nicergoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
ergot alkaloid derivatives 1910 27848-84-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nicergoline
  • nicergolent
  • nicotergoline
  • cergodum
  • duracebrol
An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It may ameliorate cognitive deficits in CEREBROVASCULAR DISORDERS.
  • Molecular weight: 484.39
  • Formula: C24H26BrN3O3
  • CLOGP: 4.51
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 56.59
  • ALOGS: -4.58
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 5 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2B,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,JAK3,MAPK10,MAPK7,MET,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK 20
kinase-selectivity-class EIF2AK3 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C04AE02 CARDIOVASCULAR SYSTEM
PERIPHERAL VASODILATORS
PERIPHERAL VASODILATORS
Ergot alkaloids
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D018697 Nootropic Agents
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35554 cardiovascular drug

Related Drugs by ATC class:

C04AE Ergot alkaloids 2 drugs
dihydroergocristineergoloid mesylates

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.01 Basic
pKa2 1.22 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000167295 NUI
D01290 KEGG_DRUG
C0028008 UMLSCUI
CHEBI:31902 CHEBI
CHEMBL1372950 ChEMBL_ID
D009530 MESH_DESCRIPTOR_UI
DB00699 DRUGBANK_ID
3088 INN_ID
JCV8365FWN UNII
34040 PUBCHEM_CID
7398 RXNORM
004170 NDDF
698197004 SNOMEDCT_US
703417007 SNOMEDCT_US

Pharmaceutical products:

None