phenothiazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5597	92-84-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

phenothiazine
NSC-2037

Molecular weight: 199.27
Formula: C12H9NS
CLOGP: 3.91
LIPINSKI: 0
HAC: 1
HDO: 1
TPSA: 12.03
ALOGS: -2.71
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	133.52	86.40	37	144	145636	63343205

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	112.04	52.42	43	368	245724	79498253
Cardio-respiratory arrest	56.22	52.42	21	390	108489	79635488

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000977	Antiparasitic Agents
MeSH PA	D000981	Antiprotozoal Agents
CHEBI has role	CHEBI:48578	free radical scavengers
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:173084	ferroptosis inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

Species	Use	Relation
Horses	Removal of bots, Gastrophilus nasalis	Indication
Horses	Removal of bots, Gastrophilus intestinalis	Indication
Horses	Removal of large strongyles, Strongylus vulgaris	Indication
Horses	Removal of small strongyles	Indication
Horses	Removal of large roundworms, Parascaris equorum	Indication
Horses	Removal of pinworms, Oxyuris equi	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Dyrex T.F - 1000, Dyrex T.F - 200, Dyrex T.F - 500	Zoetis Inc.	3
Parvex Plus Suspension	Zoetis Inc.	2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin G/H synthase 2	Enzyme	P35354	PGH2_HUMAN		IC50	6.27		CHEMBL
Cannabinoid receptor 1	GPCR	P21554	CNR1_HUMAN		Ki	4.71		CHEMBL
Prostaglandin G/H synthase 1	Enzyme	P23219	PGH1_HUMAN		IC50	6.71		CHEMBL
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		IC50	6.34		CHEMBL
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	5.93		CHEMBL
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	4.83		CHEMBL
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		Ki	4.84		CHEMBL
Acetylcholinesterase	Enzyme	P22303	ACES_HUMAN		IC50	5.14		CHEMBL
Cholinesterase	Enzyme	P06276	CHLE_HUMAN		IC50	5.24		CHEMBL
Cytochrome P450 1A2	Enzyme	P05177	CP1A2_HUMAN		IC50	7.80		CHEMBL
Amine oxidase [flavin-containing] A	Enzyme	P21397	AOFA_HUMAN		IC50	6.23		CHEMBL
Alpha-synuclein	Transporter	P37840	SYUA_HUMAN		IC50	4.58		CHEMBL
Arachidonate 15-lipoxygenase	Enzyme		LOX15_RABIT		IC50	5.33		CHEMBL
Arachidonate 5-lipoxygenase	Enzyme		LOX5_RAT		IC50	5.85		CHEMBL

External reference:

ID	Source
CHEBI:37932	CHEBI
CHEMBL828	ChEMBL_ID
C031637	MESH_SUPPLEMENTAL_RECORD_UI
DB11447	DRUGBANK_ID
C0031436	UMLSCUI
4173	INN_ID
372839006	SNOMEDCT_US
765430004	SNOMEDCT_US
D02601	KEGG_DRUG
7108	PUBCHEM_CID
GS9EX7QNU6	UNII

Pharmaceutical products:

None