celecoxib ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
selective cyclo-oxygenase inhibitors 568 169590-42-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • celecoxib
  • celebrex
  • celecox
  • celocoxib
  • onsenal
A pyrazole derivative and selective CYCLOOXYGENASE 2 INHIBITOR that is used to treat symptoms associated with RHEUMATOID ARTHRITIS; OSTEOARTHRITIS and JUVENILE ARTHRITIS, as well as the management of ACUTE PAIN.
  • Molecular weight: 381.37
  • Formula: C17H14F3N3O2S
  • CLOGP: 4.57
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 77.98
  • ALOGS: -4.88
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 17.49 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
fu (Fraction unbound in plasma) 0.00 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 1998 FDA GD SEARLE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1672.90 10.11 3409 210774 307278 62967561
Rheumatoid arthritis 545.77 10.11 1988 212195 251831 63023008
Arthralgia 447.14 10.11 3366 210817 566344 62708495
Musculoskeletal stiffness 443.07 10.11 1500 212683 183118 63091721
Drug ineffective 386.33 10.11 5281 208902 1039484 62235355
Death 367.01 10.11 434 213749 373947 62900892
Ankylosing spondylitis 332.99 10.11 279 213904 10195 63264644
Toxicity to various agents 280.08 10.11 253 213930 246997 63027842
Fibromyalgia 256.47 10.11 722 213461 79698 63195141
Loss of personal independence in daily activities 245.08 10.11 804 213379 96486 63178353
Completed suicide 234.18 10.11 99 214084 145574 63129265
Pain in extremity 221.52 10.11 1890 212293 329596 62945243
C-reactive protein abnormal 215.63 10.11 479 213704 45617 63229222
Neutropenia 207.91 10.11 171 214012 174834 63100005
Condition aggravated 198.88 10.11 2152 212031 400065 62874774
Rheumatoid nodule 194.64 10.11 264 213919 16891 63257948
Maternal exposure during pregnancy 188.89 10.11 281 213902 219781 63055058
Psoriatic arthropathy 185.39 10.11 704 213479 90816 63184023
Febrile neutropenia 172.70 10.11 92 214091 118357 63156482
Drug abuse 172.20 10.11 21 214162 72497 63202342
Therapeutic product effect incomplete 170.57 10.11 854 213329 124202 63150637
Therapeutic product effect decreased 169.91 10.11 1175 213008 192012 63082827
Drug intolerance 155.88 10.11 1659 212524 307002 62967837
Exposure during pregnancy 153.51 10.11 179 214004 155368 63119471
Gait inability 152.00 10.11 458 213725 52501 63222338
Thrombocytopenia 149.11 10.11 174 214009 150983 63123856
Pulmonary toxicity 141.41 10.11 167 214016 9288 63265551
Joint swelling 138.38 10.11 1701 212482 325965 62948874
Osteoarthritis 136.32 10.11 660 213523 94683 63180156
Intentional overdose 133.31 10.11 42 214141 74110 63200729
Pain 132.95 10.11 3351 210832 737277 62537562
Neoplasm malignant 130.40 10.11 302 213881 29559 63245280
Bedridden 129.85 10.11 173 214010 10878 63263961
Lower limb fracture 128.57 10.11 265 213918 23956 63250883
Arthritis 122.67 10.11 739 213444 115182 63159657
Hyponatraemia 122.44 10.11 118 214065 111782 63163057
Gait disturbance 120.28 10.11 1041 213142 182137 63092702
Dyspnoea 119.80 10.11 1544 212639 659769 62615070
Hypotension 119.07 10.11 494 213689 272110 63002729
Acute kidney injury 118.41 10.11 472 213711 262943 63011896
International normalised ratio fluctuation 115.89 10.11 83 214100 2395 63272444
C-reactive protein increased 114.77 10.11 626 213557 94081 63180758
Anaemia 111.89 10.11 559 213624 292871 62981968
Joint injury 110.87 10.11 282 213901 29290 63245549
Ulcer 110.68 10.11 261 213922 25846 63248993
Foot deformity 107.97 10.11 269 213914 27584 63247255
Contraindicated product administered 107.48 10.11 1165 213018 216483 63058356
Musculoskeletal pain 106.52 10.11 602 213581 91675 63183164
Hypoaesthesia 105.88 10.11 948 213235 167445 63107394
Mobility decreased 105.87 10.11 736 213447 120423 63154416
Red blood cell sedimentation rate abnormal 105.67 10.11 217 213966 19565 63255274
Drug tolerance 104.35 10.11 123 214060 6826 63268013
Pharyngitis 104.12 10.11 218 213965 19925 63254914
Toothache 100.66 10.11 209 213974 18990 63255849
Inflammation 98.45 10.11 542 213641 81731 63193108
Disease progression 98.36 10.11 164 214019 122594 63152245
Electrocardiogram QT prolonged 97.97 10.11 39 214144 59491 63215348
Gastric disorder 97.79 10.11 313 213870 37056 63237783
Thyroid neoplasm 97.73 10.11 92 214091 3927 63270912
Prescribed overdose 96.70 10.11 294 213889 33859 63240980
Pyrexia 94.33 10.11 1074 213109 469404 62805435
Bone swelling 93.79 10.11 63 214120 1635 63273204
Pemphigus 91.82 10.11 315 213868 183411 63091428
Bloody discharge 91.61 10.11 60 214123 1491 63273348
Red blood cell sedimentation rate increased 91.22 10.11 341 213842 43641 63231198
Device expulsion 91.08 10.11 7 214176 34915 63239924
Nerve injury 90.73 10.11 138 214045 9808 63265031
Myocardial infarction 89.14 10.11 610 213573 99283 63175556
Immobile 88.92 10.11 105 214078 5838 63269001
Drug eruption 87.89 10.11 254 213929 28440 63246399
Foetal exposure during pregnancy 87.50 10.11 5 214178 31957 63242882
Pleural fibrosis 87.36 10.11 81 214102 3391 63271448
Gastrointestinal toxicity 86.10 10.11 118 214065 7623 63267216
White blood cell count abnormal 84.78 10.11 105 214078 6137 63268702
Foot fracture 84.46 10.11 223 213960 23691 63251148
Presbyacusis 84.28 10.11 73 214110 2792 63272047
Blood parathyroid hormone decreased 83.92 10.11 132 214051 9659 63265180
Osteoporosis 82.70 10.11 398 213785 56940 63217899
Arthropathy 80.40 10.11 1174 213009 233618 63041221
Confusional state 79.75 10.11 469 213714 235911 63038928
Treatment failure 79.04 10.11 1022 213161 198021 63076818
Seizure 76.47 10.11 213 213970 132421 63142418
Systemic lupus erythematosus rash 75.76 10.11 62 214121 2190 63272649
Therapeutic response decreased 75.40 10.11 408 213775 61117 63213722
Disability 75.15 10.11 181 214002 18166 63256673
Panniculitis 74.39 10.11 136 214047 11249 63263590
Pleural thickening 73.97 10.11 68 214115 2815 63272024
Suicide attempt 72.93 10.11 59 214124 60859 63213980
Blood magnesium increased 72.84 10.11 69 214114 2969 63271870
Enthesopathy 72.27 10.11 115 214068 8499 63266340
Granuloma skin 71.28 10.11 113 214070 8324 63266515
Sepsis 70.89 10.11 271 213912 152852 63121987
Premature delivery 68.94 10.11 10 214173 30271 63244568
Joint stiffness 68.04 10.11 301 213882 41568 63233271
Nephrolithiasis 67.61 10.11 301 213882 41683 63233156
Deformity 66.97 10.11 132 214051 11552 63263287
Tenosynovitis 66.35 10.11 145 214038 13650 63261189
Hypoglycaemia 64.92 10.11 64 214119 60001 63214838
Glossodynia 64.59 10.11 347 213836 178529 63096310
Dehydration 64.43 10.11 333 213850 173021 63101818
Abortion spontaneous 63.99 10.11 40 214143 47155 63227684
Systemic lupus erythematosus 63.50 10.11 428 213755 208490 63066349
Overdose 63.27 10.11 189 213994 114889 63159950
Syncope 60.85 10.11 198 213985 117187 63157652
Deafness neurosensory 60.13 10.11 78 214105 4777 63270062
Tachycardia 60.08 10.11 201 213982 117955 63156884
Psoriasis 60.07 10.11 500 213683 86457 63188382
Sacroiliitis 59.77 10.11 64 214119 3193 63271646
Intentional self-injury 59.61 10.11 8 214175 25679 63249160
Hypermobility syndrome 59.02 10.11 36 214147 787 63274052
Cardio-respiratory arrest 58.04 10.11 70 214113 59889 63214950
Lyme disease 56.75 10.11 64 214119 3385 63271454
Mucosal inflammation 56.74 10.11 45 214138 46883 63227956
Hypokalaemia 56.69 10.11 171 214012 103633 63171206
Skin necrosis 56.47 10.11 137 214046 13813 63261026
Intervertebral disc degeneration 55.85 10.11 147 214036 15585 63259254
Neck pain 55.26 10.11 412 213771 68906 63205933
Rotator cuff syndrome 55.08 10.11 133 214050 13369 63261470
Impaired work ability 54.78 10.11 156 214027 17319 63257520
Bunion operation 54.42 10.11 41 214142 1281 63273558
Sopor 53.65 10.11 6 214177 22158 63252681
Metabolic acidosis 53.51 10.11 44 214139 45025 63229814
Pulmonary fibrosis 52.90 10.11 270 213913 39539 63235300
Neuropathy peripheral 52.71 10.11 201 213982 113466 63161373
Intervertebral disc protrusion 52.68 10.11 188 213995 23521 63251318
Joint range of motion decreased 52.59 10.11 233 213950 32195 63242644
Anaphylactic reaction 52.20 10.11 392 213791 65708 63209131
Pancytopenia 51.99 10.11 161 214022 96772 63178067
Loss of employment 51.96 10.11 50 214133 2194 63272645
Spinal osteoarthritis 51.23 10.11 145 214038 16041 63258798
Skin ulcer 51.09 10.11 283 213900 42762 63232077
Cardiac arrest 50.86 10.11 152 214031 92393 63182446
Epigastric discomfort 50.78 10.11 86 214097 6694 63268145
Deep vein thrombosis postoperative 50.75 10.11 116 214067 11253 63263586
Musculoskeletal disorder 50.49 10.11 169 214014 20475 63254364
Platelet count decreased 50.26 10.11 211 213972 115911 63158928
Interstitial lung disease 49.94 10.11 369 213814 61539 63213300
Encephalopathy 49.30 10.11 35 214148 38585 63236254
Cognitive disorder 49.06 10.11 70 214113 55745 63219094
Malignant neoplasm progression 48.73 10.11 130 214053 81991 63192848
Multiple organ dysfunction syndrome 48.10 10.11 73 214110 56679 63218160
Bone cyst 48.05 10.11 48 214135 2206 63272633
Therapy non-responder 48.00 10.11 428 213755 75473 63199366
Respiratory failure 47.95 10.11 179 214004 101679 63173160
Constipation 47.13 10.11 508 213675 224435 63050404
Alopecia 47.10 10.11 828 213355 336708 62938131
Movement disorder 46.63 10.11 170 214013 21491 63253348
Antinuclear antibody positive 46.61 10.11 91 214092 7908 63266931
Bradycardia 46.48 10.11 112 214071 73115 63201724
Fear of injection 46.07 10.11 85 214098 7079 63267760
Investigation abnormal 46.05 10.11 44 214139 1914 63272925
Gastric ulcer 45.45 10.11 181 214002 23856 63250983
Osteopenia 44.92 10.11 158 214025 19627 63255212
Tendonitis 44.84 10.11 157 214026 19458 63255381
Anti-cyclic citrullinated peptide antibody positive 44.43 10.11 221 213962 115991 63158848
Peripheral swelling 44.07 10.11 1192 212991 264750 63010089
Sciatica 43.67 10.11 230 213953 34094 63240745
Burning mouth syndrome 43.58 10.11 25 214158 486 63274353
Sedation 43.51 10.11 40 214143 38769 63236070
Hypoxia 43.29 10.11 85 214098 59707 63215132
Osteosclerosis 42.84 10.11 59 214124 3829 63271010
Liver disorder 42.73 10.11 319 213864 53368 63221471
Somnolence 42.65 10.11 391 213792 178294 63096545
Infection 42.59 10.11 1043 213140 228130 63046709
Premature baby 42.50 10.11 9 214174 20726 63254113
Leukopenia 42.43 10.11 127 214056 77163 63197676
Pericarditis 41.75 10.11 266 213917 131313 63143526
Autoimmune disorder 41.46 10.11 140 214043 17037 63257802
Multiple sclerosis relapse 41.43 10.11 62 214121 48416 63226423
Nodule 41.10 10.11 160 214023 20866 63253973
Neutrophil count decreased 41.00 10.11 80 214103 56326 63218513
Basal cell carcinoma 40.86 10.11 195 213988 27796 63247043
Dry eye 40.64 10.11 256 213927 40505 63234334
Wound 40.39 10.11 354 213829 162909 63111930
Hunger 39.98 10.11 68 214115 5311 63269528
Fine motor skill dysfunction 39.91 10.11 64 214119 4761 63270078
Bursitis 39.69 10.11 237 213946 36804 63238035
Blood calcium decreased 39.33 10.11 20 214163 26431 63248408
Oedema 39.01 10.11 502 213681 97120 63177719
Product use in unapproved indication 38.89 10.11 401 213782 178679 63096160
Blood pressure systolic increased 38.50 10.11 283 213900 47114 63227725
Right ventricular failure 38.38 10.11 6 214177 17182 63257657
Epicondylitis 38.22 10.11 42 214141 2158 63272681
Tooth infection 38.04 10.11 140 214043 17780 63257059
Muscle spasticity 38.01 10.11 13 214170 21781 63253058
Dermatitis allergic 37.93 10.11 125 214058 15023 63259816
Grip strength decreased 37.56 10.11 162 214021 22125 63252714
Fracture 37.45 10.11 148 214035 19436 63255403
Pulmonary arterial hypertension 36.80 10.11 15 214168 22562 63252277
Multiple fractures 36.35 10.11 86 214097 8532 63266307
Alanine aminotransferase abnormal 36.24 10.11 59 214124 4445 63270394
Hospitalisation 35.95 10.11 156 214027 84925 63189914
Hepatotoxicity 35.92 10.11 231 213952 36810 63238029
Foot operation 35.91 10.11 77 214106 7154 63267685
Plasma cell myeloma 35.73 10.11 41 214142 35864 63238975
Sedation complication 35.40 10.11 3 214180 13819 63261020
Road traffic accident 35.25 10.11 228 213955 36404 63238435
Orthostatic hypotension 35.22 10.11 42 214141 36118 63238721
Joint effusion 35.14 10.11 132 214051 16928 63257911
Drug tolerance decreased 35.00 10.11 134 214049 17339 63257500
Cyst 34.99 10.11 116 214067 13983 63260856
Adjustment disorder with depressed mood 34.86 10.11 94 214089 10110 63264729
Hypervolaemia 34.66 10.11 27 214156 28386 63246453
Cholestasis 34.62 10.11 29 214154 29405 63245434
Device dislocation 34.55 10.11 22 214161 25683 63249156
Rheumatoid lung 34.54 10.11 53 214130 3795 63271044
Pharyngeal oedema 34.15 10.11 113 214070 13608 63261231
Cytomegalovirus infection 34.02 10.11 14 214169 20938 63253901
Tremor 33.92 10.11 284 213899 131955 63142884
Torsade de pointes 33.92 10.11 3 214180 13348 63261491
Tongue disorder 33.70 10.11 95 214088 10485 63264354
Dysstasia 33.51 10.11 151 214032 21015 63253824
White blood cell count decreased 33.35 10.11 304 213879 138800 63136039
Drug resistance 33.13 10.11 18 214165 22915 63251924
Pulmonary congestion 32.80 10.11 131 214052 17287 63257552
Oesophageal spasm 32.34 10.11 46 214137 3077 63271762
Acute myeloid leukaemia 32.11 10.11 9 214174 17138 63257701
Neutropenic sepsis 31.97 10.11 8 214175 16430 63258409
Blood cholesterol increased 31.27 10.11 468 213715 93564 63181275
Respiratory tract congestion 31.12 10.11 131 214052 17701 63257138
International normalised ratio increased 31.08 10.11 69 214114 46356 63228483
Synovial cyst 30.65 10.11 91 214092 10342 63264497
C-reactive protein 30.24 10.11 57 214126 4825 63270014
Fracture pain 30.19 10.11 23 214160 731 63274108
Osteomyelitis 30.16 10.11 170 214013 25850 63248989
Stress 30.12 10.11 353 213830 66814 63208025
Clostridium difficile colitis 29.92 10.11 16 214167 20553 63254286
Femur fracture 29.84 10.11 242 213941 41514 63233325
Gamma-glutamyltransferase increased 29.59 10.11 43 214140 33988 63240851
Red blood cell sedimentation rate 29.24 10.11 56 214127 4798 63270041
Palmar-plantar erythrodysaesthesia syndrome 29.19 10.11 21 214162 22994 63251845
Hyperglycaemia 29.04 10.11 61 214122 41806 63233033
Dislocation of vertebra 28.95 10.11 79 214104 8556 63266283
Fatigue 28.91 10.11 2592 211591 885436 62389403
Neoplasm progression 28.85 10.11 49 214134 36379 63238460
Spinal stenosis 28.71 10.11 113 214070 14812 63260027
Ascites 28.54 10.11 59 214124 40669 63234170
Product dose omission issue 28.28 10.11 589 213594 233724 63041115
Mental status changes 28.06 10.11 57 214126 39542 63235297
Limb discomfort 28.01 10.11 184 213999 29532 63245307
Creatinine renal clearance decreased 27.97 10.11 10 214173 16298 63258541
Epistaxis 27.96 10.11 138 214045 72587 63202252
Meniscus injury 27.87 10.11 69 214114 7045 63267794
Cytokine release syndrome 27.77 10.11 7 214176 14307 63260532
Tuberculosis 27.61 10.11 92 214091 11119 63263720
Asthenia 27.58 10.11 1037 213146 382567 62892272
Malaise 27.12 10.11 1687 212496 414267 62860572
Pulmonary embolism 26.68 10.11 258 213925 116426 63158413
Hepatic failure 26.41 10.11 50 214133 35606 63239233
Iritis 26.10 10.11 42 214141 3133 63271706
Acute respiratory failure 25.85 10.11 48 214135 34437 63240402
Respiratory arrest 25.77 10.11 44 214139 32601 63242238
Axial spondyloarthritis 25.52 10.11 16 214167 368 63274471
Pruritus allergic 25.43 10.11 29 214154 1553 63273286
Septic shock 25.29 10.11 127 214056 66502 63208337
Gastric ulcer haemorrhage 25.22 10.11 53 214130 4855 63269984
Uveitis 24.92 10.11 96 214087 12457 63262382
Cardiac failure 24.91 10.11 187 213996 88955 63185884
Diabetic ketoacidosis 24.36 10.11 20 214163 20485 63254354
Depressed level of consciousness 24.33 10.11 117 214066 61961 63212878
Tenosynovitis stenosans 24.31 10.11 42 214141 3322 63271517
Tuberculin test positive 24.29 10.11 43 214140 3468 63271371
Acute hepatic failure 24.20 10.11 16 214167 18311 63256528
Foetal death 24.14 10.11 4 214179 10976 63263863
Paranasal sinus inflammation 24.12 10.11 17 214166 478 63274361
Urticaria 24.07 10.11 731 213452 165071 63109768
Clostridium difficile infection 23.93 10.11 40 214143 29882 63244957
Tenderness 23.89 10.11 144 214039 22434 63252405
Device issue 23.83 10.11 27 214156 23754 63251085
Walking aid user 23.82 10.11 85 214098 10632 63264207
Full blood count decreased 23.50 10.11 32 214151 25992 63248847
COVID-19 23.43 10.11 256 213927 112847 63161992
Cardiogenic shock 23.22 10.11 16 214167 17916 63256923
Swollen joint count increased 23.14 10.11 204 213979 35850 63238989
Breast cyst excision 22.94 10.11 9 214174 70 63274769
Psychotic disorder 22.84 10.11 32 214151 25680 63249159
Blood bilirubin increased 22.63 10.11 58 214125 37082 63237757
Premature labour 22.61 10.11 7 214176 12497 63262342
Myelosuppression 22.59 10.11 28 214155 23675 63251164
Synovial fluid analysis 22.53 10.11 34 214149 2399 63272440
Spinal pain 22.52 10.11 96 214087 13043 63261796
Hepatocellular injury 22.46 10.11 36 214147 27345 63247494
Hepatic cytolysis 22.39 10.11 12 214171 15395 63259444
Lethargy 22.27 10.11 105 214078 55902 63218937
Progressive multifocal leukoencephalopathy 22.17 10.11 8 214175 12963 63261876
Joint prosthesis user 22.16 10.11 8 214175 48 63274791
Fall 22.07 10.11 1090 213093 391244 62883595
Back pain 21.82 10.11 1095 213088 263050 63011789
Posterior reversible encephalopathy syndrome 21.77 10.11 16 214167 17329 63257510
Urinary tract infection 21.65 10.11 704 213479 263980 63010859
Wrist deformity 21.51 10.11 31 214152 2099 63272740
Iron deficiency 21.18 10.11 63 214120 7167 63267672
Red blood cell count decreased 21.15 10.11 220 213963 40425 63234414
Wound infection 21.05 10.11 134 214049 21276 63253563
Blood glucose increased 20.97 10.11 181 214002 83575 63191264
Respiratory depression 20.95 10.11 10 214173 13705 63261134
Kidney infection 20.93 10.11 142 214041 23034 63251805
Poisoning 20.91 10.11 10 214173 13690 63261149
Pallor 20.81 10.11 45 214138 30523 63244316
Hip surgery 20.77 10.11 39 214144 3292 63271547
Allergy to chemicals 20.71 10.11 37 214146 3005 63271834
Hypertension 20.69 10.11 1146 213037 278157 62996682
Abdominal pain upper 20.54 10.11 872 213311 205572 63069267
Liver injury 20.42 10.11 302 213881 60218 63214621
Off label use 20.40 10.11 1979 212204 672483 62602356
Upper limb fracture 20.08 10.11 121 214062 18847 63255992
Gelatinous transformation of the bone marrow 20.03 10.11 5 214178 5 63274834
Tooth disorder 20.02 10.11 163 214020 27994 63246845
Coma 19.96 10.11 131 214052 64233 63210606
Colitis 19.88 10.11 90 214093 48438 63226401
Amblyopia 19.81 10.11 12 214171 259 63274580
Rash pruritic 19.63 10.11 297 213886 59502 63215337
Hepatic steatosis 19.63 10.11 165 214018 28604 63246235
Hyperkalaemia 19.62 10.11 105 214078 54098 63220741
Balance disorder 19.58 10.11 186 213997 84236 63190603
Pneumonia aspiration 19.50 10.11 56 214127 34484 63240355
Knee arthroplasty 19.28 10.11 273 213910 53933 63220906
Status epilepticus 19.19 10.11 14 214169 15219 63259620
Abdominal distension 19.18 10.11 193 213990 86422 63188417
Mass excision 19.17 10.11 13 214170 343 63274496
Disability assessment scale score increased 19.11 10.11 37 214146 3196 63271643
Myelodysplastic syndrome 19.10 10.11 17 214166 16737 63258102
Oesophageal pain 19.06 10.11 40 214143 3661 63271178
Pulmonary hypertension 18.96 10.11 63 214120 37060 63237779
Somatic symptom disorder 18.95 10.11 33 214150 2627 63272212
Haemodynamic instability 18.81 10.11 4 214179 9186 63265653
Vomiting 18.78 10.11 1629 212554 557988 62716851
Coeliac disease 18.55 10.11 10 214173 12787 63262052
Prescribed underdose 18.55 10.11 167 214016 29522 63245317
Chills 18.48 10.11 270 213913 113108 63161731
Respiratory distress 18.47 10.11 56 214127 33895 63240944
Hypersensitivity vasculitis 18.40 10.11 42 214141 4070 63270769
Pulmonary oedema 18.40 10.11 109 214074 54764 63220075
Generalised tonic-clonic seizure 17.92 10.11 45 214138 28971 63245868
Lymphocyte count decreased 17.87 10.11 48 214135 30209 63244630
Transplant rejection 17.84 10.11 7 214176 10773 63264066
Nail injury 17.80 10.11 16 214167 643 63274196
Back disorder 17.74 10.11 79 214104 10938 63263901
Infective pulmonary exacerbation of cystic fibrosis 17.72 10.11 4 214179 8813 63266026
Hyperbilirubinaemia 17.67 10.11 8 214175 11306 63263533
Metastases to liver 17.64 10.11 33 214150 23606 63251233
Dysarthria 17.62 10.11 79 214104 42632 63232207
Migraine 17.59 10.11 465 213718 102881 63171958
Hypercalcaemia 17.53 10.11 159 214024 28163 63246676
Suicidal ideation 17.41 10.11 131 214052 62290 63212549
Haematotoxicity 17.41 10.11 5 214178 9371 63265468
Thrombotic microangiopathy 17.24 10.11 7 214176 10554 63264285
Pneumonitis 17.16 10.11 61 214122 35161 63239678
Bone marrow oedema 16.90 10.11 21 214162 1231 63273608
Drug reaction with eosinophilia and systemic symptoms 16.89 10.11 58 214125 33778 63241061
Electrolyte imbalance 16.84 10.11 26 214157 20050 63254789
Myofascial pain syndrome 16.83 10.11 29 214154 2289 63272550
Ejection fraction decreased 16.82 10.11 31 214152 22301 63252538
Eosinophilia 16.77 10.11 32 214151 22724 63252115
Flushing 16.75 10.11 167 214016 74920 63199919
Epilepsy 16.70 10.11 42 214141 27023 63247816
Granuloma 16.69 10.11 50 214133 5711 63269128
Malignant melanoma 16.49 10.11 79 214104 11277 63263562
Presyncope 16.46 10.11 44 214139 27741 63247098
Muscle injury 16.45 10.11 141 214042 65204 63209635
Wrong technique in product usage process 16.38 10.11 133 214050 62207 63212632
Abortion induced 16.38 10.11 7 214176 10235 63264604
Scleritis 16.36 10.11 42 214141 4386 63270453
Caesarean section 16.36 10.11 20 214163 17012 63257827
Ankle arthroplasty 16.32 10.11 25 214158 1788 63273051
Accidental overdose 16.13 10.11 34 214149 23275 63251564
Hepatic encephalopathy 16.09 10.11 9 214174 11273 63263566
Inflammatory bowel disease 16.06 10.11 39 214144 3934 63270905
Mania 16.06 10.11 11 214172 12356 63262483
Cartilage injury 16.05 10.11 26 214157 1951 63272888
Rhabdomyolysis 15.99 10.11 85 214098 43866 63230973
Entropion 15.98 10.11 7 214176 74 63274765
Pleural effusion 15.89 10.11 220 213963 92990 63181849
Pregnancy 15.89 10.11 67 214116 36769 63238070
Drug interaction 15.87 10.11 622 213561 228509 63046330
Bronchitis 15.83 10.11 542 213641 124393 63150446
Synovial rupture 15.80 10.11 10 214173 234 63274605
Pneumonia 15.70 10.11 1327 212856 455440 62819399
Spondylolisthesis 15.69 10.11 36 214147 3500 63271339
Macular degeneration 15.69 10.11 37 214146 24339 63250500
No adverse event 15.67 10.11 79 214104 41326 63233513
Synovitis 15.66 10.11 776 213407 186142 63088697
Sciatic nerve neuropathy 15.60 10.11 12 214171 387 63274452
Musculoskeletal discomfort 15.58 10.11 109 214074 17858 63256981
Blood pressure diastolic abnormal 15.55 10.11 93 214090 14449 63260390
Brain oedema 15.48 10.11 15 214168 14180 63260659
Genital haemorrhage 15.41 10.11 3 214180 7329 63267510
Decreased appetite 15.38 10.11 691 213492 250361 63024478
Malignant polyp 15.38 10.11 9 214174 182 63274657
Unevaluable event 15.22 10.11 106 214077 51280 63223559
Chest discomfort 15.22 10.11 270 213913 109699 63165140
Body temperature increased 15.22 10.11 69 214114 37123 63237716
Anuria 15.21 10.11 12 214171 12539 63262300
Cerebral haemorrhage 15.12 10.11 53 214130 30676 63244163
Mydriasis 15.04 10.11 11 214172 11945 63262894
Injection related reaction 15.03 10.11 16 214167 793 63274046
Infusion related reaction 15.00 10.11 676 213507 244845 63029994
Oral herpes 14.95 10.11 144 214039 25930 63248909
Gastric perforation 14.90 10.11 23 214160 1656 63273183
Ventricular fibrillation 14.83 10.11 11 214172 11856 63262983
Hepatic cirrhosis 14.78 10.11 39 214144 24695 63250144
Dysphagia 14.77 10.11 210 213973 88375 63186464
Full blood count abnormal 14.75 10.11 56 214127 31661 63243178
Device leakage 14.71 10.11 3 214180 7093 63267746
Angina unstable 14.70 10.11 55 214128 7040 63267799
Blood potassium increased 14.68 10.11 109 214074 18200 63256639
Dystonia 14.61 10.11 15 214168 13804 63261035
Vitamin K deficiency 14.56 10.11 12 214171 428 63274411
Body height decreased 14.55 10.11 70 214113 10008 63264831
Insomnia 14.55 10.11 876 213307 214376 63060463
Osteogenesis imperfecta 14.46 10.11 14 214169 619 63274220
Circulatory collapse 14.36 10.11 33 214150 21905 63252934
Uterine perforation 14.32 10.11 3 214180 6960 63267879
Metastases to bone 14.26 10.11 31 214152 20988 63253851
Joint destruction 14.25 10.11 50 214133 6202 63268637
Polyneuropathy 14.15 10.11 17 214166 14572 63260267
Complication of device insertion 14.11 10.11 4 214179 7560 63267279
Dressler's syndrome 14.09 10.11 3 214180 0 63274839
Bone marrow failure 14.09 10.11 51 214132 29239 63245600
Bacteraemia 14.05 10.11 23 214160 17325 63257514
Hand deformity 14.03 10.11 420 213763 159037 63115802
Carpal tunnel syndrome 13.99 10.11 119 214064 20698 63254141
Tendon rupture 13.97 10.11 60 214123 8179 63266660
Ventricular tachycardia 13.95 10.11 29 214154 19950 63254889
Parkinsonism 13.94 10.11 9 214174 10430 63264409
Delusion 13.93 10.11 12 214171 12005 63262834
Device related infection 13.89 10.11 37 214146 23355 63251484
Left ventricular dysfunction 13.86 10.11 12 214171 11976 63262863
Aspergillus infection 13.82 10.11 5 214178 8088 63266751
Blood potassium decreased 13.82 10.11 84 214099 41942 63232897
Renal failure 13.81 10.11 297 213886 117355 63157484
Anaphylactic shock 13.79 10.11 131 214052 23502 63251337
Bronchomalacia 13.76 10.11 9 214174 223 63274616
Metabolic surgery 13.61 10.11 19 214164 1249 63273590
Diarrhoea 13.60 10.11 2163 212020 713203 62561636
Miosis 13.51 10.11 4 214179 7349 63267490
Type 2 diabetes mellitus 13.48 10.11 296 213887 63572 63211267
Hallucination, auditory 13.47 10.11 14 214169 12810 63262029
Klebsiella infection 13.47 10.11 6 214177 8560 63266279
Dry mouth 13.44 10.11 351 213832 77512 63197327
Pericardial effusion 13.38 10.11 54 214129 30004 63244835
Medulloblastoma 13.32 10.11 5 214178 34 63274805
Limb injury 13.30 10.11 138 214045 25339 63249500
Chondropathy 13.20 10.11 26 214157 2274 63272565
Enterococcal infection 13.14 10.11 5 214178 7843 63266996
Exostosis 13.02 10.11 104 214079 17758 63257081
Gestational diabetes 13.01 10.11 6 214177 8390 63266449
Glomerulonephritis minimal lesion 12.99 10.11 9 214174 246 63274593
Toxic epidermal necrolysis 12.93 10.11 43 214140 25291 63249548
Ulcer haemorrhage 12.91 10.11 44 214139 5378 63269461
Disorientation 12.89 10.11 79 214104 39373 63235466
Drug ineffective for unapproved indication 12.88 10.11 65 214118 33998 63240841
Agitation 12.88 10.11 134 214049 59623 63215216
Low birth weight baby 12.88 10.11 4 214179 7125 63267714
Gluten sensitivity 12.84 10.11 13 214170 607 63274232
Bone disorder 12.83 10.11 119 214064 21207 63253632
Synovial disorder 12.82 10.11 24 214159 2021 63272818
Knee operation 12.78 10.11 47 214136 5966 63268873
Blood lactic acid increased 12.76 10.11 4 214179 7082 63267757
Post procedural haemorrhage 12.74 10.11 57 214126 7907 63266932
Groin pain 12.72 10.11 68 214115 10135 63264704
Oculomucocutaneous syndrome 12.68 10.11 7 214176 126 63274713
Aggression 12.61 10.11 39 214144 23459 63251380
Parotid gland enlargement 12.57 10.11 15 214168 843 63273996
Patellofemoral pain syndrome 12.50 10.11 13 214170 627 63274212
Maternal exposure before pregnancy 12.48 10.11 5 214178 7598 63267241
Vertebral foraminal stenosis 12.41 10.11 16 214167 974 63273865
Tongue cancer recurrent 12.40 10.11 4 214179 16 63274823
Lip dry 12.35 10.11 92 214091 15378 63259461
Extrapyramidal disorder 12.34 10.11 16 214167 13268 63261571
Tumour necrosis factor receptor-associated periodic syndrome 12.21 10.11 6 214177 84 63274755
Dyskinesia 12.14 10.11 61 214122 31941 63242898
Retinitis 12.08 10.11 3 214180 6193 63268646
Dactylitis 12.05 10.11 27 214156 2585 63272254
Eye injury 12.04 10.11 29 214154 2910 63271929
Unintended pregnancy 12.03 10.11 3 214180 6176 63268663
Lip and/or oral cavity cancer 12.03 10.11 15 214168 883 63273956
Neuroprosthesis implantation 12.02 10.11 3 214180 3 63274836
Vascular graft infection 11.93 10.11 5 214178 47 63274792
Aphasia 11.90 10.11 64 214119 32936 63241903
Abnormal behaviour 11.90 10.11 35 214148 21391 63253448
Tubo-ovarian abscess 11.89 10.11 10 214173 367 63274472
Immunoglobulins decreased 11.89 10.11 18 214165 1274 63273565
Spondylitis 11.87 10.11 37 214146 4317 63270522
Impaired healing 11.79 10.11 440 213743 102102 63172737
Aplastic anaemia 11.79 10.11 9 214174 9560 63265279
Medication error 11.78 10.11 116 214067 52168 63222671
Hip arthroplasty 11.76 10.11 226 213957 47420 63227419
Emphysema 11.72 10.11 70 214113 10868 63263971
Febrile bone marrow aplasia 11.72 10.11 5 214178 7320 63267519
Adrenal suppression 11.68 10.11 15 214168 909 63273930
Therapy interrupted 11.67 10.11 63 214120 32392 63242447
Stenosis 11.64 10.11 19 214164 1435 63273404
Meningitis streptococcal 11.60 10.11 7 214176 150 63274689
Interferon gamma release assay positive 11.57 10.11 5 214178 51 63274788
Polyarthritis 11.57 10.11 66 214117 10080 63264759
Transfusion 11.57 10.11 21 214162 15196 63259643
Nasopharyngitis 11.55 10.11 1002 213181 253255 63021584
Sickle cell anaemia with crisis 11.52 10.11 3 214180 6000 63268839
Lithotripsy 11.52 10.11 4 214179 21 63274818
Spinal cord injury cervical 11.52 10.11 4 214179 21 63274818
Depression 11.52 10.11 790 213393 195702 63079137
Mood swings 11.50 10.11 28 214155 18220 63256619
Neuralgia 11.50 10.11 136 214047 25790 63249049
Stress cardiomyopathy 11.50 10.11 9 214174 9441 63265398
Residual urine volume increased 11.48 10.11 5 214178 52 63274787
Dermatitis 11.43 10.11 97 214086 16861 63257978
Vascular graft occlusion 11.41 10.11 8 214175 223 63274616
Coronary artery surgery 11.40 10.11 5 214178 53 63274786
Periarticular disorder 11.40 10.11 5 214178 53 63274786
Temporomandibular joint syndrome 11.38 10.11 35 214148 4054 63270785
Tachypnoea 11.35 10.11 26 214157 17276 63257563
Lactic acidosis 11.33 10.11 79 214104 38208 63236631
Ligament sprain 11.31 10.11 78 214105 12722 63262117
Sleep disorder due to general medical condition, insomnia type 11.29 10.11 117 214066 52100 63222739
Lacrimation increased 11.25 10.11 34 214149 20597 63254242
Aspiration 11.22 10.11 12 214171 10839 63264000
Myocarditis 11.15 10.11 11 214172 10314 63264525
Seronegative arthritis 11.13 10.11 34 214149 3925 63270914
Hypotonia 11.10 10.11 9 214174 9276 63265563
Coagulopathy 11.10 10.11 34 214149 20510 63254329
Irritable bowel syndrome 10.88 10.11 204 213979 82208 63192631
Pathogen resistance 10.84 10.11 4 214179 6394 63268445
Product complaint 10.70 10.11 77 214106 12732 63262107
Blood pressure diastolic increased 10.69 10.11 64 214119 9946 63264893
Helicobacter infection 10.66 10.11 235 213948 92550 63182289
Rheumatoid factor 10.64 10.11 9 214174 333 63274506
Device breakage 10.62 10.11 14 214169 11528 63263311
Breast cancer stage I 10.56 10.11 5 214178 6884 63267955
Chronic kidney disease 10.53 10.11 100 214083 45298 63229541
Quality of life decreased 10.52 10.11 58 214125 8745 63266094
Anal abscess 10.52 10.11 37 214146 4595 63270244
Rheumatic fever 10.47 10.11 204 213979 42907 63231932
Toe operation 10.45 10.11 13 214170 763 63274076
Benign abdominal neoplasm 10.41 10.11 7 214176 182 63274657
Cystitis 10.41 10.11 251 213932 54740 63220099
Coeliac artery compression syndrome 10.40 10.11 6 214177 118 63274721
Wrist fracture 10.40 10.11 80 214103 13507 63261332
Discomfort 10.38 10.11 460 213723 166914 63107925
Necrotising fasciitis 10.37 10.11 28 214155 3013 63271826
Breath sounds abnormal 10.37 10.11 68 214115 10905 63263934
Neuroma 10.37 10.11 10 214173 440 63274399
Dysgeusia 10.37 10.11 104 214079 46606 63228233
Injury 10.37 10.11 322 213861 72925 63201914
Exposure to toxic agent 10.34 10.11 3 214180 5584 63269255
Inappropriate antidiuretic hormone secretion 10.33 10.11 23 214160 15439 63259400
Crepitations 10.31 10.11 54 214129 7986 63266853
Postrenal failure 10.31 10.11 7 214176 185 63274654
Dysuria 10.29 10.11 69 214114 33669 63241170
Sinus bradycardia 10.26 10.11 21 214162 14530 63260309
Purpura senile 10.22 10.11 11 214172 552 63274287
Vascular device infection 10.19 10.11 6 214177 7306 63267533
Hypoalbuminaemia 10.18 10.11 15 214168 11790 63263049
Perseveration 10.16 10.11 8 214175 267 63274572
Surgery 10.15 10.11 174 214009 35738 63239101
Wrong product administered 10.14 10.11 4 214179 6137 63268702
Serotonin syndrome 10.14 10.11 56 214127 28626 63246213

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Ankylosing spondylitis 447.87 10.63 214 63406 5390 34887921
Drug hypersensitivity 297.72 10.63 529 63091 80000 34813311
Psoriatic arthropathy 253.36 10.63 241 63379 19557 34873754
Arthralgia 177.13 10.63 694 62926 169347 34723964
Pain 162.89 10.63 770 62850 203905 34689406
Toxicity to various agents 130.71 10.63 104 63516 200258 34693053
Death 129.94 10.63 338 63282 397711 34495600
Arthritis 118.31 10.63 208 63412 31138 34862173
Musculoskeletal stiffness 107.18 10.63 252 63368 46428 34846883
Rheumatoid arthritis 102.99 10.63 220 63400 38018 34855293
Osteoarthritis 102.36 10.63 155 63465 20487 34872824
Psoriasis 100.75 10.63 220 63400 38592 34854719
Myocardial infarction 94.95 10.63 454 63166 120631 34772680
Neck pain 82.74 10.63 158 63462 25191 34868120
Back pain 79.63 10.63 434 63186 121355 34771956
Arthropathy 78.50 10.63 160 63460 26747 34866564
Drug ineffective 75.16 10.63 1206 62414 455545 34437766
Febrile neutropenia 75.07 10.63 83 63537 136766 34756545
Joint swelling 71.76 10.63 256 63364 59634 34833677
Completed suicide 67.71 10.63 48 63572 98120 34795191
Victim of child abuse 63.86 10.63 32 63588 895 34892416
Drug interaction 60.41 10.63 210 63410 225736 34667575
Acute kidney injury 58.16 10.63 322 63298 304666 34588645
Drug abuse 56.67 10.63 58 63562 99038 34794273
Axial spondyloarthritis 56.44 10.63 22 63598 330 34892981
Sacroiliitis 54.53 10.63 34 63586 1464 34891847
Juvenile idiopathic arthritis 54.22 10.63 37 63583 1860 34891451
Synovitis 53.90 10.63 94 63526 13972 34879339
Knee arthroplasty 53.67 10.63 67 63553 7377 34885934
Neutropenia 53.33 10.63 130 63490 156648 34736663
Drug dependence 52.60 10.63 128 63492 24089 34869222
Therapeutic product effect incomplete 51.37 10.63 205 63415 50336 34842975
Nephrolithiasis 51.26 10.63 146 63474 30187 34863124
Nightmare 51.07 10.63 93 63527 14298 34879013
Epidural lipomatosis 48.99 10.63 28 63592 1026 34892285
Hypotension 48.47 10.63 223 63397 221426 34671885
Intervertebral disc protrusion 46.87 10.63 73 63547 9883 34883428
Hyperhidrosis 46.26 10.63 265 63355 75427 34817884
Product used for unknown indication 45.38 10.63 26 63594 957 34892354
Brain scan abnormal 45.30 10.63 25 63595 855 34892456
Coronary artery disease 45.20 10.63 191 63429 48114 34845197
General physical health deterioration 43.89 10.63 106 63514 128163 34765148
Thrombocytopenia 43.22 10.63 143 63477 156104 34737207
Cerebral artery thrombosis 42.48 10.63 23 63597 757 34892554
Sepsis 41.06 10.63 160 63460 166401 34726910
Inflammatory pain 39.30 10.63 15 63605 212 34893099
Multiple organ dysfunction syndrome 39.20 10.63 49 63571 76517 34816794
Fibromyalgia 38.24 10.63 37 63583 3063 34890248
Muscle swelling 37.70 10.63 17 63603 373 34892938
Child abuse 36.23 10.63 17 63603 410 34892901
Therapeutic product effect decreased 36.16 10.63 142 63478 34601 34858710
Pleural thickening 34.76 10.63 16 63604 369 34892942
Joint range of motion decreased 33.56 10.63 53 63567 7259 34886052
Hypoglycaemia 33.53 10.63 30 63590 54610 34838701
Off label use 33.47 10.63 550 63070 418974 34474337
Exostosis 33.23 10.63 42 63578 4681 34888630
Pain in extremity 33.10 10.63 364 63256 126149 34767162
Pancytopenia 33.04 10.63 78 63542 95079 34798232
Nasopharyngitis 32.81 10.63 229 63391 69739 34823572
Enthesopathy 32.43 10.63 41 63579 4572 34888739
Red blood cell sedimentation rate increased 32.25 10.63 59 63561 9103 34884208
Grip strength decreased 32.09 10.63 34 63586 3135 34890176
Intentional overdose 31.92 10.63 20 63600 43654 34849657
Spinal pain 31.74 10.63 46 63574 5843 34887468
Heart rate decreased 31.64 10.63 128 63492 31617 34861694
Intervertebral disc degeneration 31.53 10.63 48 63572 6369 34886942
Anaemia 31.23 10.63 273 63347 233062 34660249
Cardiogenic shock 29.93 10.63 6 63614 26612 34866699
Cardio-respiratory arrest 29.75 10.63 34 63586 55239 34838072
Sedation 29.73 10.63 95 63525 20911 34872400
Product prescribing error 29.16 10.63 100 63520 22827 34870484
Cytomegalovirus infection 29.16 10.63 6 63614 26129 34867182
Transposition of the great vessels 28.85 10.63 15 63605 454 34892857
Blood pressure fluctuation 28.58 10.63 106 63514 25143 34868168
Foetal exposure during pregnancy 28.46 10.63 17 63603 38084 34855227
Gait disturbance 28.07 10.63 257 63363 84883 34808428
Granuloma 27.94 10.63 32 63588 3219 34890092
Oesophageal fibrosis 27.63 10.63 11 63609 175 34893136
Drug tolerance 27.57 10.63 30 63590 2852 34890459
Loss of personal independence in daily activities 27.10 10.63 126 63494 33053 34860258
Hernia 26.78 10.63 56 63564 9527 34883784
Inflammation 26.55 10.63 112 63508 28183 34865128
Leukopenia 26.53 10.63 46 63574 62810 34830501
Hypoaesthesia 26.44 10.63 197 63423 61247 34832064
Oesophagogastric fundoplasty 26.00 10.63 6 63614 10 34893301
Anxiety 25.96 10.63 286 63334 99142 34794169
Coma 25.79 10.63 27 63593 45651 34847660
Coronary artery stenosis 25.49 10.63 55 63565 9561 34883750
Emotional distress 25.06 10.63 72 63548 14954 34878357
Xyphoid retraction 24.90 10.63 10 63610 163 34893148
Mycobacterium tuberculosis complex test positive 24.63 10.63 20 63600 1312 34891999
Uveitis 24.62 10.63 47 63573 7488 34885823
Diarrhoea 24.61 10.63 532 63088 389380 34503931
Electrocardiogram QT prolonged 24.51 10.63 23 63597 40929 34852382
Bradycardia 24.47 10.63 64 63556 75354 34817957
Respiratory depression 24.40 10.63 75 63545 16170 34877141
Hypokalaemia 24.20 10.63 43 63577 58171 34835140
Splenic embolism 23.55 10.63 10 63610 189 34893122
Septic shock 23.27 10.63 61 63559 71773 34821538
Premature baby 22.98 10.63 4 63616 19629 34873682
Mobility decreased 22.85 10.63 112 63508 30016 34863295
Coronary artery occlusion 22.80 10.63 57 63563 10905 34882406
Depression 22.53 10.63 273 63347 96825 34796486
Hypomagnesaemia 22.43 10.63 6 63614 21845 34871466
Foot deformity 22.38 10.63 34 63586 4503 34888808
Blood pressure increased 22.34 10.63 252 63368 87850 34805461
Osteopenia 22.05 10.63 35 63585 4814 34888497
Rhabdomyolysis 21.99 10.63 58 63562 68105 34825206
Interstitial lung disease 21.99 10.63 198 63422 65084 34828227
Pyrexia 21.68 10.63 452 63168 332561 34560750
Musculoskeletal pain 21.57 10.63 115 63505 31848 34861463
Joint injury 21.55 10.63 50 63570 9123 34884188
Syndesmophyte 21.49 10.63 8 63612 105 34893206
Rheumatoid lung 21.45 10.63 16 63604 926 34892385
Blood cholesterol increased 21.40 10.63 84 63536 20459 34872852
Hip arthroplasty 21.30 10.63 33 63587 4446 34888865
Body temperature decreased 21.30 10.63 62 63558 12972 34880339
Cerebrovascular accident 21.24 10.63 242 63378 84569 34808742
Road traffic accident 21.22 10.63 75 63545 17375 34875936
Gastrointestinal adenocarcinoma 21.08 10.63 7 63613 64 34893247
Sideroblastic anaemia 21.02 10.63 10 63610 249 34893062
Platelet count decreased 20.81 10.63 130 63490 119587 34773724
Rotator cuff syndrome 20.67 10.63 37 63583 5612 34887699
Degenerative bone disease 20.61 10.63 7 63613 69 34893242
Ankle fracture 20.47 10.63 31 63589 4094 34889217
Confusional state 20.45 10.63 166 63454 143994 34749317
Cytokine release syndrome 20.45 10.63 8 63612 22869 34870442
Spinal osteoarthritis 20.43 10.63 44 63576 7639 34885672
Arachnoiditis 20.29 10.63 11 63609 363 34892948
C-reactive protein increased 20.27 10.63 168 63452 53930 34839381
Lactic acidosis 20.26 10.63 20 63600 34752 34858559
Drug resistance 20.18 10.63 11 63609 25916 34867395
Diaphragmatic injury 20.05 10.63 8 63612 128 34893183
Chest pain 20.00 10.63 333 63287 126429 34766882
Agitation 19.95 10.63 47 63573 57352 34835959
Product use issue 19.91 10.63 189 63431 63027 34830284
Angina unstable 19.59 10.63 56 63564 11597 34881714
Periarthritis 19.46 10.63 16 63604 1068 34892243
Abdominal discomfort 19.40 10.63 180 63440 59655 34833656
Iritis 19.30 10.63 18 63602 1423 34891888
Investigation abnormal 19.28 10.63 12 63608 515 34892796
Cardiac arrest 19.09 10.63 100 63520 96059 34797252
Chest expansion decreased 19.04 10.63 8 63612 147 34893164
Benign abdominal neoplasm 19.01 10.63 7 63613 89 34893222
Gastric ulcer haemorrhage 18.98 10.63 35 63585 5431 34887880
Bone marrow oedema 18.95 10.63 13 63607 659 34892652
Hospitalisation 18.67 10.63 48 63572 56854 34836457
Vitamin B1 decreased 18.50 10.63 10 63610 328 34892983
Spinal disorder 18.39 10.63 30 63590 4222 34889089
Lumbar spinal stenosis 18.23 10.63 23 63597 2559 34890752
Drug level increased 17.75 10.63 9 63611 22087 34871224
Dyspepsia 17.67 10.63 121 63499 36611 34856700
Spinal stenosis 17.38 10.63 33 63587 5236 34888075
Carpal tunnel syndrome 17.35 10.63 31 63589 4695 34888616
Herpes zoster 16.95 10.63 114 63506 34285 34859026
Energy increased 16.95 10.63 16 63604 1284 34892027
Knee operation 16.95 10.63 20 63600 2077 34891234
Tumour lysis syndrome 16.92 10.63 5 63615 17054 34876257
Adenocarcinoma of appendix 16.79 10.63 7 63613 126 34893185
Synovial cyst 16.74 10.63 21 63599 2323 34890988
Intervertebral disc disorder 16.67 10.63 19 63601 1901 34891410
Seizure 16.64 10.63 117 63503 104740 34788571
Inappropriate schedule of product administration 16.62 10.63 180 63440 62116 34831195
Neurotoxicity 16.60 10.63 6 63614 18004 34875307
Oesophageal infection 16.52 10.63 9 63611 300 34893011
Back disorder 16.45 10.63 37 63583 6614 34886697
Diverticulitis 16.35 10.63 76 63544 19928 34873383
Mass 16.33 10.63 41 63579 7864 34885447
Tendon disorder 16.29 10.63 23 63597 2852 34890459
Bronchial wall thickening 16.26 10.63 16 63604 1352 34891959
Hypoxia 16.21 10.63 49 63571 55046 34838265
Foot fracture 16.05 10.63 31 63589 4980 34888331
Drug withdrawal syndrome 15.96 10.63 75 63545 19759 34873552
Gingival ulceration 15.94 10.63 9 63611 322 34892989
Musculoskeletal disorder 15.89 10.63 35 63585 6169 34887142
Small intestine ulcer 15.86 10.63 10 63610 439 34892872
Injury 15.75 10.63 77 63543 20610 34872701
Fracture 15.73 10.63 37 63583 6812 34886499
Hyperlipidaemia 15.61 10.63 60 63560 14469 34878842
Hyperkalaemia 15.61 10.63 69 63551 69320 34823991
Pregnancy of partner 15.57 10.63 9 63611 337 34892974
Ascites 15.50 10.63 39 63581 46532 34846779
Tenderness 15.42 10.63 37 63583 6897 34886414
Peptic ulcer 15.38 10.63 22 63598 2761 34890550
Areflexia 15.36 10.63 23 63597 3008 34890303
Suicide attempt 15.28 10.63 30 63590 39086 34854225
Overdose 15.24 10.63 100 63520 90959 34802352
Granulomatous liver disease 15.23 10.63 11 63609 606 34892705
Generalised tonic-clonic seizure 15.05 10.63 10 63610 21164 34872147
Hyperbilirubinaemia 14.87 10.63 6 63614 16837 34876474
Neuroleptic malignant syndrome 14.87 10.63 7 63613 17927 34875384
Tachycardia 14.75 10.63 92 63528 84680 34808631
Gastric ulcer 14.72 10.63 62 63558 15588 34877723
Agranulocytosis 14.70 10.63 13 63607 23808 34869503
Spondyloarthropathy 14.64 10.63 11 63609 644 34892667
Hypercholesterolaemia 14.63 10.63 42 63578 8720 34884591
Inflammatory bowel disease 14.57 10.63 22 63598 2898 34890413
Marrow hyperplasia 14.57 10.63 14 63606 1149 34892162
Orchitis noninfective 14.46 10.63 4 63616 18 34893293
Hypervolaemia 14.43 10.63 9 63611 19700 34873611
Facet joint syndrome 14.33 10.63 8 63612 280 34893031
Nervousness 14.33 10.63 53 63567 12553 34880758
Hepatic cirrhosis 14.32 10.63 66 63554 17248 34876063
Rib fracture 14.29 10.63 58 63562 14342 34878969
Joint space narrowing 14.03 10.63 7 63613 194 34893117
Intermittent claudication 13.97 10.63 19 63601 2275 34891036
Duodenal ulcer 13.96 10.63 46 63574 10286 34883025
Insomnia 13.91 10.63 266 63354 103641 34789670
Chronic tonsillitis 13.86 10.63 3 63617 3 34893308
Status epilepticus 13.86 10.63 3 63617 12611 34880700
Chronic idiopathic pain syndrome 13.80 10.63 4 63616 22 34893289
Spinal compression fracture 13.76 10.63 36 63584 7080 34886231
Tendonitis 13.54 10.63 42 63578 9098 34884213
Aggression 13.46 10.63 32 63588 38932 34854379
Metabolic acidosis 13.46 10.63 38 63582 43642 34849669
Cardiac failure 13.43 10.63 104 63516 91144 34802167
Myalgia intercostal 13.37 10.63 4 63616 25 34893286
Impaired work ability 13.34 10.63 35 63585 6895 34886416
Medulloblastoma 13.34 10.63 5 63615 67 34893244
Drug abuser 13.33 10.63 25 63595 3929 34889382
Hyponatraemia 13.24 10.63 92 63528 82599 34810712
Hyperglycaemia 13.19 10.63 33 63587 39447 34853864
Post procedural infection 13.13 10.63 28 63592 4828 34888483
Mucosal inflammation 13.12 10.63 32 63588 38590 34854721
Tenosynovitis 13.11 10.63 27 63593 4543 34888768
Gastrointestinal haemorrhage 13.06 10.63 230 63390 88247 34805064
Thermal burn 13.04 10.63 20 63600 2671 34890640
Inadequate analgesia 12.88 10.63 21 63599 2954 34890357
Musculoskeletal discomfort 12.82 10.63 38 63582 8030 34885281
Blood bilirubin increased 12.80 10.63 32 63588 38264 34855047
Hypertension 12.79 10.63 332 63288 136111 34757200
Transient ischaemic attack 12.71 10.63 90 63530 27523 34865788
Hepatitis chronic persistent 12.65 10.63 3 63617 6 34893305
Upper-airway cough syndrome 12.63 10.63 23 63597 3535 34889776
Vomiting 12.52 10.63 349 63271 247272 34646039
Ankle operation 12.51 10.63 7 63613 246 34893065
Renal failure 12.48 10.63 165 63455 130392 34762919
Acute hepatic failure 12.45 10.63 5 63615 14069 34879242
Drug eruption 12.36 10.63 70 63550 19828 34873483
HLA-B*27 positive 12.30 10.63 4 63616 34 34893277
Osteomyelitis 12.24 10.63 60 63560 16076 34877235
Post procedural fistula 12.20 10.63 5 63615 86 34893225
Papillary renal cell carcinoma 12.14 10.63 7 63613 261 34893050
Obesity 12.10 10.63 51 63569 12827 34880484
Bacteraemia 11.88 10.63 11 63609 19706 34873605
Epistaxis 11.88 10.63 60 63560 58191 34835120
Gastrooesophageal reflux disease 11.74 10.63 113 63507 37811 34855500
Neuropathy peripheral 11.74 10.63 96 63524 83167 34810144
Sleep apnoea syndrome 11.65 10.63 70 63550 20251 34873060
Cystitis bacterial 11.65 10.63 5 63615 97 34893214
Ulcer 11.64 10.63 39 63581 8796 34884515
Rebound psychosis 11.62 10.63 6 63614 179 34893132
Aspergillus infection 11.43 10.63 4 63616 12250 34881061
Pulmonary granuloma 11.40 10.63 14 63606 1516 34891795
Nerve compression 11.39 10.63 21 63599 3258 34890053
Postoperative delirium 11.32 10.63 6 63614 189 34893122
Pulmonary tuberculosis 11.26 10.63 26 63594 4728 34888583
Sinusitis 11.21 10.63 120 63500 41282 34852029
Cerebrospinal fluid retention 11.13 10.63 3 63617 12 34893299
Cholestasis 11.11 10.63 20 63600 26928 34866383
Therapeutic response shortened 10.95 10.63 34 63586 7370 34885941
Mitral valve incompetence 10.94 10.63 55 63565 14888 34878423
Arteriosclerosis 10.93 10.63 47 63573 11921 34881390
Haemophagocytic lymphohistiocytosis 10.85 10.63 5 63615 12968 34880343
Hepatitis B virus test positive 10.85 10.63 7 63613 320 34892991
Sensitivity to weather change 10.72 10.63 14 63606 1612 34891699

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1885.90 9.87 3195 224705 295721 79220767
Rheumatoid arthritis 730.01 9.87 1746 226154 206724 79309764
Arthralgia 613.34 9.87 3234 224666 568569 78947919
Ankylosing spondylitis 596.39 9.87 394 227506 11811 79504677
Musculoskeletal stiffness 499.22 9.87 1357 226543 173651 79342837
Drug ineffective 497.69 9.87 4985 222915 1075928 78440560
Toxicity to various agents 456.93 9.87 324 227576 421216 79095272
Death 448.08 9.87 578 227322 565936 78950552
Psoriatic arthropathy 406.83 9.87 769 227131 77230 79439258
Pain 366.10 9.87 3334 224566 700468 78816020
Completed suicide 342.15 9.87 137 227763 245630 79270858
Therapeutic product effect decreased 327.60 9.87 1122 226778 162741 79353747
Fibromyalgia 310.60 9.87 614 227286 63726 79452762
Joint swelling 284.21 9.87 1597 226303 287049 79229439
Febrile neutropenia 276.80 9.87 158 227742 230841 79285647
Contraindicated product administered 266.75 9.87 1022 226878 156516 79359972
Acute kidney injury 265.66 9.87 692 227208 518712 78997776
Neutropenia 263.59 9.87 260 227640 287450 79229038
Drug abuse 260.87 9.87 71 227829 162620 79353868
Arthropathy 260.77 9.87 1100 226800 176011 79340477
Pain in extremity 247.54 9.87 1836 226064 362702 79153786
Drug intolerance 240.17 9.87 1431 226469 262688 79253800
Rheumatoid nodule 237.85 9.87 271 227629 17167 79499321
Therapeutic product effect incomplete 224.44 9.87 900 227000 140745 79375743
Thrombocytopenia 220.40 9.87 260 227640 264999 79251489
Arthritis 201.61 9.87 754 227146 114126 79402362
Osteoarthritis 201.48 9.87 628 227272 86681 79429807
Loss of personal independence in daily activities 197.57 9.87 694 227206 101886 79414602
Hypotension 194.77 9.87 628 227272 439689 79076799
C-reactive protein abnormal 182.95 9.87 418 227482 47949 79468539
Anaemia 171.90 9.87 672 227228 444343 79072145
Condition aggravated 168.88 9.87 2179 225721 498945 79017543
Mobility decreased 163.82 9.87 738 227162 121437 79395051
Intentional overdose 155.85 9.87 54 227846 105906 79410582
Sepsis 155.77 9.87 336 227564 269092 79247396
Inflammation 147.07 9.87 594 227306 93159 79423329
Foot deformity 146.63 9.87 254 227646 23820 79492668
Lower limb fracture 142.79 9.87 246 227654 22969 79493519
Hyponatraemia 142.70 9.87 179 227721 177669 79338819
Drug tolerance 141.26 9.87 148 227752 8527 79507961
Psoriasis 139.25 9.87 566 227334 89021 79427467
Ulcer 132.67 9.87 276 227624 29696 79486792
Red blood cell sedimentation rate increased 130.51 9.87 356 227544 45586 79470902
Electrocardiogram QT prolonged 129.63 9.87 48 227852 90338 79426150
Pyrexia 124.44 9.87 1290 226610 677419 78839069
Pancytopenia 122.64 9.87 177 227723 165568 79350920
Red blood cell sedimentation rate abnormal 120.97 9.87 216 227684 20747 79495741
C-reactive protein increased 120.90 9.87 705 227195 128322 79388166
Dyspnoea 119.65 9.87 1728 226172 855297 78661191
Treatment failure 116.19 9.87 860 227040 169626 79346862
Hypoaesthesia 115.08 9.87 892 227008 178460 79338028
Thyroid neoplasm 114.52 9.87 85 227815 3079 79513409
Multiple organ dysfunction syndrome 113.10 9.87 106 227794 120140 79396348
International normalised ratio fluctuation 110.05 9.87 86 227814 3368 79513120
Foot fracture 109.95 9.87 213 227687 21768 79494720
Musculoskeletal pain 109.71 9.87 580 227320 101774 79414714
Synovitis 109.41 9.87 772 227128 149962 79366526
Hypoglycaemia 107.32 9.87 80 227820 101514 79414974
Cardiac arrest 106.74 9.87 206 227694 171890 79344598
Gastric disorder 106.25 9.87 290 227610 37143 79479345
Gait inability 105.22 9.87 389 227511 58528 79457960
Gait disturbance 103.12 9.87 975 226925 206531 79309957
Blood parathyroid hormone decreased 102.22 9.87 138 227762 10398 79506090
Pleural thickening 101.02 9.87 77 227823 2905 79513583
Joint injury 100.41 9.87 254 227646 31081 79485407
Bone swelling 100.28 9.87 62 227838 1652 79514836
Cardio-respiratory arrest 99.32 9.87 98 227802 108412 79408076
Myocardial infarction 98.48 9.87 879 227021 183250 79333238
Peripheral swelling 98.13 9.87 1190 226710 268427 79248061
Neoplasm malignant 97.95 9.87 254 227646 31556 79484932
Enthesopathy 97.68 9.87 142 227758 11466 79505022
Seizure 97.48 9.87 250 227650 188584 79327904
Confusional state 97.15 9.87 523 227377 317474 79199014
Drug interaction 96.65 9.87 742 227158 414441 79102047
Neck pain 96.18 9.87 449 227451 74968 79441520
Drug eruption 94.91 9.87 309 227591 43626 79472862
Tachycardia 92.80 9.87 234 227666 177534 79338954
Bradycardia 92.38 9.87 153 227747 135404 79381084
Panniculitis 92.21 9.87 143 227757 12228 79504260
Tenosynovitis 91.98 9.87 162 227738 15392 79501096
Presbyacusis 90.80 9.87 69 227831 2591 79513897
Deformity 88.95 9.87 123 227777 9482 79507006
Prescribed overdose 87.82 9.87 273 227627 37610 79478878
Granuloma skin 87.25 9.87 119 227781 9055 79507433
Bloody discharge 85.72 9.87 59 227841 1894 79514594
Disease progression 84.83 9.87 258 227642 184104 79332384
Overdose 84.60 9.87 258 227642 183948 79332540
Therapeutic response decreased 84.50 9.87 397 227503 66456 79450032
Systemic lupus erythematosus rash 83.55 9.87 57 227843 1803 79514685
Impaired work ability 83.34 9.87 178 227722 19503 79496985
Joint range of motion decreased 82.92 9.87 246 227654 33036 79483452
Leukopenia 82.70 9.87 128 227772 116385 79400103
Drug tolerance decreased 81.75 9.87 139 227761 12839 79503649
Nephrolithiasis 79.09 9.87 332 227568 52959 79463529
Osteoporosis 78.67 9.87 335 227565 53777 79462711
Grip strength decreased 78.30 9.87 185 227715 21684 79494804
Nerve injury 77.73 9.87 114 227786 9278 79507210
Sacroiliitis 77.72 9.87 73 227827 3681 79512807
Disability 77.35 9.87 159 227741 16961 79499527
Pleural fibrosis 76.78 9.87 76 227824 4091 79512397
Mucosal inflammation 76.67 9.87 62 227838 75518 79440970
Blood cholesterol increased 76.17 9.87 454 227446 83266 79433222
Metabolic acidosis 76.14 9.87 74 227826 82455 79434033
Suicide attempt 75.77 9.87 75 227825 82857 79433631
Bedridden 75.60 9.87 129 227771 11950 79504538
Platelet count decreased 74.97 9.87 294 227606 194370 79322118
Syncope 74.35 9.87 263 227637 179186 79337302
Musculoskeletal disorder 74.16 9.87 179 227721 21269 79495219
Hypokalaemia 73.32 9.87 192 227708 143848 79372640
Swollen joint count increased 70.51 9.87 183 227717 22744 79493744
Sciatica 70.27 9.87 232 227668 32990 79483498
Cytomegalovirus infection 69.47 9.87 18 227882 42626 79473862
Sopor 69.15 9.87 7 227893 33003 79483485
Septic shock 68.55 9.87 156 227744 122645 79393843
Respiratory failure 67.91 9.87 276 227624 180635 79335853
Somnolence 67.56 9.87 403 227497 238578 79277910
Lyme disease 67.17 9.87 64 227836 3286 79513202
Hypoxia 67.16 9.87 120 227780 103123 79413365
Axial spondyloarthritis 67.05 9.87 33 227867 553 79515935
Nasopharyngitis 66.49 9.87 1057 226843 252824 79263664
Back pain 66.49 9.87 1230 226670 302950 79213538
Deep vein thrombosis postoperative 66.20 9.87 114 227786 10638 79505850
Neurotoxicity 65.33 9.87 8 227892 32510 79483978
Intervertebral disc protrusion 65.05 9.87 181 227719 23440 79493048
Osteopenia 64.28 9.87 154 227746 18210 79498278
Cardiogenic shock 64.01 9.87 20 227880 41894 79474594
Dehydration 62.76 9.87 433 227467 247754 79268734
Swelling 62.02 9.87 916 226984 215795 79300693
Encephalopathy 61.51 9.87 61 227839 67336 79449152
Pulmonary fibrosis 60.99 9.87 269 227631 43843 79472645
Cytokine release syndrome 60.97 9.87 14 227886 35984 79480504
Road traffic accident 60.92 9.87 267 227633 43397 79473091
Intentional self-injury 60.40 9.87 10 227890 32409 79484079
Tendonitis 60.19 9.87 177 227723 23653 79492835
Drug resistance 59.54 9.87 23 227877 42190 79474298
Blood magnesium increased 59.21 9.87 61 227839 3445 79513043
Ascites 58.56 9.87 78 227822 75484 79441004
Skin necrosis 58.35 9.87 147 227753 17940 79498548
Intervertebral disc degeneration 58.11 9.87 135 227765 15650 79500838
Deafness neurosensory 57.48 9.87 84 227816 6814 79509674
Multiple fractures 57.35 9.87 91 227809 7935 79508553
Toothache 56.96 9.87 155 227745 19815 79496673
Autoimmune disorder 56.75 9.87 138 227762 16474 79500014
Hyperkalaemia 56.32 9.87 155 227745 114243 79402245
Rheumatoid lung 56.25 9.87 65 227835 4180 79512308
Skin ulcer 56.06 9.87 304 227596 53846 79462642
Rhabdomyolysis 55.96 9.87 133 227767 102998 79413490
Bursitis 55.30 9.87 226 227674 35618 79480870
Loss of employment 54.89 9.87 51 227849 2536 79513952
Rotator cuff syndrome 54.60 9.87 123 227777 13972 79502516
Dry eye 53.96 9.87 229 227671 36702 79479786
Cholestasis 53.79 9.87 42 227858 52067 79464421
Orthostatic hypotension 53.40 9.87 49 227851 56115 79460373
Neuropathy peripheral 52.13 9.87 217 227683 141088 79375400
Joint stiffness 51.98 9.87 243 227657 40587 79475901
Adjustment disorder with depressed mood 51.62 9.87 93 227807 8993 79507495
Hypervolaemia 51.36 9.87 29 227871 42661 79473827
Exposure during pregnancy 51.31 9.87 135 227765 100997 79415491
Cardiac failure 51.00 9.87 248 227652 154594 79361894
Device expulsion 50.42 9.87 7 227893 25854 79490634
Hyperglycaemia 50.16 9.87 77 227823 70258 79446230
Coma 49.82 9.87 136 227764 100513 79415975
Victim of child abuse 49.57 9.87 32 227868 921 79515567
Spinal pain 49.55 9.87 125 227775 15267 79501221
Neutrophil count decreased 49.54 9.87 123 227777 93836 79422652
Rash 49.30 9.87 2071 225829 576287 78940201
Knee arthroplasty 49.04 9.87 249 227651 42999 79473489
Spinal osteoarthritis 48.89 9.87 132 227768 16795 79499693
Hypermobility syndrome 48.88 9.87 26 227874 516 79515972
Gastric ulcer 48.58 9.87 209 227691 33696 79482792
Blood pressure systolic increased 48.52 9.87 343 227557 66643 79449845
Malaise 48.50 9.87 1783 226117 488086 79028402
Product use in unapproved indication 48.11 9.87 470 227430 249889 79266599
Mental status changes 48.04 9.87 73 227827 66886 79449602
Pharyngitis 47.99 9.87 157 227743 22218 79494270
Epistaxis 47.82 9.87 161 227739 111354 79405134
Bunion operation 47.15 9.87 31 227869 921 79515567
Agitation 46.95 9.87 138 227762 99577 79416911
Neutropenic sepsis 46.90 9.87 10 227890 27054 79489434
Infection 46.89 9.87 960 226940 240752 79275736
Renal failure 46.75 9.87 359 227541 200609 79315879
Acute respiratory failure 46.61 9.87 61 227839 59480 79457008
Nodule 46.34 9.87 158 227742 22836 79493652
Blood bilirubin increased 45.81 9.87 74 227826 66158 79450330
Tooth infection 45.78 9.87 138 227762 18694 79497794
Dislocation of vertebra 45.21 9.87 81 227819 7799 79508689
Epigastric discomfort 45.09 9.87 81 227819 7815 79508673
Rheumatic fever 44.92 9.87 181 227719 28344 79488144
Pulmonary toxicity 44.88 9.87 108 227792 12806 79503682
Impaired healing 44.55 9.87 414 227486 87241 79429247
Fear of injection 44.39 9.87 78 227822 7396 79509092
Premature delivery 44.26 9.87 7 227893 23460 79493028
Cognitive disorder 43.94 9.87 83 227817 69843 79446645
Red blood cell sedimentation rate 43.83 9.87 66 227834 5499 79510989
Burning mouth syndrome 42.87 9.87 24 227876 529 79515959
Fine motor skill dysfunction 42.86 9.87 64 227836 5293 79511195
Hunger 42.22 9.87 64 227836 5364 79511124
Poisoning deliberate 42.15 9.87 3 227897 18825 79497663
Cyst 42.08 9.87 110 227790 13730 79502758
Hepatic failure 41.77 9.87 69 227831 61143 79455345
Clostridium difficile colitis 41.70 9.87 20 227880 32263 79484225
Osteosclerosis 41.59 9.87 54 227846 3917 79512571
Osteomyelitis 41.40 9.87 195 227705 32670 79483818
Foot operation 40.96 9.87 65 227835 5668 79510820
Femur fracture 40.69 9.87 218 227682 38434 79478054
Epicondylitis 40.64 9.87 40 227860 2138 79514350
Poisoning 40.53 9.87 11 227889 25261 79491227
Right ventricular failure 40.07 9.87 9 227891 23488 79493000
Tremor 39.94 9.87 303 227597 169780 79346708
Product use issue 39.91 9.87 831 227069 208991 79307497
Oesophageal spasm 39.36 9.87 49 227851 3407 79513081
Joint effusion 39.17 9.87 127 227773 17887 79498601
Blood calcium decreased 39.17 9.87 21 227879 31798 79484690
Immobile 39.14 9.87 71 227829 6902 79509586
Pulmonary arterial hypertension 39.11 9.87 16 227884 28350 79488138
Antinuclear antibody positive 38.90 9.87 76 227824 7814 79508674
Constipation 38.81 9.87 572 227328 282478 79234010
Plasma cell myeloma 38.27 9.87 58 227842 53201 79463287
Status epilepticus 38.14 9.87 12 227888 25029 79491459
Aggression 38.08 9.87 54 227846 50904 79465584
Synovial cyst 38.06 9.87 87 227813 9978 79506510
Limb discomfort 37.85 9.87 190 227710 32660 79483828
Gastric ulcer haemorrhage 37.48 9.87 81 227819 8946 79507542
Respiratory arrest 37.32 9.87 67 227833 57483 79459005
Psychotic disorder 37.18 9.87 38 227862 41364 79475124
Maternal exposure during pregnancy 37.12 9.87 233 227667 136305 79380183
Interstitial lung disease 37.06 9.87 488 227412 112112 79404376
C-reactive protein 36.34 9.87 57 227843 4922 79511566
Granuloma 36.24 9.87 76 227824 8221 79508267
Back disorder 36.20 9.87 93 227807 11485 79505003
Migraine 36.16 9.87 396 227504 87097 79429391
Posterior reversible encephalopathy syndrome 35.95 9.87 15 227885 26266 79490222
Aspergillus infection 35.50 9.87 6 227894 19155 79497333
Acute hepatic failure 35.45 9.87 21 227879 30092 79486396
Walking aid user 35.41 9.87 85 227815 10063 79506425
Hyperbilirubinaemia 35.18 9.87 13 227887 24505 79491983
Hip arthroplasty 35.18 9.87 198 227702 35558 79480930
Bone cyst 34.89 9.87 46 227854 3387 79513101
Liver disorder 34.79 9.87 338 227562 72079 79444409
Pharyngeal oedema 34.73 9.87 114 227786 16158 79500330
Depressed level of consciousness 34.67 9.87 150 227750 96502 79419986
Diabetic ketoacidosis 34.59 9.87 28 227872 34094 79482394
Tongue disorder 34.53 9.87 103 227797 13872 79502616
Movement disorder 34.52 9.87 162 227738 27097 79489391
Stress 34.14 9.87 363 227537 79249 79437239
Lactic acidosis 34.13 9.87 96 227804 70263 79446225
Fracture pain 34.12 9.87 23 227877 713 79515775
Tenderness 34.07 9.87 146 227754 23496 79492992
Transplant rejection 34.05 9.87 7 227893 19430 79497058
Eosinophilia 33.93 9.87 48 227852 45297 79471191
International normalised ratio increased 33.85 9.87 126 227774 84595 79431893
Sedation complication 33.68 9.87 3 227897 15666 79500822
Iritis 33.66 9.87 48 227852 3807 79512681
Epidural lipomatosis 33.66 9.87 28 227872 1200 79515288
Gamma-glutamyltransferase increased 33.40 9.87 66 227834 54614 79461874
Bronchopulmonary aspergillosis 33.40 9.87 11 227889 22283 79494205
Respiratory tract congestion 33.34 9.87 129 227771 19825 79496663
Inflammatory pain 33.34 9.87 26 227874 1015 79515473
Investigation abnormal 33.19 9.87 35 227865 2031 79514457
Bacteraemia 33.19 9.87 27 227873 32797 79483691
Dysstasia 33.05 9.87 162 227738 27584 79488904
Inflammatory bowel disease 32.31 9.87 58 227842 5593 79510895
Type 2 diabetes mellitus 32.21 9.87 276 227624 56846 79459642
Torsade de pointes 31.75 9.87 8 227892 19304 79497184
Gastrointestinal toxicity 31.67 9.87 71 227829 8038 79508450
Cerebral haemorrhage 31.58 9.87 74 227826 57599 79458889
Upper limb fracture 31.54 9.87 118 227782 17849 79498639
Abdominal discomfort 31.54 9.87 939 226961 249788 79266700
Generalised tonic-clonic seizure 31.37 9.87 48 227852 43862 79472626
Ventricular fibrillation 31.37 9.87 27 227873 31899 79484589
Rash pruritic 31.37 9.87 328 227572 71301 79445187
Progressive multifocal leukoencephalopathy 31.15 9.87 10 227890 20590 79495898
Bronchitis 30.87 9.87 535 227365 130109 79386379
Off label use 30.72 9.87 2206 225694 905009 78611479
Depression 30.63 9.87 824 227076 215966 79300522
Liver injury 30.60 9.87 271 227629 56343 79460145
Pneumonia aspiration 30.57 9.87 94 227806 66873 79449615
Spinal stenosis 30.51 9.87 107 227793 15684 79500804
Exostosis 29.83 9.87 111 227789 16747 79499741
Myelosuppression 29.81 9.87 43 227857 40253 79476235
Asthenia 29.38 9.87 1180 226720 510509 79005979
Tenosynovitis stenosans 29.38 9.87 40 227860 3038 79513450
Tumour lysis syndrome 29.17 9.87 16 227884 23923 79492565
Hepatic cytolysis 29.16 9.87 21 227879 27130 79489358
Tuberculin test positive 29.12 9.87 42 227858 3366 79513122
Palmar-plantar erythrodysaesthesia syndrome 29.09 9.87 31 227869 33103 79483385
Wrist deformity 29.03 9.87 33 227867 2084 79514404
Chills 29.03 9.87 305 227595 159929 79356559
COVID-19 29.02 9.87 299 227601 157375 79359113
Child abuse 28.93 9.87 17 227883 412 79516076
Colitis 28.66 9.87 110 227790 73197 79443291
Hepatocellular injury 28.59 9.87 58 227842 47535 79468953
Kidney infection 28.51 9.87 131 227769 21720 79494768
White blood cell count decreased 28.47 9.87 373 227527 187915 79328573
Meniscus injury 28.41 9.87 61 227839 6707 79509781
Tooth disorder 28.32 9.87 149 227751 26084 79490404
Allergy to chemicals 28.22 9.87 36 227864 2566 79513922
Basal cell carcinoma 28.01 9.87 193 227707 37182 79479306
Urticaria 27.91 9.87 710 227190 184491 79331997
Hypertension 27.84 9.87 1184 226716 329808 79186680
Brain oedema 27.84 9.87 19 227881 25244 79491244
Wound infection 27.81 9.87 139 227761 23852 79492636
Synovial fluid analysis 27.76 9.87 34 227866 2325 79514163
Carpal tunnel syndrome 27.69 9.87 120 227780 19408 79497080
Pathogen resistance 27.68 9.87 4 227896 14338 79502150
Neuroleptic malignant syndrome 27.46 9.87 23 227877 27536 79488952
Drug reaction with eosinophilia and systemic symptoms 27.36 9.87 93 227807 64151 79452337
Abdominal distension 27.22 9.87 215 227685 119435 79397053
Ventricular tachycardia 27.03 9.87 49 227851 41886 79474602
Miosis 27.02 9.87 6 227894 15783 79500705
Bone marrow failure 26.86 9.87 67 227833 51040 79465448
Klebsiella infection 26.85 9.87 6 227894 15714 79500774
Prescribed underdose 26.80 9.87 160 227740 29354 79487134
Myofascial pain syndrome 26.67 9.87 31 227869 2006 79514482
Benign abdominal neoplasm 26.59 9.87 14 227886 272 79516216
Alanine aminotransferase abnormal 26.47 9.87 70 227830 8797 79507691
Dysarthria 26.09 9.87 102 227798 67520 79448968
Hospitalisation 26.03 9.87 160 227740 94076 79422412
Eye disorder 25.98 9.87 134 227766 23278 79493210
Tachypnoea 25.98 9.87 32 227868 32031 79484457
Blood glucose increased 25.97 9.87 207 227693 114768 79401720
Blood lactic acid increased 25.93 9.87 3 227897 12741 79503747
Mydriasis 25.92 9.87 9 227891 17634 79498854
Pulmonary oedema 25.88 9.87 147 227753 88107 79428381
Uveitis 25.87 9.87 106 227794 16724 79499764
Drug level increased 25.86 9.87 46 227854 39605 79476883
Brain scan abnormal 25.74 9.87 24 227876 1199 79515289
Clostridium difficile infection 25.66 9.87 52 227848 42633 79473855
Adverse event 25.56 9.87 274 227626 59940 79456548
Toxic epidermal necrolysis 25.38 9.87 56 227844 44525 79471963
Coronary artery stenosis 25.35 9.87 86 227814 12398 79504090
Agranulocytosis 25.28 9.87 57 227843 44973 79471515
Malignant neoplasm progression 24.98 9.87 258 227642 135732 79380756
Diarrhoea 24.98 9.87 2172 225728 878317 78638171
Blood pressure diastolic abnormal 24.97 9.87 115 227785 19087 79497401
Body height decreased 24.87 9.87 67 227833 8513 79507975
Juvenile idiopathic arthritis 24.86 9.87 47 227853 4716 79511772
Oedema 24.85 9.87 480 227420 119100 79397388
Enterococcal infection 24.77 9.87 7 227893 15653 79500835
Neoplasm progression 24.71 9.87 71 227829 51611 79464877
Presyncope 24.69 9.87 50 227850 41004 79475484
Oesophageal pain 24.57 9.87 44 227856 4235 79512253
Pneumonia 24.54 9.87 1592 226308 658654 78857834
Product used for unknown indication 24.53 9.87 26 227874 1518 79514970
Herpes zoster 24.50 9.87 388 227512 92695 79423793
Haematotoxicity 24.43 9.87 7 227893 15512 79500976
Disability assessment scale score increased 24.42 9.87 39 227861 3419 79513069
Abortion spontaneous 24.38 9.87 29 227871 29478 79487010
Febrile bone marrow aplasia 24.29 9.87 4 227896 13016 79503472
Hypomagnesaemia 24.26 9.87 62 227838 46849 79469639
Creatinine renal clearance decreased 24.19 9.87 12 227888 18990 79497498
Transaminases increased 24.07 9.87 72 227828 51671 79464817
Accidental overdose 23.98 9.87 48 227852 39533 79476955
Thrombotic microangiopathy 23.83 9.87 14 227886 20155 79496333
Pallor 23.77 9.87 69 227831 49993 79466495
Extrapyramidal disorder 23.76 9.87 18 227882 22661 79493827
Myelodysplastic syndrome 23.76 9.87 31 227869 30270 79486218
Musculoskeletal discomfort 23.76 9.87 116 227784 19719 79496769
Serotonin syndrome 23.68 9.87 59 227841 44968 79471520
Abdominal pain upper 23.65 9.87 821 227079 222998 79293490
Anaphylactic reaction 23.54 9.87 353 227547 83390 79433098
Joint destruction 23.28 9.87 52 227848 5873 79510615
Paranasal sinus inflammation 23.27 9.87 12 227888 223 79516265
COVID-19 pneumonia 23.15 9.87 29 227871 28820 79487668
Device dislocation 23.13 9.87 24 227876 25946 79490542
Ankle arthroplasty 23.03 9.87 25 227875 1500 79514988
Delusion 22.99 9.87 15 227885 20408 79496080
Oesophageal fibrosis 22.86 9.87 11 227889 175 79516313
Haematuria 22.80 9.87 110 227790 68726 79447762
Amblyopia 22.66 9.87 12 227888 236 79516252
Muscle swelling 22.61 9.87 19 227881 826 79515662
Muscle spasticity 22.55 9.87 17 227883 21458 79495030
Blood pressure fluctuation 22.50 9.87 292 227608 66853 79449635
Sleep disorder 22.50 9.87 357 227543 85320 79431168
Dyspepsia 22.49 9.87 436 227464 108251 79408237
Pulmonary embolism 22.44 9.87 350 227550 171304 79345184
Cardiotoxicity 22.31 9.87 4 227896 12235 79504253
Acute respiratory distress syndrome 22.21 9.87 59 227841 44008 79472480
Device related infection 22.17 9.87 40 227860 34254 79482234
Left ventricular dysfunction 22.10 9.87 14 227886 19347 79497141
Leukocytosis 22.04 9.87 58 227842 43397 79473091
Labelled drug-drug interaction medication error 21.98 9.87 28 227872 27622 79488866
Hepatic encephalopathy 21.90 9.87 22 227878 24144 79492344
Cerebral artery thrombosis 21.85 9.87 21 227879 1090 79515398
Hypercalcaemia 21.83 9.87 186 227714 38244 79478244
Epstein-Barr virus infection 21.79 9.87 7 227893 14409 79502079
Aplastic anaemia 21.77 9.87 12 227888 17893 79498595
Infective pulmonary exacerbation of cystic fibrosis 21.76 9.87 5 227895 12846 79503642
Hyperammonaemia 21.63 9.87 3 227897 11090 79505398
Cytopenia 21.58 9.87 16 227884 20367 79496121
Scleritis 21.52 9.87 42 227858 4314 79512174
Dyskinesia 21.04 9.87 62 227838 44711 79471777
Spondyloarthropathy 21.02 9.87 20 227880 1025 79515463
Fracture 20.97 9.87 120 227780 21681 79494807
Hallucination 20.96 9.87 151 227749 85594 79430894
Spinal compression fracture 20.91 9.87 100 227800 16858 79499630
Pneumonitis 20.89 9.87 96 227804 60764 79455724
Schizophrenia 20.82 9.87 9 227891 15431 79501057
Haemophagocytic lymphohistiocytosis 20.82 9.87 19 227881 21818 79494670
Multiple sclerosis relapse 20.76 9.87 66 227834 46467 79470021
Haemodynamic instability 20.63 9.87 12 227888 17370 79499118
Xyphoid retraction 20.56 9.87 10 227890 163 79516325
Inappropriate antidiuretic hormone secretion 20.55 9.87 27 227873 26286 79490202
Product complaint 20.46 9.87 84 227816 13265 79503223
Vomiting 20.43 9.87 1632 226268 664196 78852292
Nephropathy toxic 20.39 9.87 17 227883 20402 79496086
Pericardial effusion 20.33 9.87 66 227834 46171 79470317
Parkinsonism 20.33 9.87 11 227889 16573 79499915
Knee operation 20.32 9.87 49 227851 5817 79510671
Suspected suicide 20.30 9.87 3 227897 10573 79505915
Angina unstable 20.04 9.87 97 227803 16430 79500058
Injury 20.00 9.87 322 227578 77174 79439314
Fall 19.98 9.87 1165 226735 486464 79030024
Pancreatitis acute 19.67 9.87 74 227826 49530 79466958
Salivary hypersecretion 19.65 9.87 8 227892 14216 79502272
Pulmonary hypertension 19.54 9.87 71 227829 48009 79468479
Injection site reaction 19.53 9.87 241 227659 54544 79461944
Medulloblastoma 19.50 9.87 8 227892 85 79516403
Emotional distress 19.42 9.87 187 227713 39782 79476706
Muscle rigidity 19.31 9.87 17 227883 19865 79496623
Disorientation 19.26 9.87 103 227797 62673 79453815
Bone marrow oedema 19.07 9.87 24 227876 1687 79514801
Device issue 19.02 9.87 30 227870 27078 79489410
Therapy non-responder 19.00 9.87 370 227530 91935 79424553
Abnormal behaviour 18.94 9.87 48 227852 36373 79480115
Suicidal ideation 18.87 9.87 134 227766 76206 79440282
Osteogenesis imperfecta 18.86 9.87 14 227886 507 79515981
Dystonia 18.81 9.87 20 227880 21379 79495109
Splenic embolism 18.64 9.87 10 227890 202 79516286
Sideroblastic anaemia 18.59 9.87 11 227889 270 79516218
Ligament sprain 18.53 9.87 82 227818 13382 79503106
Lip dry 18.35 9.87 90 227810 15328 79501160
Epilepsy 18.19 9.87 58 227842 40802 79475686
Systemic infection 18.19 9.87 3 227897 9749 79506739
Feeling abnormal 18.09 9.87 589 227311 158610 79357878
Joint prosthesis user 18.09 9.87 7 227893 63 79516425
Dysphagia 18.07 9.87 243 227657 121893 79394595
Lethargy 18.06 9.87 147 227753 81145 79435343
Pleural effusion 18.05 9.87 299 227601 144963 79371525
Blood potassium decreased 18.04 9.87 70 227830 46442 79470046
Coronary artery disease 18.02 9.87 275 227625 65199 79451289
Anuria 17.97 9.87 20 227880 20943 79495545
Muscle twitching 17.76 9.87 27 227873 24737 79491751
Bone disorder 17.60 9.87 104 227796 19009 79497479
Entropion 17.53 9.87 7 227893 69 79516419
Electrolyte imbalance 17.41 9.87 39 227861 30842 79485646
Vascular device infection 17.40 9.87 4 227896 10272 79506216
Localised infection 17.37 9.87 174 227726 37401 79479087
Product dose omission issue 17.32 9.87 557 227343 246980 79269508
Medication error 17.20 9.87 120 227780 68522 79447966
Rheumatoid factor positive 17.12 9.87 253 227647 59586 79456902
Pulmonary congestion 16.92 9.87 134 227766 26966 79489522
Cystitis haemorrhagic 16.71 9.87 3 227897 9169 79507319
Renal cancer 16.69 9.87 7 227893 12219 79504269
Exposure to toxic agent 16.68 9.87 3 227897 9155 79507333
Dactylitis 16.67 9.87 29 227871 2728 79513760
Acute myeloid leukaemia 16.61 9.87 40 227860 30845 79485643
Diaphragmatic injury 16.58 9.87 8 227892 128 79516360
Coronary artery occlusion 16.54 9.87 87 227813 15228 79501260
Haemorrhage intracranial 16.53 9.87 31 227869 26162 79490326
Finger deformity 16.53 9.87 53 227847 7421 79509067
Dry mouth 16.52 9.87 348 227552 87671 79428817
Aspiration 16.45 9.87 20 227880 20138 79496350
Body temperature decreased 16.41 9.87 152 227748 31993 79484495
Chronic kidney disease 16.41 9.87 116 227784 66038 79450450
Lip and/or oral cavity cancer 16.38 9.87 18 227882 1095 79515393
Staphylococcal sepsis 16.33 9.87 11 227889 14715 79501773
Coeliac disease 16.32 9.87 6 227894 11345 79505143
Synovial disorder 16.31 9.87 24 227876 1959 79514529
Wrong product administered 16.31 9.87 3 227897 9009 79507479
Heart rate decreased 16.26 9.87 287 227613 70029 79446459
Sciatic nerve neuropathy 16.18 9.87 12 227888 434 79516054
Ejection fraction decreased 16.16 9.87 48 227852 34529 79481959
Mania 16.12 9.87 17 227883 18243 79498245
Product monitoring error 16.04 9.87 3 227897 8903 79507585
Sinus tachycardia 16.01 9.87 53 227847 36855 79479633
Blood pressure increased 15.98 9.87 748 227152 210612 79305876
Blood pressure systolic abnormal 15.98 9.87 94 227806 17153 79499335
Mass excision 15.96 9.87 11 227889 354 79516134
Hypersensitivity 15.95 9.87 909 226991 261330 79255158
General physical health deterioration 15.92 9.87 634 227266 274604 79241884
Subdural haematoma 15.91 9.87 42 227858 31392 79485096
Aphasia 15.87 9.87 74 227826 46658 79469830
Failure to thrive 15.82 9.87 7 227893 11837 79504651
Blood lactate dehydrogenase increased 15.81 9.87 58 227842 39112 79477376
Immune reconstitution inflammatory syndrome 15.81 9.87 10 227890 13831 79502657
Drug dependence 15.70 9.87 182 227718 40587 79475901
Hyperthermia 15.69 9.87 17 227883 18020 79498468
Blood phosphorus increased 15.69 9.87 5 227895 10342 79506146
Dermatitis allergic 15.64 9.87 97 227803 18033 79498455
Respiratory distress 15.62 9.87 100 227800 58239 79458249
Hallucination, visual 15.62 9.87 45 227855 32684 79483804
Gelatinous transformation of the bone marrow 15.58 9.87 5 227895 24 79516464
Restlessness 15.56 9.87 74 227826 46418 79470070
Transfusion 15.54 9.87 23 227877 21307 79495181
Quality of life decreased 15.52 9.87 65 227835 10355 79506133
X-ray abnormal 15.47 9.87 44 227856 5769 79510719
Lymphocyte count decreased 15.41 9.87 76 227824 47213 79469275
Hallucination, auditory 15.39 9.87 22 227878 20671 79495817
Breast cancer stage III 15.19 9.87 62 227838 9764 79506724
Hypothermia 15.18 9.87 26 227874 22720 79493768
Device leakage 15.17 9.87 6 227894 10850 79505638
Sensitivity to weather change 15.09 9.87 54 227846 7993 79508495
Circulatory collapse 15.06 9.87 56 227844 37612 79478876
Hypovolaemia 15.03 9.87 17 227883 17674 79498814
Polyneuropathy 14.88 9.87 29 227871 24122 79492366
Red blood cell count decreased 14.85 9.87 239 227661 57274 79459214
Tuberculosis 14.84 9.87 84 227816 15114 79501374
Ankle fracture 14.77 9.87 91 227809 16878 79499610
Limb injury 14.76 9.87 139 227761 29389 79487099
Orchitis noninfective 14.75 9.87 4 227896 9 79516479
Cystitis 14.71 9.87 222 227678 52510 79463978
Renal tubular necrosis 14.63 9.87 31 227869 25008 79491480
Blood pressure diastolic increased 14.62 9.87 81 227819 14461 79502027
Malignant polyp 14.55 9.87 8 227892 170 79516318
Unevaluable event 14.51 9.87 96 227804 55489 79460999
Hypernatraemia 14.47 9.87 12 227888 14439 79502049
Blood creatine phosphokinase increased 14.46 9.87 120 227780 65970 79450518
Myocarditis 14.36 9.87 25 227875 21708 79494780
Neutrophil count increased 14.33 9.87 40 227860 29356 79487132
Atrioventricular block first degree 14.30 9.87 9 227891 12482 79504006
Therapy interrupted 14.30 9.87 44 227856 31297 79485191
Cervical radiculopathy 14.28 9.87 18 227882 1267 79515221
Patellofemoral pain syndrome 14.27 9.87 12 227888 522 79515966
Hyperthyroidism 14.27 9.87 26 227874 22183 79494305
Unresponsive to stimuli 14.24 9.87 97 227803 55691 79460797
Tubo-ovarian abscess 14.21 9.87 10 227890 333 79516155
Facet joint syndrome 14.19 9.87 67 227833 11235 79505253
Lumbar spinal stenosis 14.08 9.87 40 227860 5242 79511246
Periarthritis 14.05 9.87 28 227872 2920 79513568
Syndesmophyte 14.05 9.87 6 227894 71 79516417
Post procedural infection 13.94 9.87 67 227833 11317 79505171
Foetal death 13.88 9.87 3 227897 8041 79508447
Chest expansion decreased 13.87 9.87 8 227892 187 79516301
Peritonitis bacterial 13.85 9.87 5 227895 9562 79506926
Insomnia 13.80 9.87 844 227056 244326 79272162
Oedema peripheral 13.76 9.87 585 227315 251703 79264785
Papillary renal cell carcinoma 13.73 9.87 9 227891 266 79516222
Bronchial wall thickening 13.71 9.87 26 227874 2615 79513873
Catatonia 13.69 9.87 4 227896 8752 79507736
Splenomegaly 13.60 9.87 24 227876 20730 79495758
Inappropriate schedule of product administration 13.56 9.87 488 227412 133140 79383348
Therapy partial responder 13.43 9.87 18 227882 17379 79499109
Hernia 13.32 9.87 89 227811 16970 79499518
Intestinal ischaemia 13.31 9.87 11 227889 13259 79503229
Hip surgery 13.28 9.87 29 227871 3226 79513262
Tendinous contracture 13.16 9.87 7 227893 139 79516349
Hyperlipidaemia 13.13 9.87 123 227777 25970 79490518
White blood cell count increased 13.13 9.87 143 227757 74490 79441998
Residual urine volume increased 13.12 9.87 5 227895 43 79516445
Burning sensation 13.09 9.87 238 227662 58394 79458094
Wrist fracture 13.07 9.87 68 227832 11853 79504635
Tongue cancer recurrent 13.05 9.87 4 227896 16 79516472
Small intestine ulcer 13.04 9.87 13 227887 706 79515782
Polyarthritis 12.96 9.87 69 227831 12133 79504355
Blood creatinine increased 12.82 9.87 341 227559 154716 79361772
Metastases to liver 12.74 9.87 40 227860 28274 79488214
Apathy 12.72 9.87 11 227889 12966 79503522
Full blood count decreased 12.70 9.87 37 227863 26782 79489706
Asphyxia 12.67 9.87 9 227891 11711 79504777
Nail injury 12.60 9.87 12 227888 616 79515872
Duodenal ulcer 12.54 9.87 85 227815 16284 79500204
Sinusitis 12.53 9.87 681 227219 194820 79321668
Glomerular filtration rate decreased 12.53 9.87 29 227871 22673 79493815
Brain herniation 12.45 9.87 3 227897 7460 79509028
Haemolysis 12.39 9.87 11 227889 12801 79503687
Metabolic surgery 12.35 9.87 16 227884 1158 79515330
Intervertebral disc disorder 12.34 9.87 36 227864 4789 79511699
Rales 12.34 9.87 24 227876 19977 79496511
Tooth abscess 12.32 9.87 84 227816 16126 79500362
Injection related reaction 12.30 9.87 15 227885 1021 79515467
Obesity 12.30 9.87 154 227746 34971 79481517
Spinal disorder 12.29 9.87 60 227840 10200 79506288
Exposure via skin contact 12.27 9.87 9 227891 320 79516168
Gastritis 12.23 9.87 199 227701 47794 79468694
Urosepsis 12.23 9.87 37 227863 26458 79490030
Vertebral foraminal stenosis 12.19 9.87 16 227884 1173 79515315
Drug ineffective for unapproved indication 12.15 9.87 91 227809 51147 79465341
Oral herpes 12.15 9.87 126 227774 27328 79489160
Soft tissue swelling 12.11 9.87 18 227882 1483 79515005
Full blood count abnormal 12.09 9.87 67 227833 40407 79476081
Drug level decreased 12.06 9.87 14 227886 14388 79502100
Atrioventricular block complete 12.02 9.87 18 227882 16592 79499896
Erythema multiforme 11.98 9.87 89 227811 17562 79498926
Second primary malignancy 11.97 9.87 14 227886 14336 79502152
Therapeutic response shortened 11.94 9.87 82 227818 15781 79500707
Gastrooesophageal reflux disease 11.92 9.87 386 227514 103860 79412628
Dermatitis exfoliative generalised 11.90 9.87 3 227897 7238 79509250
Peripheral vascular disorder 11.89 9.87 50 227850 7980 79508508
Product prescribing error 11.86 9.87 187 227713 44626 79471862
Meningitis streptococcal 11.86 9.87 7 227893 171 79516317
Tendon rupture 11.83 9.87 67 227833 12059 79504429
Spondylitis 11.81 9.87 35 227865 4696 79511792
Fluid retention 11.79 9.87 135 227765 69674 79446814
Torticollis 11.78 9.87 23 227877 2364 79514124
Sickle cell anaemia with crisis 11.71 9.87 4 227896 7918 79508570
Coeliac artery compression syndrome 11.71 9.87 6 227894 110 79516378
Blood sodium decreased 11.69 9.87 52 227848 33203 79483285
Pleurisy 11.66 9.87 60 227840 10415 79506073
Coagulopathy 11.65 9.87 58 227842 35948 79480540
Pregnancy of partner 11.62 9.87 8 227892 257 79516231
Atrial fibrillation 11.61 9.87 455 227445 197431 79319057
Musculoskeletal chest pain 11.61 9.87 115 227785 24649 79491839
Pulmonary haemorrhage 11.60 9.87 15 227885 14702 79501786
Myalgia intercostal 11.59 9.87 4 227896 25 79516463
Breast cyst excision 11.59 9.87 4 227896 25 79516463
Device use error 11.56 9.87 3 227897 7098 79509390
Spondylolisthesis 11.52 9.87 27 227873 3148 79513340
Back injury 11.52 9.87 60 227840 10463 79506025
Substance abuse 11.49 9.87 8 227892 10518 79505970
Malnutrition 11.44 9.87 30 227870 22472 79494016
Gingival bleeding 11.43 9.87 18 227882 16258 79500230
Influenza 11.42 9.87 466 227434 129140 79387348
Cardiolipin antibody positive 11.41 9.87 7 227893 184 79516304
Serum ferritin increased 11.40 9.87 7 227893 9840 79506648
Skin texture abnormal 11.38 9.87 10 227890 462 79516026
Gingival ulceration 11.36 9.87 14 227886 963 79515525
Toe operation 11.35 9.87 11 227889 577 79515911
Hepatitis chronic persistent 11.30 9.87 3 227897 6 79516482
Mood swings 11.29 9.87 25 227875 19855 79496633
Bone density decreased 11.26 9.87 71 227829 13276 79503212
Myasthenia gravis 11.22 9.87 8 227892 10391 79506097
Diverticulum 11.21 9.87 77 227823 14819 79501669
Ingrowing nail 11.20 9.87 25 227875 2822 79513666
Pleuritic pain 11.19 9.87 58 227842 10094 79506394
Degenerative bone disease 11.15 9.87 6 227894 122 79516366
Gynaecomastia 11.14 9.87 4 227896 7677 79508811
Premature labour 11.14 9.87 5 227895 8385 79508103
Cataract 11.14 9.87 244 227656 61876 79454612
Abnormal loss of weight 11.11 9.87 5 227895 8371 79508117
Vitamin K deficiency 11.11 9.87 12 227888 716 79515772
Acidosis 11.11 9.87 25 227875 19737 79496751
Hypertensive crisis 11.09 9.87 27 227873 20743 79495745
Cardiac disorder 11.07 9.87 256 227644 65501 79450987
Product administration error 11.07 9.87 50 227850 31796 79484692
Haemodialysis 11.03 9.87 22 227878 18146 79498342
Dermatitis 10.98 9.87 101 227799 21220 79495268
Chondropathy 10.96 9.87 23 227877 2489 79513999
Lung consolidation 10.87 9.87 6 227894 8941 79507547
Pelvic adhesions 10.82 9.87 8 227892 288 79516200
Catheter site infection 10.82 9.87 3 227897 6792 79509696
Sleep disorder due to a general medical condition 10.79 9.87 15 227885 14262 79502226
Rheumatoid factor 10.79 9.87 9 227891 387 79516101
Haemoptysis 10.79 9.87 105 227795 55894 79460594
Personality change 10.75 9.87 8 227892 10162 79506326
Bacterial sepsis 10.71 9.87 5 227895 8193 79508295
Neuralgia 10.69 9.87 144 227756 33240 79483248
Feeling jittery 10.64 9.87 68 227832 12773 79503715
Depressed mood 10.61 9.87 88 227812 48392 79468096
Lymphopenia 10.61 9.87 48 227852 30509 79485979
Psychomotor hyperactivity 10.58 9.87 20 227880 16829 79499659
Uterine disorder 10.57 9.87 21 227879 2186 79514302
Hypophosphataemia 10.54 9.87 26 227874 19887 79496601
Pseudomonas infection 10.52 9.87 28 227872 20875 79495613
Infective tenosynovitis 10.50 9.87 9 227891 402 79516086
Shock 10.49 9.87 77 227823 43471 79473017
Urinary tract infection 10.49 9.87 660 227240 273852 79242636
Respiratory syncytial virus infection 10.46 9.87 7 227893 9395 79507093
Mycobacterium tuberculosis complex test positive 10.41 9.87 24 227876 2768 79513720
Blood alkaline phosphatase increased 10.41 9.87 124 227776 63540 79452948
Inadequate analgesia 10.40 9.87 33 227867 4596 79511892
Intestinal obstruction 10.39 9.87 76 227824 42944 79473544
Purpura senile 10.39 9.87 10 227890 520 79515968
Limb deformity 10.37 9.87 28 227872 3562 79512926
Hypoalbuminaemia 10.37 9.87 29 227871 21268 79495220
Bradykinesia 10.36 9.87 5 227895 8038 79508450
Chronic idiopathic pain syndrome 10.34 9.87 4 227896 36 79516452
Disturbance in attention 10.33 9.87 94 227806 50707 79465781
Nasal polyps 10.32 9.87 4 227896 7323 79509165
Stress cardiomyopathy 10.31 9.87 10 227890 11156 79505332
Jaundice 10.30 9.87 100 227800 53249 79463239
Gluten sensitivity 10.28 9.87 9 227891 414 79516074
Balance disorder 10.24 9.87 210 227690 98647 79417841
Adrenal suppression 10.19 9.87 16 227884 1383 79515105
Oesophageal carcinoma 10.15 9.87 10 227890 11074 79505414
Magnetic resonance imaging spinal abnormal 10.11 9.87 7 227893 227 79516261
Tumour necrosis factor receptor-associated periodic syndrome 10.09 9.87 5 227895 85 79516403
Rebound effect 10.09 9.87 4 227896 7222 79509266
Tendon disorder 10.07 9.87 44 227856 7142 79509346
Ovarian cystectomy 10.04 9.87 5 227895 86 79516402
Blood magnesium decreased 10.02 9.87 20 227880 16492 79499996
Body temperature increased 10.01 9.87 80 227820 44340 79472148
Myopathy 10.01 9.87 28 227872 20535 79495953
Fracture delayed union 10.01 9.87 20 227880 2090 79514398
Liver function test abnormal 10.00 9.87 127 227773 64348 79452140
Cardiac stress test abnormal 9.97 9.87 12 227888 806 79515682
Akathisia 9.95 9.87 14 227886 13245 79503243
Vitamin B1 decreased 9.88 9.87 10 227890 553 79515935
Paraesthesia mucosal 9.88 9.87 4 227896 41 79516447
Atrial tachycardia 9.87 9.87 4 227896 7129 79509359
Myoclonus 9.87 9.87 43 227857 27617 79488871

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C08CA51 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC L01XX33 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Other antineoplastic agents
ATC M01AH01 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Coxibs
ATC N02AJ16 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D052246 Cyclooxygenase 2 Inhibitors
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:50629 COX-2 inhibitor
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatoid arthritis indication 69896004 DOID:7148
Dysmenorrhea indication 266599000
Osteoarthritis indication 396275006
Juvenile rheumatoid arthritis indication 410795001
Acute postoperative pain indication 107401000119105
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Gastrointestinal hemorrhage contraindication 74474003
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Asthma contraindication 195967001 DOID:2841
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thromboembolic disorder contraindication 371039008
Cardiovascular event risk contraindication 395112001
Smokes tobacco daily contraindication 449868002




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.79 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 10MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 2.5MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 5MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 10MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 9408837 Feb. 28, 2030 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 2.5MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 9408837 Feb. 28, 2030 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 5MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 9408837 Feb. 28, 2030 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
56MG;44MG SEGLENTIS KOWA PHARMS N213426 Oct. 15, 2021 RX TABLET ORAL 10238668 April 19, 2030 A METHOD FOR TREATMENT OF PAIN IN ADULTS USING TRAMADOL HYDROCHLORIDE AND CELECOXIB
56MG;44MG SEGLENTIS KOWA PHARMS N213426 Oct. 15, 2021 RX TABLET ORAL 10548909 April 19, 2030 A METHOD FOR TREATMENT OF PAIN IN ADULTS USING TRAMADOL HYDROCHLORIDE AND CELECOXIB
56MG;44MG SEGLENTIS KOWA PHARMS N213426 Oct. 15, 2021 RX TABLET ORAL 11478488 April 19, 2030 A METHOD FOR TREATMENT OF PAIN IN ADULTS USING TRAMADOL HYDROCHLORIDE AND CELECOXIB
25MG/ML ELYXYB SCILEX HLDG N212157 May 5, 2020 DISCN SOLUTION ORAL 10376527 May 27, 2036 ACUTE TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS
25MG/ML ELYXYB SCILEX HLDG N212157 May 5, 2020 DISCN SOLUTION ORAL 10722456 May 27, 2036 ACUTE TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS
25MG/ML ELYXYB SCILEX HLDG N212157 May 5, 2020 DISCN SOLUTION ORAL 10799517 May 27, 2036 ACUTE TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS
25MG/ML ELYXYB SCILEX HLDG N212157 May 5, 2020 DISCN SOLUTION ORAL 9572819 May 27, 2036 ACUTE TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS
25MG/ML ELYXYB SCILEX HLDG N212157 May 5, 2020 DISCN SOLUTION ORAL 9795620 May 27, 2036 ACUTE TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS
25MG/ML ELYXYB SCILEX HLDG N212157 May 5, 2020 DISCN SOLUTION ORAL 9949990 May 27, 2036 ACUTE TREATMENT OF MIGRAINE WITH OR WITHOUT AURA IN ADULTS
EQ 10MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 10925835 June 14, 2038 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 2.5MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 10925835 June 14, 2038 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 5MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 10925835 June 14, 2038 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
25MG/ML ELYXYB SCILEX HLDG N212157 May 5, 2020 DISCN SOLUTION ORAL May 5, 2023 NEW PRODUCT
56MG;44MG SEGLENTIS KOWA PHARMS N213426 Oct. 15, 2021 RX TABLET ORAL Oct. 15, 2024 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7.24 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 7.30 CHEMBL
D(1A) dopamine receptor GPCR Ki 4.85 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 5.48 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.14 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 6.16 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 4.92 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 6.18 WOMBAT-PK
Cytochrome P450 2D6 Enzyme IC50 6 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 4.86 DRUG MATRIX
Carbonic anhydrase 2 Enzyme IC50 7.68 WOMBAT-PK
Carbonic anhydrase 1 Enzyme Ki 4.30 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.06 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 4.80 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 7.74 CHEMBL
Arachidonate 5-lipoxygenase Enzyme IC50 5.76 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 6.10 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 7.03 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 5.66 CHEMBL
cGMP-specific 3',5'-cyclic phosphodiesterase Enzyme IC50 4.44 CHEMBL
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Enzyme IC50 5.03 DRUG MATRIX
Histone deacetylase 1 Enzyme IC50 5.93 CHEMBL
Histone deacetylase 6 Enzyme IC50 6.19 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.13 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 7.03 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 6.16 CHEMBL
Cytochrome c oxidase subunit 2 Enzyme IC50 6.27 CHEMBL
3-phosphoinositide-dependent protein kinase 1 Kinase IC50 4.32 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 7.01 CHEMBL
Prostaglandin E synthase Enzyme IC50 6.37 CHEMBL
Mitogen-activated protein kinase 14 Kinase IC50 6.09 CHEMBL
Carbonic anhydrase Enzyme Ki 6.76 CHEMBL
Progesterone receptor Transcription factor Ki 5.63 DRUG MATRIX
Prostaglandin G/H synthase 2 Enzyme IC50 9.29 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 9.15 CHEMBL
Cyclooxygenase 2; Prostaglandin G/H synthase-2; Uncharacterized protein Enzyme IC50 6.05 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 6.54 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 8.43 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 7.24 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.96 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.85 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.25 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 7.40 CHEMBL
Carbonic anhydrase Enzyme Ki 6.85 CHEMBL
Carbonic anhydrase Enzyme Ki 4.41 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 7.35 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.11 CHEMBL
Carbonic anhydrase Enzyme Ki 6.97 CHEMBL
Carbonic anhydrase Enzyme Ki 7.68 CHEMBL
Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase Enzyme Ki 5.11 CHEMBL
Carbonic anhydrase Enzyme Ki 6.94 CHEMBL
Alpha carbonic anhydrase Enzyme Ki 7.47 CHEMBL
Cytochrome c oxidase subunit 2 Enzyme IC50 7.22 CHEMBL
Carbonic anhydrase Enzyme Ki 6.16 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 5.51 CHEMBL
Astrosclerin-3 Enzyme Ki 6.14 CHEMBL
Beta-carbonic anhydrase 1 Enzyme Ki 4.99 CHEMBL
Delta carbonic anhydrase Unclassified Ki 6.58 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 6.15 CHEMBL
Cytochrome c oxidase subunit 1 Enzyme IC50 4.61 CHEMBL
Carbonic anhydrase, alpha family Unclassified Ki 6.01 CHEMBL
Carbonate dehydratase Enzyme Ki 8.16 CHEMBL

External reference:

IDSource
4021143 VUID
N0000148596 NUI
D00567 KEGG_DRUG
140587 RXNORM
C0538927 UMLSCUI
CHEBI:41423 CHEBI
CEL PDB_CHEM_ID
CHEMBL118 ChEMBL_ID
DB00482 DRUGBANK_ID
D000068579 MESH_DESCRIPTOR_UI
2662 PUBCHEM_CID
2892 IUPHAR_LIGAND_ID
7767 INN_ID
JCX84Q7J1L UNII
14020 MMSL
174627 MMSL
7872 MMSL
d04380 MMSL
007731 NDDF
116081000 SNOMEDCT_US
370187009 SNOMEDCT_US
4021143 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1515 CAPSULE 50 mg ORAL NDA 31 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1515 CAPSULE 50 mg ORAL NDA 31 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1520 CAPSULE 100 mg ORAL NDA 31 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1520 CAPSULE 100 mg ORAL NDA 31 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1525 CAPSULE 200 mg ORAL NDA 31 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1525 CAPSULE 200 mg ORAL NDA 31 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1530 CAPSULE 400 mg ORAL NDA 31 sections
CELEBREX HUMAN PRESCRIPTION DRUG LABEL 1 0025-1530 CAPSULE 400 mg ORAL NDA 31 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7165 CAPSULE 100 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7165 CAPSULE 100 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7165 CAPSULE 100 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7166 CAPSULE 200 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7166 CAPSULE 200 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7166 CAPSULE 200 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7170 CAPSULE 400 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7170 CAPSULE 400 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7170 CAPSULE 400 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7306 CAPSULE 50 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7306 CAPSULE 50 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0093-7306 CAPSULE 50 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7150 CAPSULE 200 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7150 CAPSULE 200 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7160 CAPSULE 100 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7160 CAPSULE 100 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7165 CAPSULE 50 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7165 CAPSULE 50 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7170 CAPSULE 400 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0378-7170 CAPSULE 400 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3982 CAPSULE 50 mg ORAL ANDA 30 sections
Celecoxib HUMAN PRESCRIPTION DRUG LABEL 1 0591-3982 CAPSULE 50 mg ORAL ANDA 30 sections