ergoloid mesylates 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5035 8067-24-1

Description:

MoleculeDescription

Synonyms:

  • ergoloid mesylate
  • ergoloid mesylates
  • codergocrine mesilate
  • ergoloid mesilates
  • codergocrine
  • ergoloid
  • codergine mesylate
  • codergocrine methanesulfonate
  • ergoloid methanesulfonate
  • hydergine
  • dihydroergotoxine mesilate
  • dihydroergotoxine mesylate
A mixture of the mesylates (methane sulfonates) of DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and the alpha- and beta-isomers of DIHYDROERGOCRYPTINE. The substance produces a generalized peripheral vasodilation and a fall in arterial pressure and has been used to treat symptoms of mild to moderate impairment of mental function in the elderly.
  • Molecular weight:
  • Formula: None
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3 mg O
3 mg P

ADMET properties:

PropertyValueReference
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Nov. 5, 1953 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C04AE01 CARDIOVASCULAR SYSTEM
PERIPHERAL VASODILATORS
PERIPHERAL VASODILATORS
Ergot alkaloids
ATC C04AE51 CARDIOVASCULAR SYSTEM
PERIPHERAL VASODILATORS
PERIPHERAL VASODILATORS
Ergot alkaloids
MeSH PA D018663 Adrenergic Agents
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018697 Nootropic Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:37890 alpha-adrenergic receptor blockaders
CHEBI has role CHEBI:66980 intelligence enhancer
CHEBI has role CHEBI:66991 sympatholytic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Dementia indication 52448006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
X3S33EX3KW UNII
D02268 KEGG_DRUG
4030210 VUID
N0000181828 NUI
4017835 VANDF
4030210 VANDF
C0014708 UMLSCUI
CHEBI:34706 CHEBI
CHEMBL2311030 ChEMBL_ID
592735 PUBCHEM_CID
DB01049 DRUGBANK_ID
CHEMBL2364968 ChEMBL_ID
D004877 MESH_DESCRIPTOR_UI
151870 RXNORM
3561 MMSL
4672 MMSL
7878 MMSL
892 MMSL
d00902 MMSL
350622001 SNOMEDCT_US
387468003 SNOMEDCT_US
000698 NDDF
004532 NDDF

Pharmaceutical products:

None