evogliptin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
dipeptidyl aminopeptidase-IV inhibitors 5239 1222102-29-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • evogliptin
  • suganon
  • DA-1229
Evogliptin is an orally bioavailable, selective dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus. DPP-4 inhibitors control glucose levels by preventing the breakdown of the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), which stimulate insulin secretion in response to the increased levels of glucose in the period following meals.
  • Molecular weight: 401.43
  • Formula: C19H26F3N3O3
  • CLOGP: 2.80
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 84.66
  • ALOGS: -3.56
  • ROTB: 7

Drug dosage:

DoseUnitRoute
5 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 2, 2015 Korean Food and Drug Administration (KFDA) Dong-A ST

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A10BD22 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Combinations of oral blood glucose lowering drugs
ATC A10BH07 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Dipeptidyl peptidase 4 (DPP-4) inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.97 acidic
pKa2 8.14 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dipeptidyl peptidase 4 Enzyme INHIBITOR IC50 9.05 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.10 CHEMBL

External reference:

IDSource
09118300L7 UNII
C4279601 UMLSCUI
8VU PDB_CHEM_ID
CHEMBL1779710 ChEMBL_ID
25022354 PUBCHEM_CID
DB12625 DRUGBANK_ID
D11023 KEGG_DRUG
C557982 MESH_SUPPLEMENTAL_RECORD_UI
9654 INN_ID

Pharmaceutical products:

None