oxiglutatione 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5130 27025-41-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxiglutatione
  • glutathione disulfide
  • glutathione disulphide
A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized.
  • Molecular weight: 612.63
  • Formula: C20H32N6O12S2
  • CLOGP: -5.83
  • LIPINSKI: 3
  • HAC: 18
  • HDO: 10
  • TPSA: 317.64
  • ALOGS: -3.18
  • ROTB: 21
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT1,FLT3,GRK2,GSK3B,IGF1R,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 62
kinase-selectivity-class ACVR2B,AXL,CDK9,GRK2,MAP2K6,MAPK7,PIK3CG,TEK,TGFBR1 9
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.67 acidic
pKa2 2.27 acidic
pKa3 3.26 acidic
pKa4 3.86 acidic
pKa5 11.86 acidic
pKa6 12.46 acidic
pKa7 13.72 acidic
pKa8 9.96 Basic
pKa9 9.36 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
CHEBI:17858 CHEBI
D00031 KEGG_DRUG
CHEMBL1372 ChEMBL_ID
6835 IUPHAR_LIGAND_ID
DB03310 DRUGBANK_ID
25953 RXNORM
4789 MMSL
005967 NDDF
C0061516 UMLSCUI
GDS PDB_CHEM_ID
6698 INN_ID
65359 PUBCHEM_CID
ULW86O013H UNII
D019803 MESH_DESCRIPTOR_UI
ULW86O013H INXIGHT DRUGS

Pharmaceutical products:

None