Explore drug information in your own words.
Type a question in the search bar above to get started. Each question is answered independently.
Select a question to fill the search bar, then submit it or edit it first.
AI can make mistakes. Verify answers against the original sources before relying on them.
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5794 | None |
| Molecule | Description |
|---|---|
|
Synonyms:
|
Lerodalcibep-liga is a recombinant fusion protein that binds PCSK9 with picomolar affinity. PCSK9 binds to low-density lipoprotein receptor (LDLR) on the surface of hepatocytes to promote LDLR degradation within the liver. By inhibiting the binding of PCSK9 to LDLR, lerodalcibep-liga increases the number of LDLRs available to clear LDL-C from the blood, thereby lowering LDL-C levels.
|
None
None
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 12, 2025 | FDA | LIB Therapeutics, Inc. |
None
None
None
None
| Source | Code | Description |
|---|---|---|
| ATC | C10AX19 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, PLAIN Other lipid modifying agents |
| MeSH PA | D000091362 | PCSK9 Inhibitors |
| MeSH PA | D000924 | Anticholesteremic Agents |
| MeSH PA | D000960 | Hypolipidemic Agents |
| MeSH PA | D000963 | Antimetabolites |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011480 | Protease Inhibitors |
| MeSH PA | D015842 | Serine Proteinase Inhibitors |
| MeSH PA | D057847 | Lipid Regulating Agents |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| CHEBI has role | CHEBI:35821 | anticholesteremic drug |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Familial hypercholesterolemia - heterozygous | indication | 238079002 |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Proprotein convertase subtilisin/kexin type 9 | Enzyme | ANTAGONIST | Kd | 10.22 | DRUG LABEL | DRUG LABEL |
| ID | Source |
|---|---|
| 4044629 | VANDF |
| 4044630 | VANDF |
| C6056818 | UMLSCUI |
| CHEBI:758294 | CHEBI |
| CHEMBL4650405 | ChEMBL_ID |
| 2250073-78-8 | SECONDARY_CAS_RN |
| 44600 | MMSL |
| d10356 | MMSL |
| 020317 | NDDF |
| 14319 | IUPHAR_LIGAND_ID |
| 11209 | INN_ID |
| 2729426 | RXNORM |
| C000731963 | MESH_SUPPLEMENTAL_RECORD_UI |
| D13095 | KEGG_DRUG |
| 1PHP3QG5PZ | UNII |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| LEROCHOL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 84685-300 | INJECTION, SOLUTION | 300 mg | SUBCUTANEOUS | BLA | 28 sections |