molidustat 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors | 5486 | 1154028-82-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
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Molidustat (BAY 85–3934) is a novel, orally bioavailable HIF-PH inhibitor that mimics hypoxia by stabilizing HIF-a subunits. Molidustat inhibits HIF-PH, allowing the accumulation of HIF, which then translocates to the nucleus where it activates the transcription of erythropoietin (EPO) and other hypoxia-inducible genes, thereby increasing endogenous EPO levels and formation of the red blood cell.
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Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 22, 2021 | PMDA | BAYER YAKUHIN, Ltd |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Renal anemia | indication | 234348004 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Egl nine homolog 1 | Enzyme | INHIBITOR | IC50 | 6.55 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Egl nine homolog 2 | Enzyme | INHIBITOR | IC50 | 6.32 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Egl nine homolog 3 | Enzyme | INHIBITOR | IC50 | 6.35 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Hypoxia-inducible factor 1-alpha inhibitor | Enzyme | IC50 | 4.51 | CHEMBL | |||||
| Prolyl 4-hydroxylase | Unclassified | Ki | 4.79 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| A1H | PDB_CHEM_ID |
| QEQ | PDB_CHEM_ID |
| CHEMBL3646118 | ChEMBL_ID |
| C000603972 | MESH_SUPPLEMENTAL_RECORD_UI |
| 8456 | IUPHAR_LIGAND_ID |
| 1375799-59-9 | SECONDARY_CAS_RN |
| DB15642 | DRUGBANK_ID |
| D11273 | KEGG_DRUG |
| C4078705 | UMLSCUI |
| CHEMBL3931782 | ChEMBL_ID |
| 9655 | INN_ID |
| 59603622 | PUBCHEM_CID |
| 2637534 | RXNORM |
| 9JH486CZ13 | UNII |
Pharmaceutical products:
None