carfenazine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
516 2622-30-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carphenazine
  • carfenazine
  • carphenazin
  • proketazine
  • carphenazine maleate
  • proketazine maleate
  • Molecular weight: 425.59
  • Formula: C24H31N3O2S
  • CLOGP: 3.44
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 47.02
  • ALOGS: -4.06
  • ROTB: 8

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA WYETH AYERST

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:48561 dopaminergic antagonist
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:37930 phenothiazine antipsychotic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Chronic schizophrenia indication 83746006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.21 Basic
pKa2 4.21 Basic
pKa3 1.58 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST DRUGBANK CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST CHEMBL CHEMBL

External reference:

IDSource
D02644 KEGG_DRUG
0HX1Z0A2MC UNII
2975-34-0 SECONDARY_CAS_RN
782144003 SNOMEDCT_US
004593 NDDF
1179 INN_ID
DB01038 DRUGBANK_ID
CHEBI:51235 CHEBI
7140 IUPHAR_LIGAND_ID
CHEMBL1201328 ChEMBL_ID
CHEMBL2358147 ChEMBL_ID
18104 PUBCHEM_CID

Pharmaceutical products:

None