All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

cefpiramide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
antibiotics, cefalosporanic acid derivatives	552	70797-11-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: cefpiramide sodium cefpiramide	antipseudomonal cephalosporin derivative Molecular weight: 612.64 Formula: C25H24N8O7S2 CLOGP: 2.36 LIPINSKI: 2 HAC: 15 HDO: 5 TPSA: 212.76 ALOGS: -3.96 ROTB: 9 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
2	g	P

ADMET properties:

Property	Value	Reference
Vd (Volume of distribution)	0.15 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.48 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.03 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	5.40 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	-1.543		High	0.80
caco2-efflux	Caco-2 efflux ratio (BA/AB)	0.989		High	0.80
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	0.392	10^-6 cm/s	High	0.80
dh-clint	Dog hepatocyte intrinsic clearance	0.953	uL/min/10^6 cells	High	0.80
dppb	Dog plasma protein binding (% unbound)	43.190	%	High	0.80
fcs-ppb	Fetal calf serum protein binding (% unbound)	40.230	%	High	0.80
herg	hERG pIC50	4.490	pIC50	High	0.80
hh-clint	Human hepatocyte intrinsic clearance	1.371	uL/min/10^6 cells	High	0.80
hlm-clint	Human liver microsomal intrinsic clearance	3.459	uL/min/mg protein	High	0.80
hppb	Human plasma protein binding (% unbound)	16.700	%	High	0.80
kinase-safety-class	ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,GRK3,GSK3B,ITK,JAK2,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKDC,STK33,SYK,TEK	31
kinase-selectivity-class	AXL,CDK9,DYRK1B,EIF2AK3,GRK2,MAPK7	6
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	0.421		High	0.80
mh-clint	Mouse hepatocyte intrinsic clearance	2.089		High	0.80
mppb	Mouse plasma protein binding (% unbound)	45.460		High	0.80
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	0.627		High	0.80
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	25.880	%	High	0.80
rh-clint	Rat hepatocyte intrinsic clearance	1.250	uL/min/10^6 cells	High	0.80
rh-fuinc	Rat hepatocyte fraction unbound in incubation	87.420	%	High	0.80
rppb	Rat plasma protein binding (% unbound)	20.300	%	High	0.80
solubility-dd	Solubility at pH 7.4 in DMSO	937.562	uM	High	0.80

Approvals:

Date	Agency	Company	Orphan
Jan. 31, 1989	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J01DD11	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Third-generation cephalosporins
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000900	Anti-Bacterial Agents
CHEBI has role	CHEBI:36047	antibacterial drug

Related Drugs by ATC class:

J01DD Third-generation cephalosporins 17 drugs

cefcapenecefdinircefditoren pivoxilcefetametcefiximecefmenoximecefodizimecefoperazonecefotaximecefpodoxime proxetilcefsulodinceftazidime show all 17 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.63	acidic
pKa2	4.77	acidic
pKa3	7.36	acidic
pKa4	11.57	acidic
pKa5	3.44	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Bacterial penicillin-binding protein	Enzyme		PBPA_ECOLI PBPB_ECOLI DACC_ECOLI PBP2_ECOLI FTSI_ECOLI DACA_ECOLI DACB_ECOLI	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
D01904	KEGG_DRUG
74849-93-7	SECONDARY_CAS_RN
C0055010	UMLSCUI
CHEBI:59213	CHEBI
CHEMBL1201204	ChEMBL_ID
CHEMBL1200672	ChEMBL_ID
DB00430	DRUGBANK_ID
C036666	MESH_SUPPLEMENTAL_RECORD_UI
12027	IUPHAR_LIGAND_ID
5152	INN_ID
P936YA152N	UNII
636405	PUBCHEM_CID
010933	NDDF
010934	NDDF

Pharmaceutical products:

None