vonicog alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
blood coagulation factors	5173	109319-16-6

Description:

Molecule	Description
Synonyms: vonicog alfa vonvendi BAX 111 BAX111 von Willebrand factor von Willebrand factor (recombinant)	a purified recombinant von Willebrand factor (rVWF) expressed in Chinese Hamster Ovary (CHO) cells, acts to promote hemostasis by mediating platelet adhesion to damaged vascular sub-endothelial matrix and platelet aggregation and as a carrier protein for factor VIII, protecting it from rapid proteolysis Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

vonicog alfa
vonvendi
BAX 111
BAX111
von Willebrand factor
von Willebrand factor (recombinant)

a purified recombinant von Willebrand factor (rVWF) expressed in Chinese Hamster Ovary (CHO) cells, acts to promote hemostasis by mediating platelet adhesion to damaged vascular sub-endothelial matrix and platelet aggregation and as a carrier protein for factor VIII, protecting it from rapid proteolysis

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company
Aug. 8, 2018	EMA	BAXALTA INNOVATIONS GMBH
Dec. 8, 2015	FDA	Baxalta US Inc.
March 25, 2020	PMDA	Shire Japan K.K.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B02BD06	BLOOD AND BLOOD FORMING ORGANS ANTIHEMORRHAGICS VITAMIN K AND OTHER HEMOSTATICS Blood coagulation factors
ATC	B02BD10	BLOOD AND BLOOD FORMING ORGANS ANTIHEMORRHAGICS VITAMIN K AND OTHER HEMOSTATICS Blood coagulation factors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
von Willebrand disorder	indication	128105004	DOID:12531

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
5PKM8P0G5I	UNII
4025436	VANDF
4035891	VANDF
C4291409	UMLSCUI
CHEMBL2107873	ChEMBL_ID
D08681	KEGG_DRUG
DB12872	DRUGBANK_ID
CHEMBL4298126	ChEMBL_ID
9215	INN_ID
6755	IUPHAR_LIGAND_ID
DB13133	DRUGBANK_ID
11274	RXNORM
22168	MMSL
244142	MMSL
d05873	MMSL
007302	NDDF
016621	NDDF
121227005	SNOMEDCT_US
18288009	SNOMEDCT_US
346711005	SNOMEDCT_US
D014841	MESH_DESCRIPTOR_UI

Pharmaceutical products:

None