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| Stem definition | Drug id | CAS RN |
|---|---|---|
| ergot alkaloid derivatives | 5035 | 8067-24-1 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
A mixture of the mesylates (methane sulfonates) of DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and the alpha- and beta-isomers of DIHYDROERGOCRYPTINE. The substance produces a generalized peripheral vasodilation and a fall in arterial pressure and has been used to treat symptoms of mild to moderate impairment of mental function in the elderly.
|
| Dose | Unit | Route |
|---|---|---|
| 3 | mg | O |
| 3 | mg | P |
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 25 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 5, 1953 | FDA | NOVARTIS |
None
None
None
None
| Source | Code | Description |
|---|---|---|
| ATC | C04AE01 | CARDIOVASCULAR SYSTEM PERIPHERAL VASODILATORS PERIPHERAL VASODILATORS Ergot alkaloids |
| ATC | C04AE51 | CARDIOVASCULAR SYSTEM PERIPHERAL VASODILATORS PERIPHERAL VASODILATORS Ergot alkaloids |
| MeSH PA | D000317 | Adrenergic alpha-Antagonists |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D014665 | Vasodilator Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018674 | Adrenergic Antagonists |
| MeSH PA | D018697 | Nootropic Agents |
| CHEBI has role | CHEBI:35620 | vasodilator agent |
| CHEBI has role | CHEBI:37890 | α-adrenergic antagonist |
| CHEBI has role | CHEBI:66980 | nootropic agent |
| CHEBI has role | CHEBI:66991 | sympatholytic agent |
| CHEBI has role | CHEBI:35554 | cardiovascular drug |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Dementia | indication | 52448006 |
None
None
None
None
None
None
| ID | Source |
|---|---|
| X3S33EX3KW | UNII |
| D02268 | KEGG_DRUG |
| 4030210 | VUID |
| N0000181828 | NUI |
| 4017835 | VANDF |
| C0014708 | UMLSCUI |
| CHEBI:34706 | CHEBI |
| CHEMBL2311030 | ChEMBL_ID |
| 592735 | PUBCHEM_CID |
| DB01049 | DRUGBANK_ID |
| CHEMBL2364968 | ChEMBL_ID |
| D004877 | MESH_DESCRIPTOR_UI |
| 151870 | RXNORM |
| 3561 | MMSL |
| 4672 | MMSL |
| 7878 | MMSL |
| 892 | MMSL |
| d00902 | MMSL |
| 000698 | NDDF |
| 004532 | NDDF |
| 350622001 | SNOMEDCT_US |
| 387214005 | SNOMEDCT_US |
None