citalopram 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
663 59729-33-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • citalopram
  • nitalapram
  • bonitrile
  • citalopram hydrobromide
A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
  • Molecular weight: 324.40
  • Formula: C20H21FN2O
  • CLOGP: 3.13
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 36.26
  • ALOGS: -4.74
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.03 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 12 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.64 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 12 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.20 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 33 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 17, 1998 FDA FOREST LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1339.66 9.40 1906 182457 131927 55975777
Toxicity to various agents 1179.16 9.40 2398 181965 222166 55885538
Drug abuse 1060.48 9.40 1205 183158 66405 56041299
Electrocardiogram QT prolonged 611.93 9.40 822 183541 53766 56053938
Serotonin syndrome 596.09 9.40 573 183790 25917 56081787
Drug interaction 521.04 9.40 1690 182673 208065 55899639
Overdose 498.95 9.40 1083 183280 104747 56002957
Intentional overdose 485.90 9.40 831 183532 67286 56040418
Systemic lupus erythematosus 465.37 9.40 32 184331 180046 55927658
Pemphigus 458.47 9.40 12 184351 157200 55950504
Hand deformity 413.60 9.40 5 184358 134487 55973217
Synovitis 410.06 9.40 31 184332 161274 55946430
Suicide attempt 402.49 9.40 698 183665 57138 56050566
Drug ineffective 382.89 9.40 1634 182729 917355 55190349
Sopor 326.10 9.40 372 183991 20550 56087154
Suicidal ideation 320.19 9.40 632 183731 57110 56050594
Treatment failure 319.42 9.40 82 184281 170310 55937394
Depression 312.95 9.40 1293 183070 178824 55928880
Glossodynia 312.71 9.40 60 184303 152398 55955306
Pericarditis 311.32 9.40 10 184353 108913 55998791
Anxiety 306.50 9.40 1349 183014 191823 55915881
Anti-cyclic citrullinated peptide antibody positive 297.36 9.40 5 184358 98595 56009109
Agitation 295.93 9.40 601 183762 55435 56052269
Intentional self-injury 291.66 9.40 384 183979 24608 56083096
Drug intolerance 286.73 9.40 267 184096 264551 55843153
Alopecia 278.35 9.40 331 184032 293127 55814577
Hyponatraemia 276.04 9.40 848 183515 101291 56006413
Rheumatoid arthritis 265.86 9.40 533 183830 382071 55725633
Arthropathy 259.74 9.40 168 184195 200107 55907597
Infusion related reaction 232.80 9.40 205 184158 208726 55898978
Torsade de pointes 231.80 9.40 243 184120 12197 56095507
Wound 222.46 9.40 88 184275 138716 55968988
Respiratory arrest 220.04 9.40 375 183988 30250 56077454
Temperature regulation disorder 218.45 9.40 152 184211 4316 56103388
Abdominal discomfort 211.22 9.40 365 183998 276909 55830795
Therapeutic product effect decreased 210.49 9.40 149 184214 169303 55938401
Rheumatoid factor positive 206.17 9.40 4 184359 69056 56038648
Helicobacter infection 204.90 9.40 8 184355 73260 56034444
Cardio-respiratory arrest 203.44 9.40 514 183849 54807 56052897
Duodenal ulcer perforation 196.24 9.40 6 184357 68336 56039368
Tremor 193.62 9.40 848 183515 120241 55987463
Poisoning 193.22 9.40 224 184139 12589 56095115
Contraindicated product administered 189.75 9.40 198 184165 186088 55921616
Off label use 188.69 9.40 1061 183302 555119 55552585
Rash 187.73 9.40 904 183459 492143 55615561
Discomfort 179.55 9.40 122 184241 141639 55966065
Joint swelling 178.61 9.40 431 183932 289369 55818335
Panic attack 163.85 9.40 263 184100 20184 56087520
Hyperhidrosis 156.56 9.40 667 183696 93421 56014283
Muscle injury 145.89 9.40 6 184357 52494 56055210
Swelling 142.66 9.40 363 184000 239408 55868296
Cardiac arrest 142.14 9.40 610 183753 85704 56022000
Food allergy 135.96 9.40 156 184207 8668 56099036
Infection 135.28 9.40 283 184080 199923 55907781
Fall 132.43 9.40 1768 182595 355742 55751962
Somnolence 130.80 9.40 950 183413 162463 55945241
Folliculitis 130.38 9.40 14 184349 54965 56052739
Sleep disorder due to general medical condition, insomnia type 127.42 9.40 3 184360 43335 56064369
Maternal exposure during pregnancy 120.59 9.40 277 184086 189276 55918428
Mydriasis 116.80 9.40 162 184201 10909 56096795
Disturbance in attention 116.13 9.40 299 184064 32241 56075463
Irritability 115.16 9.40 281 184082 29307 56078397
Myoclonus 114.29 9.40 190 184173 15013 56092691
Product use issue 114.25 9.40 277 184086 185764 55921940
Akathisia 113.62 9.40 141 184222 8511 56099193
Accidental overdose 110.99 9.40 222 184141 20239 56087465
Withdrawal syndrome 110.74 9.40 209 184154 18253 56089451
Electrocardiogram QRS complex prolonged 107.62 9.40 110 184253 5357 56102347
Foetal exposure during pregnancy 106.78 9.40 297 184066 33526 56074178
Bruxism 106.32 9.40 86 184277 3080 56104624
Restlessness 105.08 9.40 254 184109 26332 56081372
Coeliac disease 104.19 9.40 148 184215 10191 56097513
Unresponsive to stimuli 103.55 9.40 282 184081 31443 56076261
Seizure 103.32 9.40 733 183630 124386 55983318
Peripheral swelling 102.01 9.40 409 183954 234317 55873387
Irritable bowel syndrome 100.77 9.40 49 184314 68409 56039295
Impaired healing 100.54 9.40 82 184281 86759 56020945
Drug withdrawal syndrome 98.96 9.40 244 184119 25613 56082091
Blister 97.61 9.40 128 184235 108759 55998945
Aggression 92.12 9.40 215 184148 21791 56085913
Intentional product use issue 91.71 9.40 115 184248 99618 56008086
Anorgasmia 90.99 9.40 42 184321 523 56107181
Febrile neutropenia 90.64 9.40 128 184235 105417 56002287
Sinusitis 86.63 9.40 343 184020 197238 55910466
Hepatic enzyme increased 83.35 9.40 285 184078 171099 55936605
Long QT syndrome 81.66 9.40 73 184290 3003 56104701
Loss of consciousness 80.80 9.40 624 183739 108725 55998979
Nightmare 80.06 9.40 173 184190 16653 56091051
Muscle rigidity 79.73 9.40 133 184230 10538 56097166
Stomatitis 79.68 9.40 173 184190 120637 55987067
Ill-defined disorder 78.99 9.40 65 184298 68478 56039226
Immunodeficiency 77.88 9.40 167 184196 15990 56091714
Depressed mood 76.84 9.40 278 184085 36081 56071623
Muscle twitching 75.01 9.40 165 184198 16077 56091627
Psoriatic arthropathy 72.67 9.40 81 184282 73927 56033777
Galactorrhoea 72.40 9.40 76 184287 3819 56103885
Exposure via ingestion 71.32 9.40 65 184298 2743 56104961
Small for dates baby 71.26 9.40 72 184291 3458 56104246
Pyrexia 70.23 9.40 958 183405 417815 55689889
Arthralgia 69.71 9.40 1190 183173 500479 55607225
Confusional state 68.24 9.40 1008 183355 207147 55900557
Pain 68.10 9.40 1654 182709 661530 55446174
Disorientation 67.51 9.40 268 184095 36345 56071359
Dizziness 66.61 9.40 1657 182706 374483 55733221
Obsessive-compulsive disorder 66.56 9.40 71 184292 3635 56104069
Memory impairment 65.64 9.40 497 183866 86060 56021644
Dyskinesia 65.32 9.40 227 184136 28881 56078823
Accidental death 64.15 9.40 51 184312 1781 56105923
C-reactive protein increased 64.06 9.40 99 184264 78585 56029119
Mania 63.69 9.40 126 184237 11394 56096310
Extrapyramidal disorder 63.38 9.40 131 184232 12225 56095479
Hallucination 60.91 9.40 320 184043 48829 56058875
Self-injurious ideation 60.86 9.40 55 184308 2295 56105409
Product prescribing error 58.40 9.40 188 184175 22998 56084706
Rash erythematous 56.64 9.40 257 184106 36964 56070740
C-reactive protein abnormal 56.25 9.40 25 184338 36784 56070920
Crying 55.97 9.40 176 184187 21264 56086440
Haematemesis 55.86 9.40 214 184149 28544 56079160
Rheumatic fever 55.65 9.40 13 184350 28814 56078890
Coma scale abnormal 55.60 9.40 74 184289 4789 56102915
Hypersensitivity 55.13 9.40 555 183808 255853 55851851
Psychomotor hyperactivity 55.00 9.40 108 184255 9712 56097992
Malignant neoplasm progression 54.88 9.40 98 184265 73489 56034215
Hip arthroplasty 54.81 9.40 29 184334 38594 56069110
Yawning 54.25 9.40 37 184326 1016 56106688
Bradycardia 54.25 9.40 393 183970 67111 56040593
Alcoholism 53.90 9.40 50 184313 2159 56105545
Myocardial stunning 53.49 9.40 20 184343 139 56107565
Parkinsonism 53.49 9.40 105 184258 9441 56098263
Interstitial lung disease 53.28 9.40 65 184298 56998 56050706
Inappropriate antidiuretic hormone secretion 52.83 9.40 130 184233 13626 56094078
Bradyphrenia 52.82 9.40 85 184278 6535 56101169
Ventricular septal defect 52.04 9.40 66 184297 4072 56103632
Hyperreflexia 51.21 9.40 74 184289 5176 56102528
Intentional product misuse 49.85 9.40 314 184049 51190 56056514
Psychotic disorder 49.67 9.40 180 184183 23378 56084326
Antidepressant drug level above therapeutic 49.28 9.40 25 184338 388 56107316
Lethargy 48.18 9.40 311 184052 51130 56056574
Neutropenia 47.44 9.40 313 184050 157854 55949850
Nasopharyngitis 47.18 9.40 479 183884 220480 55887224
Depressed level of consciousness 46.18 9.40 330 184033 56103 56051601
Medication error 46.00 9.40 266 184097 42069 56065635
Generalised tonic-clonic seizure 45.47 9.40 195 184168 27371 56080333
Knee arthroplasty 45.05 9.40 47 184316 44212 56063492
Pancytopenia 44.83 9.40 145 184218 88570 56019134
Loss of libido 44.55 9.40 35 184328 1201 56106503
Blood cholesterol increased 44.55 9.40 108 184255 72471 56035233
Atrial septal defect 44.53 9.40 78 184285 6428 56101276
Syncope 44.06 9.40 545 183818 107654 56000050
Drug dependence 44.02 9.40 168 184195 22365 56085339
Pulseless electrical activity 43.97 9.40 81 184282 6943 56100761
Bursitis 43.88 9.40 193 184170 27389 56080315
Alcohol abuse 42.88 9.40 42 184321 1942 56105762
Anger 42.41 9.40 108 184255 11564 56096140
Mood swings 42.37 9.40 136 184227 16611 56091093
Illness anxiety disorder 42.33 9.40 16 184347 115 56107589
Nicotine dependence 41.60 9.40 27 184336 681 56107023
Respiratory disorder neonatal 41.27 9.40 30 184333 914 56106790
Obsessive thoughts 41.20 9.40 24 184339 496 56107208
Therapeutic product effect incomplete 40.96 9.40 193 184170 105838 56001866
Drug withdrawal syndrome neonatal 40.48 9.40 41 184322 1975 56105729
Impulsive behaviour 40.47 9.40 36 184327 1471 56106233
Posturing 40.24 9.40 23 184340 458 56107246
Product use in unapproved indication 39.59 9.40 284 184079 140538 55967166
Cerebral vasoconstriction 39.03 9.40 31 184332 1081 56106623
Hypokinesia 39.00 9.40 111 184252 12692 56095012
Ventricular tachycardia 38.96 9.40 133 184230 16768 56090936
Pneumonia 38.76 9.40 1026 183337 406072 55701632
Disease progression 38.57 9.40 195 184168 104978 56002726
Septic shock 38.55 9.40 89 184274 60746 56046958
Bradykinesia 38.28 9.40 62 184301 4792 56102912
Hypoglycaemia 38.18 9.40 313 184050 55502 56052202
Abnormal dreams 37.92 9.40 92 184271 9557 56098147
Libido decreased 37.82 9.40 43 184320 2365 56105339
Catatonia 37.39 9.40 55 184308 3909 56103795
Thinking abnormal 37.18 9.40 93 184270 9848 56097856
Calcium deficiency 37.09 9.40 29 184334 988 56106716
Abnormal behaviour 37.05 9.40 148 184215 20124 56087580
Angle closure glaucoma 36.00 9.40 39 184324 2032 56105672
Labelled drug-drug interaction issue 35.97 9.40 26 184337 785 56106919
Suicidal behaviour 35.78 9.40 42 184321 2391 56105313
Lower respiratory tract infection 35.51 9.40 225 184138 114569 55993135
Condition aggravated 35.28 9.40 860 183503 344038 55763666
Hepatic function abnormal 34.83 9.40 37 184326 34521 56073183
Fibromyalgia 34.79 9.40 91 184272 59512 56048192
Arthritis 34.45 9.40 189 184174 99663 56008041
Congenital thrombocytopenia 34.41 9.40 11 184352 44 56107660
Concussion 33.89 9.40 80 184283 8166 56099538
Major depression 33.84 9.40 76 184287 7508 56100196
Ductus arteriosus premature closure 33.71 9.40 18 184345 312 56107392
Macular degeneration 33.70 9.40 10 184353 18898 56088806
Cytomegalovirus infection 32.97 9.40 11 184352 19285 56088419
Mucosal inflammation 32.83 9.40 56 184307 42754 56064950
Hostility 32.74 9.40 35 184328 1796 56105908
Ventricular arrhythmia 32.69 9.40 48 184315 3406 56104298
Apathy 32.51 9.40 77 184286 7877 56099827
Speech disorder 32.28 9.40 222 184141 37271 56070433
Restless legs syndrome 32 9.40 125 184238 16822 56090882
Hyperprolactinaemia 31.97 9.40 49 184314 3612 56104092
Insomnia 31.74 9.40 838 183525 191022 55916682
Thrombocytopenia 31.73 9.40 289 184074 135935 55971769
Panic reaction 31.69 9.40 50 184313 3780 56103924
Dystonia 31.54 9.40 101 184262 12320 56095384
Alcohol use 31.53 9.40 36 184327 1989 56105715
Rabbit syndrome 31.22 9.40 17 184346 307 56107397
Rib deformity 31.19 9.40 15 184348 206 56107498
Carcinoid heart disease 30.64 9.40 9 184354 25 56107679
Ventricular fibrillation 30.53 9.40 92 184271 10860 56096844
Drug tolerance decreased 30.34 9.40 4 184359 13407 56094297
Tenosynovitis 29.98 9.40 3 184360 12458 56095246
Musculoskeletal stiffness 29.75 9.40 347 184016 155660 55952044
Myelosuppression 29.74 9.40 10 184353 17445 56090259
Injection site pain 29.71 9.40 243 184120 116875 55990829
Bipolar I disorder 29.69 9.40 32 184331 1658 56106046
Tearfulness 29.54 9.40 48 184315 3720 56103984
Hypochloraemia 29.34 9.40 32 184331 1680 56106024
Cholecystitis chronic 29.20 9.40 84 184279 9664 56098040
Sputum purulent 29.18 9.40 25 184338 971 56106733
Emotional distress 29.14 9.40 182 184181 29581 56078123
Physical assault 28.91 9.40 24 184339 892 56106812
Liver disorder 28.85 9.40 64 184299 44306 56063398
Paranoia 28.78 9.40 89 184274 10655 56097049
Nervousness 28.76 9.40 178 184185 28837 56078867
Female sexual arousal disorder 28.76 9.40 7 184356 6 56107698
Brain injury 28.71 9.40 64 184299 6291 56101413
Hallucination, auditory 28.62 9.40 93 184270 11431 56096273
Gastrointestinal disorder 28.51 9.40 234 184129 112468 55995236
Premature delivery 28.37 9.40 28 184335 27032 56080672
Selective eating disorder 28.22 9.40 33 184330 1871 56105833
Secondary immunodeficiency 28.21 9.40 27 184336 1213 56106491
Rheumatoid nodule 28.09 9.40 7 184356 14850 56092854
Coma 28.06 9.40 309 184054 59346 56048358
Flat affect 27.90 9.40 28 184335 1334 56106370
Toxicologic test abnormal 27.70 9.40 21 184342 683 56107021
Homicidal ideation 27.68 9.40 31 184332 1677 56106027
Disturbance in sexual arousal 27.67 9.40 11 184352 92 56107612
Amnesia 27.62 9.40 252 184111 46070 56061634
Alcohol poisoning 27.53 9.40 32 184331 1803 56105901
Stiff person syndrome 27.32 9.40 16 184347 334 56107370
Maternal drugs affecting foetus 27.31 9.40 55 184308 5038 56102666
Hypotonia 27.19 9.40 76 184287 8601 56099103
COVID-19 27.04 9.40 140 184223 74918 56032786
Hyperkinesia 26.99 9.40 30 184333 1609 56106095
Congenital pulmonary valve atresia 26.93 9.40 10 184353 68 56107636
Drug resistance 26.90 9.40 17 184346 20525 56087179
Potentiating drug interaction 26.87 9.40 48 184315 4018 56103686
Mental disorder 26.75 9.40 150 184213 23454 56084250
Pneumocystis jirovecii pneumonia 26.74 9.40 9 184354 15692 56092012
Drug eruption 26.62 9.40 27 184336 25736 56081968
Skin ulcer 26.52 9.40 54 184309 38554 56069150
Post viral fatigue syndrome 26.36 9.40 15 184348 296 56107408
Photosensitivity reaction 26.27 9.40 101 184262 13492 56094212
Mobility decreased 26.21 9.40 203 184160 98788 56008916
Dissociation 26.04 9.40 37 184326 2548 56105156
Optic ischaemic neuropathy 25.80 9.40 24 184339 1040 56106664
Dementia 25.75 9.40 118 184245 17040 56090664
Histrionic personality disorder 25.62 9.40 9 184354 51 56107653
Palmar-plantar erythrodysaesthesia syndrome 25.50 9.40 19 184344 21046 56086658
Mutism 24.94 9.40 27 184336 1406 56106298
Platelet count decreased 24.63 9.40 226 184137 106157 56001547
Urinary retention 24.63 9.40 167 184196 27907 56079797
Personality change 24.52 9.40 57 184306 5760 56101944
Hypocoagulable state 24.24 9.40 23 184340 1022 56106682
Injection site reaction 24.22 9.40 91 184272 53156 56054548
Polyhydramnios 23.90 9.40 32 184331 2083 56105621
Cognitive disorder 23.80 9.40 256 184107 48877 56058827
Pupillary reflex impaired 23.74 9.40 31 184332 1969 56105735
Red blood cell sedimentation rate abnormal 23.71 9.40 16 184347 18657 56089047
Acute myeloid leukaemia 23.70 9.40 13 184350 16959 56090745
Foetal chromosome abnormality 23.69 9.40 7 184356 20 56107684
Negative thoughts 23.47 9.40 21 184342 865 56106839
Adrenal insufficiency 23.45 9.40 11 184352 15686 56092018
Pruritus 23.44 9.40 825 183538 315798 55791906
Infantile apnoea 23.36 9.40 21 184342 870 56106834
Dyspnoea 23.35 9.40 1649 182714 590928 55516776
Cystoid macular oedema 23.33 9.40 27 184336 1514 56106190
Libido increased 23.32 9.40 25 184338 1287 56106417
Dermatillomania 23.28 9.40 11 184352 145 56107559
Labelled drug-drug interaction medication error 23.14 9.40 87 184276 11499 56096205
Sinus tachycardia 23.08 9.40 139 184224 22305 56085399
Cataract 23.04 9.40 88 184275 51159 56056545
Goitre 22.83 9.40 54 184309 5519 56102185
Product dose omission issue 22.73 9.40 504 183859 204249 55903455
Hypokalaemia 22.70 9.40 435 183928 94002 56013702
Bone marrow failure 22.62 9.40 36 184327 28250 56079454
Neuropathy, ataxia, retinitis pigmentosa syndrome 22.39 9.40 8 184355 48 56107656
Red blood cell sedimentation rate increased 22.07 9.40 55 184308 36568 56071136
Abnormal weight gain 22.03 9.40 26 184337 1489 56106215
Tachyphrenia 22.01 9.40 24 184339 1260 56106444
Postmortem blood drug level increased 21.85 9.40 17 184346 575 56107129
Injection site erythema 21.85 9.40 156 184207 77292 56030412
Gestational diabetes 21.79 9.40 67 184296 7997 56099707
Melaena 21.74 9.40 163 184200 28127 56079577
Hypertonia 21.71 9.40 44 184319 4048 56103656
Hypoxic-ischaemic encephalopathy 21.63 9.40 43 184320 3902 56103802
Orthostatic intolerance 21.60 9.40 22 184341 1067 56106637
Adrenergic syndrome 21.52 9.40 7 184356 30 56107674
Talipes 21.39 9.40 25 184338 1417 56106287
Basal ganglion degeneration 21.34 9.40 15 184348 433 56107271
Delirium 21.28 9.40 223 184140 42294 56065410
Hallucination, visual 21.13 9.40 113 184250 17355 56090349
Sedation complication 21.12 9.40 6 184357 11666 56096038
Hypotonia neonatal 21.01 9.40 22 184341 1102 56106602
Post-traumatic neck syndrome 20.95 9.40 29 184334 1949 56105755
Pulmonary arterial hypertension 20.94 9.40 34 184329 26469 56081235
Substance abuse 20.93 9.40 46 184317 4479 56103225
Product substitution issue 20.87 9.40 99 184264 14500 56093204
Drug hypersensitivity 20.84 9.40 715 183648 274490 55833214
Neonatal respiratory depression 20.65 9.40 8 184355 62 56107642
Diaphragmatic rupture 20.64 9.40 12 184351 247 56107457
Cardiac failure 20.51 9.40 171 184192 81922 56025782
Liver function test increased 20.49 9.40 38 184325 28095 56079609
Vascular access site thrombosis 20.48 9.40 7 184356 36 56107668
Pulmonary valve stenosis congenital 20.38 9.40 10 184353 144 56107560
Pregnancy 20.35 9.40 181 184182 32852 56074852
Neoplasm progression 20.15 9.40 47 184316 31969 56075735
Therapy non-responder 20.15 9.40 118 184245 61237 56046467
Pruritus allergic 20.14 9.40 23 184340 1271 56106433
Dysarthria 20.06 9.40 208 184155 39342 56068362
Antidepressant drug level increased 20.06 9.40 12 184351 261 56107443
Cardiac failure congestive 20.02 9.40 187 184176 87533 56020171
CFTR gene mutation 20.02 9.40 9 184354 105 56107599
Self esteem decreased 20.00 9.40 16 184347 564 56107140
Neuropathy peripheral 19.94 9.40 228 184135 102665 56005039
Activation syndrome 19.89 9.40 11 184352 205 56107499
Iris coloboma 19.87 9.40 7 184356 40 56107664
Fear 19.81 9.40 99 184264 14809 56092895
Tachycardia 19.73 9.40 470 183893 105406 56002298
Bronchomalacia 19.61 9.40 11 184352 211 56107493
Facial paralysis 19.57 9.40 91 184272 13220 56094484
Adverse event 19.54 9.40 104 184259 55272 56052432
Leukopenia 19.47 9.40 144 184219 70796 56036908
Neonatal hypoxia 19.44 9.40 15 184348 501 56107203
Clonus 19.43 9.40 43 184320 4206 56103498
Osmotic demyelination syndrome 19.31 9.40 16 184347 593 56107111
Hospitalisation 19.29 9.40 155 184208 74845 56032859
Product administration error 19.26 9.40 126 184237 20803 56086901
Epilepsy 19.18 9.40 145 184218 25086 56082618
Substance abuser 19.18 9.40 6 184357 22 56107682
Plasma cell myeloma 19.15 9.40 83 184280 46563 56061141
Head injury 19.03 9.40 144 184219 24922 56082782
Agonal rhythm 18.97 9.40 6 184357 23 56107681
Cytokine release syndrome 18.93 9.40 6 184357 10869 56096835
Sexual inhibition 18.90 9.40 4 184359 0 56107704
Acquired epileptic aphasia 18.90 9.40 4 184359 0 56107704
Infected dermal cyst 18.88 9.40 14 184349 440 56107264
CYP3A4 polymorphism 18.88 9.40 8 184355 80 56107624
Feeling abnormal 18.86 9.40 572 183791 133030 55974674
Orgasm abnormal 18.79 9.40 8 184355 81 56107623
Atonic urinary bladder 18.70 9.40 8 184355 82 56107622
Alcohol interaction 18.67 9.40 30 184333 2303 56105401
Panic disorder 18.54 9.40 31 184332 2460 56105244
Cerebrospinal fluid retention 18.53 9.40 8 184355 84 56107620
Meconium in amniotic fluid 18.40 9.40 11 184352 239 56107465
Sternal fracture 18.29 9.40 28 184335 2062 56105642
Localised infection 18.27 9.40 39 184324 27373 56080331
Multiple sclerosis relapse 18.19 9.40 226 184137 44677 56063027
Caput succedaneum 18.16 9.40 5 184358 10 56107694
Fluid retention 18.12 9.40 263 184100 53815 56053889
Social avoidant behaviour 17.99 9.40 33 184330 2819 56104885
Stress 17.99 9.40 282 184081 58628 56049076
Vascular access site infection 17.98 9.40 7 184356 55 56107649
Mood altered 17.97 9.40 89 184274 13266 56094438
Hypersomnia 17.96 9.40 103 184260 16238 56091466
Cholecystectomy 17.94 9.40 71 184292 9613 56098091
Panniculitis 17.92 9.40 5 184358 9837 56097867
Haematotoxicity 17.82 9.40 3 184360 8380 56099324
Areflexia 17.80 9.40 33 184330 2842 56104862
Constipation 17.73 9.40 820 183543 201123 55906581
Therapeutic response decreased 17.57 9.40 101 184262 52657 56055047
Amputation stump pain 17.54 9.40 6 184357 31 56107673
Social problem 17.52 9.40 17 184346 777 56106927
Rhabdomyolysis 17.50 9.40 207 184156 40451 56067253
Meningitis streptococcal 17.44 9.40 9 184354 145 56107559
Metastases to bone 17.40 9.40 23 184340 19485 56088219
Retinal coloboma 17.38 9.40 6 184357 32 56107672
Vertigo 17.34 9.40 263 184100 54309 56053395
Sebaceous gland infection 17.33 9.40 9 184354 147 56107557
Mental impairment 17.27 9.40 85 184278 12637 56095067
Cardiac steatosis 17.23 9.40 6 184357 33 56107671
Lipoedema 17.10 9.40 11 184352 273 56107431
Hepatotoxicity 17.10 9.40 49 184314 31104 56076600
Depression suicidal 17.10 9.40 24 184339 1634 56106070
Tissue infiltration 16.92 9.40 15 184348 610 56107094
Respiratory tract infection 16.83 9.40 61 184302 36010 56071694
Non-cardiogenic pulmonary oedema 16.82 9.40 15 184348 615 56107089
Respiratory disorder 16.80 9.40 56 184307 33901 56073803
Differential white blood cell count abnormal 16.77 9.40 16 184347 716 56106988
Metastases to liver 16.77 9.40 28 184335 21558 56086146
Skin swelling 16.75 9.40 30 184333 2516 56105188
Aspiration 16.60 9.40 69 184294 9552 56098152
Neuroleptic malignant syndrome 16.53 9.40 78 184285 11400 56096304
Injection site swelling 16.42 9.40 80 184283 43498 56064206
Aspartate aminotransferase increased 16.41 9.40 182 184181 82420 56025284
Transplant rejection 16.39 9.40 6 184357 9928 56097776
Urticaria 16.37 9.40 355 184008 144321 55963383
Soft tissue injury 16.27 9.40 23 184340 1576 56106128
Hypertonic bladder 16.26 9.40 34 184329 3198 56104506
Pyelonephritis chronic 16.14 9.40 10 184353 232 56107472
Kinematic imbalances due to suboccipital strain 16.14 9.40 4 184359 4 56107700
Decerebrate posture 16.07 9.40 8 184355 119 56107585
Circulatory collapse 16.07 9.40 120 184243 20683 56087021
Bipolar II disorder 15.97 9.40 11 184352 307 56107397
Morbid thoughts 15.95 9.40 14 184349 562 56107142
Hyporeflexia 15.89 9.40 24 184339 1747 56105957
Hippocampal sclerosis 15.85 9.40 7 184356 78 56107626
Pulmonary valve disease 15.84 9.40 5 184358 19 56107685
Polymenorrhagia 15.77 9.40 6 184357 44 56107660
Urethral haemorrhage 15.66 9.40 6 184357 45 56107659
Antisocial behaviour 15.57 9.40 11 184352 320 56107384
Herpes zoster 15.56 9.40 166 184197 75723 56031981
Akinesia 15.49 9.40 22 184341 1514 56106190
Respiratory alkalosis 15.45 9.40 29 184334 2522 56105182
Increased appetite 15.35 9.40 63 184300 8672 56099032
Postmortem blood drug level 15.17 9.40 8 184355 135 56107569
Dry mouth 15.17 9.40 295 184068 63910 56043794
Muscle tightness 15.14 9.40 73 184290 10763 56096941
Paraesthesia 15.14 9.40 546 183817 129968 55977736
Loss of personal independence in daily activities 15.11 9.40 182 184181 81187 56026517
Polydipsia 15.09 9.40 33 184330 3202 56104502
Uterine enlargement 15.09 9.40 19 184344 1164 56106540
Tension 14.99 9.40 31 184332 2893 56104811
Borderline personality disorder 14.96 9.40 15 184348 714 56106990
Dysponesis 14.88 9.40 4 184359 7 56107697
Dysaesthesia 14.86 9.40 38 184325 4078 56103626
Female orgasmic disorder 14.81 9.40 6 184357 53 56107651
Initial insomnia 14.75 9.40 46 184317 5533 56102171
Acute kidney injury 14.60 9.40 642 183721 240121 55867583
Dissociative amnesia 14.59 9.40 5 184358 26 56107678
Neutrophil count abnormal 14.51 9.40 29 184334 2641 56105063
Miosis 14.43 9.40 51 184312 6541 56101163
Vertigo CNS origin 14.43 9.40 5 184358 27 56107677
Accommodation disorder 14.42 9.40 11 184352 361 56107343
Balance disorder 14.35 9.40 340 184023 76180 56031524
Pneumonia viral 14.28 9.40 3 184360 7155 56100549
Blood pressure decreased 14.18 9.40 272 184091 58778 56048926
Periventricular leukomalacia 14.13 9.40 7 184356 103 56107601
Injection site pruritus 14.11 9.40 80 184283 41851 56065853
Hallucinations, mixed 14.11 9.40 39 184324 4385 56103319
Hypertension 14.08 9.40 655 183708 243623 55864081
Tic 14.01 9.40 19 184344 1252 56106452
Incoherent 13.98 9.40 38 184325 4231 56103473
Urine abnormality 13.96 9.40 51 184312 6648 56101056
Hypercalcaemia 13.92 9.40 40 184323 25371 56082333
Pupil fixed 13.90 9.40 22 184341 1668 56106036
Amniorrhexis 13.86 9.40 5 184358 31 56107673
Ureteric dilatation 13.86 9.40 5 184358 31 56107673
Peripheral circulatory failure 13.83 9.40 16 184347 897 56106807
Obesity 13.83 9.40 123 184240 22325 56085379
Sensory disturbance 13.74 9.40 79 184284 12464 56095240
Reflexes abnormal 13.66 9.40 13 184350 580 56107124
Bronchopulmonary aspergillosis 13.62 9.40 5 184358 8259 56099445
Mental status changes 13.61 9.40 185 184178 37316 56070388
Blood ethanol increased 13.61 9.40 7 184356 112 56107592
Indifference 13.61 9.40 7 184356 112 56107592
Multiple organ dysfunction syndrome 13.60 9.40 109 184254 52661 56055043
Trisomy 18 13.59 9.40 5 184358 33 56107671
Fibrous histiocytoma 13.58 9.40 12 184351 486 56107218
Anaesthesia 13.50 9.40 11 184352 398 56107306
Activated partial thromboplastin time abnormal 13.50 9.40 7 184356 114 56107590
Drug dose titration not performed 13.50 9.40 12 184351 490 56107214
Adjusted calcium decreased 13.49 9.40 8 184355 171 56107533
Poor quality sleep 13.47 9.40 102 184261 17653 56090051
Disinhibition 13.47 9.40 15 184348 806 56106898
Thrombotic microangiopathy 13.45 9.40 7 184356 9404 56098300
Hypervigilance 13.38 9.40 10 184353 318 56107386
Accidental exposure to product 13.36 9.40 39 184324 24608 56083096
Ocular hyperaemia 13.25 9.40 33 184330 21946 56085758
Blood creatine phosphokinase increased 13.24 9.40 145 184218 27807 56079897
Visual field defect 13.24 9.40 47 184316 6042 56101662
Peritoneal perforation 13.23 9.40 7 184356 119 56107585
Delusion 13.19 9.40 72 184291 11143 56096561
Creatinine renal clearance decreased 13.15 9.40 17 184346 14542 56093162
Joint range of motion decreased 13.13 9.40 41 184322 25324 56082380
Pancreatitis 13.09 9.40 214 184149 44866 56062838
Impaired self-care 13.08 9.40 22 184341 1754 56105950
Pneumonitis 13.05 9.40 56 184307 31508 56076196
Hyperacusis 13.05 9.40 23 184340 1905 56105799
Conversion disorder 13.02 9.40 21 184342 1617 56106087
Trismus 13.01 9.40 33 184330 3525 56104179
Bone erosion 13.00 9.40 18 184345 14956 56092748
Renal impairment 12.98 9.40 186 184177 80527 56027177
Live birth 12.97 9.40 28 184335 19577 56088127
Bradycardia neonatal 12.95 9.40 15 184348 842 56106862
Psychiatric symptom 12.86 9.40 40 184323 4804 56102900
Hip surgery 12.84 9.40 29 184334 2876 56104828
Affective disorder 12.83 9.40 44 184319 5559 56102145
Pulmonary fibrosis 12.80 9.40 52 184311 29706 56077998
Pleural effusion 12.71 9.40 200 184163 85280 56022424
Hyponatraemic syndrome 12.67 9.40 12 184351 532 56107172
Bronchial hyperreactivity 12.63 9.40 20 184343 1517 56106187
Tardive dyskinesia 12.62 9.40 56 184307 7975 56099729
Pulmonary toxicity 12.61 9.40 5 184358 7878 56099826
Ejection fraction decreased 12.59 9.40 29 184334 19812 56087892
Menopause 12.55 9.40 26 184337 2430 56105274
Cerebral ventricular rupture 12.53 9.40 8 184355 196 56107508
Multiple drug therapy 12.48 9.40 28 184335 2764 56104940
Hepatic steatosis 12.42 9.40 136 184227 26078 56081626
Post procedural haematuria 12.36 9.40 5 184358 44 56107660
Neutrophil count decreased 12.34 9.40 104 184259 49718 56057986
Pseudomonas infection 12.30 9.40 9 184354 10062 56097642
Pleurisy 12.17 9.40 5 184358 7711 56099993
Osteonecrosis of jaw 12.13 9.40 62 184301 33296 56074408
Blood bilirubin increased 12.13 9.40 62 184301 33292 56074412
Merycism 12.11 9.40 8 184355 208 56107496
Electrolyte substitution therapy 12.10 9.40 3 184360 3 56107701
Bisexuality 12.10 9.40 3 184360 3 56107701
Onychogryphosis 12.10 9.40 3 184360 3 56107701
Cervix haematoma uterine 12.10 9.40 3 184360 3 56107701
Anti-neuronal antibody positive 12.10 9.40 3 184360 3 56107701
Alanine aminotransferase increased 12.03 9.40 225 184138 93437 56014267
Neutrophil Pelger-Huet anomaly present 12.01 9.40 6 184357 90 56107614
Apgar score low 12.01 9.40 13 184350 677 56107027
Crepitations 11.90 9.40 4 184359 6980 56100724
Periodic limb movement disorder 11.88 9.40 8 184355 215 56107489
Aphasia 11.85 9.40 152 184211 30263 56077441
Blood creatinine increased 11.80 9.40 188 184175 80003 56027701
Biliary dyskinesia 11.79 9.40 26 184337 2537 56105167
Hyperventilation 11.77 9.40 43 184320 5605 56102099
Vascular encephalopathy 11.77 9.40 10 184353 384 56107320
Sunburn 11.76 9.40 26 184337 2542 56105162
Somatic symptom disorder 11.68 9.40 23 184340 2072 56105632
Congenital tricuspid valve incompetence 11.66 9.40 6 184357 96 56107608
Gastrointestinal sounds abnormal 11.60 9.40 33 184330 3772 56103932
Microphthalmos 11.59 9.40 7 184356 155 56107549
Psychogenic seizure 11.59 9.40 20 184343 1629 56106075
Agitation neonatal 11.53 9.40 11 184352 492 56107212
Therapy interrupted 11.52 9.40 44 184319 25581 56082123
Atrophic vulvovaginitis 11.48 9.40 20 184343 1641 56106063
Acidosis 11.42 9.40 66 184297 10435 56097269
Lip swelling 11.41 9.40 134 184229 26138 56081566
Reversible airways obstruction 11.36 9.40 18 184345 1366 56106338
Marital problem 11.35 9.40 7 184356 161 56107543
Throat clearing 11.34 9.40 19 184344 1511 56106193
Blunted affect 11.29 9.40 8 184355 234 56107470
Asthma 11.24 9.40 464 183899 112306 55995398
Movement disorder 11.22 9.40 104 184259 19094 56088610
Gallbladder disorder 11.21 9.40 96 184267 17238 56090466
Throat irritation 11.19 9.40 62 184301 32621 56075083
Vaginal haemorrhage 11.17 9.40 131 184232 25542 56082162
Right ventricular failure 11.17 9.40 23 184340 16356 56091348
Toxic epidermal necrolysis 11.15 9.40 36 184327 22006 56085698
Pickwickian syndrome 11.13 9.40 9 184354 322 56107382
Neuroglycopenia 11.11 9.40 10 184353 415 56107289
Phobia 11.11 9.40 9 184354 323 56107381
Antipsychotic drug level above therapeutic 11.09 9.40 15 184348 986 56106718
Type 2 diabetes mellitus 11.08 9.40 99 184264 46763 56060941
Choanal atresia 11.06 9.40 4 184359 25 56107679
Diastolic hypertension 11.06 9.40 4 184359 25 56107679
Exposure to allergen 11.00 9.40 8 184355 244 56107460
Drug abuser 10.96 9.40 27 184336 2832 56104872
Pulmonary valve incompetence 10.95 9.40 17 184346 1267 56106437
Analgesic drug level above therapeutic 10.95 9.40 7 184356 172 56107532
Nodal arrhythmia 10.94 9.40 16 184347 1131 56106573
Tuberculosis 10.90 9.40 12 184351 11017 56096687
Dermatochalasis 10.90 9.40 3 184360 6 56107698
Congenital megacolon 10.90 9.40 3 184360 6 56107698
Poor feeding infant 10.88 9.40 8 184355 248 56107456
Respiratory rate increased 10.85 9.40 73 184290 12164 56095540
Systolic hypertension 10.76 9.40 10 184353 433 56107271
Ankylosing spondylitis 10.73 9.40 10 184353 9920 56097784
Atrial fibrillation 10.70 9.40 273 184090 108624 55999080
Oromandibular dystonia 10.68 9.40 10 184353 437 56107267
Fear of injection 10.64 9.40 4 184359 6511 56101193
Sexually inappropriate behaviour 10.61 9.40 6 184357 117 56107587
Anaemia 10.55 9.40 744 183619 266767 55840937
Upper respiratory tract infection 10.54 9.40 307 184056 70981 56036723
Joint ankylosis 10.53 9.40 14 184349 905 56106799
Teratogenicity 10.53 9.40 8 184355 261 56107443
Drug screen positive 10.52 9.40 30 184333 3434 56104270
Agoraphobia 10.52 9.40 9 184354 349 56107355
Pancreatic injury 10.44 9.40 4 184359 30 56107674
Bronchitis 10.39 9.40 284 184079 112027 55995677
Carcinoid syndrome 10.39 9.40 6 184357 122 56107582
Caesarean section 10.34 9.40 89 184274 16002 56091702
Cytopenia 10.34 9.40 10 184353 9745 56097959
Tendonitis 10.28 9.40 28 184335 18069 56089635
Apnoea 10.27 9.40 49 184314 7193 56100511
Nystagmus 10.22 9.40 42 184321 5783 56101921
Irregular sleep wake rhythm disorder 10.21 9.40 7 184356 194 56107510
Sleep disorder 10.17 9.40 292 184071 67371 56040333
Unintentional medical device removal 10.17 9.40 3 184360 5691 56102013
Hypocalcaemia 10.15 9.40 54 184309 28706 56078998
Hypercholesterolaemia 10.15 9.40 20 184343 14453 56093251
Parotid gland enlargement 10.14 9.40 13 184350 811 56106893
Chronic spontaneous urticaria 10.14 9.40 15 184348 1072 56106632
Inner ear disorder 10.13 9.40 10 184353 467 56107237
Hypersexuality 10.13 9.40 10 184353 467 56107237
Frequent bowel movements 10.12 9.40 90 184273 16334 56091370
Umbilical artery vascular resistance increased 10.11 9.40 4 184359 33 56107671
Neonatal sinus tachycardia 10.11 9.40 4 184359 33 56107671
Oral neoplasm benign 10.05 9.40 3 184360 9 56107695
Drug level increased 10.04 9.40 108 184255 20617 56087087
Product administered to patient of inappropriate age 9.98 9.40 26 184337 2822 56104882
Angiodermatitis 9.95 9.40 5 184358 76 56107628
Perinatal depression 9.93 9.40 11 184352 588 56107116
Nasal obstruction 9.89 9.40 16 184347 1235 56106469
Surgery 9.87 9.40 64 184299 32422 56075282
Cleft lip and palate 9.85 9.40 9 184354 381 56107323
Corneal reflex decreased 9.85 9.40 6 184357 135 56107569
White blood cell count decreased 9.83 9.40 326 184037 125664 55982040
Antisocial personality disorder 9.81 9.40 3 184360 10 56107694
Tumour lysis syndrome 9.78 9.40 7 184356 7916 56099788
Upper gastrointestinal haemorrhage 9.77 9.40 92 184271 16962 56090742
Drug level above therapeutic 9.77 9.40 34 184329 4328 56103376
Myocardial fibrosis 9.76 9.40 12 184351 717 56106987
Repetitive speech 9.71 9.40 8 184355 294 56107410
Glaucoma 9.70 9.40 27 184336 17302 56090402
Neonatal infection 9.69 9.40 6 184357 139 56107565
Violence-related symptom 9.66 9.40 9 184354 391 56107313
Thyroiditis 9.65 9.40 21 184342 2031 56105673
Personality disorder 9.64 9.40 38 184325 5135 56102569
Sudden cardiac death 9.63 9.40 21 184342 2033 56105671
Lung disorder 9.63 9.40 118 184245 52479 56055225
Gait inability 9.60 9.40 89 184274 41729 56065975
Posterior reversible encephalopathy syndrome 9.59 9.40 24 184339 15936 56091768
Blood copper decreased 9.59 9.40 3 184360 11 56107693
Ceruloplasmin decreased 9.59 9.40 3 184360 11 56107693
Skin warm 9.57 9.40 37 184326 4954 56102750
Maternal exposure during breast feeding 9.57 9.40 30 184333 3617 56104087
Platelet function test abnormal 9.56 9.40 5 184358 83 56107621
Immune thrombocytopenia 9.51 9.40 59 184304 9566 56098138
Ascites 9.46 9.40 78 184285 37466 56070238
Therapy partial responder 9.45 9.40 7 184356 7778 56099926
No adverse event 9.43 9.40 75 184288 36299 56071405
Maternal exposure timing unspecified 9.43 9.40 3 184360 5420 56102284

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 996.88 10.77 1248 86865 90266 31518965
Toxicity to various agents 830.42 10.77 1661 86452 179826 31429405
Serotonin syndrome 496.35 10.77 414 87699 18359 31590872
Drug abuse 482.41 10.77 870 87243 86888 31522343
Suicidal ideation 381.77 10.77 488 87625 35918 31573313
Intentional overdose 295.99 10.77 462 87651 40927 31568304
Overdose 286.54 10.77 688 87425 83976 31525255
Suicide attempt 241.93 10.77 398 87715 36850 31572381
Depression 230.58 10.77 663 87450 90152 31519079
Anxiety 229.59 10.77 663 87450 90370 31518861
Drug interaction 196.97 10.77 1117 86996 207426 31401805
Foetal exposure during pregnancy 191.57 10.77 379 87734 40497 31568734
Paranoia 166.98 10.77 175 87938 10380 31598851
Electrocardiogram QT prolonged 165.83 10.77 342 87771 37645 31571586
Psychotic disorder 160.87 10.77 250 87863 22043 31587188
Obsessive-compulsive disorder 156.16 10.77 121 87992 4816 31604415
Intentional self-injury 154.67 10.77 188 87925 13127 31596104
Disinhibition 151.37 10.77 94 88019 2599 31606632
Respiratory disorder neonatal 146.16 10.77 75 88038 1420 31607811
Antipsychotic drug level below therapeutic 133.06 10.77 78 88035 1937 31607294
Off label use 131.77 10.77 509 87604 346765 31262466
Aggression 130.21 10.77 307 87806 36984 31572247
Poisoning 127.72 10.77 151 87962 10240 31598991
Tearfulness 125.69 10.77 74 88039 1853 31607378
Agitation neonatal 125.56 10.77 61 88052 1022 31608209
Drug withdrawal syndrome neonatal 122.40 10.77 91 88022 3401 31605830
Agitation 118.94 10.77 376 87737 53793 31555438
Loss of libido 118.18 10.77 77 88036 2318 31606913
Depression suicidal 114.97 10.77 66 88047 1574 31607657
Pyrexia 112.81 10.77 449 87664 303391 31305840
Therapeutic product effect variable 112.37 10.77 69 88044 1869 31607362
Febrile neutropenia 112.23 10.77 104 88009 121745 31487486
Irritability 111.76 10.77 216 87897 22673 31586558
Depressive symptom 109.33 10.77 70 88043 2044 31607187
Depressed mood 108.96 10.77 184 87929 17391 31591840
Respiratory arrest 108.27 10.77 231 87882 26026 31583205
Restlessness 106.27 10.77 214 87899 23147 31586084
Akathisia 105.44 10.77 115 87998 7138 31602093
Hypertonia neonatal 104.32 10.77 41 88072 398 31608833
Psychiatric decompensation 101.12 10.77 65 88048 1911 31607320
Neonatal respiratory distress syndrome 99.14 10.77 84 88029 3801 31605430
Confusional state 97.22 10.77 669 87444 132665 31476566
Disturbance in attention 96.61 10.77 201 87912 22249 31586982
Small for dates baby 95.27 10.77 80 88033 3575 31605656
Intrusive thoughts 90.20 10.77 33 88080 258 31608973
Euphoric mood 89.53 10.77 88 88025 4832 31604399
Increased appetite 87.75 10.77 98 88015 6246 31602985
Sexual dysfunction 87.41 10.77 95 88018 5873 31603358
Orgasmic sensation decreased 85.70 10.77 23 88090 51 31609180
Tremor 85.21 10.77 429 87684 75991 31533240
Atrial septal defect 84.03 10.77 100 88013 6827 31602404
Erectile dysfunction 82.51 10.77 172 87941 19063 31590168
Pneumonia 77.18 10.77 581 87532 334731 31274500
Homicidal ideation 72.30 10.77 59 88054 2532 31606699
Temperature regulation disorder 72.01 10.77 35 88078 587 31608644
Psychomotor skills impaired 70.49 10.77 63 88050 3064 31606167
Anger 69.43 10.77 117 87996 11036 31598195
Acute kidney injury 67.01 10.77 479 87634 279235 31329996
Asphyxia 64.83 10.77 80 88033 5671 31603560
Cardio-respiratory arrest 64.56 10.77 300 87813 51426 31557805
Interstitial lung disease 64.46 10.77 46 88067 61357 31547874
Neonatal hypoxia 63.38 10.77 28 88085 373 31608858
Malignant neoplasm progression 60.98 10.77 78 88035 78920 31530311
Maternal drugs affecting foetus 60.45 10.77 64 88049 3839 31605392
Libido decreased 60.45 10.77 68 88045 4368 31604863
Tachyphrenia 59.74 10.77 39 88074 1178 31608053
Hepatic function abnormal 59.73 10.77 20 88093 41202 31568029
Accidental death 58.76 10.77 49 88064 2168 31607063
Neonatal seizure 58.34 10.77 28 88085 456 31608775
Rheumatoid arthritis 58.31 10.77 30 88083 47779 31561452
Sepsis 57.79 10.77 222 87891 151707 31457524
Sedation 57.54 10.77 148 87965 18817 31590414
Genital hypoaesthesia 57.44 10.77 22 88091 198 31609033
Hallucination, auditory 55.82 10.77 102 88011 10258 31598973
Septic shock 55.68 10.77 61 88052 66097 31543134
Hallucination 55.59 10.77 266 87847 46144 31563087
Cryptorchism 54.93 10.77 45 88068 1942 31607289
Fall 54.35 10.77 771 87342 185318 31423913
Diarrhoea 54.13 10.77 674 87439 351735 31257496
Somnambulism 53.74 10.77 52 88061 2800 31606431
Exposure during pregnancy 53.26 10.77 90 88023 8508 31600723
Panic attack 52.46 10.77 90 88023 8613 31600618
Intentional product misuse 51.76 10.77 226 87887 37725 31571506
Sopor 51.54 10.77 105 88008 11447 31597784
Homicide 51.04 10.77 32 88081 900 31608331
Muscle twitching 50.78 10.77 86 88027 8144 31601087
Cytomegalovirus infection 50.60 10.77 5 88108 24702 31584529
Multiple organ dysfunction syndrome 49.93 10.77 70 88043 68133 31541098
Somnolence 49.86 10.77 458 87655 98987 31510244
Mood swings 49.05 10.77 80 88033 7344 31601887
Muscle rigidity 49.03 10.77 94 88019 9803 31599428
Platelet count decreased 48.99 10.77 151 87962 110284 31498947
Rhinitis perennial 48.95 10.77 22 88091 306 31608925
Withdrawal syndrome 48.18 10.77 103 88010 11614 31597617
Hypospadias 48.09 10.77 51 88062 3065 31606166
Disturbance in sexual arousal 47.72 10.77 17 88096 122 31609109
Hallucination, visual 47.65 10.77 123 87990 15671 31593560
Prescription drug used without a prescription 47.35 10.77 36 88077 1392 31607839
Obesity 47.30 10.77 99 88014 11001 31598230
Cardiac failure 46.88 10.77 106 88007 85847 31523384
Mydriasis 46.58 10.77 73 88040 6479 31602752
Mental impairment 46.57 10.77 90 88023 9442 31599789
Poverty of speech 45.93 10.77 19 88094 213 31609018
Drug screen positive 45.72 10.77 55 88058 3797 31605434
Bradycardia neonatal 45.55 10.77 30 88083 920 31608311
Logorrhoea 45.05 10.77 43 88070 2276 31606955
Drug ineffective 45.01 10.77 802 87311 394771 31214460
Derealisation 44.95 10.77 25 88088 560 31608671
Hypoglycaemia neonatal 44.38 10.77 38 88075 1744 31607487
Coma scale abnormal 43.93 10.77 53 88060 3670 31605561
Cardiac arrest 43.04 10.77 407 87706 88655 31520576
Neutropenia 42.59 10.77 223 87890 140141 31469090
Hypomania 42.58 10.77 41 88072 2194 31607037
Product use in unapproved indication 42.29 10.77 138 87975 99033 31510198
Renal failure 42.02 10.77 188 87925 123142 31486089
Prescribed overdose 41.54 10.77 84 88029 9108 31600123
Hanging 41.48 10.77 15 88098 113 31609118
Amnesia 41.25 10.77 151 87962 23251 31585980
Drug reaction with eosinophilia and systemic symptoms 41.05 10.77 16 88097 30002 31579229
Hyperhidrosis 40.94 10.77 324 87789 67069 31542162
COVID-19 40.38 10.77 56 88057 54765 31554466
Haemangioma congenital 40.19 10.77 22 88091 477 31608754
Psychomotor retardation 39.53 10.77 47 88066 3205 31606026
Depressed level of consciousness 39.04 10.77 211 87902 38390 31570841
Hyperreflexia 38.14 10.77 44 88069 2905 31606326
Premature ejaculation 37.88 10.77 14 88099 113 31609118
Congenital ureteropelvic junction obstruction 37.66 10.77 12 88101 58 31609173
Vasoplegia syndrome 37.60 10.77 34 88079 1679 31607552
Bipolar disorder 37.54 10.77 49 88064 3675 31605556
Atrial fibrillation 37.24 10.77 176 87937 113607 31495624
Alcohol use 37.23 10.77 45 88068 3122 31606109
Stomatitis 37.04 10.77 33 88080 39405 31569826
Anorgasmia 37.02 10.77 24 88089 716 31608515
Mental disorder 36.96 10.77 103 88010 13731 31595500
Inappropriate antidiuretic hormone secretion 36.77 10.77 91 88022 11296 31597935
Parathyroid gland enlargement 36.65 10.77 14 88099 125 31609106
Drug withdrawal syndrome 36.49 10.77 125 87988 18625 31590606
Disease progression 36.45 10.77 129 87984 90335 31518896
Mucosal inflammation 35.85 10.77 26 88087 34401 31574830
Upper respiratory fungal infection 35.52 10.77 14 88099 137 31609094
Anaemia 35.51 10.77 401 87712 213121 31396110
Congenital hepatomegaly 34.84 10.77 9 88104 16 31609215
Drug resistance 34.64 10.77 11 88102 23442 31585789
Myoclonus 34.31 10.77 101 88012 13889 31595342
Electrocardiogram QRS complex prolonged 34.15 10.77 50 88063 4179 31605052
Mania 33.59 10.77 77 88036 9100 31600131
Pleural effusion 33.52 10.77 102 88011 74818 31534413
Respiratory failure 33.15 10.77 157 87956 101292 31507939
Neuropathy peripheral 33.13 10.77 104 88009 75545 31533686
Dyskinesia 32.80 10.77 130 87983 20780 31588451
Negative thoughts 32.65 10.77 21 88092 618 31608613
Renal impairment 32.26 10.77 127 87986 86222 31523009
Infantile apnoea 31.97 10.77 24 88089 910 31608321
Newborn persistent pulmonary hypertension 31.93 10.77 12 88101 102 31609129
Oedema peripheral 31.92 10.77 177 87936 109662 31499569
Hyperventilation 31.82 10.77 37 88076 2464 31606767
Adjustment disorder 31.73 10.77 26 88087 1122 31608109
Forced expiratory volume 31.62 10.77 12 88101 105 31609126
Thrombocytopenia 31.43 10.77 250 87863 142497 31466734
Apgar score low 31.37 10.77 23 88090 841 31608390
Gun shot wound 30.71 10.77 25 88088 1069 31608162
Apathy 30.21 10.77 60 88053 6422 31602809
Cytokine release syndrome 30.15 10.77 5 88108 16637 31592594
Failure to suspend medication 29.70 10.77 17 88096 403 31608828
Pneumonitis 29.57 10.77 25 88088 30627 31578604
Circulatory collapse 29.57 10.77 121 87992 19623 31589608
Loss of consciousness 29.53 10.77 337 87776 77018 31532213
Dyslipidaemia 29.49 10.77 59 88054 6347 31602884
Optic nerve hypoplasia 29.33 10.77 6 88107 0 31609231
Psychomotor hyperactivity 29.20 10.77 71 88042 8716 31600515
Patent ductus arteriosus 29.10 10.77 40 88073 3153 31606078
Tardive dyskinesia 29.03 10.77 54 88059 5505 31603726
Ventricular septal defect 29.01 10.77 43 88070 3634 31605597
Pancytopenia 28.59 10.77 135 87978 87181 31522050
Congenital pulmonary hypertension 28.33 10.77 9 88104 43 31609188
Selective eating disorder 28.06 10.77 29 88084 1691 31607540
Toxicologic test abnormal 27.95 10.77 18 88095 531 31608700
Spontaneous penile erection 27.75 10.77 13 88100 200 31609031
Hyperbilirubinaemia neonatal 27.50 10.77 20 88093 722 31608509
C-reactive protein increased 27.33 10.77 59 88054 48591 31560640
Nightmare 27.29 10.77 85 88028 12052 31597179
Infection 27.22 10.77 126 87987 81805 31527426
Prostate cancer 27.10 10.77 39 88074 37562 31571669
Disorientation 27.10 10.77 162 87951 30582 31578649
Major depression 26.98 10.77 45 88068 4208 31605023
Torsade de pointes 26.77 10.77 59 88054 6791 31602440
Foot deformity 26.45 10.77 44 88069 4105 31605126
Pneumocystis jirovecii pneumonia 26.18 10.77 9 88104 18242 31590989
Decreased appetite 26.13 10.77 286 87827 152931 31456300
Unresponsive to stimuli 26.06 10.77 141 87972 25659 31583572
Impulsive behaviour 25.98 10.77 30 88083 1983 31607248
Sexual relationship change 25.94 10.77 7 88106 16 31609215
Limb deformity 25.79 10.77 17 88096 522 31608709
Sexually inappropriate behaviour 25.74 10.77 16 88097 443 31608788
Tremor neonatal 25.39 10.77 15 88098 378 31608853
Radiologically isolated syndrome 25.19 10.77 6 88107 6 31609225
Clonus 25.17 10.77 33 88080 2486 31606745
Hospitalisation 25.10 10.77 64 88049 49743 31559488
Pregnancy 25.06 10.77 13 88100 252 31608979
Disseminated intravascular coagulation 24.87 10.77 13 88100 20524 31588707
Drug hypersensitivity 24.50 10.77 111 88002 72488 31536743
Congenital hypercoagulation 24.44 10.77 5 88108 0 31609231
Panic reaction 23.96 10.77 24 88089 1348 31607883
Hypertonia 23.87 10.77 41 88072 3927 31605304
Conduction disorder 23.82 10.77 28 88085 1886 31607345
Heat stroke 23.71 10.77 20 88093 899 31608332
Leukaemia 23.44 10.77 41 88072 3984 31605247
Feeling abnormal 23.42 10.77 252 87861 56750 31552481
Neonatal pneumonia 23.20 10.77 10 88103 125 31609106
Bronchopulmonary aspergillosis 22.78 10.77 5 88108 13629 31595602
Oedema 22.78 10.77 53 88060 42508 31566723
Kinematic imbalances due to suboccipital strain 22.77 10.77 6 88107 12 31609219
Peripheral swelling 22.76 10.77 104 88009 67761 31541470
Weight increased 22.69 10.77 340 87773 82607 31526624
Parkinsonism 22.55 10.77 59 88054 7577 31601654
Antipsychotic drug level increased 22.49 10.77 37 88076 3421 31605810
Eosinophilia 22.39 10.77 19 88094 23234 31585997
Haemophagocytic lymphohistiocytosis 22.32 10.77 3 88110 11675 31597556
Drug-induced liver injury 22.15 10.77 21 88092 24342 31584889
Tic 22.10 10.77 27 88086 1894 31607337
Bladder trabeculation 22.10 10.77 5 88108 3 31609228
Myelosuppression 22.03 10.77 7 88106 14913 31594318
Myocardial fibrosis 21.95 10.77 21 88092 1115 31608116
Dreamy state 21.85 10.77 6 88107 15 31609216
Neonatal disorder 21.75 10.77 18 88095 788 31608443
Synovitis 21.57 10.77 4 88109 12279 31596952
Congenital hydronephrosis 21.39 10.77 17 88096 702 31608529
Tumour lysis syndrome 21.36 10.77 8 88105 15377 31593854
Myocardial infarction 21.29 10.77 207 87906 113247 31495984
Hypotonia neonatal 21.23 10.77 22 88091 1287 31607944
Lactic acidosis 21.22 10.77 35 88078 31902 31577329
Drug dependence 21.21 10.77 121 87992 22458 31586773
Congenital central nervous system anomaly 21.21 10.77 15 88098 518 31608713
Brain oedema 21.11 10.77 81 88032 12751 31596480
Infusion related reaction 21.08 10.77 66 88047 47989 31561242
Finnegan score increased 21.06 10.77 6 88107 18 31609213
Seizure 20.71 10.77 391 87722 99377 31509854
Plasma cell myeloma 20.56 10.77 84 88029 56447 31552784
Thrombosis 20.52 10.77 61 88052 45090 31564141
Interstitial granulomatous dermatitis 20.45 10.77 10 88103 170 31609061
Gender dysphoria 20.44 10.77 7 88106 44 31609187
Blood alcohol increased 20.39 10.77 17 88096 752 31608479
Postmortem blood drug level increased 20.33 10.77 11 88102 233 31608998
Agoraphobia 20.28 10.77 11 88102 234 31608997
Mental status changes 20.25 10.77 170 87943 35798 31573433
Pilonidal cyst congenital 20.15 10.77 6 88107 22 31609209
Impaired work ability 20.08 10.77 48 88065 5829 31603402
Hyponatraemia 19.98 10.77 302 87811 73497 31535734
Maternal exposure during breast feeding 19.84 10.77 23 88090 1526 31607705
Constipation 19.73 10.77 235 87878 123756 31485475
Hyponatraemic syndrome 19.69 10.77 10 88103 185 31609046
Victim of chemical submission 19.68 10.77 7 88106 50 31609181
Wrong product administered 19.65 10.77 43 88070 4925 31604306
Decreased interest 19.36 10.77 27 88086 2158 31607073
Haematuria 19.34 10.77 65 88048 46249 31562982
Pulmonary oedema 19.34 10.77 199 87914 44303 31564928
Rash 19.31 10.77 420 87693 201066 31408165
Persistent foetal circulation 19.28 10.77 12 88101 333 31608898
Bone marrow failure 19.26 10.77 30 88083 27978 31581253
Dyspnoea 19.15 10.77 771 87342 342708 31266523
Delusion 19.14 10.77 75 88038 11922 31597309
Joint swelling 19.06 10.77 80 88033 53351 31555880
Hyperbilirubinaemia 19.02 10.77 10 88103 15740 31593491
Wrong patient received product 18.87 10.77 29 88084 2530 31606701
Dysphemia 18.83 10.77 22 88091 1472 31607759
Osmolar gap abnormal 18.83 10.77 6 88107 29 31609202
Substance abuse 18.83 10.77 53 88060 7105 31602126
Epistaxis 18.79 10.77 81 88032 53626 31555605
Toxic epidermal necrolysis 18.74 10.77 16 88097 19508 31589723
Anhidrosis 18.71 10.77 8 88105 98 31609133
Choanal atresia 18.66 10.77 5 88108 11 31609220
Infant irritability 18.50 10.77 6 88107 31 31609200
Tachycardia 18.42 10.77 306 87807 75901 31533330
Intestinal congestion 18.36 10.77 5 88108 12 31609219
Periventricular leukomalacia 18.34 10.77 6 88107 32 31609199
Bladder cancer 18.31 10.77 9 88104 14716 31594515
Acute myeloid leukaemia 18.29 10.77 15 88098 18657 31590574
Hypercalcaemia 18.27 10.77 8 88105 13992 31595239
Hepatitis C virus test positive 18.24 10.77 11 88102 288 31608943
Myelodysplastic syndrome 18.21 10.77 16 88097 19235 31589996
Duodenal ulcer perforation 18.10 10.77 22 88091 1535 31607696
Hypertrophic cardiomyopathy 17.97 10.77 17 88096 890 31608341
Suicidal behaviour 17.91 10.77 21 88092 1411 31607820
Exposure via ingestion 17.90 10.77 25 88088 2000 31607231
Cough 17.65 10.77 266 87847 134548 31474683
Diffuse large B-cell lymphoma stage II 17.35 10.77 6 88107 39 31609192
Nasopharyngitis 17.24 10.77 104 88009 63141 31546090
Neonatal infection 17.21 10.77 12 88101 405 31608826
Libido disorder 17.14 10.77 10 88103 246 31608985
Abnormal behaviour 16.97 10.77 119 87994 23709 31585522
Bronchopulmonary aspergillosis allergic 16.97 10.77 14 88099 610 31608621
Opiates positive 16.93 10.77 13 88100 510 31608721
Parkinson's disease 16.87 10.77 21 88092 1502 31607729
Jaundice 16.78 10.77 37 88076 30250 31578981
Oesophageal perforation 16.71 10.77 17 88096 973 31608258
Liver disorder 16.70 10.77 36 88077 29671 31579560
Influenza 16.66 10.77 65 88048 44260 31564971
Poor quality sleep 16.56 10.77 53 88060 7625 31601606
Coordination abnormal 16.51 10.77 51 88062 7200 31602031
Economic problem 16.50 10.77 19 88094 1252 31607979
Schizoaffective disorder 16.45 10.77 19 88094 1256 31607975
Hand deformity 16.41 10.77 30 88083 3017 31606214
Thinking abnormal 16.39 10.77 43 88070 5530 31603701
Osteonecrosis of jaw 16.37 10.77 14 88099 17057 31592174
Arachnoid cyst 16.33 10.77 9 88104 198 31609033
Blood bilirubin increased 16.31 10.77 47 88066 35089 31574142
Facial spasm 16.20 10.77 9 88104 201 31609030
Urinary retention 16.20 10.77 154 87959 33571 31575660
Blood creatinine increased 16.09 10.77 164 87949 88914 31520317
Rectourethral fistula 16.07 10.77 5 88108 22 31609209
Dissociation 16.01 10.77 19 88094 1293 31607938
Xanthoma 16.00 10.77 7 88106 91 31609140
Urticaria 15.98 10.77 94 88019 57423 31551808
Colitis 15.97 10.77 45 88068 33842 31575389
Slow response to stimuli 15.97 10.77 15 88098 778 31608453
Cyanosis neonatal 15.96 10.77 10 88103 281 31608950
Blood catecholamines decreased 15.90 10.77 4 88109 6 31609225
Spermatozoa morphology abnormal 15.90 10.77 4 88109 6 31609225
Poor feeding infant 15.83 10.77 12 88101 462 31608769
Acute myocardial infarction 15.80 10.77 80 88033 50743 31558488
Caesarean section 15.79 10.77 23 88090 1913 31607318
Congenital pneumonia 15.73 10.77 7 88106 95 31609136
Generalised tonic-clonic seizure 15.67 10.77 102 88011 19829 31589402
Insomnia 15.53 10.77 359 87754 94477 31514754
Morbid thoughts 15.44 10.77 9 88104 221 31609010
Memory impairment 15.39 10.77 168 87945 37962 31571269
Arthropathy 15.39 10.77 27 88086 24024 31585207
Hydrocele 15.37 10.77 23 88090 1960 31607271
Incontinence 15.28 10.77 41 88072 5345 31603886
Physical assault 15.20 10.77 17 88096 1085 31608146
Positive end-expiratory pressure 15.18 10.77 4 88109 8 31609223
Intentional product use issue 15.16 10.77 78 88035 49269 31559962
Anomaly of external ear congenital 15.10 10.77 7 88106 105 31609126
Acute stress disorder 15.06 10.77 8 88105 163 31609068
Priapism 15.00 10.77 37 88076 4583 31604648
Eye haematoma 14.94 10.77 6 88107 62 31609169
Granulocytopenia 14.92 10.77 44 88069 6055 31603176
Cytopenia 14.83 10.77 6 88107 11004 31598227
Cardiac failure congestive 14.82 10.77 145 87968 79242 31529989
Bacterial infection 14.80 10.77 10 88103 13729 31595502
Lymphoma 14.68 10.77 6 88107 10937 31598294
Holoprosencephaly 14.66 10.77 3 88110 0 31609231
Gas poisoning 14.66 10.77 3 88110 0 31609231
Visual snow syndrome 14.66 10.77 3 88110 0 31609231
Self-injurious ideation 14.64 10.77 20 88093 1567 31607664
Muscle mass 14.61 10.77 9 88104 245 31608986
Gastrointestinal mucosal exfoliation 14.59 10.77 7 88106 114 31609117
Rhinorrhoea 14.57 10.77 26 88087 22986 31586245
Genital anaesthesia 14.57 10.77 4 88109 10 31609221
Hypertrophic scar 14.57 10.77 4 88109 10 31609221
Infantile vomiting 14.52 10.77 5 88108 32 31609199
Testicular atrophy 14.37 10.77 12 88101 532 31608699
JC virus CSF test positive 14.37 10.77 7 88106 118 31609113
Abnormal dreams 14.37 10.77 48 88065 7060 31602171
Salivary hypersecretion 14.34 10.77 51 88062 7741 31601490
Radicular pain 14.29 10.77 6 88107 70 31609161
Hepatic failure 14.28 10.77 45 88068 32657 31576574
Resting tremor 14.19 10.77 13 88100 653 31608578
White blood cell count decreased 14.15 10.77 165 87948 87233 31521998
Thrombotic stroke 14.14 10.77 9 88104 260 31608971
Cognitive disorder 14.13 10.77 118 87995 24805 31584426
Medication error 14.10 10.77 110 88003 22662 31586569
Pulmonary embolism 14.06 10.77 152 87961 81494 31527737
Vestibular disorder 13.96 10.77 16 88097 1049 31608182
Dyspnoea exertional 13.94 10.77 58 88055 38779 31570452
Opisthotonus 13.91 10.77 11 88102 451 31608780
Accidental overdose 13.87 10.77 93 88020 18257 31590974
Pulmonary arterial hypertension 13.82 10.77 5 88108 9816 31599415
Scleroderma renal crisis 13.81 10.77 7 88106 129 31609102
Ventricular flutter 13.78 10.77 6 88107 77 31609154
Pleurothotonus 13.74 10.77 16 88097 1067 31608164
Head circumference abnormal 13.68 10.77 5 88108 39 31609192
Iron binding capacity total increased 13.68 10.77 5 88108 39 31609192
Ascites 13.66 10.77 63 88050 40950 31568281
Tendon disorder 13.61 10.77 25 88088 2523 31606708
Oesophageal atresia 13.58 10.77 11 88102 467 31608764
Drug dispensed to wrong patient 13.56 10.77 11 88102 468 31608763
Psychiatric symptom 13.49 10.77 29 88084 3282 31605949
Sleep disorder due to a general medical condition 13.47 10.77 32 88081 3870 31605361
Brugada syndrome 13.36 10.77 13 88100 705 31608526
Oesophageal carcinoma 13.31 10.77 3 88110 8030 31601201
Pneumonia bacterial 13.25 10.77 6 88107 10290 31598941
Accidental poisoning 13.16 10.77 13 88100 718 31608513
Psoriatic arthropathy 13.01 10.77 22 88091 19861 31589370
Renal disorder 13.01 10.77 29 88084 23616 31585615
Congenital hydrocephalus 13.00 10.77 6 88107 89 31609142
Alcoholism 12.97 10.77 29 88084 3370 31605861
Abdominal distension 12.96 10.77 85 88028 50599 31558632
Erythema 12.93 10.77 152 87961 80253 31528978
Micropenis 12.86 10.77 5 88108 47 31609184
Teratogenicity 12.77 10.77 5 88108 48 31609183
Activation syndrome 12.77 10.77 6 88107 93 31609138
Cardiogenic shock 12.73 10.77 27 88086 22381 31586850
Liver function test increased 12.72 10.77 10 88103 12704 31596527
Blood urea increased 12.61 10.77 40 88073 28972 31580259
Angle closure glaucoma 12.60 10.77 14 88099 887 31608344
Syncope 12.60 10.77 318 87795 84864 31524367
Tension 12.46 10.77 21 88092 1980 31607251
Bronchial disorder 12.45 10.77 17 88096 1332 31607899
Carbon monoxide poisoning 12.43 10.77 6 88107 99 31609132
Blood pressure fluctuation 12.41 10.77 28 88085 22708 31586523
Crystalluria 12.38 10.77 10 88103 423 31608808
Mood altered 12.38 10.77 51 88062 8295 31600936
Staphylococcal sepsis 12.28 10.77 5 88108 9132 31600099
Open reduction of fracture 12.27 10.77 6 88107 102 31609129
Haematospermia 12.25 10.77 9 88104 330 31608901
Pruritus 12.23 10.77 260 87853 124907 31484324
Haemoglobin decreased 12.23 10.77 230 87883 112445 31496786
Angioedema 12.19 10.77 50 88063 33568 31575663
Male orgasmic disorder 12.17 10.77 6 88107 104 31609127
Personality change 12.12 10.77 35 88078 4760 31604471
Respiratory distress 12.11 10.77 50 88063 33503 31575728
Graft versus host disease 12.08 10.77 7 88106 10440 31598791
Myositis 12.05 10.77 8 88105 11086 31598145
Coagulation factor increased 12.01 10.77 5 88108 57 31609174
Lacrimation increased 11.99 10.77 3 88110 7479 31601752
Semen volume decreased 11.93 10.77 9 88104 344 31608887
Hyperuricaemia 11.89 10.77 3 88110 7435 31601796
Social avoidant behaviour 11.83 10.77 26 88087 2987 31606244
Venoocclusive liver disease 11.83 10.77 3 88110 7409 31601822
Floppy infant 11.82 10.77 6 88107 111 31609120
Dystonia 11.80 10.77 58 88055 10167 31599064
Leukopenia 11.77 10.77 226 87887 57602 31551629
Pulmonary valve stenosis 11.75 10.77 9 88104 352 31608879
Osteoporosis 11.73 10.77 9 88104 11574 31597657
Arthralgia 11.67 10.77 326 87787 151098 31458133
Asthma 11.64 10.77 70 88043 42541 31566690
Product administered to patient of inappropriate age 11.61 10.77 25 88088 2832 31606399
Adjusted calcium increased 11.57 10.77 4 88109 26 31609205
Genital pain 11.55 10.77 7 88106 185 31609046
Toxic skin eruption 11.52 10.77 7 88106 10173 31599058
Personality disorder 11.52 10.77 15 88098 1122 31608109
Kidney transplant rejection 11.52 10.77 3 88110 7279 31601952
Cleft lip and palate 11.51 10.77 10 88103 468 31608763
Drug abuser 11.48 10.77 30 88083 3850 31605381
Hepatic enzyme increased 11.46 10.77 56 88057 35852 31573379
Bronchitis 11.44 10.77 62 88051 38655 31570576
Coagulation factor VII level decreased 11.44 10.77 6 88107 119 31609112
COVID-19 pneumonia 11.39 10.77 11 88102 12644 31596587
Alcoholic psychosis 11.39 10.77 3 88110 6 31609225
Pulmonary artery stenosis congenital 11.37 10.77 10 88103 476 31608755
Product use issue 11.30 10.77 102 88011 56657 31552574
Palmar-plantar erythrodysaesthesia syndrome 11.21 10.77 16 88097 15467 31593764
Long QT syndrome 11.21 10.77 22 88091 2334 31606897
Thrombotic microangiopathy 11.20 10.77 6 88107 9345 31599886
CSF white blood cell count positive 11.19 10.77 4 88109 29 31609202
Infertility 11.19 10.77 7 88106 196 31609035
Antipsychotic drug level above therapeutic 11.11 10.77 15 88098 1162 31608069
Dysarthria 11.11 10.77 137 87976 31880 31577351
Emotional disorder 11.11 10.77 36 88077 5213 31604018
Application site hypersensitivity 11.09 10.77 6 88107 127 31609104
Contraindicated product administered 11.08 10.77 24 88089 19748 31589483
Musculoskeletal pain 11.05 10.77 44 88069 29784 31579447
Bradyphrenia 10.99 10.77 32 88081 4372 31604859
Yawning 10.99 10.77 10 88103 498 31608733
Alcohol poisoning 10.94 10.77 26 88087 3145 31606086
Klebsiella infection 10.93 10.77 4 88109 7799 31601432
Alcohol interaction 10.87 10.77 24 88089 2765 31606466
Bradykinesia 10.86 10.77 28 88085 3564 31605667
HIV peripheral neuropathy 10.85 10.77 4 88109 32 31609199
Poor personal hygiene 10.80 10.77 8 88105 297 31608934
Rash maculo-papular 10.80 10.77 36 88077 25683 31583548

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2162.44 9.70 3087 219585 224048 70481724
Toxicity to various agents 1838.07 9.70 3836 218836 378336 70327436
Drug abuse 1413.25 9.70 2011 220661 145245 70560527
Serotonin syndrome 1004.21 9.70 923 221749 41191 70664581
Overdose 696.77 9.70 1602 221070 168143 70537629
Electrocardiogram QT prolonged 680.19 9.70 1057 221615 82460 70623312
Intentional overdose 650.85 9.70 1134 221538 97301 70608471
Drug interaction 593.63 9.70 2569 220103 378872 70326900
Suicidal ideation 543.29 9.70 864 221808 68732 70637040
Suicide attempt 475.53 9.70 877 221795 78633 70627139
Anxiety 409.51 9.70 1569 221103 218761 70487011
Depression 386.32 9.70 1437 221235 197537 70508235
Intentional self-injury 364.71 9.70 473 222199 31177 70674595
Respiratory arrest 344.15 9.70 612 222060 53321 70652451
Sopor 326.04 9.70 445 222227 30822 70674950
Poisoning 323.55 9.70 377 222295 22245 70683527
Agitation 314.17 9.70 817 221855 92558 70613214
Synovitis 300.51 9.70 29 222643 129199 70576573
Off label use 277.44 9.70 1296 221376 741764 69964008
Drug ineffective 273.46 9.70 1781 220891 937971 69767801
Cardio-respiratory arrest 265.13 9.70 806 221866 99871 70605901
Torsade de pointes 236.17 9.70 288 222384 17828 70687944
Tremor 226.70 9.70 1029 221643 154595 70551177
Hyponatraemia 222.47 9.70 1044 221628 159043 70546729
Hand deformity 222.22 9.70 12 222660 86470 70619302
Systemic lupus erythematosus 219.09 9.70 30 222642 101872 70603900
Febrile neutropenia 199.61 9.70 208 222464 204110 70501662
Temperature regulation disorder 196.84 9.70 140 222532 4304 70701468
Treatment failure 190.05 9.70 108 222564 144034 70561738
Pemphigus 189.46 9.70 20 222652 83016 70622756
Hyperhidrosis 183.40 9.70 859 221813 130727 70575045
Pericarditis 177.29 9.70 27 222645 84678 70621094
Psychotic disorder 173.66 9.70 373 222299 37328 70668444
Aggression 172.30 9.70 433 222239 48013 70657759
Cardiac arrest 171.63 9.70 970 221702 158864 70546908
Panic attack 168.90 9.70 272 222400 21847 70683925
Restlessness 168.51 9.70 394 222278 41734 70664038
Drug intolerance 162.56 9.70 287 222385 225400 70480372
Pyrexia 160.22 9.70 1182 221490 605770 70100002
Loss of libido 159.92 9.70 99 222573 2398 70703374
Arthropathy 159.04 9.70 142 222530 149915 70555857
Disturbance in attention 158.47 9.70 389 222283 42505 70663267
Infusion related reaction 154.54 9.70 238 222434 197296 70508476
Paranoia 152.16 9.70 227 222445 17061 70688711
Somnolence 149.39 9.70 1173 221499 214433 70491339
Fall 147.77 9.70 2081 220591 442015 70263757
Irritability 144.77 9.70 350 222322 37875 70667897
Therapeutic product effect decreased 143.74 9.70 142 222530 142876 70562896
Withdrawal syndrome 142.90 9.70 270 222402 24634 70681138
Confusional state 142.79 9.70 1442 221230 282956 70422816
Helicobacter infection 142.12 9.70 8 222664 55648 70650124
Electrocardiogram QRS complex prolonged 141.17 9.70 164 222508 9642 70696130
Depressed mood 139.75 9.70 376 222296 43444 70662328
Food allergy 138.81 9.70 152 222520 8372 70697400
Mydriasis 137.75 9.70 209 222463 15944 70689828
Rheumatoid factor positive 129.93 9.70 5 222667 48395 70657377
Rheumatoid arthritis 128.89 9.70 476 222196 291329 70414443
Alopecia 126.77 9.70 271 222401 198219 70507553
Joint swelling 126.15 9.70 392 222280 252819 70452953
Coeliac disease 121.64 9.70 146 222526 8887 70696885
Interstitial lung disease 120.92 9.70 91 222581 104594 70601178
Infection 120.78 9.70 305 222367 210480 70495292
Muscle twitching 120.06 9.70 220 222452 19607 70686165
Anorgasmia 118.42 9.70 61 222611 1024 70704748
Muscle rigidity 114.27 9.70 208 222464 18442 70687330
Myoclonus 113.70 9.70 254 222418 26101 70679671
Glossodynia 112.26 9.70 66 222606 86421 70619351
Malignant neoplasm progression 112.14 9.70 130 222542 121609 70584163
Rash 111.97 9.70 1044 221628 509518 70196254
Pneumonia 110.40 9.70 1269 221403 594963 70110809
Depression suicidal 109.89 9.70 83 222589 2804 70702968
Akathisia 109.02 9.70 162 222510 12131 70693641
Accidental overdose 108.63 9.70 298 222374 34823 70670949
Unresponsive to stimuli 107.26 9.70 383 222289 51548 70654224
Loss of consciousness 106.59 9.70 845 221827 154871 70550901
Nightmare 106.41 9.70 223 222449 21933 70683839
Accidental death 105.64 9.70 92 222580 3816 70701956
Seizure 105.49 9.70 935 221737 177027 70528745
Obsessive-compulsive disorder 103.93 9.70 105 222567 5265 70700507
Intentional product misuse 103.88 9.70 510 222162 79085 70626687
Product use in unapproved indication 102.75 9.70 322 222350 207156 70498616
Tearfulness 100.55 9.70 100 222572 4920 70700852
Septic shock 100.07 9.70 123 222549 112135 70593637
Muscle injury 99.95 9.70 5 222667 38489 70667283
Drug withdrawal syndrome 99.61 9.70 276 222396 32439 70673333
Neutropenia 99.35 9.70 442 222230 256714 70449058
Coma scale abnormal 99.31 9.70 125 222547 7991 70697781
Hepatic function abnormal 93.90 9.70 48 222624 67948 70637824
Bruxism 93.25 9.70 84 222588 3645 70702127
Hallucination 91.35 9.70 477 222195 75783 70629989
Wound 90.31 9.70 106 222566 98626 70607146
Stomatitis 90.16 9.70 166 222506 128345 70577427
Hyperreflexia 90.08 9.70 114 222558 7328 70698444
Sleep disorder due to general medical condition, insomnia type 88.63 9.70 6 222666 35726 70670046
Libido decreased 87.69 9.70 92 222580 4824 70700948
Orgasmic sensation decreased 86.04 9.70 22 222650 30 70705742
Abdominal discomfort 85.92 9.70 364 222308 214294 70491478
Depressive symptom 85.43 9.70 93 222579 5088 70700684
Duodenal ulcer perforation 85.38 9.70 27 222645 51085 70654687
Peripheral swelling 85.23 9.70 417 222255 236146 70469626
Mania 84.99 9.70 175 222497 16999 70688773
Acute kidney injury 84.34 9.70 1019 221653 473605 70232167
Homicidal ideation 83.39 9.70 75 222597 3248 70702524
Cytomegalovirus infection 82.44 9.70 13 222659 39745 70666027
Exposure via ingestion 82.40 9.70 89 222583 4826 70700946
Erectile dysfunction 77.75 9.70 147 222525 13415 70692357
C-reactive protein increased 77.30 9.70 143 222529 110374 70595398
Psychiatric decompensation 76.11 9.70 68 222604 2919 70702853
Intrusive thoughts 74.81 9.70 33 222639 384 70705388
Anger 74.73 9.70 160 222512 15972 70689800
Intentional product use issue 74.22 9.70 167 222505 119975 70585797
Dyskinesia 74.04 9.70 290 222382 40784 70664988
Pancytopenia 73.74 9.70 236 222436 150871 70554901
Inappropriate antidiuretic hormone secretion 73.48 9.70 199 222473 23077 70682695
Disturbance in sexual arousal 72.61 9.70 26 222646 165 70705607
Thrombocytopenia 71.63 9.70 448 222224 238662 70467110
Immunodeficiency 71.08 9.70 165 222507 17390 70688382
Disinhibition 70.05 9.70 58 222614 2243 70703529
Long QT syndrome 69.93 9.70 85 222587 5242 70700530
Mood swings 69.83 9.70 168 222504 18118 70687654
Mucosal inflammation 69.73 9.70 66 222606 67784 70637988
Tachyphrenia 69.67 9.70 54 222618 1897 70703875
Platelet count decreased 69.60 9.70 305 222367 177917 70527855
Impulsive behaviour 68.80 9.70 62 222610 2692 70703080
Contraindicated product administered 68.68 9.70 206 222466 134406 70571366
Psychomotor hyperactivity 67.99 9.70 150 222522 15283 70690489
Sexual dysfunction 66.49 9.70 93 222579 6588 70699184
Disorientation 66.42 9.70 358 222314 57565 70648207
Discomfort 66.40 9.70 145 222527 105291 70600481
Disease progression 66.23 9.70 260 222412 156412 70549360
Galactorrhoea 65.28 9.70 66 222606 3312 70702460
Depressed level of consciousness 65.11 9.70 484 222188 86947 70618825
Cardiac failure 64.71 9.70 232 222440 143309 70562463
Folliculitis 63.49 9.70 27 222645 42543 70663229
Memory impairment 62.95 9.70 502 222170 92139 70613633
Multiple organ dysfunction syndrome 62.90 9.70 156 222516 108359 70597413
Sepsis 62.48 9.70 480 222192 244065 70461707
Psychomotor skills impaired 62.26 9.70 72 222600 4212 70701560
Drug dependence 58.97 9.70 253 222419 37068 70668704
Blister 58.67 9.70 144 222528 100382 70605390
Alcoholism 58.47 9.70 71 222601 4374 70701398
Drug resistance 57.31 9.70 24 222648 38166 70667606
Generalised tonic-clonic seizure 57.27 9.70 271 222401 41390 70664382
Dizziness 57.08 9.70 1882 220790 462259 70243513
C-reactive protein abnormal 56.69 9.70 25 222647 38554 70667218
Amnesia 55.56 9.70 316 222356 51839 70653933
Parkinsonism 55.55 9.70 138 222534 15187 70690585
Self-injurious ideation 55.18 9.70 60 222612 3278 70702494
Bradyphrenia 54.79 9.70 106 222566 9840 70695932
Alcohol use 54.61 9.70 70 222602 4557 70701215
Hallucination, auditory 53.22 9.70 152 222520 18176 70687596
Hallucination, visual 52.77 9.70 207 222465 29130 70676642
Homicide 52.14 9.70 37 222635 1133 70704639
Bursitis 51.92 9.70 193 222479 26480 70679292
Major depression 51.73 9.70 95 222577 8479 70697293
Sinusitis 51.68 9.70 315 222357 168880 70536892
Psoriatic arthropathy 51.60 9.70 77 222595 64694 70641078
Renal impairment 51.07 9.70 255 222417 143682 70562090
Yawning 50.69 9.70 38 222634 1269 70704503
Myocardial stunning 50.54 9.70 20 222652 173 70705599
Drug screen positive 50.41 9.70 76 222596 5764 70700008
COVID-19 50.32 9.70 167 222505 105590 70600182
Myelosuppression 50.21 9.70 16 222656 30129 70675643
Pneumocystis jirovecii pneumonia 50.05 9.70 16 222656 30066 70675706
Medication error 49.97 9.70 328 222344 56584 70649188
Cytokine release syndrome 49.86 9.70 11 222661 26456 70679316
Irritable bowel syndrome 49.34 9.70 52 222620 50798 70654974
Mental disorder 48.98 9.70 197 222475 28043 70677729
Abnormal dreams 48.92 9.70 105 222567 10498 70695274
Genital hypoaesthesia 48.46 9.70 19 222653 160 70705612
Swelling 48.17 9.70 370 222302 188169 70517603
Lethargy 48.01 9.70 402 222270 74848 70630924
Impaired healing 47.89 9.70 101 222571 74273 70631499
Cerebral vasoconstriction 47.66 9.70 37 222635 1303 70704469
Haematemesis 47.04 9.70 288 222384 48509 70657263
Arthralgia 47.02 9.70 1212 221460 502178 70203594
Haemophagocytic lymphohistiocytosis 46.64 9.70 4 222668 19608 70686164
Thinking abnormal 46.32 9.70 111 222561 11940 70693832
Drug reaction with eosinophilia and systemic symptoms 46.18 9.70 69 222603 57944 70647828
Nasopharyngitis 46.17 9.70 460 222212 221746 70484026
Product use issue 46.02 9.70 353 222319 179584 70526188
Hepatic enzyme increased 45.52 9.70 297 222375 156693 70549079
Rhinitis perennial 45.45 9.70 22 222650 321 70705451
Physical assault 44.67 9.70 38 222634 1526 70704246
Maternal exposure during pregnancy 44.04 9.70 199 222473 115146 70590626
Toxicologic test abnormal 43.66 9.70 35 222637 1292 70704480
Cardiac failure congestive 43.59 9.70 248 222424 135209 70570563
Alcohol abuse 43.43 9.70 66 222606 5041 70700731
Insomnia 43.40 9.70 941 221731 216865 70488907
Mental impairment 43.38 9.70 136 222536 17119 70688653
Negative thoughts 43.13 9.70 35 222637 1315 70704457
Anaemia 42.98 9.70 952 221720 402471 70303301
Psychomotor retardation 42.95 9.70 69 222603 5529 70700243
Atrial fibrillation 42.87 9.70 371 222301 183977 70521795
Liver disorder 42.74 9.70 80 222592 61488 70644284
Bradykinesia 42.61 9.70 81 222591 7421 70698351
Bone marrow failure 42.30 9.70 55 222617 48955 70656817
Panic reaction 41.83 9.70 59 222613 4212 70701560
Asphyxia 41.64 9.70 97 222575 10245 70695527
Dyspnoea 41.46 9.70 1986 220686 768074 69937698
Pleural effusion 41.28 9.70 246 222426 132618 70573154
Diarrhoea 41.05 9.70 2026 220646 781315 69924457
Ill-defined disorder 40.83 9.70 68 222604 54673 70651099
Sedation 40.22 9.70 268 222404 46463 70659309
Nicotine dependence 40.22 9.70 28 222644 831 70704941
Premature ejaculation 39.90 9.70 13 222659 59 70705713
Acute myeloid leukaemia 39.59 9.70 24 222648 30916 70674856
Renal failure 39.44 9.70 391 222281 188679 70517093
Angle closure glaucoma 39.20 9.70 46 222626 2733 70703039
Bronchopulmonary aspergillosis 39.02 9.70 9 222663 20993 70684779
Bradycardia 38.90 9.70 578 222094 124037 70581735
Clonus 38.51 9.70 70 222602 6198 70699574
Plasma cell myeloma 38.06 9.70 111 222561 73090 70632682
Antidepressant drug level above therapeutic 37.99 9.70 24 222648 603 70705169
Somnambulism 37.87 9.70 63 222609 5197 70700575
Coma 36.94 9.70 446 222226 91398 70614374
Increased appetite 36.82 9.70 94 222578 10519 70695253
Dissociation 36.63 9.70 49 222623 3327 70702445
Lower respiratory tract infection 36.49 9.70 204 222468 111709 70594063
Urinary retention 36.43 9.70 286 222386 52234 70653538
Abnormal behaviour 36.11 9.70 209 222463 34500 70671272
Suicidal behaviour 35.70 9.70 46 222626 3010 70702762
Calcium deficiency 35.65 9.70 25 222647 751 70705021
Hypertonia 35.49 9.70 69 222603 6429 70699343
Neuropathy peripheral 34.81 9.70 244 222428 126652 70579120
Logorrhoea 34.75 9.70 53 222619 4061 70701711
Crying 34.49 9.70 145 222527 21054 70684718
Substance abuse 34.00 9.70 87 222585 9750 70696022
Syncope 33.98 9.70 719 221953 164990 70540782
Arthritis 33.94 9.70 175 222497 97805 70607967
Pneumonitis 33.61 9.70 76 222596 54521 70651251
Prostate cancer 33.58 9.70 29 222643 31134 70674638
Catatonia 33.54 9.70 77 222595 8056 70697716
Knee arthroplasty 33.36 9.70 35 222637 34266 70671506
Tic 33.29 9.70 42 222630 2691 70703081
Restless legs syndrome 33.12 9.70 130 222542 18298 70687474
Extrapyramidal disorder 33.03 9.70 141 222531 20609 70685163
Adrenal insufficiency 33.01 9.70 19 222653 25176 70680596
Hyperventilation 32.97 9.70 71 222601 7115 70698657
Tumour lysis syndrome 32.74 9.70 13 222659 21347 70684425
Ascites 32.58 9.70 106 222566 67441 70638331
Pulmonary arterial hypertension 32.55 9.70 33 222639 32822 70672950
Fibromyalgia 32.54 9.70 63 222609 47811 70657961
Concussion 32.30 9.70 78 222594 8431 70697341
Haematotoxicity 31.95 9.70 3 222669 13671 70692101
Myelodysplastic syndrome 31.75 9.70 28 222644 29757 70676015
Drug eruption 31.41 9.70 47 222625 39449 70666323
Alcohol poisoning 31.05 9.70 52 222620 4313 70701459
Apathy 30.99 9.70 95 222577 11813 70693959
Product prescribing error 30.92 9.70 219 222453 38733 70667039
Blood creatinine increased 30.54 9.70 294 222378 142707 70563065
Rabbit syndrome 30.44 9.70 17 222655 338 70705434
Palmar-plantar erythrodysaesthesia syndrome 30.40 9.70 30 222642 30217 70675555
Antipsychotic drug level below therapeutic 30.34 9.70 25 222647 960 70704812
Hip arthroplasty 30.33 9.70 26 222646 28014 70677758
Prescription drug used without a prescription 30.24 9.70 42 222630 2955 70702817
Illness anxiety disorder 30.15 9.70 15 222657 233 70705539
Aspartate aminotransferase increased 29.75 9.70 255 222417 126723 70579049
Tachycardia 29.67 9.70 679 221993 157867 70547905
Derealisation 29.66 9.70 30 222642 1506 70704266
Toxic epidermal necrolysis 29.63 9.70 49 222623 39508 70666264
Hostility 29.63 9.70 36 222636 2219 70703553
Neoplasm progression 29.47 9.70 61 222611 45167 70660605
Sexually inappropriate behaviour 29.43 9.70 19 222653 496 70705276
Spontaneous penile erection 29.34 9.70 12 222660 114 70705658
Post viral fatigue syndrome 29.34 9.70 16 222656 303 70705469
Hyponatraemic syndrome 29.18 9.70 22 222650 741 70705031
Obsessive thoughts 29.09 9.70 25 222647 1018 70704754
Female sexual arousal disorder 29.05 9.70 7 222665 6 70705766
Hypomania 29.02 9.70 61 222611 6011 70699761
Labelled drug-drug interaction issue 28.97 9.70 25 222647 1024 70704748
Rheumatoid nodule 28.92 9.70 6 222666 15061 70690711
Rib deformity 28.61 9.70 13 222659 163 70705609
Pulseless electrical activity 28.60 9.70 99 222573 13116 70692656
Tardive dyskinesia 28.49 9.70 82 222590 9847 70695925
Circulatory collapse 28.48 9.70 200 222472 35274 70670498
Forced expiratory volume 28.44 9.70 11 222661 89 70705683
Therapeutic product effect incomplete 28.42 9.70 240 222432 119642 70586130
Oedema peripheral 28.20 9.70 525 222147 227566 70478206
Myocardial fibrosis 28.10 9.70 30 222642 1605 70704167
Premature delivery 28.00 9.70 16 222656 21288 70684484
Emotional distress 27.75 9.70 206 222466 36982 70668790
Neonatal infection 27.63 9.70 8 222664 22 70705750
Poverty of speech 27.41 9.70 19 222653 560 70705212
Bladder cancer 27.25 9.70 10 222662 17232 70688540
Posterior reversible encephalopathy syndrome 27.17 9.70 22 222650 24380 70681392
Haematuria 27.16 9.70 105 222567 63468 70642304
Sinus tachycardia 27.11 9.70 191 222481 33722 70672050
Nervousness 27.10 9.70 179 222493 30941 70674831
Euphoric mood 27.07 9.70 64 222608 6825 70698947
Parathyroid gland enlargement 26.95 9.70 12 222660 143 70705629
Myocardial infarction 26.89 9.70 378 222294 171267 70534505
Neutrophil count decreased 26.86 9.70 153 222519 83403 70622369
Blood bilirubin increased 26.86 9.70 97 222575 59804 70645968
Pseudomonas infection 26.83 9.70 13 222659 18981 70686791
Eosinophilia 26.59 9.70 54 222618 40265 70665507
Skin ulcer 26.52 9.70 71 222601 48074 70657698
Postmortem blood drug level increased 26.51 9.70 21 222651 762 70705010
Transplant rejection 26.34 9.70 12 222660 18159 70687613
Respiratory distress 26.19 9.70 86 222586 54564 70651208
Condition aggravated 26.17 9.70 1087 221585 426548 70279224
Alcohol interaction 26.14 9.70 50 222622 4603 70701169
Mental status changes 26.06 9.70 308 222364 62793 70642979
Antidepressant drug level increased 25.86 9.70 16 222656 387 70705385
Drug hypersensitivity 25.77 9.70 627 222045 261832 70443940
Flat affect 25.76 9.70 31 222641 1892 70703880
Incoherent 25.65 9.70 65 222607 7241 70698531
Thrombotic microangiopathy 25.54 9.70 12 222660 17836 70687936
Cholecystitis chronic 25.53 9.70 76 222596 9300 70696472
Hyperprolactinaemia 25.50 9.70 48 222624 4365 70701407
Dystonia 25.50 9.70 126 222546 19580 70686192
Enterocolitis 25.50 9.70 5 222667 13061 70692711
Orgasm abnormal 25.36 9.70 12 222660 166 70705606
Osteonecrosis of jaw 25.30 9.70 57 222615 40945 70664827
Rash erythematous 25.28 9.70 261 222411 51457 70654315
Red blood cell sedimentation rate increased 25.27 9.70 52 222620 38590 70667182
Gun shot wound 25.20 9.70 24 222648 1119 70704653
Obesity 25.17 9.70 157 222515 26614 70679158
Carcinoid heart disease 25.15 9.70 9 222663 57 70705715
Hypersensitivity 25.09 9.70 540 222132 229272 70476500
Dementia 24.80 9.70 137 222535 22228 70683544
Optic ischaemic neuropathy 24.62 9.70 36 222636 2656 70703116
Hypochloraemia 24.54 9.70 32 222640 2119 70703653
Urticaria 24.52 9.70 362 222310 162687 70543085
Hypercalcaemia 24.47 9.70 44 222628 34341 70671431
Radiologically isolated syndrome 24.46 9.70 6 222666 6 70705766
Drug-induced liver injury 24.41 9.70 92 222580 56021 70649751
Panic disorder 24.34 9.70 37 222635 2827 70702945
Failure to suspend medication 24.18 9.70 16 222656 436 70705336
Speech disorder 24.13 9.70 254 222418 50326 70655446
Pathogen resistance 24.06 9.70 6 222666 13273 70692499
Lactic acidosis 23.74 9.70 114 222558 64910 70640862
Hypokinesia 23.66 9.70 113 222559 17319 70688453
Rheumatic fever 23.59 9.70 13 222659 17647 70688125
Tension 23.54 9.70 44 222628 3980 70701792
Dissociative amnesia 23.33 9.70 10 222662 108 70705664
Red blood cell sedimentation rate abnormal 23.30 9.70 16 222656 19287 70686485
Libido increased 23.21 9.70 29 222643 1840 70703932
Cognitive disorder 23.20 9.70 293 222379 60663 70645109
Hospitalisation 23.02 9.70 158 222514 82410 70623362
Injection site pain 22.97 9.70 247 222425 117372 70588400
Delirium 22.85 9.70 345 222327 74269 70631503
Atonic urinary bladder 22.73 9.70 9 222663 78 70705694
Neuropathy, ataxia, retinitis pigmentosa syndrome 22.72 9.70 8 222664 48 70705724
Anhidrosis 22.65 9.70 12 222660 214 70705558
Liver function test increased 22.60 9.70 45 222627 33802 70671970
Personality change 22.38 9.70 70 222602 8800 70696972
Blood cholesterol increased 22.02 9.70 116 222556 64488 70641284
Skin swelling 21.88 9.70 37 222635 3094 70702678
Dreamy state 21.80 9.70 8 222664 55 70705717
Pain 21.68 9.70 1690 220982 627126 70078646
Sputum purulent 21.45 9.70 23 222649 1237 70704535
Cytopenia 21.39 9.70 14 222658 17309 70688463
Social avoidant behaviour 21.36 9.70 46 222626 4610 70701162
Aplastic anaemia 21.34 9.70 13 222659 16703 70689069
Hypogammaglobulinaemia 21.32 9.70 5 222667 11533 70694239
Disseminated intravascular coagulation 21.31 9.70 46 222626 33552 70672220
Foetal chromosome abnormality 21.13 9.70 6 222666 15 70705757
Acute generalised exanthematous pustulosis 21.06 9.70 11 222661 15386 70690386
Acute myocardial infarction 21.06 9.70 138 222534 72749 70633023
Head injury 21.03 9.70 181 222491 33960 70671812
Bipolar disorder 21.03 9.70 62 222610 7546 70698226
Venoocclusive liver disease 21.02 9.70 4 222668 10674 70695098
Neonatal seizure 20.91 9.70 5 222667 4 70705768
Brain injury 20.81 9.70 77 222595 10540 70695232
Vascular access site thrombosis 20.77 9.70 7 222665 36 70705736
Dysphemia 20.76 9.70 37 222635 3226 70702546
Rash maculo-papular 20.63 9.70 85 222587 50460 70655312
Hanging 20.61 9.70 9 222663 102 70705670
Hypocalcaemia 20.54 9.70 72 222600 44787 70660985
Prescribed overdose 20.52 9.70 151 222521 27030 70678742
Antipsychotic drug level above therapeutic 20.37 9.70 28 222644 1951 70703821
Activation syndrome 20.33 9.70 12 222660 266 70705506
Epstein-Barr virus infection 20.28 9.70 8 222664 13190 70692582
Therapy interrupted 20.23 9.70 29 222643 24773 70680999
Dysarthria 20.21 9.70 291 222381 62022 70643750
Poor quality sleep 20.18 9.70 121 222551 20228 70685544
Pruritus 20.16 9.70 883 221789 344677 70361095
Bronchomalacia 20.05 9.70 11 222661 211 70705561
Herpes zoster 20.04 9.70 171 222501 85064 70620708
Facial spasm 20.00 9.70 17 222655 682 70705090
Abnormal weight gain 19.89 9.70 30 222642 2276 70703496
Histrionic personality disorder 19.88 9.70 7 222665 42 70705730
Cytomegalovirus viraemia 19.82 9.70 6 222666 11679 70694093
Hyperuricaemia 19.78 9.70 5 222667 10961 70694811
Hepatocellular carcinoma 19.73 9.70 4 222668 10204 70695568
White blood cell count decreased 19.68 9.70 396 222276 169745 70536027
Hypersomnia 19.66 9.70 122 222550 20642 70685130
Diaphragmatic rupture 19.64 9.70 11 222661 220 70705552
Polyneuropathy 19.56 9.70 23 222649 21392 70684380
Pupillary reflex impaired 19.56 9.70 36 222636 3218 70702554
Conduction disorder 19.39 9.70 35 222637 3083 70702689
Cerebrospinal fluid retention 19.38 9.70 8 222664 78 70705694
Interstitial granulomatous dermatitis 19.37 9.70 11 222661 226 70705546
Decreased interest 19.36 9.70 37 222635 3404 70702368
Opiates positive 19.34 9.70 19 222653 921 70704851
Menopause 19.30 9.70 26 222646 1777 70703995
Psychiatric symptom 19.19 9.70 55 222617 6589 70699183
Adjustment disorder 19.18 9.70 35 222637 3109 70702663
Agoraphobia 19.16 9.70 15 222657 535 70705237
Sexual inhibition 19.07 9.70 4 222668 0 70705772
Nocturnal emission 19.07 9.70 4 222668 0 70705772
Spermatozoa morphology abnormal 19.07 9.70 4 222668 0 70705772
Heat stroke 19.01 9.70 24 222648 1539 70704233
Muscle tightness 18.78 9.70 80 222592 11682 70694090
Respiratory tract infection 18.78 9.70 69 222603 42329 70663443
Graft versus host disease 18.74 9.70 12 222660 15011 70690761
Gender dysphoria 18.73 9.70 7 222665 51 70705721
Intestinal congestion 18.72 9.70 5 222667 9 70705763
Upper respiratory fungal infection 18.70 9.70 12 222660 310 70705462
Hypertension 18.62 9.70 750 221922 295283 70410489
Blood alcohol increased 18.61 9.70 21 222651 1196 70704576
COVID-19 pneumonia 18.60 9.70 25 222647 21944 70683828
Oedema 18.47 9.70 222 222450 103359 70602413
Delusion 18.39 9.70 113 222559 19052 70686720
Cataract 18.37 9.70 101 222571 55544 70650228
Alanine aminotransferase increased 18.36 9.70 339 222333 147141 70558631
Libido disorder 18.23 9.70 11 222661 254 70705518
Loss of bladder sensation 18.22 9.70 8 222664 92 70705680
Hepatic cytolysis 18.20 9.70 20 222652 19172 70686600
Pulmonary alveolar haemorrhage 18.19 9.70 5 222667 10364 70695408
Sternal fracture 18.07 9.70 29 222643 2322 70703450
CFTR gene mutation 18.07 9.70 8 222664 94 70705678
Musculoskeletal stiffness 17.97 9.70 341 222331 147419 70558353
Hyperbilirubinaemia 17.81 9.70 27 222645 22541 70683231
Multiple sclerosis relapse 17.77 9.70 210 222462 42807 70662965
Genital anaesthesia 17.75 9.70 5 222667 12 70705760
Cholangitis 17.75 9.70 7 222665 11542 70694230
Sebaceous gland infection 17.75 9.70 9 222663 146 70705626
Semen volume decreased 17.64 9.70 7 222665 61 70705711
Dermatitis bullous 17.62 9.70 9 222663 12748 70693024
Drug withdrawal syndrome neonatal 17.60 9.70 11 222661 271 70705501
Dry mouth 17.58 9.70 315 222357 70142 70635630
Multiple drug therapy 17.56 9.70 34 222638 3158 70702614
Pulmonary toxicity 17.51 9.70 6 222666 10792 70694980
Post-traumatic neck syndrome 17.49 9.70 26 222646 1947 70703825
Subclavian artery thrombosis 17.47 9.70 6 222666 33 70705739
Sexual relationship change 17.47 9.70 5 222667 13 70705759
Hypersexuality 17.44 9.70 23 222649 1540 70704232
Cystitis haemorrhagic 17.39 9.70 3 222669 8590 70697182
Drug abuser 17.38 9.70 49 222623 5815 70699957
Product dose omission issue 17.33 9.70 535 222137 216933 70488839
Basal ganglion degeneration 17.32 9.70 13 222659 435 70705337
Influenza 17.24 9.70 252 222420 113448 70592324
Kidney transplant rejection 17.11 9.70 5 222667 9956 70695816
Personality disorder 17.08 9.70 47 222625 5501 70700271
Colorectal cancer 17.05 9.70 3 222669 8467 70697305
Tuberculosis 17.02 9.70 13 222659 14835 70690937
Mood altered 17.00 9.70 99 222573 16376 70689396
Schizoaffective disorder 17.00 9.70 26 222646 1997 70703775
Hypoalbuminaemia 16.98 9.70 21 222651 19101 70686671
Lung disorder 16.97 9.70 138 222534 69346 70636426
Atrophic vulvovaginitis 16.95 9.70 20 222652 1195 70704577
Morbid thoughts 16.91 9.70 16 222656 740 70705032
Amputation stump pain 16.90 9.70 6 222666 37 70705735
Electrolyte substitution therapy 16.84 9.70 4 222668 3 70705769
CYP3A4 polymorphism 16.80 9.70 7 222665 70 70705702
Metastases to liver 16.77 9.70 35 222637 25843 70679929
Legal problem 16.76 9.70 9 222663 165 70705607
Localised infection 16.71 9.70 51 222621 33107 70672665
Bronchitis 16.70 9.70 263 222409 116980 70588792
Meningitis streptococcal 16.67 9.70 9 222663 167 70705605
Incontinence 16.64 9.70 83 222589 12945 70692827
Vasoplegia syndrome 16.61 9.70 33 222639 3123 70702649
Thrombosis 16.53 9.70 154 222518 75251 70630521
Bone erosion 16.49 9.70 14 222658 15159 70690613
Feeling abnormal 16.39 9.70 573 222099 141746 70564026
Ventricular arrhythmia 16.37 9.70 58 222614 7772 70698000
Caesarean section 16.31 9.70 76 222596 11531 70694241
Bacteraemia 16.31 9.70 43 222629 29266 70676506
Right ventricular failure 16.30 9.70 28 222644 22246 70683526
Cystoid macular oedema 16.28 9.70 25 222647 1927 70703845
Sensory disturbance 16.20 9.70 86 222586 13746 70692026
Basal cell carcinoma 16.17 9.70 53 222619 33645 70672127
Pneumonia bacterial 16.16 9.70 17 222655 16624 70689148
Polymenorrhagia 16.14 9.70 6 222666 43 70705729
Epistaxis 16.07 9.70 226 222446 102401 70603371
Cardiac steatosis 16.02 9.70 6 222666 44 70705728
Balance disorder 15.93 9.70 383 222289 89745 70616027
Meconium in amniotic fluid 15.90 9.70 7 222665 81 70705691
Drug level above therapeutic 15.89 9.70 57 222615 7685 70698087
Pulmonary oedema 15.89 9.70 354 222318 81924 70623848
Violence-related symptom 15.79 9.70 15 222657 697 70705075
Mucormycosis 15.78 9.70 3 222669 8011 70697761
Cough 15.71 9.70 848 221824 324529 70381243
Soft tissue injury 15.71 9.70 23 222649 1699 70704073
Antipsychotic drug level increased 15.68 9.70 45 222627 5395 70700377
Organising pneumonia 15.59 9.70 6 222666 10044 70695728
Panniculitis 15.56 9.70 7 222665 10669 70695103
Hypoglycaemia 15.49 9.70 397 222275 93967 70611805
Respiratory depression 15.48 9.70 132 222540 24699 70681073
Aspergillus infection 15.47 9.70 20 222652 17848 70687924
Accidental poisoning 15.41 9.70 22 222650 1588 70704184
Lipoedema 15.35 9.70 9 222663 197 70705575
Vertigo 15.25 9.70 279 222393 62364 70643408
Nystagmus 15.22 9.70 64 222608 9291 70696481
Therapy non-responder 15.22 9.70 161 222511 76754 70629018
Bipolar I disorder 15.22 9.70 24 222648 1893 70703879
Gastrointestinal disorder 15.18 9.70 236 222436 105191 70600581
Adenovirus infection 15.10 9.70 3 222669 7765 70698007
Dysaesthesia 15.08 9.70 44 222628 5324 70700448
Wrong product administered 15.08 9.70 59 222613 8292 70697480
Self-medication 15.05 9.70 39 222633 4404 70701368
Dysponesis 15.04 9.70 4 222668 7 70705765
Polyhydramnios 15.04 9.70 21 222651 1485 70704287
Chronic kidney disease 15.03 9.70 121 222551 60936 70644836
Ejection fraction decreased 15.02 9.70 48 222624 30714 70675058
Coordination abnormal 14.96 9.70 94 222578 15972 70689800
Dermatillomania 14.95 9.70 9 222663 207 70705565
Ankylosing spondylitis 14.95 9.70 9 222663 11637 70694135
Blunted affect 14.95 9.70 12 222660 444 70705328
Blood uric acid increased 14.93 9.70 5 222667 9124 70696648
Fear 14.80 9.70 114 222558 20697 70685075
Diffuse large B-cell lymphoma 14.80 9.70 12 222660 13290 70692482
Lymphoma 14.79 9.70 16 222656 15446 70690326
Therapeutic response decreased 14.78 9.70 115 222557 58338 70647434
Uterine enlargement 14.76 9.70 16 222656 871 70704901
Hypervigilance 14.65 9.70 12 222660 457 70705315
Pregnancy 14.61 9.70 126 222546 23655 70682117
Posturing 14.58 9.70 17 222655 1003 70704769
Neuroleptic malignant syndrome 14.54 9.70 135 222537 25872 70679900
Hyperkinesia 14.50 9.70 28 222644 2595 70703177
Female orgasmic disorder 14.49 9.70 5 222667 28 70705744
New daily persistent headache 14.30 9.70 3 222669 0 70705772
Gas poisoning 14.30 9.70 3 222669 0 70705772
Feeling of despair 14.29 9.70 28 222644 2623 70703149
Vascular access site infection 14.29 9.70 7 222665 105 70705667
Intervertebral disc disorder 14.27 9.70 39 222633 4546 70701226
Post-traumatic stress disorder 14.23 9.70 38 222634 4369 70701403
Toxic skin eruption 14.17 9.70 26 222646 20136 70685636
Paraesthesia 14.13 9.70 575 222097 144962 70560810
Differential white blood cell count abnormal 14.12 9.70 23 222649 1865 70703907
Self esteem decreased 14.10 9.70 16 222656 917 70704855
Hallucinations, mixed 14.06 9.70 48 222624 6314 70699458
Job dissatisfaction 13.98 9.70 6 222666 65 70705707
Renal cancer 13.94 9.70 10 222662 11786 70693986
Wrong technique in product usage process 13.92 9.70 143 222529 68555 70637217
Gestational diabetes 13.91 9.70 46 222626 5955 70699817
Orthostatic intolerance 13.86 9.70 22 222650 1745 70704027
Acute respiratory failure 13.84 9.70 105 222567 53560 70652212
Musculoskeletal pain 13.76 9.70 200 222472 90127 70615645
End stage renal disease 13.74 9.70 9 222663 11124 70694648
Metastases to lung 13.71 9.70 19 222653 16465 70689307
Vertigo CNS origin 13.67 9.70 5 222667 34 70705738
Vaginal haemorrhage 13.66 9.70 110 222562 20242 70685530
Adrenergic syndrome 13.62 9.70 7 222665 117 70705655
Adverse event 13.61 9.70 95 222577 49366 70656406
Trismus 13.61 9.70 41 222631 5050 70700722
Parkinson's disease 13.60 9.70 22 222650 1773 70703999
Hepatitis C virus test positive 13.57 9.70 10 222662 325 70705447
Proteinuria 13.54 9.70 47 222625 29327 70676445
Acute stress disorder 13.52 9.70 11 222661 415 70705357
Injection site erythema 13.50 9.70 155 222517 72769 70633003
Mutism 13.47 9.70 24 222648 2092 70703680
Initial insomnia 13.42 9.70 47 222625 6262 70699510
Ventricular tachycardia 13.40 9.70 174 222498 36249 70669523
Potentiating drug interaction 13.40 9.70 56 222616 8108 70697664
Haemolysis 13.38 9.70 10 222662 11541 70694231
Acute graft versus host disease in skin 13.38 9.70 3 222669 7134 70698638
Movement disorder 13.37 9.70 125 222547 24004 70681768
Saliva altered 13.27 9.70 11 222661 426 70705346
Haematospermia 13.23 9.70 9 222663 257 70705515
Injection site reaction 13.11 9.70 97 222575 49755 70656017
Blood catecholamines decreased 13.10 9.70 4 222668 14 70705758
Renal disorder 13.09 9.70 68 222604 37941 70667831
Metastases to bone 13.09 9.70 32 222640 22344 70683428
Heparin-induced thrombocytopenia 13.05 9.70 6 222666 9031 70696741
Product administration error 13.03 9.70 146 222526 29377 70676395
Cushingoid 13.03 9.70 5 222667 8383 70697389
Therapy partial responder 12.97 9.70 12 222660 12462 70693310
Testicular atrophy 12.93 9.70 10 222662 350 70705422
Tissue infiltration 12.88 9.70 13 222659 651 70705121
Product storage error 12.88 9.70 16 222656 14525 70691247
Osmolar gap abnormal 12.88 9.70 6 222666 80 70705692
Oliguria 12.88 9.70 17 222655 15034 70690738
Systolic hypertension 12.85 9.70 13 222659 653 70705119
Agranulocytosis 12.83 9.70 74 222598 40224 70665548
Osmotic demyelination syndrome 12.83 9.70 18 222654 1279 70704493
Executive dysfunction 12.82 9.70 9 222663 271 70705501
Pneumonia viral 12.78 9.70 5 222667 8287 70697485
Economic problem 12.77 9.70 24 222648 2180 70703592
Dysphoria 12.76 9.70 37 222635 4461 70701311
Disability 12.74 9.70 17 222655 14966 70690806
Cholestasis 12.66 9.70 93 222579 47779 70657993
Pyelonephritis chronic 12.61 9.70 9 222663 278 70705494
Thirst 12.60 9.70 84 222588 14565 70691207
Stupor 12.58 9.70 47 222625 6462 70699310
Cardiac death 12.57 9.70 19 222653 1444 70704328
Drug level increased 12.50 9.70 172 222500 36297 70669475
Bipolar II disorder 12.50 9.70 10 222662 368 70705404
Pelvic fracture 12.50 9.70 69 222603 11192 70694580
Adjusted calcium decreased 12.49 9.70 8 222664 206 70705566
Tobacco user 12.46 9.70 13 222659 677 70705095
Stoma site infection 12.46 9.70 18 222654 1314 70704458
Hypokalaemia 12.43 9.70 517 222155 130671 70575101
Peripheral circulatory failure 12.42 9.70 16 222656 1047 70704725
Azoospermia 12.41 9.70 7 222665 142 70705630
Swollen tongue 12.41 9.70 174 222498 36872 70668900
Skin laceration 12.36 9.70 130 222542 25748 70680024
Melaena 12.35 9.70 247 222425 56108 70649664
Phobia 12.34 9.70 10 222662 375 70705397
Antisocial behaviour 12.29 9.70 12 222660 577 70705195
Throat irritation 12.25 9.70 63 222609 35241 70670531
Creatinine renal clearance decreased 12.25 9.70 22 222650 17178 70688594
Maternal exposure during breast feeding 12.24 9.70 24 222648 2250 70703522
Bisexuality 12.23 9.70 3 222669 3 70705769
Cervix haematoma uterine 12.23 9.70 3 222669 3 70705769
Antidepressant drug level below therapeutic 12.23 9.70 3 222669 3 70705769
Cholecystectomy 12.21 9.70 56 222616 8441 70697331
Facial paralysis 12.19 9.70 105 222567 19703 70686069
Gastrointestinal mucosal exfoliation 12.19 9.70 8 222664 215 70705557
Marital problem 12.16 9.70 8 222664 216 70705556
Shock haemorrhagic 12.15 9.70 24 222648 18082 70687690
Anaphylactic reaction 12.13 9.70 164 222508 74810 70630962
Hypoxia 12.11 9.70 213 222459 93131 70612641
Electrocardiogram QT interval abnormal 12.10 9.70 9 222663 297 70705475
Hypocoagulable state 12.08 9.70 22 222650 1951 70703821
Pleurisy 11.99 9.70 8 222664 9791 70695981
Wrong patient received product 11.90 9.70 36 222636 4444 70701328
Hypoxic-ischaemic encephalopathy 11.90 9.70 50 222622 7258 70698514
Myositis 11.90 9.70 23 222649 17466 70688306
Hepatitis fulminant 11.87 9.70 3 222669 6578 70699194
Hepatotoxicity 11.85 9.70 85 222587 43901 70661871
Anaphylactic shock 11.83 9.70 57 222615 32433 70673339
Pemphigoid 11.83 9.70 16 222656 14006 70691766
Hepatic steatosis 11.81 9.70 160 222512 33653 70672119
Cardiac failure chronic 11.76 9.70 9 222663 10260 70695512
Male orgasmic disorder 11.75 9.70 5 222667 53 70705719
Feeling guilty 11.73 9.70 14 222658 847 70704925
JC virus CSF test positive 11.71 9.70 7 222665 159 70705613
Hyperthermia 11.68 9.70 91 222581 16580 70689192
Somatic symptom disorder 11.63 9.70 22 222650 2008 70703764
Blood osmolarity decreased 11.63 9.70 17 222655 1254 70704518
Arrhythmia 11.62 9.70 244 222428 55899 70649873
Drug ineffective for unapproved indication 11.62 9.70 72 222600 38466 70667306
Teratogenicity 11.56 9.70 8 222664 235 70705537
Osteoporosis 11.55 9.70 98 222574 48809 70656963
Accommodation disorder 11.53 9.70 11 222661 514 70705258
Detoxification 11.53 9.70 6 222666 103 70705669
Autoscopy 11.50 9.70 5 222667 56 70705716
Unintentional medical device removal 11.48 9.70 4 222668 7120 70698652
Poor personal hygiene 11.48 9.70 11 222661 517 70705255
Injection site pruritus 11.44 9.70 74 222598 39136 70666636
Decreased appetite 11.44 9.70 813 221859 303967 70401805
Drug dose titration not performed 11.44 9.70 13 222659 746 70705026
Psychogenic seizure 11.43 9.70 21 222651 1875 70703897
Dermatitis exfoliative generalised 11.43 9.70 3 222669 6411 70699361
Device related infection 11.41 9.70 57 222615 32128 70673644
Neuroglycopenia 11.36 9.70 10 222662 421 70705351
Peritoneal perforation 11.33 9.70 7 222665 169 70705603
Product substitution issue 11.33 9.70 98 222574 18415 70687357
Social problem 11.30 9.70 17 222655 1287 70704485
Affective disorder 11.28 9.70 50 222622 7429 70698343
Exposure to allergen 11.24 9.70 8 222664 246 70705526
Mobility decreased 11.24 9.70 242 222430 102757 70603015
Adjusted calcium increased 11.20 9.70 5 222667 60 70705712
Spermatozoa progressive motility decreased 11.20 9.70 5 222667 60 70705712
Therapy cessation 11.18 9.70 61 222611 33615 70672157
Blood ethanol increased 11.18 9.70 12 222660 646 70705126
Stress 11.17 9.70 286 222386 67680 70638092
Akinesia 11.14 9.70 28 222644 3103 70702669
Persistent depressive disorder 11.13 9.70 15 222657 1026 70704746
Diffuse large B-cell lymphoma stage II 11.08 9.70 6 222666 112 70705660
Nephropathy 11.08 9.70 7 222665 8818 70696954
Hypervolaemia 11.05 9.70 76 222596 39630 70666142
Gastrointestinal sounds abnormal 11.03 9.70 38 222634 5023 70700749
Alcoholic psychosis 11.02 9.70 3 222669 6 70705766
Bulimia nervosa 10.97 9.70 8 222664 256 70705516
Peripheral ischaemia 10.92 9.70 7 222665 8751 70697021
Oropharyngeal pain 10.88 9.70 225 222447 96085 70609687
Stiff person syndrome 10.87 9.70 9 222663 348 70705424
Macular degeneration 10.87 9.70 5 222667 7523 70698249
Injection site swelling 10.86 9.70 85 222587 43072 70662700
Pneumothorax 10.84 9.70 43 222629 25803 70679969
Pyelonephritis 10.82 9.70 26 222646 18263 70687509
Amniorrhexis 10.72 9.70 4 222668 29 70705743
Eye haematoma 10.67 9.70 6 222666 121 70705651
Drug dispensed to wrong patient 10.64 9.70 11 222661 567 70705205
Cellulitis 10.63 9.70 233 222439 98695 70607077
Extensor plantar response 10.63 9.70 19 222653 1661 70704111
Carbon monoxide poisoning 10.62 9.70 8 222664 269 70705503
Cardiac tamponade 10.54 9.70 7 222665 8588 70697184
Feeling of body temperature change 10.51 9.70 37 222635 4942 70700830
Affect lability 10.49 9.70 61 222611 10085 70695687
Reflexes abnormal 10.48 9.70 13 222659 819 70704953
Tendonitis 10.47 9.70 35 222637 22087 70683685
Clostridium difficile infection 10.46 9.70 75 222597 38741 70667031
Atrial flutter 10.44 9.70 31 222641 20296 70685476
Inguinal mass 10.41 9.70 7 222665 196 70705576
Acute hepatic failure 10.40 9.70 48 222624 27624 70678148
Therapeutic product effect variable 10.38 9.70 19 222653 1691 70704081
Thrombotic stroke 10.33 9.70 12 222660 705 70705067
Ocular hyperaemia 10.33 9.70 41 222631 24598 70681174
Anaesthesia 10.33 9.70 10 222662 476 70705296
Borderline personality disorder 10.30 9.70 13 222659 833 70704939
Agonal rhythm 10.27 9.70 5 222667 74 70705698
Angiodermatitis 10.27 9.70 5 222667 74 70705698
Vitreous floaters 10.25 9.70 45 222627 6659 70699113
Biliary dyskinesia 10.21 9.70 23 222649 2376 70703396
Chronic sinusitis 10.21 9.70 7 222665 8444 70697328
Slow response to stimuli 10.20 9.70 19 222653 1714 70704058
Neoplasm malignant 10.18 9.70 51 222621 28723 70677049
Genito-pelvic pain/penetration disorder 10.17 9.70 3 222669 9 70705763
Hepatocellular injury 10.16 9.70 94 222578 45997 70659775
Infective pulmonary exacerbation of cystic fibrosis 10.13 9.70 14 222658 12144 70693628
Coronary artery bypass 10.11 9.70 3 222669 5917 70699855
Conversion disorder 10.09 9.70 19 222653 1729 70704043
Heterophoria 10.07 9.70 4 222668 35 70705737
Tricuspid valve incompetence 10.02 9.70 26 222646 17791 70687981
Priapism 9.97 9.70 32 222640 4078 70701694
Heavy menstrual bleeding 9.93 9.70 71 222601 12594 70693178
Colour blindness 9.90 9.70 9 222663 395 70705377
Miosis 9.89 9.70 77 222595 14024 70691748
Scleroedema 9.88 9.70 4 222668 37 70705735
Respiratory disorder 9.87 9.70 77 222595 39046 70666726
Fibrous histiocytoma 9.87 9.70 11 222661 618 70705154
Coagulation factor increased 9.86 9.70 5 222667 81 70705691
Breast cancer female 9.86 9.70 11 222661 10475 70695297
Pneumonia fungal 9.85 9.70 10 222662 9943 70695829
Lung neoplasm malignant 9.85 9.70 42 222630 24700 70681072
Haemoglobin decreased 9.83 9.70 535 222137 204624 70501148
Vaginal discharge 9.80 9.70 34 222638 4509 70701263
Pulmonary hypertension 9.79 9.70 96 222576 46440 70659332
HIV peripheral neuropathy 9.78 9.70 4 222668 38 70705734
Cardiomegaly 9.78 9.70 119 222553 24426 70681346
Benign prostatic hyperplasia 9.77 9.70 11 222661 10432 70695340
Emotional poverty 9.77 9.70 12 222660 748 70705024
Pupillary light reflex tests abnormal 9.76 9.70 8 222664 305 70705467
Allergic sinusitis 9.74 9.70 10 222662 511 70705261
Granulocytopenia 9.73 9.70 62 222610 10585 70695187
Trisomy 18 9.70 9.70 5 222667 84 70705688

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cryptorchism 34.98 29.56 38 1433 371 87950
Respiratory disorder neonatal 34.30 29.56 80 1391 1586 86735

Pharmacologic Action:

SourceCodeDescription
ATC N06AB04 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Selective serotonin reuptake inhibitors
FDA MoA N0000000109 Serotonin Uptake Inhibitors
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50949 SSRI
CHEBI has role CHEBI:76779 post-proline endopeptidase inhibitors
CHEBI has role CHEBI:77402 EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
FDA EPC N0000175696 Serotonin Reuptake Inhibitor
MeSH PA D000928 Antidepressive Agents
MeSH PA D018687 Antidepressive Agents, Second-Generation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Generalized anxiety disorder indication 21897009 DOID:14320
Depressive disorder indication 35489007
Major depressive disorder indication 370143000
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Obsessive-compulsive disorder off-label use 191736004 DOID:10933
Menopausal flushing off-label use 198436008
Panic disorder off-label use 371631005 DOID:594
Suicidal thoughts contraindication 6471006
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Torsades de pointes contraindication 31722008
Upper gastrointestinal hemorrhage contraindication 37372002
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Heart disease contraindication 56265001 DOID:114
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Epilepsy contraindication 84757009 DOID:1826
Hyponatremia contraindication 89627008
Prolonged QT interval contraindication 111975006
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Serotonin syndrome contraindication 371089000
Myocardial infarction in recovery phase contraindication 418044006
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005
Congenital long QT syndrome contraindication 442917000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Kd 8.94 WOMBAT-PK CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.40 WOMBAT-PK
Sodium-dependent noradrenaline transporter Transporter Ki 5.21 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 5.19 PDSP
5-hydroxytryptamine receptor 2B GPCR Ki 5.93 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.21 WOMBAT-PK
Histamine H1 receptor GPCR Ki 6.46 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 5.88 PDSP
Sodium-dependent dopamine transporter Transporter Ki 4.78 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 6.15 DRUG MATRIX
Acetylcholinesterase Enzyme IC50 4.13 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.73 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.78 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 5.74 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 5.76 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 4.30 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 8.82 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.03 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.54 CHEMBL
Transporter Transporter Ki 5.21 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 8.54 CHEMBL
Transporter Transporter Ki 5.23 CHEMBL
Sigma intracellular receptor 2 Unclassified Ki 5.27 CHEMBL

External reference:

IDSource
4021129 VUID
N0000148583 NUI
D00822 KEGG_DRUG
59729-32-7 SECONDARY_CAS_RN
221078 RXNORM
4021129 VANDF
4021130 VANDF
C0008845 UMLSCUI
CHEBI:3723 CHEBI
CHEMBL549 ChEMBL_ID
CHEMBL399730 ChEMBL_ID
DB00215 DRUGBANK_ID
CHEMBL1200781 ChEMBL_ID
D015283 MESH_DESCRIPTOR_UI
2771 PUBCHEM_CID
7547 IUPHAR_LIGAND_ID
4138 INN_ID
0DHU5B8D6V UNII
21814 MMSL
62559 MMSL
7486 MMSL
d04332 MMSL
005106 NDDF
005107 NDDF
116521005 SNOMEDCT_US
321986007 SNOMEDCT_US
372596005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0054-0062 SOLUTION 10 mg ORAL ANDA 27 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0054-0062 SOLUTION 10 mg ORAL ANDA 27 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0121-0848 SOLUTION 10 mg ORAL ANDA 32 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0121-1696 SOLUTION 20 mg ORAL ANDA 32 sections
Citalopram Human Prescription Drug Label 1 0185-0371 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Citalopram Human Prescription Drug Label 1 0185-0372 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Citalopram Human Prescription Drug Label 1 0185-0373 TABLET, FILM COATED 40 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6231 TABLET, FILM COATED 10 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6231 TABLET, FILM COATED 10 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6232 TABLET, FILM COATED 20 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6232 TABLET, FILM COATED 20 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6233 TABLET, FILM COATED 40 mg ORAL ANDA 39 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0378-6233 TABLET, FILM COATED 40 mg ORAL ANDA 39 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4010 TABLET, FILM COATED 10 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4010 TABLET, FILM COATED 10 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4020 TABLET, FILM COATED 20 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4020 TABLET, FILM COATED 20 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4040 TABLET, FILM COATED 40 mg ORAL NDA 35 sections
Celexa HUMAN PRESCRIPTION DRUG LABEL 1 0456-4040 TABLET, FILM COATED 40 mg ORAL NDA 35 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8022 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8022 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8023 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8023 TABLET, FILM COATED 20 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8141 TABLET, FILM COATED 40 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0615-8141 TABLET, FILM COATED 40 mg ORAL ANDA 31 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0713-4740 TABLET 10 mg ORAL ANDA 19 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0713-4741 TABLET 20 mg ORAL ANDA 19 sections
Citalopram HUMAN PRESCRIPTION DRUG LABEL 1 0713-4742 TABLET 40 mg ORAL ANDA 19 sections
Citalopram Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 1 0904-6084 TABLET 10 mg ORAL ANDA 25 sections
Citalopram Hydrobromide HUMAN PRESCRIPTION DRUG LABEL 1 0904-6084 TABLET 10 mg ORAL ANDA 25 sections