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azaperone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| tranquillizers, neuroleptics, 4'-fluoro-4-piperidinobutyrophenone derivatives | 5590 | 1649-18-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A butyrophenone used in the treatment of PSYCHOSES
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D006993 | Hypnotics and Sedatives |
| MeSH PA | D011619 | Psychotropic Drugs |
| MeSH PA | D014150 | Antipsychotic Agents |
| MeSH PA | D015259 | Dopamine Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018492 | Dopamine Antagonists |
| CHEBI has role | CHEBI:35476 | antipsychotic agent |
| CHEBI has role | CHEBI:48561 | dopaminergic antagonist |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Swine | Control of aggressiveness | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Stresnil Injection | Elanco US Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | GPCR | Ki | 7.28 | CHEMBL | |||||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 6.47 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 8.12 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2A | GPCR | Ki | 7.34 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.87 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 7 | GPCR | Ki | 6.94 | CHEMBL | |||||
| D(3) dopamine receptor | GPCR | Ki | 7.28 | CHEMBL | |||||
| D(4) dopamine receptor | GPCR | Ki | 8.20 | CHEMBL | |||||
| Transmembrane protein 97 | Enzyme | Ki | 7.30 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:88301 | CHEBI |
| CHEMBL340211 | ChEMBL_ID |
| DB11376 | DRUGBANK_ID |
| 96229001 | SNOMEDCT_US |
| C0004477 | UMLSCUI |
| D001376 | MESH_DESCRIPTOR_UI |
| 2331 | INN_ID |
| D02620 | KEGG_DRUG |
| 15443 | PUBCHEM_CID |
| 19BV78AK7W | UNII |
| 2601502 | RXNORM |
Pharmaceutical products:
None