 79499635 |
Calcium deficiency | 33.66 | 9.72 | 25 | 236050 | 874 | 79507439 |
Hyperventilation | 33.49 | 9.72 | 73 | 236002 | 7826 | 79500487 |
Toxic epidermal necrolysis | 33.46 | 9.72 | 50 | 236025 | 44531 | 79463782 |
Illness anxiety disorder | 33.26 | 9.72 | 16 | 236059 | 245 | 79508068 |
Red blood cell sedimentation rate increased | 33.07 | 9.72 | 53 | 236022 | 45889 | 79462424 |
COVID-19 | 32.90 | 9.72 | 303 | 235772 | 157371 | 79350942 |
Prostate cancer | 32.84 | 9.72 | 30 | 236045 | 33238 | 79475075 |
Parathyroid gland enlargement | 32.83 | 9.72 | 14 | 236061 | 159 | 79508154 |
Rheumatoid nodule | 32.72 | 9.72 | 6 | 236069 | 17432 | 79490881 |
Condition aggravated | 32.70 | 9.72 | 1184 | 234891 | 499940 | 79008373 |
Product prescribing error | 32.63 | 9.72 | 236 | 235839 | 44577 | 79463736 |
Neoplasm progression | 32.37 | 9.72 | 65 | 236010 | 51617 | 79456696 |
Tic | 32.30 | 9.72 | 42 | 236033 | 2944 | 79505369 |
Drug eruption | 32.28 | 9.72 | 50 | 236025 | 43885 | 79464428 |
Tardive dyskinesia | 32.24 | 9.72 | 86 | 235989 | 10485 | 79497828 |
Oedema peripheral | 31.83 | 9.72 | 540 | 235535 | 251748 | 79256565 |
Aspartate aminotransferase increased | 31.78 | 9.72 | 260 | 235815 | 138381 | 79369932 |
Forced expiratory volume | 31.72 | 9.72 | 12 | 236063 | 97 | 79508216 |
Extrapyramidal disorder | 31.52 | 9.72 | 142 | 235933 | 22537 | 79485776 |
Palmar-plantar erythrodysaesthesia syndrome | 31.39 | 9.72 | 31 | 236044 | 33103 | 79475210 |
Hepatic cytolysis | 31.20 | 9.72 | 21 | 236054 | 27130 | 79481183 |
Tumour lysis syndrome | 31.06 | 9.72 | 16 | 236059 | 23923 | 79484390 |
Rabbit syndrome | 31.02 | 9.72 | 17 | 236058 | 346 | 79507967 |
Blood bilirubin increased | 30.83 | 9.72 | 97 | 235978 | 66135 | 79442178 |
Hostility | 30.63 | 9.72 | 36 | 236039 | 2274 | 79506039 |
Pulseless electrical activity | 30.63 | 9.72 | 102 | 235973 | 14058 | 79494255 |
Bladder cancer | 30.27 | 9.72 | 10 | 236065 | 19516 | 79488797 |
Premature delivery | 29.98 | 9.72 | 16 | 236059 | 23451 | 79484862 |
Hyponatraemic syndrome | 29.90 | 9.72 | 22 | 236053 | 758 | 79507555 |
Restless legs syndrome | 29.59 | 9.72 | 128 | 235947 | 19964 | 79488349 |
Alcohol poisoning | 29.51 | 9.72 | 52 | 236023 | 4769 | 79503544 |
Female sexual arousal disorder | 29.46 | 9.72 | 7 | 236068 | 6 | 79508307 |
Spontaneous penile erection | 29.40 | 9.72 | 12 | 236063 | 121 | 79508192 |
Blood creatinine increased | 29.40 | 9.72 | 305 | 235770 | 154752 | 79353561 |
Emotional distress | 29.39 | 9.72 | 211 | 235864 | 39758 | 79468555 |
Derealisation | 29.35 | 9.72 | 30 | 236045 | 1619 | 79506694 |
Eosinophilia | 29.29 | 9.72 | 56 | 236019 | 45289 | 79463024 |
Neutrophil count decreased | 29.15 | 9.72 | 161 | 235914 | 93798 | 79414515 |
Myelodysplastic syndrome | 29.11 | 9.72 | 28 | 236047 | 30273 | 79478040 |
Circulatory collapse | 28.95 | 9.72 | 201 | 235874 | 37467 | 79470846 |
Arthritis | 28.88 | 9.72 | 210 | 235865 | 114670 | 79393643 |
Post viral fatigue syndrome | 28.87 | 9.72 | 16 | 236059 | 333 | 79507980 |
Obsessive thoughts | 28.59 | 9.72 | 25 | 236050 | 1107 | 79507206 |
Musculoskeletal stiffness | 28.57 | 9.72 | 356 | 235719 | 174652 | 79333661 |
Thrombotic microangiopathy | 28.46 | 9.72 | 12 | 236063 | 20157 | 79488156 |
Myocardial fibrosis | 28.33 | 9.72 | 30 | 236045 | 1688 | 79506625 |
Neonatal infection | 28.09 | 9.72 | 8 | 236067 | 22 | 79508291 |
Posterior reversible encephalopathy syndrome | 28.02 | 9.72 | 22 | 236053 | 26259 | 79482054 |
Poverty of speech | 27.98 | 9.72 | 19 | 236056 | 575 | 79507738 |
Nervousness | 27.90 | 9.72 | 182 | 235893 | 33233 | 79475080 |
Alcohol interaction | 27.82 | 9.72 | 51 | 236024 | 4823 | 79503490 |
Mental status changes | 27.78 | 9.72 | 312 | 235763 | 66647 | 79441666 |
Drug tolerance decreased | 27.77 | 9.72 | 3 | 236072 | 12975 | 79495338 |
Skin ulcer | 27.60 | 9.72 | 76 | 235999 | 54074 | 79454239 |
Antidepressant drug level increased | 27.55 | 9.72 | 17 | 236058 | 435 | 79507878 |
Therapeutic product effect incomplete | 27.52 | 9.72 | 277 | 235798 | 141368 | 79366945 |
Flat affect | 27.39 | 9.72 | 32 | 236043 | 2009 | 79506304 |
Postmortem blood drug level increased | 26.99 | 9.72 | 21 | 236054 | 788 | 79507525 |
Dementia | 26.84 | 9.72 | 144 | 235931 | 24515 | 79483798 |
Dystonia | 26.81 | 9.72 | 130 | 235945 | 21269 | 79487044 |
Hypersensitivity | 26.73 | 9.72 | 582 | 235493 | 261657 | 79246656 |
Liver function test increased | 26.68 | 9.72 | 48 | 236027 | 39725 | 79468588 |
Sinus tachycardia | 26.65 | 9.72 | 194 | 235881 | 36714 | 79471599 |
Drug hypersensitivity | 26.42 | 9.72 | 678 | 235397 | 298238 | 79210075 |
Hypokinesia | 26.23 | 9.72 | 119 | 235956 | 18941 | 79489372 |
COVID-19 pneumonia | 26.19 | 9.72 | 28 | 236047 | 28821 | 79479492 |
Obesity | 26.16 | 9.72 | 186 | 235889 | 34939 | 79473374 |
Hypercalcaemia | 26.12 | 9.72 | 46 | 236029 | 38384 | 79469929 |
Speech disorder | 26.00 | 9.72 | 261 | 235814 | 54184 | 79454129 |
Haematuria | 25.98 | 9.72 | 110 | 235965 | 68726 | 79439587 |
Incoherent | 25.95 | 9.72 | 65 | 236010 | 7627 | 79500686 |
Gun shot wound | 25.92 | 9.72 | 24 | 236051 | 1146 | 79507167 |
Cytopenia | 25.89 | 9.72 | 14 | 236061 | 20369 | 79487944 |
Cholecystitis chronic | 25.70 | 9.72 | 76 | 235999 | 9830 | 79498483 |
Orgasm abnormal | 25.59 | 9.72 | 12 | 236063 | 173 | 79508140 |
Carcinoid heart disease | 25.40 | 9.72 | 9 | 236066 | 59 | 79508254 |
Respiratory distress | 25.39 | 9.72 | 88 | 235987 | 58251 | 79450062 |
Enterocolitis | 25.15 | 9.72 | 6 | 236069 | 14506 | 79493807 |
Brain injury | 24.94 | 9.72 | 83 | 235992 | 11434 | 79496879 |
Osteonecrosis of jaw | 24.88 | 9.72 | 57 | 236018 | 43169 | 79465144 |
Polyhydramnios | 24.82 | 9.72 | 28 | 236047 | 1692 | 79506621 |
Radiologically isolated syndrome | 24.81 | 9.72 | 6 | 236069 | 6 | 79508307 |
Pathogen resistance | 24.72 | 9.72 | 6 | 236069 | 14336 | 79493977 |
Sexually inappropriate behaviour | 24.65 | 9.72 | 17 | 236058 | 528 | 79507785 |
Libido increased | 24.59 | 9.72 | 30 | 236045 | 1971 | 79506342 |
Prescribed overdose | 24.48 | 9.72 | 194 | 235881 | 37689 | 79470624 |
Lactic acidosis | 24.41 | 9.72 | 116 | 235959 | 70243 | 79438070 |
Failure to suspend medication | 24.35 | 9.72 | 16 | 236059 | 458 | 79507855 |
Pseudomonas infection | 24.24 | 9.72 | 16 | 236059 | 20887 | 79487426 |
Blood uric acid increased | 24.21 | 9.72 | 5 | 236070 | 13355 | 79494958 |
Neuroleptic malignant syndrome | 24.18 | 9.72 | 152 | 235923 | 27407 | 79480906 |
Tension | 23.79 | 9.72 | 45 | 236030 | 4359 | 79503954 |
Transplant rejection | 23.76 | 9.72 | 14 | 236061 | 19423 | 79488890 |
White blood cell count decreased | 23.74 | 9.72 | 403 | 235672 | 187885 | 79320428 |
Dysarthria | 23.63 | 9.72 | 305 | 235770 | 67317 | 79440996 |
Optic ischaemic neuropathy | 23.62 | 9.72 | 36 | 236039 | 2925 | 79505388 |
Dissociative amnesia | 23.57 | 9.72 | 10 | 236065 | 112 | 79508201 |
Urticaria | 23.48 | 9.72 | 396 | 235679 | 184805 | 79323508 |
Delusion | 23.42 | 9.72 | 121 | 235954 | 20302 | 79488011 |
Panic disorder | 23.34 | 9.72 | 36 | 236039 | 2956 | 79505357 |
Upper respiratory fungal infection | 23.30 | 9.72 | 14 | 236061 | 341 | 79507972 |
Atonic urinary bladder | 23.24 | 9.72 | 9 | 236066 | 78 | 79508235 |
Dysphemia | 23.19 | 9.72 | 39 | 236036 | 3445 | 79504868 |
Neuropathy, ataxia, retinitis pigmentosa syndrome | 23.18 | 9.72 | 8 | 236067 | 48 | 79508265 |
Injection site pain | 23.16 | 9.72 | 259 | 235816 | 129579 | 79378734 |
Bipolar I disorder | 23.11 | 9.72 | 30 | 236045 | 2099 | 79506214 |
Cognitive disorder | 23.03 | 9.72 | 312 | 235763 | 69614 | 79438699 |
Anhidrosis | 23.01 | 9.72 | 12 | 236063 | 220 | 79508093 |
Drug-induced liver injury | 22.94 | 9.72 | 109 | 235966 | 66008 | 79442305 |
Skin swelling | 22.91 | 9.72 | 42 | 236033 | 3972 | 79504341 |
Therapeutic product effect variable | 22.89 | 9.72 | 29 | 236046 | 1980 | 79506333 |
Rash maculo-papular | 22.81 | 9.72 | 87 | 235988 | 55991 | 79452322 |
Bipolar disorder | 22.80 | 9.72 | 62 | 236013 | 7645 | 79500668 |
Sebaceous gland infection | 22.72 | 9.72 | 11 | 236064 | 171 | 79508142 |
Vertigo | 22.65 | 9.72 | 308 | 235767 | 68774 | 79439539 |
Hypomania | 22.63 | 9.72 | 61 | 236014 | 7483 | 79500830 |
Hypersomnia | 22.59 | 9.72 | 131 | 235944 | 22955 | 79485358 |
Prescription drug used without a prescription | 22.39 | 9.72 | 42 | 236033 | 4043 | 79504270 |
Dreamy state | 22.26 | 9.72 | 8 | 236067 | 55 | 79508258 |
Psychiatric symptom | 22.23 | 9.72 | 58 | 236017 | 6977 | 79501336 |
Venoocclusive liver disease | 22.19 | 9.72 | 4 | 236071 | 11767 | 79496546 |
Social avoidant behaviour | 22.16 | 9.72 | 46 | 236029 | 4768 | 79503545 |
Hypochloraemia | 22.11 | 9.72 | 32 | 236043 | 2483 | 79505830 |
Gestational diabetes | 22.10 | 9.72 | 54 | 236021 | 6239 | 79502074 |
Antipsychotic drug level above therapeutic | 22.10 | 9.72 | 29 | 236046 | 2051 | 79506262 |
Oedema | 21.94 | 9.72 | 237 | 235838 | 119343 | 79388970 |
Red blood cell sedimentation rate abnormal | 21.78 | 9.72 | 18 | 236057 | 20945 | 79487368 |
Personality change | 21.77 | 9.72 | 73 | 236002 | 10097 | 79498216 |
Aplastic anaemia | 21.74 | 9.72 | 13 | 236062 | 17892 | 79490421 |
Disseminated intravascular coagulation | 21.67 | 9.72 | 46 | 236029 | 35796 | 79472517 |
Herpes zoster | 21.59 | 9.72 | 174 | 235901 | 92909 | 79415404 |
Respiratory tract infection | 21.49 | 9.72 | 73 | 236002 | 48616 | 79459697 |
Foetal chromosome abnormality | 21.48 | 9.72 | 6 | 236069 | 15 | 79508298 |
Myocardial infarction | 21.34 | 9.72 | 400 | 235675 | 183729 | 79324584 |
Schizoaffective disorder | 21.32 | 9.72 | 29 | 236046 | 2123 | 79506190 |
Polyneuropathy | 21.30 | 9.72 | 24 | 236051 | 24127 | 79484186 |
Epstein-Barr virus infection | 21.29 | 9.72 | 8 | 236067 | 14408 | 79493905 |
Swollen tongue | 21.27 | 9.72 | 206 | 235869 | 42364 | 79465949 |
Sputum purulent | 21.26 | 9.72 | 23 | 236052 | 1326 | 79506987 |
Hypogammaglobulinaemia | 21.21 | 9.72 | 6 | 236069 | 12945 | 79495368 |
Neonatal seizure | 21.20 | 9.72 | 5 | 236070 | 4 | 79508309 |
Drug ineffective for unapproved indication | 21.16 | 9.72 | 79 | 235996 | 51159 | 79457154 |
Muscle tightness | 21.15 | 9.72 | 85 | 235990 | 12829 | 79495484 |
Pulmonary toxicity | 21.12 | 9.72 | 6 | 236069 | 12908 | 79495405 |
Adverse event | 21.05 | 9.72 | 99 | 235976 | 60115 | 79448198 |
Bronchomalacia | 21.02 | 9.72 | 12 | 236063 | 265 | 79508048 |
Vascular access site thrombosis | 21.02 | 9.72 | 7 | 236068 | 37 | 79508276 |
CFTR gene mutation | 20.89 | 9.72 | 9 | 236066 | 105 | 79508208 |
Abnormal weight gain | 20.89 | 9.72 | 32 | 236043 | 2612 | 79505701 |
Activation syndrome | 20.70 | 9.72 | 12 | 236063 | 273 | 79508040 |
Hypocalcaemia | 20.60 | 9.72 | 77 | 235998 | 49847 | 79458466 |
Pruritus | 20.48 | 9.72 | 957 | 235118 | 393691 | 79114622 |
Poor quality sleep | 20.35 | 9.72 | 126 | 235949 | 22596 | 79485717 |
Delirium | 20.34 | 9.72 | 358 | 235717 | 84269 | 79424044 |
Pupillary reflex impaired | 20.31 | 9.72 | 36 | 236039 | 3317 | 79504996 |
Therapy non-responder | 20.29 | 9.72 | 175 | 235900 | 92130 | 79416183 |
Bone erosion | 20.24 | 9.72 | 14 | 236061 | 17833 | 79490480 |
Diaphragmatic rupture | 20.24 | 9.72 | 11 | 236064 | 220 | 79508093 |
Hyperuricaemia | 20.21 | 9.72 | 5 | 236070 | 11794 | 79496519 |
Foetal death | 20.19 | 9.72 | 61 | 236014 | 7983 | 79500330 |
Gastrointestinal disorder | 20.16 | 9.72 | 248 | 235827 | 121957 | 79386356 |
Pulmonary arterial hypertension | 20.16 | 9.72 | 33 | 236042 | 28333 | 79479980 |
Alanine aminotransferase increased | 20.15 | 9.72 | 349 | 235726 | 162221 | 79346092 |
Lung disorder | 19.89 | 9.72 | 148 | 235927 | 80409 | 79427904 |
Interstitial granulomatous dermatitis | 19.76 | 9.72 | 11 | 236064 | 231 | 79508082 |
Histrionic personality disorder | 19.74 | 9.72 | 7 | 236068 | 46 | 79508267 |
Chronic sinusitis | 19.62 | 9.72 | 7 | 236068 | 13019 | 79495294 |
Tinnitus | 19.50 | 9.72 | 209 | 235866 | 44124 | 79464189 |
Gender dysphoria | 19.37 | 9.72 | 7 | 236068 | 49 | 79508264 |
Pulmonary alveolar haemorrhage | 19.35 | 9.72 | 5 | 236070 | 11452 | 79496861 |
Neuroglycopenia | 19.35 | 9.72 | 14 | 236061 | 470 | 79507843 |
Spermatozoa morphology abnormal | 19.30 | 9.72 | 4 | 236071 | 0 | 79508313 |
Sexual inhibition | 19.30 | 9.72 | 4 | 236071 | 0 | 79508313 |
Nocturnal emission | 19.30 | 9.72 | 4 | 236071 | 0 | 79508313 |
Agoraphobia | 19.28 | 9.72 | 15 | 236060 | 563 | 79507750 |
Acute myocardial infarction | 19.28 | 9.72 | 141 | 235934 | 76895 | 79431418 |
Dermatitis bullous | 19.27 | 9.72 | 9 | 236066 | 14236 | 79494077 |
Facial spasm | 19.23 | 9.72 | 17 | 236058 | 764 | 79507549 |
Opiates positive | 19.22 | 9.72 | 19 | 236056 | 985 | 79507328 |
Orthostatic intolerance | 19.17 | 9.72 | 26 | 236049 | 1898 | 79506415 |
Therapy interrupted | 19.13 | 9.72 | 40 | 236035 | 31301 | 79477012 |
Cytomegalovirus viraemia | 19.12 | 9.72 | 7 | 236068 | 12814 | 79495499 |
Self-medication | 19.06 | 9.72 | 45 | 236030 | 5087 | 79503226 |
Decreased interest | 19.02 | 9.72 | 37 | 236038 | 3660 | 79504653 |
Cholangitis | 19.02 | 9.72 | 7 | 236068 | 12769 | 79495544 |
Intestinal congestion | 19.01 | 9.72 | 5 | 236070 | 9 | 79508304 |
Hypoalbuminaemia | 18.97 | 9.72 | 21 | 236054 | 21276 | 79487037 |
Acute generalised exanthematous pustulosis | 18.96 | 9.72 | 14 | 236061 | 17240 | 79491073 |
Macular degeneration | 18.94 | 9.72 | 5 | 236070 | 11291 | 79497022 |
Hyperbilirubinaemia | 18.89 | 9.72 | 27 | 236048 | 24491 | 79483822 |
Autoimmune disorder | 18.88 | 9.72 | 13 | 236062 | 16599 | 79491714 |
Menopause | 18.85 | 9.72 | 27 | 236048 | 2075 | 79506238 |
Conduction disorder | 18.84 | 9.72 | 35 | 236040 | 3344 | 79504969 |
Head injury | 18.75 | 9.72 | 181 | 235894 | 37188 | 79471125 |
Pulmonary oedema | 18.67 | 9.72 | 366 | 235709 | 87888 | 79420425 |
Loss of bladder sensation | 18.59 | 9.72 | 8 | 236067 | 93 | 79508220 |
Blood alcohol increased | 18.55 | 9.72 | 21 | 236054 | 1274 | 79507039 |
Ventricular arrhythmia | 18.52 | 9.72 | 63 | 236012 | 8777 | 79499536 |
Fear | 18.51 | 9.72 | 120 | 235955 | 21866 | 79486447 |
Heat stroke | 18.49 | 9.72 | 24 | 236051 | 1679 | 79506634 |
Drug abuser | 18.42 | 9.72 | 49 | 236026 | 5964 | 79502349 |
Product dose omission issue | 18.42 | 9.72 | 575 | 235500 | 246962 | 79261351 |
Pneumonia bacterial | 18.41 | 9.72 | 18 | 236057 | 19313 | 79489000 |
Cerebrospinal fluid retention | 18.37 | 9.72 | 8 | 236067 | 96 | 79508217 |
Libido disorder | 18.27 | 9.72 | 11 | 236064 | 269 | 79508044 |
Metastases to liver | 18.26 | 9.72 | 35 | 236040 | 28279 | 79480034 |
Genital anaesthesia | 18.04 | 9.72 | 5 | 236070 | 12 | 79508301 |
Panniculitis | 18.04 | 9.72 | 7 | 236068 | 12364 | 79495949 |
Hospitalisation | 18.00 | 9.72 | 185 | 235890 | 94051 | 79414262 |
Therapy partial responder | 18.00 | 9.72 | 15 | 236060 | 17382 | 79490931 |
Basal ganglion degeneration | 18 | 9.72 | 13 | 236062 | 435 | 79507878 |
Mobility decreased | 17.94 | 9.72 | 254 | 235821 | 121921 | 79386392 |
Cataract | 17.90 | 9.72 | 109 | 235966 | 62011 | 79446302 |
Pain | 17.84 | 9.72 | 1818 | 234257 | 701984 | 78806329 |
Subclavian artery thrombosis | 17.82 | 9.72 | 6 | 236069 | 33 | 79508280 |
Hanging | 17.82 | 9.72 | 9 | 236066 | 154 | 79508159 |
Influenza | 17.80 | 9.72 | 273 | 235802 | 129333 | 79378980 |
Sexual relationship change | 17.76 | 9.72 | 5 | 236070 | 13 | 79508300 |
Sternal fracture | 17.75 | 9.72 | 29 | 236046 | 2501 | 79505812 |
Semen volume decreased | 17.75 | 9.72 | 7 | 236068 | 64 | 79508249 |
Antipsychotic drug level increased | 17.70 | 9.72 | 48 | 236027 | 5909 | 79502404 |
Bacteraemia | 17.54 | 9.72 | 45 | 236030 | 32779 | 79475534 |
Post-traumatic neck syndrome | 17.48 | 9.72 | 26 | 236049 | 2068 | 79506245 |
Drug withdrawal syndrome neonatal | 17.47 | 9.72 | 11 | 236064 | 292 | 79508021 |
Atrophic vulvovaginitis | 17.30 | 9.72 | 20 | 236055 | 1241 | 79507072 |
Mood altered | 17.28 | 9.72 | 101 | 235974 | 17746 | 79490567 |
Ejection fraction decreased | 17.27 | 9.72 | 49 | 236026 | 34528 | 79473785 |
Amputation stump pain | 17.25 | 9.72 | 6 | 236069 | 37 | 79508276 |
CYP3A4 polymorphism | 17.20 | 9.72 | 7 | 236068 | 70 | 79508243 |
Hypersexuality | 17.20 | 9.72 | 23 | 236052 | 1657 | 79506656 |
Feeling abnormal | 17.18 | 9.72 | 604 | 235471 | 158595 | 79349718 |
Cystoid macular oedema | 17.12 | 9.72 | 25 | 236050 | 1955 | 79506358 |
Electrolyte substitution therapy | 17.07 | 9.72 | 4 | 236071 | 3 | 79508310 |
Legal problem | 17.07 | 9.72 | 9 | 236066 | 169 | 79508144 |
Meningitis streptococcal | 17.07 | 9.72 | 9 | 236066 | 169 | 79508144 |
Incontinence | 17.00 | 9.72 | 85 | 235990 | 14079 | 79494234 |
Lymphoma | 16.93 | 9.72 | 16 | 236059 | 17444 | 79490869 |
Morbid thoughts | 16.90 | 9.72 | 16 | 236059 | 786 | 79507527 |
Musculoskeletal pain | 16.77 | 9.72 | 208 | 235867 | 102146 | 79406167 |
Graft versus host disease | 16.76 | 9.72 | 12 | 236063 | 15014 | 79493299 |
Personality disorder | 16.76 | 9.72 | 48 | 236027 | 6098 | 79502215 |
Multiple sclerosis relapse | 16.73 | 9.72 | 211 | 235864 | 46322 | 79461991 |
Hypokalaemia | 16.68 | 9.72 | 551 | 235524 | 143489 | 79364824 |
Thrombosis | 16.52 | 9.72 | 164 | 235911 | 83936 | 79424377 |
Basal cell carcinoma | 16.52 | 9.72 | 56 | 236019 | 37319 | 79470994 |
Respiratory depression | 16.51 | 9.72 | 139 | 235936 | 27491 | 79480822 |
Hepatotoxicity | 16.48 | 9.72 | 87 | 235988 | 51265 | 79457048 |
Persistent depressive disorder | 16.35 | 9.72 | 19 | 236056 | 1186 | 79507127 |
Kidney transplant rejection | 16.32 | 9.72 | 5 | 236070 | 10241 | 79498072 |
Caesarean section | 16.32 | 9.72 | 77 | 235998 | 12458 | 79495855 |
Ventricular tachycardia | 16.32 | 9.72 | 193 | 235882 | 41742 | 79466571 |
Organising pneumonia | 16.27 | 9.72 | 6 | 236069 | 10933 | 79497380 |
Cough | 16.23 | 9.72 | 904 | 235171 | 365885 | 79142428 |
Violence-related symptom | 16.21 | 9.72 | 15 | 236060 | 716 | 79507597 |
Soft tissue injury | 16.15 | 9.72 | 23 | 236052 | 1758 | 79506555 |
Nystagmus | 16.07 | 9.72 | 65 | 236010 | 9839 | 79498474 |
Hypoglycaemia | 16.00 | 9.72 | 404 | 235671 | 101190 | 79407123 |
Therapeutic response decreased | 15.95 | 9.72 | 124 | 235951 | 66729 | 79441584 |
Accidental poisoning | 15.92 | 9.72 | 22 | 236053 | 1635 | 79506678 |
Polymenorrhagia | 15.91 | 9.72 | 6 | 236069 | 48 | 79508265 |
Acute respiratory failure | 15.87 | 9.72 | 107 | 235968 | 59434 | 79448879 |
Balance disorder | 15.84 | 9.72 | 394 | 235681 | 98463 | 79409850 |
Stress | 15.78 | 9.72 | 327 | 235748 | 79285 | 79429028 |
Toxic skin eruption | 15.78 | 9.72 | 26 | 236049 | 22267 | 79486046 |
Parkinson's disease | 15.78 | 9.72 | 22 | 236053 | 1649 | 79506664 |
Throat irritation | 15.72 | 9.72 | 65 | 236010 | 40881 | 79467432 |
Mucormycosis | 15.70 | 9.72 | 3 | 236072 | 8466 | 79499847 |
Cardiac steatosis | 15.70 | 9.72 | 6 | 236069 | 50 | 79508263 |
Adenovirus infection | 15.65 | 9.72 | 3 | 236072 | 8444 | 79499869 |
Chronic kidney disease | 15.64 | 9.72 | 123 | 235952 | 66031 | 79442282 |
Burns second degree | 15.64 | 9.72 | 28 | 236047 | 2600 | 79505713 |
Epistaxis | 15.61 | 9.72 | 234 | 235841 | 111281 | 79397032 |
Fluid retention | 15.61 | 9.72 | 292 | 235783 | 69517 | 79438796 |
Drug level above therapeutic | 15.58 | 9.72 | 59 | 236016 | 8664 | 79499649 |
Cystitis haemorrhagic | 15.49 | 9.72 | 4 | 236071 | 9168 | 79499145 |
Bronchitis | 15.39 | 9.72 | 283 | 235792 | 130361 | 79377952 |
Stupor | 15.31 | 9.72 | 50 | 236025 | 6822 | 79501491 |
Skin toxicity | 15.30 | 9.72 | 3 | 236072 | 8311 | 79500002 |
Dermatillomania | 15.29 | 9.72 | 9 | 236066 | 211 | 79508102 |
Adjustment disorder with depressed mood | 15.28 | 9.72 | 4 | 236071 | 9082 | 79499231 |
Dysponesis | 15.28 | 9.72 | 4 | 236071 | 7 | 79508306 |
Uterine enlargement | 15.23 | 9.72 | 16 | 236059 | 892 | 79507421 |
Lipoedema | 15.21 | 9.72 | 9 | 236066 | 213 | 79508100 |
Hallucinations, mixed | 15.19 | 9.72 | 50 | 236025 | 6849 | 79501464 |
Right ventricular failure | 15.19 | 9.72 | 29 | 236046 | 23468 | 79484845 |
Disability | 15.11 | 9.72 | 17 | 236058 | 17103 | 79491210 |
Hepatocellular carcinoma | 15.11 | 9.72 | 4 | 236071 | 9017 | 79499296 |
Sensory disturbance | 15.04 | 9.72 | 86 | 235989 | 14991 | 79493322 |
Posturing | 14.95 | 9.72 | 17 | 236058 | 1036 | 79507277 |
Dysphoria | 14.93 | 9.72 | 39 | 236036 | 4695 | 79503618 |
Anticholinergic syndrome | 14.89 | 9.72 | 33 | 236042 | 3578 | 79504735 |
Coordination abnormal | 14.88 | 9.72 | 95 | 235980 | 17217 | 79491096 |
Hyperkinesia | 14.88 | 9.72 | 28 | 236047 | 2701 | 79505612 |
Aspergillus infection | 14.86 | 9.72 | 21 | 236054 | 19140 | 79489173 |
Renal disorder | 14.85 | 9.72 | 69 | 236006 | 42036 | 79466277 |
Proteinuria | 14.84 | 9.72 | 48 | 236027 | 32454 | 79475859 |
Adjustment disorder | 14.77 | 9.72 | 35 | 236040 | 3965 | 79504348 |
Vasoplegia syndrome | 14.77 | 9.72 | 33 | 236042 | 3597 | 79504716 |
End stage renal disease | 14.66 | 9.72 | 9 | 236066 | 12211 | 79496102 |
Blunted affect | 14.66 | 9.72 | 12 | 236063 | 485 | 79507828 |
Female orgasmic disorder | 14.63 | 9.72 | 5 | 236070 | 29 | 79508284 |
Ankylosing spondylitis | 14.62 | 9.72 | 9 | 236066 | 12196 | 79496117 |
Hypervigilance | 14.61 | 9.72 | 12 | 236063 | 487 | 79507826 |
Agranulocytosis | 14.61 | 9.72 | 76 | 235999 | 44954 | 79463359 |
Wrong product administered | 14.51 | 9.72 | 59 | 236016 | 8953 | 79499360 |
New daily persistent headache | 14.48 | 9.72 | 3 | 236072 | 0 | 79508313 |
Gas poisoning | 14.48 | 9.72 | 3 | 236072 | 0 | 79508313 |
Intervertebral disc disorder | 14.46 | 9.72 | 39 | 236036 | 4786 | 79503527 |
Product storage error | 14.45 | 9.72 | 16 | 236059 | 16210 | 79492103 |
Dysaesthesia | 14.36 | 9.72 | 44 | 236031 | 5804 | 79502509 |
Multiple sclerosis | 14.34 | 9.72 | 114 | 235961 | 22168 | 79486145 |
Trismus | 14.24 | 9.72 | 42 | 236033 | 5425 | 79502888 |
Feeling of despair | 14.23 | 9.72 | 28 | 236047 | 2793 | 79505520 |
Localised infection | 14.20 | 9.72 | 60 | 236015 | 37515 | 79470798 |
Colorectal cancer | 14.18 | 9.72 | 4 | 236071 | 8643 | 79499670 |
Initial insomnia | 14.15 | 9.72 | 49 | 236026 | 6889 | 79501424 |
Appendicitis | 14.03 | 9.72 | 25 | 236050 | 20769 | 79487544 |
Metastases to lung | 13.99 | 9.72 | 20 | 236055 | 18143 | 79490170 |
Vertigo CNS origin | 13.96 | 9.72 | 5 | 236070 | 34 | 79508279 |
Joint range of motion decreased | 13.95 | 9.72 | 51 | 236024 | 33231 | 79475082 |
Self esteem decreased | 13.93 | 9.72 | 16 | 236059 | 986 | 79507327 |
Tobacco user | 13.86 | 9.72 | 14 | 236061 | 745 | 79507568 |
Job dissatisfaction | 13.85 | 9.72 | 6 | 236069 | 71 | 79508242 |
Meconium in amniotic fluid | 13.85 | 9.72 | 7 | 236068 | 120 | 79508193 |
Injection site reaction | 13.84 | 9.72 | 100 | 235975 | 54685 | 79453628 |
Wrong technique in product usage process | 13.71 | 9.72 | 146 | 235929 | 73729 | 79434584 |
Acute stress disorder | 13.68 | 9.72 | 11 | 236064 | 433 | 79507880 |
Vascular access site infection | 13.64 | 9.72 | 7 | 236068 | 124 | 79508189 |
Acute graft versus host disease in skin | 13.60 | 9.72 | 3 | 236072 | 7655 | 79500658 |
Creatinine renal clearance decreased | 13.60 | 9.72 | 22 | 236053 | 18980 | 79489333 |
Haematospermia | 13.59 | 9.72 | 9 | 236066 | 261 | 79508052 |
Differential white blood cell count abnormal | 13.49 | 9.72 | 23 | 236052 | 2054 | 79506259 |
Product administration error | 13.48 | 9.72 | 149 | 235926 | 31697 | 79476616 |
Anaphylactic reaction | 13.41 | 9.72 | 171 | 235904 | 83572 | 79424741 |
Melaena | 13.38 | 9.72 | 254 | 235821 | 60636 | 79447677 |
Heterophoria | 13.37 | 9.72 | 5 | 236070 | 39 | 79508274 |
Renal cancer | 13.33 | 9.72 | 10 | 236065 | 12216 | 79496097 |
Blood catecholamines decreased | 13.33 | 9.72 | 4 | 236071 | 14 | 79508299 |
Haemolysis | 13.31 | 9.72 | 11 | 236064 | 12801 | 79495512 |
Heparin-induced thrombocytopenia | 13.28 | 9.72 | 6 | 236069 | 9676 | 79498637 |
Multiple drug therapy | 13.28 | 9.72 | 34 | 236041 | 4044 | 79504269 |
Economic problem | 13.27 | 9.72 | 24 | 236051 | 2246 | 79506067 |
Arrhythmia | 13.26 | 9.72 | 255 | 235820 | 61017 | 79447296 |
Asthma | 13.22 | 9.72 | 507 | 235568 | 134588 | 79373725 |
Cholestasis | 13.22 | 9.72 | 95 | 235980 | 52014 | 79456299 |
Testicular atrophy | 13.19 | 9.72 | 10 | 236065 | 361 | 79507952 |
Vaginal haemorrhage | 13.16 | 9.72 | 110 | 235965 | 21707 | 79486606 |
Tissue infiltration | 13.09 | 9.72 | 13 | 236062 | 678 | 79507635 |
Suspected suicide | 13.07 | 9.72 | 64 | 236011 | 10512 | 79497801 |
Pyelonephritis chronic | 12.98 | 9.72 | 9 | 236066 | 282 | 79508031 |
Cushingoid | 12.98 | 9.72 | 6 | 236069 | 9546 | 79498767 |
Myositis | 12.98 | 9.72 | 23 | 236052 | 19145 | 79489168 |
Congestive hepatopathy | 12.88 | 9.72 | 36 | 236039 | 4511 | 79503802 |
Potentiating drug interaction | 12.84 | 9.72 | 56 | 236019 | 8763 | 79499550 |
Gastrointestinal toxicity | 12.84 | 9.72 | 4 | 236071 | 8105 | 79500208 |
Systolic hypertension | 12.82 | 9.72 | 13 | 236062 | 695 | 79507618 |
Executive dysfunction | 12.70 | 9.72 | 9 | 236066 | 292 | 79508021 |
Catarrh | 12.70 | 9.72 | 23 | 236052 | 2155 | 79506158 |
Anaphylactic shock | 12.69 | 9.72 | 59 | 236016 | 35937 | 79472376 |
Fibrous histiocytoma | 12.65 | 9.72 | 13 | 236062 | 706 | 79507607 |
Ocular hyperaemia | 12.64 | 9.72 | 42 | 236033 | 28164 | 79480149 |
Osteoporosis | 12.61 | 9.72 | 101 | 235974 | 54011 | 79454302 |
Jaundice cholestatic | 12.60 | 9.72 | 9 | 236066 | 11275 | 79497038 |
Hepatitis fulminant | 12.59 | 9.72 | 3 | 236072 | 7259 | 79501054 |
Marital problem | 12.59 | 9.72 | 8 | 236067 | 216 | 79508097 |
Facial paralysis | 12.58 | 9.72 | 106 | 235969 | 20966 | 79487347 |
Hyperthermia | 12.56 | 9.72 | 94 | 235981 | 17943 | 79490370 |
Adjusted calcium decreased | 12.55 | 9.72 | 8 | 236067 | 217 | 79508096 |
Saliva altered | 12.54 | 9.72 | 11 | 236064 | 489 | 79507824 |
Adrenergic syndrome | 12.53 | 9.72 | 7 | 236068 | 148 | 79508165 |
Oliguria | 12.52 | 9.72 | 18 | 236057 | 16291 | 79492022 |
Mutism | 12.52 | 9.72 | 24 | 236051 | 2348 | 79505965 |
Pregnancy | 12.47 | 9.72 | 128 | 235947 | 26723 | 79481590 |
Tuberculosis | 12.45 | 9.72 | 16 | 236059 | 15182 | 79493131 |
Bisexuality | 12.41 | 9.72 | 3 | 236072 | 3 | 79508310 |
Cervix haematoma uterine | 12.41 | 9.72 | 3 | 236072 | 3 | 79508310 |
Antidepressant drug level below therapeutic | 12.41 | 9.72 | 3 | 236072 | 3 | 79508310 |
Cardiac death | 12.37 | 9.72 | 19 | 236056 | 1555 | 79506758 |
Cholecystectomy | 12.32 | 9.72 | 58 | 236017 | 9374 | 79498939 |
Feeling guilty | 12.30 | 9.72 | 14 | 236061 | 854 | 79507459 |
Cellulitis | 12.30 | 9.72 | 238 | 235837 | 108822 | 79399491 |
Cardiac failure chronic | 12.28 | 9.72 | 9 | 236066 | 11126 | 79497187 |
Respiratory disorder | 12.26 | 9.72 | 80 | 235995 | 44776 | 79463537 |
Post-traumatic stress disorder | 12.24 | 9.72 | 37 | 236038 | 4844 | 79503469 |
Movement disorder | 12.22 | 9.72 | 129 | 235946 | 27130 | 79481183 |
Social problem | 12.21 | 9.72 | 18 | 236057 | 1420 | 79506893 |
Peripheral circulatory failure | 12.21 | 9.72 | 16 | 236059 | 1130 | 79507183 |
Electrocardiogram QT interval abnormal | 12.21 | 9.72 | 9 | 236066 | 311 | 79508002 |
Gastrointestinal mucosal exfoliation | 12.20 | 9.72 | 8 | 236067 | 228 | 79508085 |
Osmolar gap abnormal | 12.18 | 9.72 | 6 | 236069 | 97 | 79508216 |
Pleurisy | 12.17 | 9.72 | 8 | 236067 | 10467 | 79497846 |
Stiff person syndrome | 12.16 | 9.72 | 9 | 236066 | 313 | 79508000 |
Hepatitis C virus test positive | 12.15 | 9.72 | 10 | 236065 | 407 | 79507906 |
Azoospermia | 12.13 | 9.72 | 7 | 236068 | 158 | 79508155 |
Pneumonia viral | 12.06 | 9.72 | 6 | 236069 | 9152 | 79499161 |
Psychogenic seizure | 12.04 | 9.72 | 21 | 236054 | 1910 | 79506403 |
Diffuse large B-cell lymphoma stage II | 12.02 | 9.72 | 6 | 236069 | 100 | 79508213 |
Cardiomegaly | 11.95 | 9.72 | 125 | 235950 | 26227 | 79482086 |
Nephropathy | 11.92 | 9.72 | 7 | 236068 | 9731 | 79498582 |
Metastases to bone | 11.92 | 9.72 | 35 | 236040 | 24392 | 79483921 |
Pulmonary fibrosis | 11.89 | 9.72 | 79 | 235996 | 44033 | 79464280 |
Drug level increased | 11.88 | 9.72 | 174 | 235901 | 39477 | 79468836 |
Unintentional medical device removal | 11.86 | 9.72 | 4 | 236071 | 7708 | 79500605 |
Hepatic steatosis | 11.86 | 9.72 | 167 | 235908 | 37571 | 79470742 |
Detoxification | 11.81 | 9.72 | 6 | 236069 | 104 | 79508209 |
Blood osmolarity decreased | 11.79 | 9.72 | 17 | 236058 | 1314 | 79506999 |
Pelvic fracture | 11.78 | 9.72 | 69 | 236006 | 12135 | 79496178 |
Teratogenicity | 11.76 | 9.72 | 8 | 236067 | 243 | 79508070 |
Poor personal hygiene | 11.75 | 9.72 | 11 | 236064 | 533 | 79507780 |
Peritoneal perforation | 11.71 | 9.72 | 7 | 236068 | 169 | 79508144 |
JC virus CSF test positive | 11.71 | 9.72 | 7 | 236068 | 169 | 79508144 |
Exposure to allergen | 11.70 | 9.72 | 9 | 236066 | 332 | 79507981 |
Injection site erythema | 11.68 | 9.72 | 162 | 235913 | 78035 | 79430278 |
Hypoxic-ischaemic encephalopathy | 11.65 | 9.72 | 50 | 236025 | 7770 | 79500543 |
Pyelonephritis | 11.64 | 9.72 | 27 | 236048 | 20361 | 79487952 |
Colitis | 11.63 | 9.72 | 150 | 235925 | 73157 | 79435156 |
Gastrointestinal sounds abnormal | 11.62 | 9.72 | 39 | 236036 | 5396 | 79502917 |
Hypocoagulable state | 11.59 | 9.72 | 22 | 236053 | 2137 | 79506176 |
Skin laceration | 11.58 | 9.72 | 134 | 235941 | 28828 | 79479485 |
Wrong patient received product | 11.57 | 9.72 | 35 | 236040 | 4583 | 79503730 |
Osmotic demyelination syndrome | 11.52 | 9.72 | 18 | 236057 | 1495 | 79506818 |
Hypertension | 11.49 | 9.72 | 834 | 235241 | 330158 | 79178155 |
Spermatozoa progressive motility decreased | 11.48 | 9.72 | 5 | 236070 | 60 | 79508253 |
Pneumothorax | 11.48 | 9.72 | 44 | 236031 | 28279 | 79480034 |
Bipolar II disorder | 11.47 | 9.72 | 10 | 236065 | 441 | 79507872 |
Stoma site infection | 11.45 | 9.72 | 18 | 236057 | 1502 | 79506811 |
Bulimia nervosa | 11.44 | 9.72 | 8 | 236067 | 254 | 79508059 |
Foot deformity | 11.38 | 9.72 | 35 | 236040 | 24039 | 79484274 |
Inflammation | 11.38 | 9.72 | 202 | 235873 | 93551 | 79414762 |
Chronic graft versus host disease | 11.37 | 9.72 | 3 | 236072 | 6778 | 79501535 |
Drug dose titration not performed | 11.37 | 9.72 | 13 | 236062 | 797 | 79507516 |
Tricuspid valve incompetence | 11.34 | 9.72 | 26 | 236049 | 19686 | 79488627 |
Male orgasmic disorder | 11.33 | 9.72 | 5 | 236070 | 62 | 79508251 |
Peripheral ischaemia | 11.29 | 9.72 | 7 | 236068 | 9450 | 79498863 |
Lip swelling | 11.28 | 9.72 | 177 | 235898 | 40734 | 79467579 |
Injection site pruritus | 11.26 | 9.72 | 76 | 235999 | 42207 | 79466106 |
Blood ethanol increased | 11.25 | 9.72 | 12 | 236063 | 681 | 79507632 |
Hypervolaemia | 11.23 | 9.72 | 77 | 235998 | 42613 | 79465700 |
Alcoholic psychosis | 11.20 | 9.72 | 3 | 236072 | 6 | 79508307 |
Adjusted calcium increased | 11.19 | 9.72 | 5 | 236070 | 64 | 79508249 |
Pneumonia fungal | 11.19 | 9.72 | 10 | 236065 | 11200 | 79497113 |
Akinesia | 11.19 | 9.72 | 28 | 236047 | 3284 | 79505029 |
Hypopnoea | 11.18 | 9.72 | 38 | 236037 | 5291 | 79503022 |
Pickwickian syndrome | 11.15 | 9.72 | 10 | 236065 | 458 | 79507855 |
Upper respiratory tract infection | 11.14 | 9.72 | 351 | 235724 | 90817 | 79417496 |
Hypoxia | 11.13 | 9.72 | 227 | 235848 | 103016 | 79405297 |
Product substitution issue | 11.11 | 9.72 | 100 | 235975 | 20156 | 79488157 |
Contraindicated product prescribed | 11.10 | 9.72 | 19 | 236056 | 1702 | 79506611 |
Frequent bowel movements | 11.07 | 9.72 | 135 | 235940 | 29404 | 79478909 |
Decreased appetite | 11.06 | 9.72 | 868 | 235207 | 341550 | 79166763 |
Amniorrhexis | 10.95 | 9.72 | 4 | 236071 | 29 | 79508284 |
Photosensitivity reaction | 10.93 | 9.72 | 103 | 235972 | 21024 | 79487289 |
Heavy menstrual bleeding | 10.91 | 9.72 | 75 | 236000 | 13936 | 79494377 |
Cardiac tamponade | 10.89 | 9.72 | 7 | 236068 | 9269 | 79499044 |
Accommodation disorder | 10.87 | 9.72 | 11 | 236064 | 587 | 79507726 |
Antisocial behaviour | 10.86 | 9.72 | 12 | 236063 | 709 | 79507604 |
Benign prostatic hyperplasia | 10.84 | 9.72 | 11 | 236064 | 11601 | 79496712 |
Carbon monoxide poisoning | 10.84 | 9.72 | 8 | 236067 | 277 | 79508036 |
Miosis | 10.84 | 9.72 | 82 | 235993 | 15707 | 79492606 |
Diffuse large B-cell lymphoma | 10.80 | 9.72 | 12 | 236063 | 12137 | 79496176 |
Therapy cessation | 10.77 | 9.72 | 66 | 236009 | 37496 | 79470817 |
Pancreatitis relapsing | 10.76 | 9.72 | 14 | 236061 | 982 | 79507331 |
Parotid gland enlargement | 10.74 | 9.72 | 14 | 236061 | 984 | 79507329 |
Dermatitis exfoliative generalised | 10.72 | 9.72 | 4 | 236071 | 7237 | 79501076 |
Autoscopy | 10.61 | 9.72 | 5 | 236070 | 73 | 79508240 |
Emotional disorder | 10.60 | 9.72 | 76 | 235999 | 14311 | 79494002 |
Angiodermatitis | 10.55 | 9.72 | 5 | 236070 | 74 | 79508239 |
Atrial flutter | 10.54 | 9.72 | 31 | 236044 | 21594 | 79486719 |
Inguinal mass | 10.54 | 9.72 | 7 | 236068 | 204 | 79508109 |
Thrombotic stroke | 10.46 | 9.72 | 12 | 236063 | 739 | 79507574 |
Subdural haemorrhage | 10.43 | 9.72 | 40 | 236035 | 5908 | 79502405 |
Gallbladder disorder | 10.36 | 9.72 | 95 | 235980 | 19245 | 79489068 |
Genito-pelvic pain/penetration disorder | 10.34 | 9.72 | 3 | 236072 | 9 | 79508304 |
Tendonitis | 10.33 | 9.72 | 36 | 236039 | 23794 | 79484519 |
Feeling of body temperature change | 10.33 | 9.72 | 37 | 236038 | 5289 | 79503024 |
Extensor plantar response | 10.33 | 9.72 | 19 | 236056 | 1802 | 79506511 |
Palpitations | 10.31 | 9.72 | 466 | 235609 | 126144 | 79382169 |
Gastrointestinal procedural complication | 10.30 | 9.72 | 7 | 236068 | 212 | 79508101 |
Slow response to stimuli | 10.30 | 9.72 | 19 | 236056 | 1806 | 79506507 |
Biliary dyskinesia | 10.20 | 9.72 | 23 | 236052 | 2522 | 79505791 |
Agonal rhythm | 10.20 | 9.72 | 5 | 236070 | 80 | 79508233 |
Joint effusion | 10.17 | 9.72 | 24 | 236051 | 17990 | 79490323 |
Coagulation factor increased | 10.14 | 9.72 | 5 | 236070 | 81 | 79508232 |
Anaesthesia | 10.14 | 9.72 | 10 | 236065 | 517 | 79507796 |
Pupillary light reflex tests abnormal | 10.13 | 9.72 | 8 | 236067 | 307 | 79508006 |
Lower limb fracture | 10.11 | 9.72 | 35 | 236040 | 23180 | 79485133 |
Scleroedema | 10.10 | 9.72 | 4 | 236071 | 37 | 79508276 |
Liver injury | 10.06 | 9.72 | 113 | 235962 | 56501 | 79451812 |
Drug dose omission by device | 10.05 | 9.72 | 3 | 236072 | 6247 | 79502066 |
Conversion disorder | 10.03 | 9.72 | 19 | 236056 | 1842 | 79506471 |
Anhedonia | 10.02 | 9.72 | 77 | 235998 | 14821 | 79493492 |
HIV peripheral neuropathy | 10.01 | 9.72 | 4 | 236071 | 38 | 79508275 |
Alanine aminotransferase abnormal | 10.00 | 9.72 | 7 | 236068 | 8860 | 79499453 |
Borderline personality disorder | 9.97 | 9.72 | 13 | 236062 | 914 | 79507399 |
Phlebitis | 9.92 | 9.72 | 7 | 236068 | 8823 | 79499490 |
Body dysmorphic disorder | 9.91 | 9.72 | 8 | 236067 | 317 | 79507996 |
Maternal exposure during breast feeding | 9.89 | 9.72 | 24 | 236051 | 2761 | 79505552 |
Colour blindness | 9.88 | 9.72 | 9 | 236066 | 421 | 79507892 |
Polyarthritis | 9.84 | 9.72 | 13 | 236062 | 12189 | 79496124 |
Urinary incontinence | 9.81 | 9.72 | 173 | 235902 | 40736 | 79467577 |
Reflexes abnormal | 9.79 | 9.72 | 13 | 236062 | 930 | 79507383 |
Phobia | 9.77 | 9.72 | 9 | 236066 | 427 | 79507886 |
Vitreous floaters | 9.76 | 9.72 | 45 | 236030 | 7211 | 79501102 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cryptorchism | 34.98 | 29.56 | 38 | 1433 | 371 | 87950 |
Respiratory disorder neonatal | 34.30 | 29.56 | 80 | 1391 | 1586 | 86735 |
Source | Code | Description |
---|---|---|
ATC | N06AB04 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Selective serotonin reuptake inhibitors |
FDA MoA | N0000000109 | Serotonin Uptake Inhibitors |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:50949 | SSRI |
CHEBI has role | CHEBI:76779 | post-proline endopeptidase inhibitors |
CHEBI has role | CHEBI:77402 | EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors |
CHEBI has role | CHEBI:78298 | environmental contaminants |
FDA EPC | N0000175696 | Serotonin Reuptake Inhibitor |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D018687 | Antidepressive Agents, Second-Generation |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D017367 | Selective Serotonin Reuptake Inhibitors |
MeSH PA | D018490 | Serotonin Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Generalized anxiety disorder | indication | 21897009 | DOID:14320 |
Depressive disorder | indication | 35489007 | |
Major depressive disorder | indication | 370143000 | |
Posttraumatic stress disorder | off-label use | 47505003 | DOID:2055 |
Bipolar affective disorder, current episode depression | off-label use | 191627008 | DOID:3312 |
Obsessive-compulsive disorder | off-label use | 191736004 | DOID:10933 |
Menopausal flushing | off-label use | 198436008 | |
Panic disorder | off-label use | 371631005 | DOID:594 |
Suicidal thoughts | contraindication | 6471006 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Neuroleptic malignant syndrome | contraindication | 15244003 | DOID:14464 |
Torsades de pointes | contraindication | 31722008 | |
Upper gastrointestinal hemorrhage | contraindication | 37372002 | |
Hypokalemia | contraindication | 43339004 | |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Heart disease | contraindication | 56265001 | DOID:114 |
Acute nephropathy | contraindication | 58574008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Hyponatremia | contraindication | 89627008 | |
Prolonged QT interval | contraindication | 111975006 | |
Hypomagnesemia | contraindication | 190855004 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Serotonin syndrome | contraindication | 371089000 | |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Poor metabolizer due to cytochrome p450 CYP2C19 variant | contraindication | 424500005 | |
Congenital long QT syndrome | contraindication | 442917000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.33 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Kd | 8.94 | WOMBAT-PK | CHEMBL | |||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.40 | WOMBAT-PK | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.21 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.19 | PDSP | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.93 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 6.21 | WOMBAT-PK | |||||
Histamine H1 receptor | GPCR | Ki | 6.46 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 5.88 | PDSP | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 4.78 | CHEMBL | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 6.15 | DRUG MATRIX | |||||
Acetylcholinesterase | Enzyme | IC50 | 4.13 | CHEMBL | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.73 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.78 | DRUG MATRIX | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 5.74 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 5.76 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 4.30 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 8.82 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.03 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.54 | CHEMBL | |||||
Transporter | Transporter | Ki | 5.21 | CHEMBL | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 8.54 | CHEMBL | |||||
Transporter | Transporter | Ki | 5.23 | CHEMBL | |||||
Sigma intracellular receptor 2 | Unclassified | Ki | 5.27 | CHEMBL |
ID | Source |
---|---|
4021129 | VUID |
N0000148583 | NUI |
D00822 | KEGG_DRUG |
59729-32-7 | SECONDARY_CAS_RN |
221078 | RXNORM |
4021129 | VANDF |
4021130 | VANDF |
C0008845 | UMLSCUI |
CHEBI:3723 | CHEBI |
CHEMBL549 | ChEMBL_ID |
CHEMBL399730 | ChEMBL_ID |
DB00215 | DRUGBANK_ID |
CHEMBL1200781 | ChEMBL_ID |
D015283 | MESH_DESCRIPTOR_UI |
2771 | PUBCHEM_CID |
7547 | IUPHAR_LIGAND_ID |
4138 | INN_ID |
0DHU5B8D6V | UNII |
21814 | MMSL |
62559 | MMSL |
7486 | MMSL |
d04332 | MMSL |
005106 | NDDF |
005107 | NDDF |
116521005 | SNOMEDCT_US |
321986007 | SNOMEDCT_US |
372596005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0062 | SOLUTION | 10 mg | ORAL | ANDA | 27 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0062 | SOLUTION | 10 mg | ORAL | ANDA | 27 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0062 | SOLUTION | 10 mg | ORAL | ANDA | 27 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0848 | SOLUTION | 10 mg | ORAL | ANDA | 32 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1696 | SOLUTION | 20 mg | ORAL | ANDA | 32 sections |
Citalopram | Human Prescription Drug Label | 1 | 0185-0371 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
Citalopram | Human Prescription Drug Label | 1 | 0185-0372 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
Citalopram | Human Prescription Drug Label | 1 | 0185-0373 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 31 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6231 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 39 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6231 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 39 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6232 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 39 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6232 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 39 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6233 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 39 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-6233 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 39 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4010 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4010 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4010 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4020 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4020 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4020 | TABLET, FILM COATED | 20 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4040 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4040 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 35 sections |
Celexa | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0456-4040 | TABLET, FILM COATED | 40 mg | ORAL | NDA | 35 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8022 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8022 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8022 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 31 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8023 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8023 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8023 | TABLET, FILM COATED | 20 mg | ORAL | ANDA | 31 sections |
Citalopram | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8141 | TABLET, FILM COATED | 40 mg | ORAL | ANDA | 31 sections |