DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
azaperone 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
tranquillizers, neuroleptics, 4'-fluoro-4-piperidinobutyrophenone derivatives
5590
1649-18-9
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
azaperone
A butyrophenone used in the treatment of PSYCHOSES
Molecular weight: 327.40
Formula: C19H22FN3O
CLOGP: 3.59
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 36.44
ALOGS: -3.15
ROTB: 6
Drug dosage:
None
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
None
FDA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
CHEBI has role
CHEBI:35476
neuroleptics
CHEBI has role
CHEBI:48561
dopaminergic antagonists
MeSH PA
D014150
Antipsychotic Agents
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D002492
Central Nervous System Depressants
MeSH PA
D015259
Dopamine Agents
MeSH PA
D018492
Dopamine Antagonists
MeSH PA
D006993
Hypnotics and Sedatives
MeSH PA
D018377
Neurotransmitter Agents
MeSH PA
D011619
Psychotropic Drugs
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
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Species
Use
Relation
Swine
Control of aggressiveness
Indication
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🐶 Veterinary products
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Product
Applicant
Ingredients
Stresnil Injection
Elanco US Inc.
1
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Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
D(2) dopamine receptor
GPCR
P14416
DRD2_HUMAN
Ki
7.28
CHEMBL
Sigma non-opioid intracellular receptor 1
Membrane receptor
Q99720
SGMR1_HUMAN
Ki
6.47
CHEMBL
5-hydroxytryptamine receptor 1A
GPCR
P08908
5HT1A_HUMAN
Ki
8.12
CHEMBL
5-hydroxytryptamine receptor 2A
GPCR
P28223
5HT2A_HUMAN
Ki
7.34
CHEMBL
5-hydroxytryptamine receptor 2C
GPCR
P28335
5HT2C_HUMAN
Ki
5.87
CHEMBL
5-hydroxytryptamine receptor 7
GPCR
P34969
5HT7R_HUMAN
Ki
6.94
CHEMBL
D(3) dopamine receptor
GPCR
P35462
DRD3_HUMAN
Ki
7.28
CHEMBL
D(4) dopamine receptor
GPCR
P21917
DRD4_HUMAN
Ki
8.20
CHEMBL
Transmembrane protein 97
Enzyme
Q5BJF2
TMM97_HUMAN
Ki
7.30
CHEMBL
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External reference:
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ID
Source
15443
PUBCHEM_CID
19BV78AK7W
UNII
2331
INN_ID
2601502
RXNORM
96229001
SNOMEDCT_US
C0004477
UMLSCUI
CHEBI:88301
CHEBI
CHEMBL340211
ChEMBL_ID
D001376
MESH_DESCRIPTOR_UI
D02620
KEGG_DRUG
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Pharmaceutical products:
None
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Structure 🔎
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azaperone