pemafibrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
clofibrate derivatives, peroxisome proliferator activated receptor-alpha(PPAR-alpha) agonists	5248	848259-27-8

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

pemafibrate
parmodia
K-877
(R)-K-13675

Pemafibrate is a selective PPAR-alpha modulator (SPPARM-alpha) that has antihyperlipidaemic activity.

Molecular weight: 490.56
Formula: C28H30N2O6
CLOGP: 6.23
LIPINSKI: 1
HAC: 8
HDO: 1
TPSA: 94.26
ALOGS: -4.37
ROTB: 13

Drug dosage:

None

ADMET properties:

Property	Value	Reference
CL (Clearance)	4.28 mL/min/kg	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
Vd (Volume of distribution)	0.91 L/kg	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
BA (Bioavailability)	0.62 %	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

Date	Agency	Company	Orphan
July 3, 2017	PMDA	Kowa

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Dyslipidemia	indication	370992007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.58	acidic
pKa2	1.94	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Peroxisome proliferator-activated receptor alpha	Nuclear hormone receptor	Q07869	PPARA_HUMAN	AGONIST	EC50	9		SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Peroxisome proliferator-activated receptor gamma	Nuclear hormone receptor	P37231	PPARG_HUMAN	AGONIST	EC50	5.96		SCIENTIFIC LITERATURE
Peroxisome proliferator-activated receptor delta	Nuclear hormone receptor	Q03181	PPARD_HUMAN	AGONIST	EC50	5.80		SCIENTIFIC LITERATURE

External reference:

ID	Source
17VGG92R23	UNII
C4547051	UMLSCUI
CHEMBL247951	ChEMBL_ID
11526038	PUBCHEM_CID
DB15212	DRUGBANK_ID
D10711	KEGG_DRUG
CHEMBL3545412	ChEMBL_ID
9692	INN_ID
P7F	PDB_CHEM_ID
C540740	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None