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flurpiridaz F-18 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5861 | 863887-89-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Flurpiridaz F 18 is an analog of the mitochondrial complex 1 (MC-1) inhibitor, pyridaben. Flurpiridaz F 18 is extracted by the myocardium proportional to the blood flow and binds to heart tissue that has biologically active mitochondria. Therefore, radioactivity in viable myocardium is higher than in infarcted tissue.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 27, 2024 | FDA | GE HealthCare |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V09GX06 | VARIOUS DIAGNOSTIC RADIOPHARMACEUTICALS CARDIOVASCULAR SYSTEM Other cardiovascular system diagnostic radiopharmaceuticals |
| FDA MoA | N0000175869 | Positron Emitting Activity |
| FDA EPC | N0000177914 | Radioactive Diagnostic Agent |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
Related Drugs by ATC class:
V09GX Other cardiovascular system diagnostic radiopharmaceuticals 2 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Positron emission tomography for myocardial perfusion imaging | indication | 82918005 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 5-55mCi/ML | FLYRCADO | GE HLTHCARE | N215168 | Sept. 27, 2024 | RX | SOLUTION | INTRAVENOUS | 9161997 | Feb. 4, 2026 | METHOD OF POSITRON EMISSION TOMOGRAPHY (PET) FOR CARDIAC IMAGING |
| 5-55mCi/ML | FLYRCADO | GE HLTHCARE | N215168 | Sept. 27, 2024 | RX | SOLUTION | INTRAVENOUS | 8226929 | June 21, 2028 | METHOD OF POSITRON EMISSION TOMOGRAPHY (PET) FOR CARDIAC IMAGING |
| 5-55mCi/ML | FLYRCADO | GE HLTHCARE | N215168 | Sept. 27, 2024 | RX | SOLUTION | INTRAVENOUS | 9603951 | May 2, 2031 | METHOD OF POSITRON EMISSION TOMOGRAPHY (PET) FOR CARDIAC IMAGING |
| 5-55mCi/ML | FLYRCADO | GE HLTHCARE | N215168 | Sept. 27, 2024 | RX | SOLUTION | INTRAVENOUS | 8936777 | June 30, 2031 | METHOD OF POSITRON EMISSION TOMOGRAPHY (PET) FOR CARDIAC IMAGING |
| 5-55mCi/ML | FLYRCADO | GE HLTHCARE | N215168 | Sept. 27, 2024 | RX | SOLUTION | INTRAVENOUS | 9687571 | Nov. 1, 2032 | METHOD OF POSITRON EMISSION TOMOGRAPHY (PET) FOR CARDIAC IMAGING |
| 5-55mCi/ML | FLYRCADO | GE HLTHCARE | N215168 | Sept. 27, 2024 | RX | SOLUTION | INTRAVENOUS | 12527884 | May 13, 2042 | METHOD OF POSITRON EMISSION TOMOGRAPHY (PET) FOR CARDIAC DISEASES |
Orange Book exclusivity data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
|---|---|---|---|---|---|---|---|---|---|
| 5-55mCi/ML | FLYRCADO | GE HLTHCARE | N215168 | Sept. 27, 2024 | RX | SOLUTION | INTRAVENOUS | Sept. 27, 2029 | NEW CHEMICAL ENTITY |
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mitochondrial complex I (NADH dehydrogenase) | Enzyme | OTHER | IC50 | 7.78 | DRUG LABEL | DRUG LABEL |
External reference:
| ID | Source |
|---|---|
| CHEMBL2107799 | ChEMBL_ID |
| C525920 | MESH_SUPPLEMENTAL_RECORD_UI |
| C5419355 | UMLSCUI |
| CHEBI:752868 | CHEBI |
| 9248 | INN_ID |
| 11405965 | PUBCHEM_CID |
| TY3V24C029 | UNII |
| 2700762 | RXNORM |
| D10009 | KEGG_DRUG |
| 389546 | MMSL |
| 43227 | MMSL |
| d10225 | MMSL |
| 019872 | NDDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Flyrcado | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0407-8787 | INJECTION | 55 mCi | INTRAVENOUS | NDA | 25 sections |
| Flyrcado | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0407-8787 | INJECTION | 55 mCi | INTRAVENOUS | NDA | 25 sections |