sofpironium bromide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5428 1628106-94-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sofpironium bromide
  • sofpironium
  • ecclock
  • BBI-4000
Sofpironium bromide gel is a topical anticholinergic agent developed for the treatment of hyperhidrosis. The drug is designed to reduce sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site.
  • Molecular weight: 390.50
  • Formula: C22H32NO5
  • CLOGP: 1.91
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 72.83
  • ALOGS: -5.81
  • ROTB: 9

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 25, 2020 PMDA Kaken Pharmaceutical

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hyperhidrosis indication 312230002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D10989 KEGG_DRUG
7B2Y1932XU UNII
1628251-49-9 SECONDARY_CAS_RN
C4726762 UMLSCUI
CHEMBL3707223 ChEMBL_ID
86301316 PUBCHEM_CID
CHEMBL3707224 ChEMBL_ID
10398 INN_ID

Pharmaceutical products:

None