cefaloglycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 572 3577-01-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cephaloglycin
  • cefaloglycin
  • cefaloglycine
  • cephaloglycine
  • kefglycin
  • kafocin
A cephalorsporin antibiotic.
  • Molecular weight: 405.43
  • Formula: C18H19N3O6S
  • CLOGP: -2.56
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 3
  • TPSA: 139.03
  • ALOGS: -3.44
  • ROTB: 7
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.808 Moderate 0.75
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.796 Moderate 0.75
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.182 10^-6 cm/s Moderate 0.75
dh-clint Dog hepatocyte intrinsic clearance 2.339 uL/min/10^6 cells Moderate 0.75
dppb Dog plasma protein binding (% unbound) 83.530 % Moderate 0.75
fcs-ppb Fetal calf serum protein binding (% unbound) 63.690 % Moderate 0.75
herg hERG pIC50 4.410 pIC50 Moderate 0.75
hh-clint Human hepatocyte intrinsic clearance 2.535 uL/min/10^6 cells Moderate 0.75
hlm-clint Human liver microsomal intrinsic clearance 5.321 uL/min/mg protein Moderate 0.75
hppb Human plasma protein binding (% unbound) 68.180 % Moderate 0.75
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GRK3,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,NTRK2,PDK1,PDK2,PIK3CB,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK 43
kinase-selectivity-class AXL,BRAF,CDK9,DYRK1B,EIF2AK3,EPHB4,GRK2,MAP2K6,MAPK7,PDK4,STK33,SYK,TEK,TGFBR1 14
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.637 Moderate 0.70
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.568 Moderate 0.75
mh-clint Mouse hepatocyte intrinsic clearance 8.492 Moderate 0.75
mppb Mouse plasma protein binding (% unbound) 76.020 Moderate 0.75
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.885 Moderate 0.75
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 53.910 % Moderate 0.75
rat-kpuu-brain Rat brain Kpuu 0.008 % Moderate 0.70
rh-clint Rat hepatocyte intrinsic clearance 6.138 uL/min/10^6 cells Moderate 0.75
rh-fuinc Rat hepatocyte fraction unbound in incubation 88.950 % Moderate 0.75
rppb Rat plasma protein binding (% unbound) 57.370 % Moderate 0.75
solubility-dd Solubility at pH 7.4 in DMSO 1000 uM Moderate 0.75

Approvals:

DateAgencyCompanyOrphan
June 12, 1970 FDA LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
CHEBI has role CHEBI:33281 antimicrobial agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.39 acidic
pKa2 13.53 acidic
pKa3 7.67 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Bacterial penicillin-binding protein Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
D01949 KEGG_DRUG
22202-75-1 SECONDARY_CAS_RN
CHEMBL1200971 ChEMBL_ID
12193 IUPHAR_LIGAND_ID
DB00689 DRUGBANK_ID
002714 NDDF
39123009 SNOMEDCT_US
C0007721 UMLSCUI
D002507 MESH_DESCRIPTOR_UI
CHEBI:34613 CHEBI
19150 PUBCHEM_CID
NE7R11LA95 UNII

Pharmaceutical products:

None