conestat alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
enzyme inhibitors 5152 80295-38-1

Description:

MoleculeDescription

Synonyms:

  • conestat alfa
  • ruconest
  • recombinant human c1-inhibitor
recombinant human complement component 1 (C1) esterase inhibitor (rhC1INH), is an analogue of human C1INH and is obtained from the milk of rabbits expressing the gene encoding for human C1INH, the amino acid sequence of conestat alfa is identical to that of endogenous C1INH
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3.50 TU P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Oct. 28, 2010 EMA Pharming Group N.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hereditary angioedema 912.93 38.43 141 705 9224 90618377
Insurance issue 55.08 38.43 14 832 10944 90616657
Weight decreased 53.98 38.43 37 809 379873 90247728
Weight increased 44.06 38.43 34 812 417893 90209708

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hereditary angioedema 173.96 59.57 21 46 1460 42619808

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hereditary angioedema 807.49 39.81 116 572 6998 110581613
Insurance issue 55.86 39.81 13 675 10599 110578012
Weight decreased 55.71 39.81 35 653 468022 110120589
Weight increased 54.01 39.81 33 655 419611 110169000

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B06AC04 BLOOD AND BLOOD FORMING ORGANS
OTHER HEMATOLOGICAL AGENTS
OTHER HEMATOLOGICAL AGENTS
Drugs used in hereditary angioedema
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

B06AC Drugs used in hereditary angioedema 7 drugs
berotralstatdonidalorsenecallantidegaradacimabicatibantlanadelumabsebetralstat

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hereditary C1 esterase inhibitor deficiency - deficient factor indication 234619000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
5QS67N4551 UNII
C3195420 UMLSCUI
CHEBI:753329 CHEBI
CHEMBL2108350 ChEMBL_ID
DB09228 DRUGBANK_ID
8899 INN_ID
C571093 MESH_SUPPLEMENTAL_RECORD_UI
7627 IUPHAR_LIGAND_ID
1599831 RXNORM
179528 MMSL
27751 MMSL
30530 MMSL
d07742 MMSL
013852 NDDF
429316005 SNOMEDCT_US
713468002 SNOMEDCT_US
725707007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ruconest HUMAN PRESCRIPTION DRUG LABEL 1 71274-350 INJECTION, POWDER, FOR SOLUTION 2100 U INTRAVENOUS BLA 23 sections