vadadustat 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors 5420 1000025-07-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vadadustat
  • vafseo
  • AKB-6548
  • MT-6548
  • PG-1016548
Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor induces endogenous erythropoietin synthesis and enhances iron mobilization.
  • Molecular weight: 306.70
  • Formula: C14H11ClN2O4
  • CLOGP: 3.87
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 99.52
  • ALOGS: -3.85
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 24, 2023 EMA AKEBIA EUROPE LIMITED
June 29, 2020 PMDA Mitsubishi Tanabe Pharma

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B03XA08 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
OTHER ANTIANEMIC PREPARATIONS
Other antianemic preparations

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Anemia of renal disease indication 234348004
Anemia in chronic kidney disease indication 707323002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Egl nine homolog 1 Enzyme INHIBITOR IC50 7.81 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Egl nine homolog 2 Enzyme INHIBITOR IC50 7.93 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Egl nine homolog 3 Enzyme INHIBITOR IC50 8.12 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Vascular endothelial growth factor A Secreted EC50 5.12 CHEMBL
Hypoxia-inducible factor 1-alpha inhibitor Enzyme IC50 4.54 CHEMBL
Prolyl 3-hydroxylase OGFOD1 Unclassified IC50 5.85 CHEMBL
Prolyl 4-hydroxylase Unclassified Ki 6.55 CHEMBL

External reference:

IDSource
D11078 KEGG_DRUG
I60W9520VV UNII
C4519730 UMLSCUI
A1Z PDB_CHEM_ID
CHEMBL3646221 ChEMBL_ID
23634441 PUBCHEM_CID
DB12255 DRUGBANK_ID
11831 IUPHAR_LIGAND_ID
C000624313 MESH_SUPPLEMENTAL_RECORD_UI
10289 INN_ID

Pharmaceutical products:

None