beclabuvir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antivirals RNA polymerase (NS5B) inhibitors | 5215 | 958002-33-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
an NS5B inhibitor and antiviral agent
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.50 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.33 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 5.38 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 19, 2016 | PMDA | Bristol-Myers Squibb |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J05AP58 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Antivirals for treatment of HCV infections |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Chronic hepatitis C | indication | 128302006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.9 | acidic |
| pKa2 | 8.35 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 4.61 | CHEMBL | |||||
| NS5B protein | Enzyme | IC50 | 6.72 | CHEMBL | |||||
| RNA-directed RNA polymerase | Unclassified | IC50 | 6.72 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| MYW1X5CO9S | UNII |
| 958002-36-3 | SECONDARY_CAS_RN |
| C4045497 | UMLSCUI |
| CHEMBL3126842 | ChEMBL_ID |
| 56934415 | PUBCHEM_CID |
| DB12225 | DRUGBANK_ID |
| D10611 | KEGG_DRUG |
| CHEMBL3137325 | ChEMBL_ID |
| 9899 | INN_ID |
| C587012 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
None