coumafos 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| insecticides, anthelminthics, pesticides etc., phosphorous derivatives | 5667 | 56-72-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A organothiophosphorus cholinesterase inhibitor that is used as an anthelmintic, insecticide, and as nematocide
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:22153 | acaricides |
| CHEBI has role | CHEBI:33286 | agricultural chemicals |
| CHEBI has role | CHEBI:33289 | avicides |
| CHEBI has role | CHEBI:35444 | antinematodal drugs |
| CHEBI has role | CHEBI:37733 | EC 3.1.1.8 inhibitor |
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000969 | Antinematodal Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| MeSH PA | D002800 | Cholinesterase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D010575 | Pesticides |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Chickens | Control of capillary worms (Capillaria obsignata) | Indication |
| Chickens | Control of common round worm, Ascaridia galli | Indication |
| Chickens | Control of cecal worm (Heterakis gallinae) | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Meldane 2 | Elanco US Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 1 | Enzyme | Ki | 4.21 | CHEMBL | |||||
| Carbonic anhydrase 4 | Enzyme | Ki | 5.26 | CHEMBL | |||||
| Carbonic anhydrase 9 | Enzyme | Ki | 5.19 | CHEMBL | |||||
| Carbonic anhydrase 12 | Enzyme | Ki | 5.02 | CHEMBL | |||||
| Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 5.29 | CHEMBL | |||||
| Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 5.47 | CHEMBL | |||||
| Carbonic anhydrase 7 | Enzyme | Ki | 5.33 | CHEMBL | |||||
| Carbonic anhydrase 3 | Enzyme | Ki | 5.33 | CHEMBL | |||||
| Carbonic anhydrase 6 | Enzyme | Ki | 5.65 | CHEMBL | |||||
| Carbonic anhydrase 14 | Enzyme | Ki | 5.38 | CHEMBL | |||||
| Carbonic anhydrase 13 | Enzyme | Ki | 5.37 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:3903 | CHEBI |
| CHEMBL251680 | ChEMBL_ID |
| DB11390 | DRUGBANK_ID |
| C0010203 | UMLSCUI |
| 96128001 | SNOMEDCT_US |
| 1705 | INN_ID |
| D07750 | KEGG_DRUG |
| 2871 | PUBCHEM_CID |
| D003372 | MESH_DESCRIPTOR_UI |
| L08SZ5Z5JC | UNII |
Pharmaceutical products:
None