etorphine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| opioid receptor antagonists/agonists, morphinan derivates | 5537 | 14521-96-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A narcotic analgesic morphinan used as sedative in veterinary practice
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:35482 | narcotic analgesic |
| CHEBI has role | CHEBI:35717 | hypnotics |
| CHEBI has role | CHEBI:60606 | opioid agonist |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000701 | Analgesics, Opioid |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D006993 | Hypnotics and Sedatives |
| MeSH PA | D009294 | Narcotics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Wildlife | Immobilization | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| M50-50 Diprenorphine, M99 Etorphine | Wildlife Laboratories Inc. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | GPCR | AGONIST | Ki | 9.50 | IUPHAR | ||||
| Kappa-type opioid receptor | GPCR | Ki | 9.30 | CHEMBL | |||||
| Delta-type opioid receptor | GPCR | AGONIST | Ki | 8.80 | IUPHAR | ||||
| Mu-type opioid receptor | GPCR | Ki | 9.85 | CHEMBL | |||||
| Mu-type opioid receptor | GPCR | IC50 | 9.32 | CHEMBL | |||||
| Delta-type opioid receptor | GPCR | Ki | 8.54 | CHEMBL | |||||
| Delta-type opioid receptor | GPCR | Ki | 9.57 | CHEMBL | |||||
| Kappa-type opioid receptor | GPCR | IC50 | 8.74 | CHEMBL | |||||
| Kappa-type opioid receptor | GPCR | Ki | 9.74 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:4912 | CHEBI |
| CHEMBL140050 | ChEMBL_ID |
| 1625 | IUPHAR_LIGAND_ID |
| DB01497 | DRUGBANK_ID |
| D005048 | MESH_DESCRIPTOR_UI |
| C0015134 | UMLSCUI |
| 2288 | INN_ID |
| 96188003 | SNOMEDCT_US |
| 96189006 | SNOMEDCT_US |
| 13764-49-3 | SECONDARY_CAS_RN |
| D07937 | KEGG_DRUG |
| 644209 | PUBCHEM_CID |
| 42M2Y6NU9O | UNII |
Pharmaceutical products:
None