hyaluronidase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
enzymes 5033 9001-54-1

Description:

MoleculeDescription

Synonyms:

  • hyaluronidase recombinant human
  • hyaluronidase
  • wydase
  • hyaluronidase ovine
  • hyaluronidase bovine
  • vorhyaluronidase alfa (genetical recombination)
An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Aug. 25, 2021 PMDA Janssen Pharmaceutical, K.K.
March 22, 1950 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Autoimmune disorder 242.89 49.11 187 24696 76557 90527007
Deep vein thrombosis postoperative 209.88 49.11 166 24717 70643 90532921
Porphyria acute 191.06 49.11 95 24788 17880 90585684
Grip strength 180.41 49.11 74 24809 8891 90594673
Lower limb fracture 171.71 49.11 160 24723 84853 90518711
Road traffic accident 166.25 49.11 175 24708 107451 90496113
Drug ineffective 155.01 49.11 95 24788 1384203 89219361
Peripheral venous disease 152.49 49.11 149 24734 83772 90519792
Sciatica 151.53 49.11 162 24721 101220 90502344
X-ray abnormal 146.52 49.11 112 24771 45312 90558252
Bursitis 140.72 49.11 177 24706 131477 90472087
C-reactive protein abnormal 140.49 49.11 174 24709 127255 90476309
Lip dry 139.85 49.11 155 24728 100800 90502764
Retinitis 137.80 49.11 101 24782 38357 90565207
Sleep disorder due to general medical condition, insomnia type 134.34 49.11 171 24712 128523 90475041
Colitis ulcerative 128.60 49.11 117 24766 60149 90543415
Facet joint syndrome 127.64 49.11 146 24737 98243 90505321
Rectal haemorrhage 125.00 49.11 133 24750 82611 90520953
Swollen joint count increased 124.42 49.11 153 24730 111053 90492511
Adjustment disorder with depressed mood 122.70 49.11 111 24772 56642 90546922
Lupus-like syndrome 122.60 49.11 104 24779 48742 90554822
Liver disorder 120.08 49.11 157 24726 121112 90482452
Obesity 117.77 49.11 145 24738 105362 90498202
Fall 111.24 49.11 5 24878 481805 90121759
White blood cell count increased 110.36 49.11 113 24770 67128 90536436
Sleep disorder due to a general medical condition 109.71 49.11 94 24789 44644 90558920
Bone erosion 107.41 49.11 100 24783 52921 90550643
Lupus vulgaris 107.10 49.11 93 24790 44966 90558598
Swollen joint count 104.76 49.11 50 24833 8603 90594961
Dislocation of vertebra 104.69 49.11 101 24782 55867 90547697
Rheumatic fever 100.22 49.11 163 24720 152958 90450606
Frequent bowel movements 97.66 49.11 98 24785 56837 90546727
Joint range of motion decreased 95.08 49.11 149 24734 135494 90468070
Blood cholesterol increased 94.65 49.11 189 24694 207823 90395741
Hepatic cirrhosis 94.32 49.11 101 24782 63152 90540412
Lung disorder 93.30 49.11 156 24727 149727 90453837
Exostosis 90.29 49.11 91 24792 53043 90550521
Laryngitis 90.08 49.11 89 24794 50664 90552900
Type 2 diabetes mellitus 89.28 49.11 182 24701 203062 90400502
Muscle injury 87.02 49.11 166 24717 176488 90427076
Night sweats 86.87 49.11 139 24744 128627 90474937
Folliculitis 85.07 49.11 179 24704 204174 90399390
Breast cancer stage III 84.60 49.11 110 24773 84337 90519227
Pancreatitis 84.48 49.11 100 24783 69726 90533838
Duodenal ulcer perforation 84.31 49.11 187 24696 221101 90382463
Dry mouth 81.04 49.11 165 24718 183894 90419670
Asthma 79.49 49.11 193 24690 241967 90361597
Wound infection 78.92 49.11 120 24763 106282 90497282
Musculoskeletal pain 78.35 49.11 156 24727 171095 90432469
Foot deformity 76.45 49.11 88 24795 59563 90544001
Respiratory disorder 75.41 49.11 91 24792 64725 90538839
Delirium 75.01 49.11 116 24767 104243 90499321
Helicobacter infection 74.66 49.11 181 24702 226669 90376895
Pulmonary fibrosis 73.81 49.11 117 24766 107386 90496178
Hypotension 73.06 49.11 4 24879 325393 90278171
Laboratory test abnormal 71.69 49.11 72 24811 41782 90561782
Fibromyalgia 71.56 49.11 168 24715 206101 90397463
Ill-defined disorder 71.25 49.11 157 24726 184734 90418830
C-reactive protein 71.04 49.11 63 24820 31304 90572260
Rheumatoid factor positive 71.01 49.11 150 24733 171500 90432064
Pregnancy 70.37 49.11 86 24797 61961 90541603
Ear infection 70.06 49.11 91 24792 69684 90533880
Grip strength decreased 68.07 49.11 104 24779 92472 90511092
Feeling hot 68.04 49.11 95 24788 77913 90525651
Osteoarthritis 67.44 49.11 159 24724 195571 90407993
Contusion 66.77 49.11 185 24698 251031 90352533
Drug tolerance decreased 65.83 49.11 61 24822 32069 90571495
Off label use 65.11 49.11 128 24755 1102124 89501440
Maternal exposure timing unspecified 65.03 49.11 52 24831 22431 90581133
Amnesia 63.61 49.11 110 24773 108395 90495169
Drug interaction 63.32 49.11 3 24880 276450 90327114
Parophthalmia 62.93 49.11 16 24867 407 90603157
Purtscher retinopathy 61.86 49.11 13 24870 137 90603427
Liver injury 61.42 49.11 141 24742 170426 90433138
Lower respiratory tract infection 61.17 49.11 179 24704 250480 90353084
Nausea 60.47 49.11 135 24748 1110181 89493383
Discomfort 60.46 49.11 189 24694 274146 90329418
Blister 59.28 49.11 179 24704 254819 90348745
Weight fluctuation 57.81 49.11 46 24837 19703 90583861
Impaired healing 55.95 49.11 166 24717 234033 90369531
Anti-cyclic citrullinated peptide antibody positive 55.93 49.11 167 24716 236266 90367298
Walking aid user 55.23 49.11 58 24825 35448 90568116
Anaemia 54.02 49.11 15 24868 352787 90250777
Gastrointestinal disorder 53.05 49.11 173 24710 256514 90347050
Erythema 50.88 49.11 3 24880 229243 90374321
Stomatitis 50.48 49.11 178 24705 274520 90329044
Irritable bowel syndrome 49.50 49.11 147 24736 207301 90396263

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Retinal artery occlusion 53.20 51.57 10 342 2205 42618778
Local anaesthetic systemic toxicity 52.82 51.57 10 342 2290 42618693

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Autoimmune disorder 301.71 64.91 188 25323 65295 110498493
Deep vein thrombosis postoperative 265.02 64.91 167 25344 59124 110504664
Lower limb fracture 219.65 64.91 163 25348 75185 110488603
Porphyria acute 215.28 64.91 99 25412 18681 110545107
Grip strength 198.65 64.91 76 25435 9065 110554723
Road traffic accident 196.27 64.91 177 25334 107221 110456567
Sleep disorder due to general medical condition, insomnia type 190.87 64.91 173 25338 105470 110458318
Sciatica 190.31 64.91 163 25348 92236 110471552
X-ray abnormal 189.68 64.91 115 25396 38002 110525786
Swollen joint count increased 187.58 64.91 155 25356 83506 110480282
Retinitis 180.35 64.91 105 25406 32222 110531566
Peripheral venous disease 176.51 64.91 150 25361 83967 110479821
Adjustment disorder with depressed mood 169.95 64.91 113 25398 43770 110520018
Bursitis 169.52 64.91 178 25333 129740 110434048
Lip dry 167.40 64.91 157 25354 99926 110463862
C-reactive protein abnormal 166.21 64.91 176 25335 129519 110434269
Lupus-like syndrome 165.16 64.91 108 25403 40684 110523104
Rheumatic fever 154.69 64.91 165 25346 122414 110441374
Facet joint syndrome 152.62 64.91 147 25364 96681 110467107
Lupus vulgaris 150.25 64.91 95 25416 33788 110530000
Dislocation of vertebra 146.59 64.91 103 25408 43618 110520170
Muscle injury 144.22 64.91 170 25341 140637 110423151
Duodenal ulcer perforation 142.82 64.91 190 25321 177510 110386278
Bone erosion 138.87 64.91 102 25409 46269 110517519
Blood cholesterol increased 138.52 64.91 191 25320 184594 110379194
Folliculitis 137.41 64.91 181 25330 167472 110396316
Drug ineffective 134.29 64.91 94 25417 1520446 109043342
Type 2 diabetes mellitus 134.06 64.91 184 25327 177048 110386740
Obesity 133.25 64.91 147 25364 113204 110450584
Acute kidney injury 132.32 64.91 3 25508 635427 109928361
Joint range of motion decreased 131.29 64.91 151 25360 121681 110442107
Helicobacter infection 128.88 64.91 183 25328 181694 110382094
Liver disorder 126.63 64.91 160 25351 142083 110421705
Colitis ulcerative 124.83 64.91 119 25392 77244 110486544
Rheumatoid factor positive 123.46 64.91 152 25359 131488 110432300
Laryngitis 121.86 64.91 91 25420 42320 110521468
Exostosis 119.70 64.91 93 25418 45863 110517925
Discomfort 119.44 64.91 193 25318 214514 110349274
Fall 117.93 64.91 5 25506 603477 109960311
Sleep disorder due to a general medical condition 117.70 64.91 97 25414 52015 110511773
Fibromyalgia 116.73 64.91 169 25342 170740 110393048
Swollen joint count 112.97 64.91 50 25461 8624 110555164
Ill-defined disorder 112.85 64.91 159 25352 156694 110407094
Rectal haemorrhage 110.16 64.91 137 25374 119696 110444092
Anti-cyclic citrullinated peptide antibody positive 110.06 64.91 170 25341 181814 110381974
Wound infection 109.75 64.91 123 25388 96342 110467446
Breast cancer stage III 109.62 64.91 112 25399 79005 110484783
Foot deformity 108.99 64.91 90 25421 48390 110515398
Night sweats 107.21 64.91 143 25368 133840 110429948
Hepatic cirrhosis 107.16 64.91 103 25408 67523 110496265
Contusion 101.29 64.91 188 25323 233173 110330615
Hand deformity 99.85 64.91 180 25331 218326 110345462
Pulmonary fibrosis 99.18 64.91 120 25391 101922 110461866
Frequent bowel movements 98.79 64.91 101 25410 71289 110492499
Asthma 98.01 64.91 193 25318 250098 110313690
Lung disorder 97.60 64.91 160 25351 179887 110383901
White blood cell count increased 97.59 64.91 116 25395 96726 110467062
Impaired healing 97.57 64.91 168 25343 196549 110367239
Osteoarthritis 97.26 64.91 161 25350 182462 110381326
Blister 97.21 64.91 182 25329 227194 110336594
Grip strength decreased 95.97 64.91 105 25406 80069 110483719
Ear infection 94.61 64.91 93 25418 62639 110501149
Liver injury 94.44 64.91 143 25368 150270 110413518
Musculoskeletal pain 94.32 64.91 159 25352 182864 110380924
Dry mouth 94.28 64.91 167 25344 199781 110364007
Pregnancy 92.89 64.91 84 25427 50983 110512805
Irritable bowel syndrome 91.81 64.91 148 25363 164067 110399721
Drug interaction 89.00 64.91 7 25504 500176 110063612
Off label use 88.73 64.91 131 25380 1500054 109063734
Hypotension 88.71 64.91 9 25502 523840 110039948
Lower respiratory tract infection 88.65 64.91 182 25329 242924 110320864
Glossodynia 86.67 64.91 171 25340 221833 110341955
Drug tolerance decreased 85.66 64.91 62 25449 27478 110536310
Respiratory disorder 84.59 64.91 93 25418 71289 110492499
Amnesia 83.53 64.91 112 25399 105296 110458492
Laboratory test abnormal 83.12 64.91 74 25437 44005 110519783
C-reactive protein 82.51 64.91 63 25448 30268 110533520
Psoriatic arthropathy 82.22 64.91 156 25355 196605 110367183
Walking aid user 81.54 64.91 58 25453 25017 110538771
Pancreatitis 81.28 64.91 104 25407 93429 110470359
Gastrointestinal disorder 81.08 64.91 175 25336 241777 110322011
Maternal exposure timing unspecified 81.07 64.91 54 25457 20959 110542829
Hip arthroplasty 80.94 64.91 81 25430 55732 110508056
Pemphigus 79.83 64.91 162 25349 214408 110349380
Systemic lupus erythematosus 79.62 64.91 179 25332 254159 110309629
Knee arthroplasty 77.62 64.91 85 25426 64863 110498925
Arthropathy 76.59 64.91 190 25321 287332 110276456
Injury 75.87 64.91 142 25369 177123 110386665
Feeling hot 75.57 64.91 99 25412 91007 110472781
Mobility decreased 75.32 64.91 168 25343 237254 110326534
Stomatitis 73.48 64.91 180 25331 270062 110293726
Anaemia 73.38 64.91 18 25493 547068 110016720
Pericarditis 72.85 64.91 158 25353 218956 110344832
Sinusitis 72.73 64.91 190 25321 296498 110267290
Hepatic enzyme increased 72.13 64.91 199 25312 320693 110243095
Delirium 70.47 64.91 118 25393 134907 110428881
Hypercholesterolaemia 69.66 64.91 95 25416 90742 110473046
Wound 67.85 64.91 160 25351 234277 110329511
Abdominal discomfort 67.53 64.91 222 25289 393636 110170152
Alopecia 67.44 64.91 211 25300 364542 110199246

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B06AA03 BLOOD AND BLOOD FORMING ORGANS
OTHER HEMATOLOGICAL AGENTS
OTHER HEMATOLOGICAL AGENTS
Enzymes
FDA CS M0009499 Glycoside Hydrolases
FDA EPC N0000175531 Endoglycosidase
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent

Related Drugs by ATC class:

B06AA Enzymes 3 drugs
chymotrypsindornase alfatrypsin

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Systemic AL amyloidosis indication 23132008
Multiple myeloma indication 109989006 DOID:9538
Subcutaneous clysis of patient for fluid administration indication 113154008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D04456 KEGG_DRUG
4018028 VUID
N0000146371 NUI
4018028 VANDF
C0020197 UMLSCUI
CHEBI:231673 CHEBI
CHEMBL1201636 ChEMBL_ID
DB14740 DRUGBANK_ID
CHEMBL1201718 ChEMBL_ID
CHEMBL2108607 ChEMBL_ID
DB06205 DRUGBANK_ID
1300478 RXNORM
1312 MMSL
4832 MMSL
63625 MMSL
d01393 MMSL
001887 NDDF
010831 NDDF
011274 NDDF
387280008 SNOMEDCT_US
420670008 SNOMEDCT_US
420993004 SNOMEDCT_US
51132001 SNOMEDCT_US
784400007 SNOMEDCT_US
786123000 SNOMEDCT_US
D006821 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None