butylphthalide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5257 6066-49-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • butylphthalide
  • 3-Butylphthalide
  • N-Butylphthalide
3-N-Butylphthalide (NBP) is a compound found in Chinese celery seed extracts that can improve cognitive functions and may decrease Amyloid-beta levels in Alzheimer′s disease. NBP has antioxidant activities and may protect against oxidative/nitrosative stress, mitochondrial impairment and apoptosis.
  • Molecular weight: 190.24
  • Formula: C12H14O2
  • CLOGP: 2.90
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 26.30
  • ALOGS: -3.46
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 30, 2002 China Food and Drug Administration (CFDA) CSPC Ouyi Pharmaceutical

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ischemic stroke indication 422504002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium channel subfamily K member 2 Ion channel BLOCKER IC50 7.22 SCIENTIFIC LITERATURE

External reference:

IDSource
822Q956KGM UNII
C0047625 UMLSCUI
61361 PUBCHEM_CID
DB12749 DRUGBANK_ID
CHEMBL248594 ChEMBL_ID
9914 INN_ID
1484499 RXNORM

Pharmaceutical products:

None