All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

hyaluronidase 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
enzymes	5033	9001-54-1

Description:

Molecule	Description
Synonyms: hyaluronidase recombinant human hyaluronidase wydase hyaluronidase ovine hyaluronidase bovine vorhyaluronidase alfa (genetical recombination)	An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

Date	Agency	Company	Orphan
Aug. 25, 2021	PMDA	Janssen Pharmaceutical, K.K.
March 22, 1950	FDA	BAXTER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Autoimmune disorder	242.89	49.11	187	24696	76557	90527007
Deep vein thrombosis postoperative	209.88	49.11	166	24717	70643	90532921
Porphyria acute	191.06	49.11	95	24788	17880	90585684
Grip strength	180.41	49.11	74	24809	8891	90594673
Lower limb fracture	171.71	49.11	160	24723	84853	90518711
Road traffic accident	166.25	49.11	175	24708	107451	90496113
Drug ineffective	155.01	49.11	95	24788	1384203	89219361
Peripheral venous disease	152.49	49.11	149	24734	83772	90519792
Sciatica	151.53	49.11	162	24721	101220	90502344
X-ray abnormal	146.52	49.11	112	24771	45312	90558252
Bursitis	140.72	49.11	177	24706	131477	90472087
C-reactive protein abnormal	140.49	49.11	174	24709	127255	90476309
Lip dry	139.85	49.11	155	24728	100800	90502764
Retinitis	137.80	49.11	101	24782	38357	90565207
Sleep disorder due to general medical condition, insomnia type	134.34	49.11	171	24712	128523	90475041
Colitis ulcerative	128.60	49.11	117	24766	60149	90543415
Facet joint syndrome	127.64	49.11	146	24737	98243	90505321
Rectal haemorrhage	125.00	49.11	133	24750	82611	90520953
Swollen joint count increased	124.42	49.11	153	24730	111053	90492511
Adjustment disorder with depressed mood	122.70	49.11	111	24772	56642	90546922
Lupus-like syndrome	122.60	49.11	104	24779	48742	90554822
Liver disorder	120.08	49.11	157	24726	121112	90482452
Obesity	117.77	49.11	145	24738	105362	90498202
Fall	111.24	49.11	5	24878	481805	90121759
White blood cell count increased	110.36	49.11	113	24770	67128	90536436
Sleep disorder due to a general medical condition	109.71	49.11	94	24789	44644	90558920
Bone erosion	107.41	49.11	100	24783	52921	90550643
Lupus vulgaris	107.10	49.11	93	24790	44966	90558598
Swollen joint count	104.76	49.11	50	24833	8603	90594961
Dislocation of vertebra	104.69	49.11	101	24782	55867	90547697
Rheumatic fever	100.22	49.11	163	24720	152958	90450606
Frequent bowel movements	97.66	49.11	98	24785	56837	90546727
Joint range of motion decreased	95.08	49.11	149	24734	135494	90468070
Blood cholesterol increased	94.65	49.11	189	24694	207823	90395741
Hepatic cirrhosis	94.32	49.11	101	24782	63152	90540412
Lung disorder	93.30	49.11	156	24727	149727	90453837
Exostosis	90.29	49.11	91	24792	53043	90550521
Laryngitis	90.08	49.11	89	24794	50664	90552900
Type 2 diabetes mellitus	89.28	49.11	182	24701	203062	90400502
Muscle injury	87.02	49.11	166	24717	176488	90427076
Night sweats	86.87	49.11	139	24744	128627	90474937
Folliculitis	85.07	49.11	179	24704	204174	90399390
Breast cancer stage III	84.60	49.11	110	24773	84337	90519227
Pancreatitis	84.48	49.11	100	24783	69726	90533838
Duodenal ulcer perforation	84.31	49.11	187	24696	221101	90382463
Dry mouth	81.04	49.11	165	24718	183894	90419670
Asthma	79.49	49.11	193	24690	241967	90361597
Wound infection	78.92	49.11	120	24763	106282	90497282
Musculoskeletal pain	78.35	49.11	156	24727	171095	90432469
Foot deformity	76.45	49.11	88	24795	59563	90544001
Respiratory disorder	75.41	49.11	91	24792	64725	90538839
Delirium	75.01	49.11	116	24767	104243	90499321
Helicobacter infection	74.66	49.11	181	24702	226669	90376895
Pulmonary fibrosis	73.81	49.11	117	24766	107386	90496178
Hypotension	73.06	49.11	4	24879	325393	90278171
Laboratory test abnormal	71.69	49.11	72	24811	41782	90561782
Fibromyalgia	71.56	49.11	168	24715	206101	90397463
Ill-defined disorder	71.25	49.11	157	24726	184734	90418830
C-reactive protein	71.04	49.11	63	24820	31304	90572260
Rheumatoid factor positive	71.01	49.11	150	24733	171500	90432064
Pregnancy	70.37	49.11	86	24797	61961	90541603
Ear infection	70.06	49.11	91	24792	69684	90533880
Grip strength decreased	68.07	49.11	104	24779	92472	90511092
Feeling hot	68.04	49.11	95	24788	77913	90525651
Osteoarthritis	67.44	49.11	159	24724	195571	90407993
Contusion	66.77	49.11	185	24698	251031	90352533
Drug tolerance decreased	65.83	49.11	61	24822	32069	90571495
Off label use	65.11	49.11	128	24755	1102124	89501440
Maternal exposure timing unspecified	65.03	49.11	52	24831	22431	90581133
Amnesia	63.61	49.11	110	24773	108395	90495169
Drug interaction	63.32	49.11	3	24880	276450	90327114
Parophthalmia	62.93	49.11	16	24867	407	90603157
Purtscher retinopathy	61.86	49.11	13	24870	137	90603427
Liver injury	61.42	49.11	141	24742	170426	90433138
Lower respiratory tract infection	61.17	49.11	179	24704	250480	90353084
Nausea	60.47	49.11	135	24748	1110181	89493383
Discomfort	60.46	49.11	189	24694	274146	90329418
Blister	59.28	49.11	179	24704	254819	90348745
Weight fluctuation	57.81	49.11	46	24837	19703	90583861
Impaired healing	55.95	49.11	166	24717	234033	90369531
Anti-cyclic citrullinated peptide antibody positive	55.93	49.11	167	24716	236266	90367298
Walking aid user	55.23	49.11	58	24825	35448	90568116
Anaemia	54.02	49.11	15	24868	352787	90250777
Gastrointestinal disorder	53.05	49.11	173	24710	256514	90347050
Erythema	50.88	49.11	3	24880	229243	90374321
Stomatitis	50.48	49.11	178	24705	274520	90329044
Irritable bowel syndrome	49.50	49.11	147	24736	207301	90396263

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Retinal artery occlusion	53.20	51.57	10	342	2205	42618778
Local anaesthetic systemic toxicity	52.82	51.57	10	342	2290	42618693

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Autoimmune disorder	301.71	64.91	188	25323	65295	110498493
Deep vein thrombosis postoperative	265.02	64.91	167	25344	59124	110504664
Lower limb fracture	219.65	64.91	163	25348	75185	110488603
Porphyria acute	215.28	64.91	99	25412	18681	110545107
Grip strength	198.65	64.91	76	25435	9065	110554723
Road traffic accident	196.27	64.91	177	25334	107221	110456567
Sleep disorder due to general medical condition, insomnia type	190.87	64.91	173	25338	105470	110458318
Sciatica	190.31	64.91	163	25348	92236	110471552
X-ray abnormal	189.68	64.91	115	25396	38002	110525786
Swollen joint count increased	187.58	64.91	155	25356	83506	110480282
Retinitis	180.35	64.91	105	25406	32222	110531566
Peripheral venous disease	176.51	64.91	150	25361	83967	110479821
Adjustment disorder with depressed mood	169.95	64.91	113	25398	43770	110520018
Bursitis	169.52	64.91	178	25333	129740	110434048
Lip dry	167.40	64.91	157	25354	99926	110463862
C-reactive protein abnormal	166.21	64.91	176	25335	129519	110434269
Lupus-like syndrome	165.16	64.91	108	25403	40684	110523104
Rheumatic fever	154.69	64.91	165	25346	122414	110441374
Facet joint syndrome	152.62	64.91	147	25364	96681	110467107
Lupus vulgaris	150.25	64.91	95	25416	33788	110530000
Dislocation of vertebra	146.59	64.91	103	25408	43618	110520170
Muscle injury	144.22	64.91	170	25341	140637	110423151
Duodenal ulcer perforation	142.82	64.91	190	25321	177510	110386278
Bone erosion	138.87	64.91	102	25409	46269	110517519
Blood cholesterol increased	138.52	64.91	191	25320	184594	110379194
Folliculitis	137.41	64.91	181	25330	167472	110396316
Drug ineffective	134.29	64.91	94	25417	1520446	109043342
Type 2 diabetes mellitus	134.06	64.91	184	25327	177048	110386740
Obesity	133.25	64.91	147	25364	113204	110450584
Acute kidney injury	132.32	64.91	3	25508	635427	109928361
Joint range of motion decreased	131.29	64.91	151	25360	121681	110442107
Helicobacter infection	128.88	64.91	183	25328	181694	110382094
Liver disorder	126.63	64.91	160	25351	142083	110421705
Colitis ulcerative	124.83	64.91	119	25392	77244	110486544
Rheumatoid factor positive	123.46	64.91	152	25359	131488	110432300
Laryngitis	121.86	64.91	91	25420	42320	110521468
Exostosis	119.70	64.91	93	25418	45863	110517925
Discomfort	119.44	64.91	193	25318	214514	110349274
Fall	117.93	64.91	5	25506	603477	109960311
Sleep disorder due to a general medical condition	117.70	64.91	97	25414	52015	110511773
Fibromyalgia	116.73	64.91	169	25342	170740	110393048
Swollen joint count	112.97	64.91	50	25461	8624	110555164
Ill-defined disorder	112.85	64.91	159	25352	156694	110407094
Rectal haemorrhage	110.16	64.91	137	25374	119696	110444092
Anti-cyclic citrullinated peptide antibody positive	110.06	64.91	170	25341	181814	110381974
Wound infection	109.75	64.91	123	25388	96342	110467446
Breast cancer stage III	109.62	64.91	112	25399	79005	110484783
Foot deformity	108.99	64.91	90	25421	48390	110515398
Night sweats	107.21	64.91	143	25368	133840	110429948
Hepatic cirrhosis	107.16	64.91	103	25408	67523	110496265
Contusion	101.29	64.91	188	25323	233173	110330615
Hand deformity	99.85	64.91	180	25331	218326	110345462
Pulmonary fibrosis	99.18	64.91	120	25391	101922	110461866
Frequent bowel movements	98.79	64.91	101	25410	71289	110492499
Asthma	98.01	64.91	193	25318	250098	110313690
Lung disorder	97.60	64.91	160	25351	179887	110383901
White blood cell count increased	97.59	64.91	116	25395	96726	110467062
Impaired healing	97.57	64.91	168	25343	196549	110367239
Osteoarthritis	97.26	64.91	161	25350	182462	110381326
Blister	97.21	64.91	182	25329	227194	110336594
Grip strength decreased	95.97	64.91	105	25406	80069	110483719
Ear infection	94.61	64.91	93	25418	62639	110501149
Liver injury	94.44	64.91	143	25368	150270	110413518
Musculoskeletal pain	94.32	64.91	159	25352	182864	110380924
Dry mouth	94.28	64.91	167	25344	199781	110364007
Pregnancy	92.89	64.91	84	25427	50983	110512805
Irritable bowel syndrome	91.81	64.91	148	25363	164067	110399721
Drug interaction	89.00	64.91	7	25504	500176	110063612
Off label use	88.73	64.91	131	25380	1500054	109063734
Hypotension	88.71	64.91	9	25502	523840	110039948
Lower respiratory tract infection	88.65	64.91	182	25329	242924	110320864
Glossodynia	86.67	64.91	171	25340	221833	110341955
Drug tolerance decreased	85.66	64.91	62	25449	27478	110536310
Respiratory disorder	84.59	64.91	93	25418	71289	110492499
Amnesia	83.53	64.91	112	25399	105296	110458492
Laboratory test abnormal	83.12	64.91	74	25437	44005	110519783
C-reactive protein	82.51	64.91	63	25448	30268	110533520
Psoriatic arthropathy	82.22	64.91	156	25355	196605	110367183
Walking aid user	81.54	64.91	58	25453	25017	110538771
Pancreatitis	81.28	64.91	104	25407	93429	110470359
Gastrointestinal disorder	81.08	64.91	175	25336	241777	110322011
Maternal exposure timing unspecified	81.07	64.91	54	25457	20959	110542829
Hip arthroplasty	80.94	64.91	81	25430	55732	110508056
Pemphigus	79.83	64.91	162	25349	214408	110349380
Systemic lupus erythematosus	79.62	64.91	179	25332	254159	110309629
Knee arthroplasty	77.62	64.91	85	25426	64863	110498925
Arthropathy	76.59	64.91	190	25321	287332	110276456
Injury	75.87	64.91	142	25369	177123	110386665
Feeling hot	75.57	64.91	99	25412	91007	110472781
Mobility decreased	75.32	64.91	168	25343	237254	110326534
Stomatitis	73.48	64.91	180	25331	270062	110293726
Anaemia	73.38	64.91	18	25493	547068	110016720
Pericarditis	72.85	64.91	158	25353	218956	110344832
Sinusitis	72.73	64.91	190	25321	296498	110267290
Hepatic enzyme increased	72.13	64.91	199	25312	320693	110243095
Delirium	70.47	64.91	118	25393	134907	110428881
Hypercholesterolaemia	69.66	64.91	95	25416	90742	110473046
Wound	67.85	64.91	160	25351	234277	110329511
Abdominal discomfort	67.53	64.91	222	25289	393636	110170152
Alopecia	67.44	64.91	211	25300	364542	110199246

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	B06AA03	BLOOD AND BLOOD FORMING ORGANS OTHER HEMATOLOGICAL AGENTS OTHER HEMATOLOGICAL AGENTS Enzymes
FDA CS	M0009499	Glycoside Hydrolases
FDA EPC	N0000175531	Endoglycosidase
CHEBI has role	CHEBI:35480	analgesic
CHEBI has role	CHEBI:35526	hypoglycemic agent
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:67079	anti-inflammatory agent
CHEBI has role	CHEBI:75835	anti-anaemic agent

Related Drugs by ATC class:

B06AA Enzymes 3 drugs

chymotrypsindornase alfatrypsin

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Systemic AL amyloidosis	indication	23132008
Multiple myeloma	indication	109989006	DOID:9538
Subcutaneous clysis of patient for fluid administration	indication	113154008

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D04456	KEGG_DRUG
4018028	VUID
N0000146371	NUI
4018028	VANDF
C0020197	UMLSCUI
CHEBI:231673	CHEBI
CHEMBL1201636	ChEMBL_ID
DB14740	DRUGBANK_ID
CHEMBL1201718	ChEMBL_ID
CHEMBL2108607	ChEMBL_ID
DB06205	DRUGBANK_ID
1300478	RXNORM
1312	MMSL
4832	MMSL
63625	MMSL
d01393	MMSL
001887	NDDF
010831	NDDF
011274	NDDF
387280008	SNOMEDCT_US
420670008	SNOMEDCT_US
420993004	SNOMEDCT_US
51132001	SNOMEDCT_US
784400007	SNOMEDCT_US
786123000	SNOMEDCT_US
D006821	MESH_DESCRIPTOR_UI

Pharmaceutical products:

None