oclacitinib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Janus kinase inhibitors, antineoplastics 5589 1208319-26-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oclacitinib
  • Molecular weight: 337.44
  • Formula: C15H23N5O2S
  • CLOGP: 1.77
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 90.98
  • ALOGS: -3.26
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Pruritus associated with allergic dermatitis Indication
Dogs Atopic dermatitis Indication

🐶 Veterinary products

ProductApplicantIngredients
apoquel Zoetis Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tyrosine-protein kinase JAK3 Kinase INHIBITOR IC50 7.02 IUPHAR
Tyrosine-protein kinase JAK1 Kinase INHIBITOR IC50 8.02 IUPHAR
Tyrosine-protein kinase JAK2 Kinase INHIBITOR IC50 7.76 IUPHAR
Non-receptor tyrosine-protein kinase TYK2 Kinase INHIBITOR IC50 7.12 IUPHAR
Tyrosine-protein kinase JAK2 Kinase INHIBITOR IC50 7.76 IUPHAR
Non-receptor tyrosine-protein kinase TYK2 Kinase INHIBITOR IC50 7.12 IUPHAR

External reference:

IDSource
CHEMBL2103874 ChEMBL_ID
C588062 MESH_SUPPLEMENTAL_RECORD_UI
9696 IUPHAR_LIGAND_ID
DB11441 DRUGBANK_ID
017725 NDDF
C3700984 UMLSCUI
9469 INN_ID
D10141 KEGG_DRUG
44631938 PUBCHEM_CID
1487006 RXNORM
99GS5XTB51 UNII

Pharmaceutical products:

None