cefamandole nafate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, cefalosporanic acid derivatives 528 42540-40-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cefamandole nafate
  • cefamandole formate sodium
  • cephamandole nafate
  • kefadol
  • kefandol
  • lampomandol
  • neocefal
  • Molecular weight: 490.51
  • Formula: C19H18N6O6S2
  • CLOGP: 0.24
  • LIPINSKI: 1
  • HAC: 12
  • HDO: 2
  • TPSA: 156.61
  • ALOGS: -3.33
  • ROTB: 9
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 100 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.683 Moderate 0.78
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.626 Moderate 0.78
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.375 10^-6 cm/s Moderate 0.78
dh-clint Dog hepatocyte intrinsic clearance 1.648 uL/min/10^6 cells Moderate 0.78
dppb Dog plasma protein binding (% unbound) 52.010 % Moderate 0.78
fcs-ppb Fetal calf serum protein binding (% unbound) 37.490 % Moderate 0.78
herg hERG pIC50 4.346 pIC50 Moderate 0.78
hh-clint Human hepatocyte intrinsic clearance 1.429 uL/min/10^6 cells Moderate 0.78
hlm-clint Human liver microsomal intrinsic clearance 3.855 uL/min/mg protein Moderate 0.78
hppb Human plasma protein binding (% unbound) 19.380 % Moderate 0.78
kinase-safety-class ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,GRK3,GSK3B,ITK,JAK2,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKDC,STK33,SYK,TEK,TTK 35
kinase-selectivity-class AXL,EIF2AK3,GRK2,MAPK7,STK33,TEK 6
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.682 Moderate 0.78
mh-clint Mouse hepatocyte intrinsic clearance 3.715 Moderate 0.78
mppb Mouse plasma protein binding (% unbound) 40.560 Moderate 0.78
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.975 Moderate 0.78
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 25.220 % Moderate 0.78
rh-clint Rat hepatocyte intrinsic clearance 1.400 uL/min/10^6 cells Moderate 0.78
rh-fuinc Rat hepatocyte fraction unbound in incubation 89.490 % Moderate 0.78
rppb Rat plasma protein binding (% unbound) 19.100 % Moderate 0.78
solubility-dd Solubility at pH 7.4 in DMSO 966.051 uM Moderate 0.78

Approvals:

DateAgencyCompanyOrphan
Sept. 27, 1978 FDA LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:50266 prodrug
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.63 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Bacterial penicillin-binding protein Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4017539 VUID
N0000179072 NUI
D00909 KEGG_DRUG
203480 RXNORM
C0054995 UMLSCUI
CHEMBL1618 ChEMBL_ID
DB14725 DRUGBANK_ID
C012810 MESH_SUPPLEMENTAL_RECORD_UI
8HDO7941DO UNII
23665731 PUBCHEM_CID
4370 MMSL
8100 MMSL
48172009 SNOMEDCT_US
CHEBI:3481 CHEBI
4017539 VANDF
002725 NDDF

Pharmaceutical products:

None