carfenazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	516	2622-30-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

carphenazine
carfenazine
carphenazin
proketazine
carphenazine maleate
proketazine maleate

Molecular weight: 425.59
Formula: C24H31N3O2S
CLOGP: 3.44
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 47.02
ALOGS: -4.06
ROTB: 8

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA	WYETH AYERST

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:37930	phenothiazine antipsychotic drugs
CHEBI has role	CHEBI:48561	dopaminergic antagonists
CHEBI has role	CHEBI:50919	antiemetico

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Chronic schizophrenia	indication	83746006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.21	Basic
pKa2	4.21	Basic
pKa3	1.58	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN	ANTAGONIST				DRUGBANK	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	ANTAGONIST				CHEMBL	CHEMBL

External reference:

ID	Source
D02644	KEGG_DRUG
C0771221	UMLSCUI
CHEBI:51235	CHEBI
CHEMBL1201328	ChEMBL_ID
CHEMBL2358147	ChEMBL_ID
DB01038	DRUGBANK_ID
7140	IUPHAR_LIGAND_ID
2975-34-0	SECONDARY_CAS_RN
18104	PUBCHEM_CID
123579002	SNOMEDCT_US
782144003	SNOMEDCT_US
1179	INN_ID
CLY16Y8Z7E	UNII
001486	NDDF
004593	NDDF

Pharmaceutical products:

None