vonicog alfa Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
blood coagulation factors 5173 109319-16-6

Description:

MoleculeDescription

Synonyms:

  • vonicog alfa
  • vonvendi
  • BAX 111
  • BAX111
  • von Willebrand factor
  • von Willebrand factor (recombinant)
a purified recombinant von Willebrand factor (rVWF) expressed in Chinese Hamster Ovary (CHO) cells, acts to promote hemostasis by mediating platelet adhesion to damaged vascular sub-endothelial matrix and platelet aggregation and as a carrier protein for factor VIII, protecting it from rapid proteolysis
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 25, 2020 PMDA Shire Japan K.K.
Aug. 8, 2018 EMA BAXALTA INNOVATIONS GMBH
Dec. 8, 2015 FDA Baxalta US Inc.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC B02BD06 BLOOD AND BLOOD FORMING ORGANS
ANTIHEMORRHAGICS
VITAMIN K AND OTHER HEMOSTATICS
Blood coagulation factors
ATC B02BD10 BLOOD AND BLOOD FORMING ORGANS
ANTIHEMORRHAGICS
VITAMIN K AND OTHER HEMOSTATICS
Blood coagulation factors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
von Willebrand disorder indication 128105004 DOID:12531

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4025436 VANDF
4035891 VANDF
C0042971 UMLSCUI
CHEMBL2107873 ChEMBL_ID
D08681 KEGG_DRUG
CHEMBL4298126 ChEMBL_ID
D014841 MESH_DESCRIPTOR_UI
9215 INN_ID
5PKM8P0G5I UNII
6755 IUPHAR_LIGAND_ID
DB13133 DRUGBANK_ID
DB12872 DRUGBANK_ID
11274 RXNORM
22168 MMSL
244142 MMSL
d05873 MMSL
007302 NDDF
016621 NDDF
121227005 SNOMEDCT_US
18288009 SNOMEDCT_US
346711005 SNOMEDCT_US

Pharmaceutical products:

None