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difamilast 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
phosphodiesterase IV (PDE IV) inhibitors	5503	937782-05-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: difamilast moizerto OPA-15406 MM36	Difamilast is a novel atopic dermatitis drug that has phosphodiesterase 4 inhibitory activity. PDE4 inhibitors are believed to improve the symptoms of atopic dermatitis through suppression of the production of chemical mediators such as pro-inflammatory cytokines and through other anti-inflammatory effects. Molecular weight: 446.45 Formula: C23H24F2N2O5 CLOGP: 4.28 LIPINSKI: 0 HAC: 7 HDO: 1 TPSA: 82.82 ALOGS: -4.29 ROTB: 10

Molecule

Description

Molfile Inchi Smiles

Synonyms:

difamilast
moizerto
OPA-15406
MM36

Difamilast is a novel atopic dermatitis drug that has phosphodiesterase 4 inhibitory activity. PDE4 inhibitors are believed to improve the symptoms of atopic dermatitis through suppression of the production of chemical mediators such as pro-inflammatory cytokines and through other anti-inflammatory effects.

Molecular weight: 446.45
Formula: C23H24F2N2O5
CLOGP: 4.28
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 82.82
ALOGS: -4.29
ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Sept. 27, 2021	PMDA	OTSUKA PHARMACEUTICAL Co., Ltd

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Atopic dermatitis	indication	24079001	DOID:3310

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Enzyme	Q07343	PDE4B_HUMAN	INHIBITOR	IC50	7.95		SCIENTIFIC LITERATURE

External reference:

ID	Source
CHEMBL3989968	ChEMBL_ID
C000711049	MESH_SUPPLEMENTAL_RECORD_UI
C119208	MESH_SUPPLEMENTAL_RECORD_UI
9776	IUPHAR_LIGAND_ID
DB14987	DRUGBANK_ID
D11314	KEGG_DRUG
C5139795	UMLSCUI
CHEMBL225555	ChEMBL_ID
10717	INN_ID
57855696	PUBCHEM_CID
T3U32GLJ0F	UNII

Pharmaceutical products:

None