cefditoren pivoxil

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Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.08 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	5 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	13.16 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	14 %

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	2.917		High	1
caco2-efflux	Caco-2 efflux ratio (BA/AB)	4.207		High	1
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	41.879	10^-6 cm/s	High	1
dh-clint	Dog hepatocyte intrinsic clearance	41.783	uL/min/10^6 cells	High	1
dppb	Dog plasma protein binding (% unbound)	2.290	%	High	1
fcs-ppb	Fetal calf serum protein binding (% unbound)	3.570	%	High	1
herg	hERG pIC50	4.782	pIC50	High	1
hh-clint	Human hepatocyte intrinsic clearance	146.893	uL/min/10^6 cells	High	1
hlm-clint	Human liver microsomal intrinsic clearance	302.691	uL/min/mg protein	High	1
hppb	Human plasma protein binding (% unbound)	1.760	%	High	1
kinase-safety-class	ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1	53
kinase-selectivity-class	AXL,BRAF,CDK9,DDR1,DYRK1B,EPHB4,GRK2,MAP2K6,MAPK7,PRKDC,STK33,SYK,TEK,TTK	14
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	12.794		High	1
mh-clint	Mouse hepatocyte intrinsic clearance	212.324		High	1
mppb	Mouse plasma protein binding (% unbound)	2.870		High	1
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	34.119		High	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	3.720	%	High	1
rh-clint	Rat hepatocyte intrinsic clearance	240.991	uL/min/10^6 cells	High	1
rh-fuinc	Rat hepatocyte fraction unbound in incubation	39.230	%	High	1
rppb	Rat plasma protein binding (% unbound)	2.420	%	High	1
solubility-dd	Solubility at pH 7.4 in DMSO	100.231	uM	High	1

Source	Code	Description
ATC	J01DD16	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Third-generation cephalosporins
FDA CS	M0003827	Cephalosporins
FDA EPC	N0000175488	Cephalosporin Antibacterial
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000900	Anti-Bacterial Agents
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:36047	antibacterial drug
CHEBI has role	CHEBI:35441	antiinfective agent
CHEBI has role	CHEBI:50266	prodrug

Disease	Relation	SNOMED_ID	DOID
Streptococcal tonsillitis	indication	41582007
Bacterial pneumonia	indication	53084003	DOID:874
Haemophilus influenzae pneumonia	indication	70036007
Pneumococcal pneumonia	indication	233607000
Streptococcus pyogenes infection	indication	302809008
Infection due to Staphylococcus aureus	indication	406602003
Acute exacerbation of chronic bronchitis	indication	425748003
Streptococcus Pneumoniae Chronic Bronchitis	indication
Haemophilus Influenzae Chronic Bronchitis	indication
Haemophilus Parainfluenzae Chronic Bronchitis	indication
Moraxella Catarrhalis Chronic Bronchitis	indication
Haemophilus Parainfluenzae Pneumonia	indication
Moraxella Catarrhalis Pneumonia	indication
Factor II deficiency	contraindication	73975000
Impaired renal function disorder	contraindication	197663003
Pseudomembranous enterocolitis	contraindication	397683000
Carnitine deficiency	contraindication	421784001

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.1	Basic
pKa2	2.02	Basic

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cefditoren pivoxil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Prolyl endopeptidase FAP	Enzyme	Q12884	SEPR_HUMAN		IC50	7.19	CHEMBL
Bacterial penicillin-binding protein	Enzyme		PBPA_ECOLI PBPB_ECOLI DACC_ECOLI PBP2_ECOLI FTSI_ECOLI DACA_ECOLI DACB_ECOLI	INHIBITOR			CHEMBL	CHEMBL
Penicillin-binding protein 3	Enzyme		Q14TG6_HAEIF				WOMBAT-PK
Penicillin-binding protein	Enzyme		Q54906_STRPY				WOMBAT-PK

ID	Source
4021286	VUID
N0000179384	NUI
D01628	KEGG_DRUG
72611	RXNORM
C0245519	UMLSCUI
CHEBI:560555	CHEBI
CHEMBL454446	ChEMBL_ID
C057710	MESH_SUPPLEMENTAL_RECORD_UI
78THA212DH	UNII
6437877	PUBCHEM_CID
DB01066	DRUGBANK_ID
16137	MMSL
170703	MMSL
d04767	MMSL
370399008	SNOMEDCT_US
370400001	SNOMEDCT_US
708598002	SNOMEDCT_US
C0287573	UMLSCUI
CHEMBL1743	ChEMBL_ID
104145-95-1	SECONDARY_CAS_RN
9870843	PUBCHEM_CID
12030	IUPHAR_LIGAND_ID
6919	INN_ID
4021286	VANDF
4024247	VANDF
C073460	MESH_SUPPLEMENTAL_RECORD_UI
81QS09V3YW	UNII
009507	NDDF
009508	NDDF
CHEBI:59343	CHEBI
78THA212DH	INXIGHT DRUGS
81QS09V3YW	INXIGHT DRUGS

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Spectracef	HUMAN PRESCRIPTION DRUG LABEL	1	44004-801	TABLET, FILM COATED	200 mg	ORAL	NDA	25 sections
Spectracef	HUMAN PRESCRIPTION DRUG LABEL	1	44004-802	TABLET, FILM COATED	400 mg	ORAL	NDA	25 sections
Cefditoren Pivoxil	HUMAN PRESCRIPTION DRUG LABEL	1	44009-801	TABLET, FILM COATED	200 mg	ORAL	NDA	25 sections
Cefditoren Pivoxil	HUMAN PRESCRIPTION DRUG LABEL	1	44009-802	TABLET, FILM COATED	400 mg	ORAL	NDA	25 sections