diprenorphine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| opioid receptor antagonists/agonists, morphinan derivates | 5526 | 14357-78-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A narcotic antagonist similar in action to NALOXONE. It is used to remobilize animals after ETORPHINE neuroleptanalgesia and is considered specific antagonist to etorphine
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D009292 | Narcotic Antagonists |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Wildlife | To reverse the effects of etorphine hydrochloride | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| M50-50 Diprenorphine, M99 Etorphine | Wildlife Laboratories Inc. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | GPCR | Ki | 10.15 | CHEMBL | |||||
| Kappa-type opioid receptor | GPCR | Ki | 10.70 | CHEMBL | |||||
| Delta-type opioid receptor | GPCR | Ki | 9.64 | CHEMBL | |||||
| Mu-type opioid receptor | GPCR | IC50 | 9.15 | CHEMBL | |||||
| Kappa-type opioid receptor | GPCR | IC50 | 8.74 | CHEMBL | |||||
| Kappa-type opioid receptor | GPCR | Kd | 10.54 | CHEMBL | |||||
| Mu-type opioid receptor | GPCR | IC50 | 8.85 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:4650 | CHEBI |
| CHEMBL281786 | ChEMBL_ID |
| 1617 | IUPHAR_LIGAND_ID |
| DB01548 | DRUGBANK_ID |
| D004174 | MESH_DESCRIPTOR_UI |
| C0012572 | UMLSCUI |
| 2639 | INN_ID |
| 28580002 | SNOMEDCT_US |
| 16808-86-9 | SECONDARY_CAS_RN |
| D07863 | KEGG_DRUG |
| 443408 | PUBCHEM_CID |
| 1F0L5N25ZZ | UNII |
Pharmaceutical products:
None