carprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-inflammatory agents, ibuprofen derivatives | 518 | 53716-49-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
anti-inflammatory drug (NSAID) of the propionic acid class with selective inhibition of COX-2 versus COX-1
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.22 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.51 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.00 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 9.90 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 31, 1987 | FDA | ROCHE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D003879 | Dermatologic Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D017319 | Photosensitizing Agents |
| MeSH PA | D011838 | Radiation-Sensitizing Agents |
| MeSH PA | D018689 | Sensory System Agents |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
| CHEBI has role | CHEBI:35544 | cyclooxygenase inhibitors |
| CHEBI has role | CHEBI:47868 | photosensitising agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Postoperative pain associated with soft tissue and orthopedic surgery | Indication |
| Dogs | Pain and inflammation associated with osteoarthritis | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Rimadyl Sterile Injectable Solution | Zoetis Inc. | 1 |
| Rimadyl Caplets | Zoetis Inc. | 1 |
| Rimadyl Chewable Tablets | Zoetis Inc. | 1 |
| Carprofen Caplets, Novox Caplets | Dechra Veterinary Products LLC | 1 |
| Vetprofen | Belcher Pharmaceuticals Inc. | 1 |
| Carprofen | Dechra Veterinary Products LLC | 1 |
| Carprieve Caplets | Norbrook Laboratories, Ltd. | 1 |
| Carprieve Injection | Norbrook Laboratories, Ltd. | 1 |
| Carprofen Sterile Injectable Solution | Dechra Veterinary Products LLC | 1 |
| quellin | Elanco US Inc. | 1 |
| Carprofen Chewable Tablets | Dechra Veterinary Products LLC | 1 |
| Carprofen Flavored Tablets | Belcher Pharmaceuticals Inc. | 1 |
| Carprofen Injection | Accord Healthcare Inc. | 1 |
| Carprieve Chewable Tablets | Norbrook Laboratories, Ltd. | 1 |
| Carprofen Tablets | Dechra Veterinary Products LLC | 1 |
| Carprofen Chewable Tablets | Cronus Pharma Specialities India Private Limited | 1 |
| Carprofen Tablets | Dechra Veterinary Products LLC | 1 |
| CARPROFEN Chewable Tablets | Felix Pharmaceuticals Pvt. Ltd. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.53 | acidic |
| pKa2 | 11.59 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 7 | CHEMBL | CHEMBL | |||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.88 | CHEMBL | |||||
| Complement C5 | Secreted | Kd | 6.24 | CHEMBL | |||||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.89 | CHEMBL | |||||
| Fatty-acid amide hydrolase 1 | Enzyme | IC50 | 4.10 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D03410 | KEGG_DRUG |
| 20343 | RXNORM |
| C0054827 | UMLSCUI |
| CHEBI:364453 | CHEBI |
| CHEMBL1316 | ChEMBL_ID |
| DB00821 | DRUGBANK_ID |
| C007005 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2581 | PUBCHEM_CID |
| 7141 | IUPHAR_LIGAND_ID |
| 3980 | INN_ID |
| FFL0D546HO | UNII |
| 125710006 | SNOMEDCT_US |
| 424611009 | SNOMEDCT_US |
| 4025237 | VANDF |
| 005102 | NDDF |
Pharmaceutical products:
None