ergoloid mesylates 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
ergot alkaloid derivatives	5035	8067-24-1

Description:

Molecule	Description
Synonyms: ergoloid mesylate ergoloid mesylates codergocrine mesilate ergoloid mesilates codergocrine ergoloid codergine mesylate codergocrine methanesulfonate ergoloid methanesulfonate hydergine dihydroergotoxine mesilate dihydroergotoxine mesylate	A mixture of the mesylates (methane sulfonates) of DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and the alpha- and beta-isomers of DIHYDROERGOCRYPTINE. The substance produces a generalized peripheral vasodilation and a fall in arterial pressure and has been used to treat symptoms of mild to moderate impairment of mental function in the elderly. Molecular weight: Formula: None CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

ergoloid mesylate
ergoloid mesylates
codergocrine mesilate
ergoloid mesilates
codergocrine
ergoloid
codergine mesylate
codergocrine methanesulfonate
ergoloid methanesulfonate
hydergine
dihydroergotoxine mesilate
dihydroergotoxine mesylate

A mixture of the mesylates (methane sulfonates) of DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and the alpha- and beta-isomers of DIHYDROERGOCRYPTINE. The substance produces a generalized peripheral vasodilation and a fall in arterial pressure and has been used to treat symptoms of mild to moderate impairment of mental function in the elderly.

Molecular weight:
Formula: None
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
3	mg	O
3	mg	P

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	25 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Nov. 5, 1953	FDA	NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C04AE01	CARDIOVASCULAR SYSTEM PERIPHERAL VASODILATORS PERIPHERAL VASODILATORS Ergot alkaloids
ATC	C04AE51	CARDIOVASCULAR SYSTEM PERIPHERAL VASODILATORS PERIPHERAL VASODILATORS Ergot alkaloids
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D000317	Adrenergic alpha-Antagonists
MeSH PA	D018674	Adrenergic Antagonists
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018697	Nootropic Agents
MeSH PA	D014665	Vasodilator Agents
CHEBI has role	CHEBI:35620	vasodilator agents
CHEBI has role	CHEBI:37890	alpha-adrenergic receptor blockaders
CHEBI has role	CHEBI:66980	intelligence enhancer
CHEBI has role	CHEBI:66991	sympatholytic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Dementia	indication	52448006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
X3S33EX3KW	UNII
D02268	KEGG_DRUG
4030210	VUID
N0000181828	NUI
4017835	VANDF
4030210	VANDF
C0014708	UMLSCUI
CHEBI:34706	CHEBI
CHEMBL2311030	ChEMBL_ID
592735	PUBCHEM_CID
DB01049	DRUGBANK_ID
CHEMBL2364968	ChEMBL_ID
D004877	MESH_DESCRIPTOR_UI
151870	RXNORM
3561	MMSL
4672	MMSL
7878	MMSL
892	MMSL
d00902	MMSL
000698	NDDF
004532	NDDF
350622001	SNOMEDCT_US
387468003	SNOMEDCT_US

Pharmaceutical products:

None