acetylcholine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 65 | 51-84-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 9, 1973 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | S01EB09 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Parasympathomimetics |
| CHEBI has role | CHEBI:35620 | vasodilator agent |
| CHEBI has role | CHEBI:38325 | muscarinic agonist |
| FDA EPC | N0000175884 | Cholinergic Receptor Agonist |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D018679 | Cholinergic Agonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D014665 | Vasodilator Agents |
Drug Use (View source of the data)
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M3 | GPCR | AGONIST | EC50 | 6.66 | CHEMBL | CHEMBL | |||
| Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | Ki | 5.10 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha4/beta2 | Ion channel | EC50 | 5.80 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M5 | GPCR | EC50 | 6.10 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M1 | GPCR | EC50 | 6.11 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M4 | GPCR | AGONIST | Ki | 5.60 | IUPHAR | ||||
| Muscarinic acetylcholine receptor M2 | GPCR | AGONIST | Ki | 6.50 | IUPHAR | ||||
| Acetylcholine receptor subunit delta | Ion channel | Ki | 7.37 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-7 | Ion channel | Ki | 5.45 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha4/beta2 | Ion channel | Ki | 8.12 | CHEMBL | |||||
| Nicotinic acetylcholine receptor alpha8 subunit | Unclassified | EC50 | 4.94 | CHEMBL | |||||
| Muscarinic acetylcholine receptor | GPCR | IC50 | 7.92 | CHEMBL | |||||
| Acetylcholine-binding protein | Unclassified | Ki | 5.50 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha3/beta2 | Ion channel | Ki | 7.39 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha3/beta4 | Ion channel | Ki | 6.21 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha2/beta2 | Ion channel | Ki | 7.96 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha4/beta4 | Ion channel | Ki | 7.24 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D000109 | MESH_DESCRIPTOR_UI |
| 4019594 | VUID |
| N0000147690 | NUI |
| C0001041 | UMLSCUI |
| D00999 | KEGG_DRUG |
| 13525006 | SNOMEDCT_US |
| 4019594 | VANDF |
| 194 | RXNORM |
| 57308006 | SNOMEDCT_US |
| 004684 | NDDF |
| AF73293C2R | UNII |
| 438 | INN_ID |
| 60-31-1 | SECONDARY_CAS_RN |
| 187 | PUBCHEM_CID |
| CHEBI:15355 | CHEBI |
| CHEMBL667 | ChEMBL_ID |
| CHEMBL1184 | ChEMBL_ID |
| ACH | PDB_CHEM_ID |
| DB03128 | DRUGBANK_ID |
| 294 | IUPHAR_LIGAND_ID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Miochol E | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-539 | KIT | 20 mg | None | NDA | 12 sections |