insulin human 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	5003	11061-68-0

Description:

Molecule	Description
Synonyms: insulin (human) insulin insulin regular human insulin susp isophane recombinant human insulin susp isophane semisynthetic purified human insulin zinc susp extended recombinant human insulin zinc susp recombinant human insulin zinc susp semisynthetic purified human insulin human base insulin human isophane insulin human insulin recombinant human insulin human (genetical recombination) humulin insulin recombinant purified human	Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism. Molecular weight: 5807.63 Formula: C257H383N65O77S6 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 2299.07 ALOGS: ROTB: None

Molecule

Description

Synonyms:

insulin (human)
insulin
insulin regular human
insulin susp isophane recombinant human
insulin susp isophane semisynthetic purified human
insulin zinc susp extended recombinant human
insulin zinc susp recombinant human
insulin zinc susp semisynthetic purified human
insulin human base
insulin human isophane
insulin human
insulin recombinant human
insulin human (genetical recombination)
humulin
insulin recombinant purified human

Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism.

Molecular weight: 5807.63
Formula: C257H383N65O77S6
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 2299.07
ALOGS:
ROTB: None

Drug dosage:

Dose	Unit	Route
40	U	P
40	U	P
40	U	P
40	U	P
40	U	P

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 21, 1997	EMA	Sanofi-Aventis Deutschland GmbH
Oct. 28, 1982	FDA	LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Blood glucose increased	1052.42	11.25	645	37681	83111	63367585
Hypoglycaemia	968.93	11.25	544	37782	59521	63391175
Blood glucose decreased	404.47	11.25	214	38112	20738	63429958
Hyperglycaemia	326.09	11.25	240	38086	41627	63409069
Diabetes mellitus inadequate control	293.33	11.25	155	38171	14971	63435725
Diabetic ketoacidosis	251.94	11.25	156	38170	20349	63430347
Blood glucose fluctuation	229.89	11.25	91	38235	4485	63446211
Toothache	228.14	11.25	143	38183	19056	63431640
Glycosylated haemoglobin increased	217.84	11.25	119	38207	12279	63438417
Pharyngitis	209.59	11.25	138	38188	20005	63430691
Diabetic retinopathy	133.63	11.25	51	38275	2276	63448420
Hypoglycaemic coma	125.13	11.25	50	38276	2525	63448171
Ketoacidosis	123.82	11.25	58	38268	4320	63446376
Blood glucose abnormal	122.94	11.25	70	38256	7822	63442874
Gait inability	118.71	11.25	153	38173	52806	63397890
Treatment failure	106.26	11.25	3	38323	199040	63251656
Cardiac failure congestive	105.05	11.25	195	38131	92238	63358458
Contraindicated product administered	104.06	11.25	7	38319	217641	63233055
Synovitis	99.11	11.25	3	38323	186915	63263781
Drug intolerance	96.51	11.25	33	38293	308628	63142068
Insulin resistance	95.68	11.25	31	38295	847	63449849
Glossodynia	94.38	11.25	3	38323	178873	63271823
Systemic lupus erythematosus	93.54	11.25	9	38317	208909	63241787
Wrong product administered	91.72	11.25	53	38273	6088	63444608
Off label use	91.19	11.25	168	38158	674294	62776402
Anti-insulin antibody positive	89.79	11.25	19	38307	84	63450612
Hyperkalaemia	87.77	11.25	134	38192	54069	63396627
Alopecia	83.82	11.25	50	38276	337486	63113210
Joint swelling	82.12	11.25	48	38278	327618	63123078
Product prescribing error	76.97	11.25	87	38239	26202	63424494
Acute kidney injury	75.55	11.25	337	37989	263078	63187618
Pain	75.39	11.25	215	38111	740413	62710283
Hypoglycaemic unconsciousness	74.88	11.25	25	38301	752	63449944
Product complaint	74.84	11.25	62	38264	12747	63437949
Incorrect dose administered	73.80	11.25	131	38195	59837	63390859
Exposure during pregnancy	70.19	11.25	230	38096	155317	63295379
Anti-insulin antibody increased	69.44	11.25	14	38312	46	63450650
Renal failure	69.16	11.25	191	38135	117461	63333235
Infusion related reaction	68.89	11.25	31	38295	245490	63205206
Abdominal discomfort	68.46	11.25	56	38270	320829	63129867
Pericarditis	66.68	11.25	3	38323	131576	63319120
Rheumatoid arthritis	65.26	11.25	36	38290	253783	63196913
Fatigue	64.44	11.25	297	38029	887731	62562965
Lactic acidosis	63.88	11.25	96	38230	38191	63412505
Discomfort	63.57	11.25	12	38314	167362	63283334
Multi-organ disorder	62.01	11.25	26	38300	1486	63449210
Diabetic neuropathy	61.31	11.25	35	38291	3929	63446767
Arthropathy	60.79	11.25	33	38293	234759	63215937
Completed suicide	58.50	11.25	9	38317	145664	63305032
Musculoskeletal stiffness	57.20	11.25	20	38306	184598	63266098
Blindness	57.13	11.25	68	38258	21631	63429065
Myocardial infarction	56.56	11.25	160	38166	99733	63350963
Eye haemorrhage	55.72	11.25	44	38282	8452	63442244
Therapeutic product effect decreased	53.23	11.25	25	38301	193162	63257534
Coronary artery disease	52.34	11.25	80	38246	32297	63418399
Foetal exposure during pregnancy	51.70	11.25	79	38247	31883	63418813
Product use issue	51.49	11.25	35	38291	220485	63230211
Dehydration	50.55	11.25	223	38103	173131	63277565
Hepatic enzyme increased	50.13	11.25	30	38296	202298	63248398
Hypoglycaemic seizure	48.09	11.25	16	38310	476	63450220
Retinopathy	46.79	11.25	27	38299	3092	63447604
Rash	45.19	11.25	180	38146	560691	62890005
Therapeutic product effect incomplete	43.36	11.25	11	38315	125045	63325651
Increased insulin requirement	43.13	11.25	10	38316	72	63450624
Expired product administered	42.68	11.25	33	38293	6148	63444548
Cerebrovascular accident	41.94	11.25	152	38174	107872	63342824
Swelling	40.33	11.25	65	38261	275313	63175383
Product storage error	39.59	11.25	47	38279	14909	63435787
Anti-insulin antibody	38.86	11.25	8	38318	30	63450666
Sepsis	38.74	11.25	189	38137	152934	63297762
Drug ineffective	37.30	11.25	428	37898	1044337	62406359
Product use in unapproved indication	36.02	11.25	33	38293	179047	63271649
Maternal exposure during pregnancy	34.95	11.25	240	38086	219822	63230874
Diabetic metabolic decompensation	34.49	11.25	18	38308	1692	63449004
Helicobacter infection	34.49	11.25	7	38319	92778	63357918
Congenital multiplex arthrogryposis	33.07	11.25	7	38319	31	63450665
Drug abuse	32.76	11.25	3	38323	72515	63378181
Central nervous system injury	32.42	11.25	9	38317	142	63450554
Type 1 diabetes mellitus	32.37	11.25	23	38303	3767	63446929
Polyhydramnios	32.33	11.25	19	38307	2252	63448444
Chronic kidney disease	32.08	11.25	79	38247	45319	63405377
Hypoaesthesia	31.86	11.25	192	38134	168201	63282495
Wrong technique in product usage process	31.58	11.25	96	38230	62244	63388452
Folliculitis	31.52	11.25	3	38323	70314	63380382
Diabetes mellitus	31.19	11.25	89	38237	55721	63394975
Irritable bowel syndrome	31.08	11.25	6	38320	82406	63368290
Nasopharyngitis	31.05	11.25	67	38259	254190	63196506
Sinusitis	30.88	11.25	56	38270	226597	63224099
Hypersensitivity	29.60	11.25	85	38241	292600	63158096
Cardiac failure	28.52	11.25	118	38208	89024	63361672
Euglycaemic diabetic ketoacidosis	28.43	11.25	21	38305	3653	63447043
Drug hypersensitivity	27.37	11.25	96	38230	310591	63140105
Medication error	26.94	11.25	81	38245	52203	63398493
Cardiac arrest	26.15	11.25	118	38208	92427	63358269
Urinary tract infection	26.01	11.25	259	38067	264425	63186271
Renal impairment	25.98	11.25	114	38212	88241	63362455
Intentional product use issue	25.20	11.25	24	38302	127868	63322828
Product dispensing error	25.02	11.25	31	38295	10274	63440422
Hypoglycaemia unawareness	24.96	11.25	7	38319	115	63450581
Foetal hypokinesia	24.93	11.25	10	38316	510	63450186
Splenic injury	24.92	11.25	8	38318	212	63450484
Blood creatinine increased	24.81	11.25	112	38214	87732	63362964
Visual acuity reduced	24.70	11.25	46	38280	21780	63428916
Lower respiratory tract infection	24.47	11.25	150	38176	132157	63318539
Gastrointestinal disorder	24.29	11.25	26	38300	131213	63319483
Peripheral swelling	24.21	11.25	81	38245	265861	63184835
No adverse event	24.08	11.25	67	38259	41338	63409358
Malnutrition	23.60	11.25	37	38289	15261	63435435
Exposure via eye contact	22.88	11.25	4	38322	4	63450692
Hepatic function abnormal	22.49	11.25	61	38265	37081	63413615
Arrhythmia	22.46	11.25	62	38264	38078	63412618
Psoriatic arthropathy	22.05	11.25	14	38312	91506	63359190
Sprue-like enteropathy	21.49	11.25	10	38316	733	63449963
Hypochromasia	21.24	11.25	8	38318	344	63450352
Antibody test negative	21.10	11.25	5	38321	40	63450656
Toxicity to various agents	20.70	11.25	78	38248	247172	63203524
Ill-defined disorder	20.40	11.25	12	38314	81743	63368953
Diabetic foot	20.32	11.25	12	38314	1435	63449261
Paraesthesia	20.30	11.25	40	38286	156926	63293770
Diabetic nephropathy	20.26	11.25	12	38314	1442	63449254
Pulmonary oedema	20.26	11.25	76	38250	54797	63395899
Premature baby	20.17	11.25	41	38285	20694	63430002
Exposure via skin contact	20.15	11.25	8	38318	397	63450299
Renal dysplasia	20.07	11.25	7	38319	241	63450455
Migraine	19.66	11.25	20	38306	103326	63347370
Rubella antibody negative	19.24	11.25	3	38323	0	63450696
Cellulitis	19.18	11.25	99	38227	81859	63368837
Disseminated intravascular coagulation	18.93	11.25	38	38288	19013	63431683
Hypoglycaemia neonatal	18.92	11.25	10	38316	965	63449731
Diabetic coma	18.75	11.25	9	38317	708	63449988
Hypoglycaemic encephalopathy	18.50	11.25	7	38319	305	63450391
Treatment noncompliance	18.45	11.25	57	38269	37268	63413428
Loss of personal independence in daily activities	18.31	11.25	19	38307	97271	63353425
Hyperchloraemia	18.21	11.25	9	38317	754	63449942
Rabbit syndrome	18.07	11.25	7	38319	325	63450371
Fall	17.78	11.25	334	37992	392000	63058696
Accidental underdose	17.78	11.25	9	38317	794	63449902
Blood creatine phosphokinase increased	17.46	11.25	49	38277	30381	63420315
Thyroid disorder	17.21	11.25	32	38294	15130	63435566
Fibromyalgia	17.15	11.25	14	38312	80406	63370290
Red blood cell sedimentation rate increased	17.02	11.25	3	38323	43979	63406717
Pericardial effusion	16.85	11.25	48	38278	30010	63420686
Neutropenia	16.82	11.25	52	38274	174953	63275743
Insomnia	16.69	11.25	70	38256	215182	63235514
Respiratory disorder neonatal	16.64	11.25	10	38316	1235	63449461
Oedema peripheral	16.50	11.25	181	38145	189330	63261366
Congenital hydronephrosis	16.45	11.25	7	38319	415	63450281
Arthralgia	16.30	11.25	244	38082	569466	62881230
Cerebral infarction	16.27	11.25	41	38285	23852	63426844
Renal injury	16.21	11.25	24	38302	9415	63441281
Bicuspid aortic valve	16.20	11.25	5	38321	116	63450580
Epidermolysis	16.18	11.25	8	38318	671	63450025
Loss of consciousness	15.95	11.25	124	38202	117997	63332699
Acute myocardial infarction	15.82	11.25	49	38277	32075	63418621
Gangrene	15.81	11.25	19	38307	6104	63444592
Anisocytosis	15.76	11.25	8	38318	710	63449986
Haemodialysis	15.73	11.25	23	38303	8924	63441772
Acidosis	15.73	11.25	26	38300	11207	63439489
Conjoined twins	15.59	11.25	6	38320	274	63450422
Inflammation	15.56	11.25	16	38310	82257	63368439
Urine output decreased	15.50	11.25	26	38300	11344	63439352
Macular oedema	15.21	11.25	15	38311	3862	63446834
Thirst	15.15	11.25	29	38297	14012	63436684
Stevens-Johnson syndrome	15.13	11.25	41	38285	24909	63425787
Agitation neonatal	14.83	11.25	7	38319	530	63450166
Mobility decreased	14.71	11.25	32	38294	121127	63329569
Macrosomia	14.36	11.25	4	38322	64	63450632
Congenital aortic valve stenosis	14.08	11.25	4	38322	69	63450627
Hydrops foetalis	14.01	11.25	7	38319	601	63450095
Pre-eclampsia	13.96	11.25	22	38304	9111	63441585
Blood urea increased	13.71	11.25	41	38285	26338	63424358
Bradycardia neonatal	13.64	11.25	8	38318	944	63449752
Hyperglycaemic hyperosmolar nonketotic syndrome	13.36	11.25	8	38318	981	63449715
Hyperaemia	13.33	11.25	11	38315	2248	63448448
Anaemia	13.00	11.25	249	38077	293181	63157515
Intercepted product selection error	12.89	11.25	3	38323	22	63450674
Urosepsis	12.83	11.25	32	38294	18492	63432204
Bipolar I disorder	12.81	11.25	10	38316	1889	63448807
Stomatitis	12.78	11.25	42	38284	138683	63312013
Toe amputation	12.50	11.25	10	38316	1957	63448739
Mental status changes	12.33	11.25	52	38274	39547	63411149
Insulin autoimmune syndrome	12.32	11.25	4	38322	110	63450586
Bradycardia	12.28	11.25	81	38245	73146	63377550
Hepatosplenic candidiasis	12.26	11.25	5	38321	266	63450430
Multiple sclerosis relapse	12.26	11.25	7	38319	48471	63402225
Diabetic ketosis	12.18	11.25	5	38321	271	63450425
Urogenital haemorrhage	12.16	11.25	5	38321	272	63450424
Angina unstable	12.13	11.25	18	38308	7077	63443619
Pneumonia aspiration	12.06	11.25	47	38279	34493	63416203
Altered state of consciousness	11.98	11.25	38	38288	25192	63425504
Shock hypoglycaemic	11.96	11.25	4	38322	121	63450575
Hypervolaemia	11.89	11.25	41	38285	28372	63422324
Toxic epidermal necrolysis	11.89	11.25	38	38288	25296	63425400
Metastases to pancreas	11.84	11.25	5	38321	291	63450405
Blood ketone body increased	11.77	11.25	5	38321	295	63450401
Product monitoring error	11.63	11.25	14	38312	4502	63446194
Protein deficiency	11.63	11.25	5	38321	304	63450392
Corynebacterium infection	11.61	11.25	6	38320	553	63450143
Congenital mitral valve incompetence	11.57	11.25	3	38323	36	63450660
Hypercreatininaemia	11.49	11.25	6	38320	565	63450131
General physical health deterioration	11.48	11.25	178	38148	201224	63249472
Neck pain	11.47	11.25	15	38311	69303	63381393

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	776.60	11.24	552	34844	54088	34867447
Blood glucose increased	749.18	11.24	585	34811	66133	34855402
Blood glucose decreased	293.56	11.24	177	35219	13060	34908475
Hyperglycaemia	234.31	11.24	242	35154	39238	34882297
Diabetes mellitus inadequate control	181.51	11.24	132	35264	13332	34908203
Glycosylated haemoglobin increased	145.51	11.24	108	35288	11252	34910283
Diabetic ketoacidosis	128.14	11.24	122	35274	17910	34903625
Anti-insulin antibody positive	125.49	11.24	31	35365	167	34921368
Blood glucose fluctuation	113.35	11.24	63	35333	3981	34917554
Completed suicide	73.95	11.24	7	35389	98161	34823374
Hypoglycaemic unconsciousness	72.09	11.24	28	35368	770	34920765
Drug abuse	69.76	11.24	9	35387	99087	34822448
Diabetic retinopathy	67.02	11.24	34	35362	1783	34919752
Incorrect dose administered	65.76	11.24	134	35262	40381	34881154
Toxicity to various agents	64.16	11.24	65	35331	200297	34721238
Blood glucose abnormal	61.85	11.24	50	35346	5902	34915633
Off label use	55.47	11.24	228	35168	419296	34502239
Anti-insulin antibody	53.14	11.24	11	35385	21	34921514
Anti-insulin antibody increased	53.10	11.24	13	35383	67	34921468
Hypoglycaemic coma	47.49	11.24	30	35366	2401	34919134
Clear cell renal cell carcinoma	43.88	11.24	22	35374	1125	34920410
Alveolar lung disease	43.79	11.24	16	35380	370	34921165
Wrong product administered	43.52	11.24	39	35357	5295	34916240
Hypoglycaemic seizure	42.18	11.24	15	35381	320	34921215
Product storage error	41.44	11.24	46	35350	8076	34913459
Hypoglycaemia unawareness	40.83	11.24	12	35384	135	34921400
Diabetic metabolic decompensation	40.12	11.24	24	35372	1742	34919793
Hypoglycaemic encephalopathy	39.98	11.24	14	35382	285	34921250
Pulmonary interstitial emphysema syndrome	39.04	11.24	16	35380	508	34921027
Drug interaction	38.43	11.24	110	35286	225836	34695699
Diabetic neuropathy	36.87	11.24	32	35364	4165	34917370
Product prescribing error	36.21	11.24	75	35321	22852	34898683
Blindness	33.64	11.24	57	35339	14929	34906606
Product complaint	32.91	11.24	35	35361	5855	34915680
Platelet distribution width increased	32.43	11.24	10	35386	134	34921401
Insulin resistance	32.38	11.24	15	35381	643	34920892
Finnegan score increased	31.59	11.24	7	35389	21	34921514
Cardiac failure congestive	30.86	11.24	166	35230	83104	34838431
Toe amputation	30.10	11.24	23	35373	2501	34919034
Drug ineffective	28.81	11.24	310	35086	456441	34465094
Diabetes mellitus	28.31	11.24	108	35288	46765	34874770
Agitation neonatal	27.81	11.24	16	35380	1080	34920455
Product dispensing error	27.73	11.24	33	35363	6241	34915294
Infant irritability	27.70	11.24	7	35389	42	34921493
Diabetic nephropathy	26.72	11.24	20	35376	2108	34919427
Toxic epidermal necrolysis	26.52	11.24	64	35332	21582	34899953
Neonatal hypoxia	25.54	11.24	11	35385	396	34921139
Hypoaldosteronism	25.44	11.24	9	35387	189	34921346
Diffuse alveolar damage	25.23	11.24	20	35376	2294	34919241
Acute myocardial infarction	24.80	11.24	114	35282	53605	34867930
Joint swelling	24.72	11.24	15	35381	59875	34861660
Peripheral arterial occlusive disease	24.50	11.24	30	35366	5844	34915691
Infusion site induration	23.61	11.24	9	35387	235	34921300
Mumps antibody test negative	23.59	11.24	4	35392	0	34921535
Hyperlipidaemia	23.49	11.24	48	35348	14481	34907054
Oedema peripheral	22.40	11.24	202	35194	119610	34801925
Treatment failure	21.77	11.24	10	35386	46687	34874848
Renal impairment	21.75	11.24	167	35229	94346	34827189
Gangrene	21.73	11.24	25	35371	4561	34916974
Floppy infant	21.44	11.24	7	35389	114	34921421
Cardiac failure	21.43	11.24	162	35234	91086	34830449
Renal failure	20.89	11.24	213	35183	130344	34791191
Neutropenia	20.73	11.24	85	35311	156693	34764842
Wrong technique in product usage process	20.17	11.24	81	35315	35905	34885630
Diabetic complication	20.01	11.24	11	35385	680	34920855
General physical health deterioration	19.92	11.24	208	35188	128061	34793474
Eosinophilic pneumonia	19.91	11.24	21	35375	3480	34918055
Disease progression	19.54	11.24	51	35345	108026	34813509
Angina pectoris	19.54	11.24	73	35323	31290	34890245
Diabetic hyperglycaemic coma	19.12	11.24	5	35391	35	34921500
Myocardial infarction	18.63	11.24	196	35200	120889	34800646
Sepsis	17.95	11.24	252	35144	166309	34755226
Product use in unapproved indication	17.95	11.24	60	35336	117439	34804096
Measles antibody negative	17.69	11.24	3	35393	0	34921535
Rubella antibody negative	17.69	11.24	3	35393	0	34921535
Vaccination site erythema	17.69	11.24	3	35393	0	34921535
Blood urea increased	17.54	11.24	69	35327	30295	34891240
Hepatic encephalopathy	17.54	11.24	43	35353	14642	34906893
Bronchopneumopathy	17.21	11.24	9	35387	503	34921032
Death	16.79	11.24	293	35103	397756	34523779
Type 1 diabetes mellitus	16.56	11.24	21	35375	4237	34917298
Glycosylated haemoglobin decreased	16.52	11.24	8	35388	379	34921156
Selective eating disorder	16.52	11.24	14	35382	1764	34919771
Lymphoproliferative disorder	16.50	11.24	17	35379	2742	34918793
Lymphangitis	16.37	11.24	9	35387	556	34920979
Agitated depression	16.36	11.24	7	35389	248	34921287
Coronary artery disease	16.35	11.24	94	35302	48211	34873324
Intentional product use issue	16.31	11.24	22	35374	59794	34861741
Hepatic function abnormal	16.12	11.24	88	35308	44275	34877260
Mucosal inflammation	15.48	11.24	10	35386	38612	34882923
Neuropathic arthropathy	15.31	11.24	6	35390	169	34921366
Renal cell carcinoma	15.23	11.24	22	35374	5026	34916509
Acute kidney injury	15.16	11.24	410	34986	304578	34616957
Somogyi phenomenon	15.15	11.24	3	35393	4	34921531
Visual acuity reduced	14.94	11.24	43	35353	16106	34905429
Diabetic coma	14.70	11.24	10	35386	907	34920628
Ketosis	14.62	11.24	8	35388	490	34921045
Leishmaniasis	14.59	11.24	7	35389	325	34921210
Diabetic foot	14.58	11.24	16	35380	2772	34918763
Microalbuminuria	14.56	11.24	9	35387	693	34920842
Urethral cancer	14.55	11.24	5	35391	96	34921439
Meningocele	14.51	11.24	4	35392	35	34921500
Visual impairment	14.37	11.24	73	35323	35729	34885806
Arthralgia	14.34	11.24	107	35289	169934	34751601
Cutaneous amyloidosis	14.22	11.24	4	35392	38	34921497
Dementia	14.09	11.24	38	35358	13710	34907825
Streptococcal infection	14.07	11.24	21	35375	4940	34916595
No adverse event	13.98	11.24	53	35343	22874	34898661
Rheumatoid arthritis	13.89	11.24	11	35385	38227	34883308
Internal haemorrhage	13.81	11.24	21	35375	5020	34916515
Spermatic cord disorder	13.54	11.24	3	35393	9	34921526
Dysphagia	13.24	11.24	27	35369	62354	34859181
Diabetic gangrene	13.16	11.24	6	35390	248	34921287
Necrosis	13.15	11.24	22	35374	5701	34915834
Medication error	13.11	11.24	56	35340	25509	34896026
Intra-abdominal haemorrhage	12.93	11.24	14	35382	2390	34919145
Impaired insulin secretion	12.87	11.24	3	35393	12	34921523
Post thrombotic syndrome	12.82	11.24	5	35391	139	34921396
Drug withdrawal syndrome neonatal	12.75	11.24	17	35379	3602	34917933
Product administration error	12.75	11.24	41	35355	16303	34905232
Glomerular filtration rate increased	12.71	11.24	7	35389	434	34921101
Sinusitis	12.58	11.24	14	35382	41388	34880147
Arrhythmia	12.32	11.24	70	35326	35738	34885797
Coombs negative haemolytic anaemia	12.28	11.24	5	35391	156	34921379
Hypochromic anaemia	12.18	11.24	9	35387	930	34920605
Pelvic abscess	12.18	11.24	9	35387	930	34920605
Antibody test negative	12.17	11.24	3	35393	16	34921519
Hyperinsulinaemia	12.04	11.24	4	35392	69	34921466
Hyperlactacidaemia	11.93	11.24	15	35381	3001	34918534
Dyspnoea	11.88	11.24	480	34916	376302	34545233
Multiple organ dysfunction syndrome	11.79	11.24	124	35272	76442	34845093
Hyperglycaemic hyperosmolar nonketotic syndrome	11.73	11.24	10	35386	1270	34920265
Cold sweat	11.67	11.24	29	35367	9958	34911577
Product monitoring error	11.65	11.24	18	35378	4363	34917172
Intercepted product dispensing error	11.63	11.24	4	35392	77	34921458
Overdose	11.63	11.24	50	35346	91009	34830526
Therapeutic product effect incomplete	11.48	11.24	21	35375	50520	34871015
Disseminated intravascular coagulation	11.35	11.24	48	35348	21768	34899767
Wound	11.34	11.24	37	35359	14827	34906708
Chronic kidney disease	11.31	11.24	76	35320	41134	34880401

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypoglycaemia	1430.78	10.40	908	58418	100686	79584376
Blood glucose increased	887.82	10.40	713	58613	114262	79570800
Hyperglycaemia	508.23	10.40	420	58906	69915	79615147
Blood glucose decreased	389.73	10.40	243	59083	25991	79659071
Diabetes mellitus inadequate control	348.49	10.40	220	59106	24044	79661018
Diabetic ketoacidosis	282.95	10.40	221	59105	33901	79651161
Glycosylated haemoglobin increased	238.16	10.40	159	59167	19101	79665961
Blood glucose fluctuation	232.62	10.40	109	59217	6573	79678489
Anti-insulin antibody positive	199.96	10.40	46	59280	250	79684812
Hypoglycaemic coma	142.46	10.40	70	59256	4690	79680372
Completed suicide	141.17	10.40	11	59315	245756	79439306
Diabetic retinopathy	137.75	10.40	60	59266	3046	79682016
Off label use	115.69	10.40	322	59004	906893	78778169
Product prescribing error	104.55	10.40	147	59179	44666	79640396
Anti-insulin antibody increased	98.71	10.40	22	59304	101	79684961
Acute kidney injury	98.42	10.40	692	58634	518712	79166350
Synovitis	98.38	10.40	3	59323	150731	79534331
Cardiac failure congestive	97.36	10.40	279	59047	142123	79542939
Drug ineffective	93.39	10.40	451	58875	1080462	78604600
Drug abuse	88.75	10.40	9	59317	162682	79522380
Ketoacidosis	87.95	10.40	61	59265	7793	79677269
Joint swelling	87.81	10.40	53	59273	288593	79396469
No adverse event	86.76	10.40	122	59204	37070	79647992
Treatment failure	86.65	10.40	12	59314	170474	79514588
Anti-insulin antibody	85.56	10.40	18	59308	59	79685003
Product complaint	84.59	10.40	74	59252	13275	79671787
Renal failure	81.85	10.40	331	58995	200637	79484425
Drug intolerance	81.03	10.40	48	59278	264071	79420991
Hypoglycaemic unconsciousness	76.76	10.40	30	59296	1153	79683909
Diabetic metabolic decompensation	76.53	10.40	41	59285	3291	79681771
Insulin resistance	75.69	10.40	31	59295	1348	79683714
Blood glucose abnormal	73.93	10.40	62	59264	10504	79674558
Toxicity to various agents	73.93	10.40	125	59201	421415	79263647
Wrong product administered	73.87	10.40	58	59268	8954	79676108
Diabetic neuropathy	73.68	10.40	50	59276	6166	79678896
Toothache	72.97	10.40	82	59244	19888	79665174
Rheumatoid arthritis	72.72	10.40	32	59294	208438	79476624
Alopecia	69.62	10.40	43	59283	231312	79453750
Hyperkalaemia	69.50	10.40	215	59111	114183	79570879
Hypoglycaemic seizure	68.32	10.40	25	59301	799	79684263
Myocardial infarction	65.44	10.40	291	59035	183838	79501224
Pharyngitis	65.44	10.40	82	59244	22293	79662769
Systemic lupus erythematosus	65.30	10.40	7	59319	121142	79563920
Glossodynia	64.19	10.40	3	59323	103334	79581728
Infusion related reaction	62.35	10.40	48	59278	230189	79454873
Sepsis	60.60	10.40	375	58951	269053	79416009
Pericarditis	58.88	10.40	5	59321	104231	79580831
Product storage error	56.53	10.40	65	59261	16161	79668901
Coronary artery disease	55.53	10.40	139	59187	65335	79619727
Musculoskeletal stiffness	54.79	10.40	31	59295	174977	79510085
Pain	54.72	10.40	304	59022	703498	78981564
Arthropathy	53.16	10.40	33	59293	177078	79507984
Increased insulin requirement	50.70	10.40	14	59312	173	79684889
Renal impairment	50.60	10.40	242	59084	157541	79527521
Abdominal discomfort	50.03	10.40	68	59258	250659	79434403
Eye haemorrhage	49.94	10.40	48	59278	9709	79675353
Acute myocardial infarction	49.79	10.40	148	59178	76888	79608174
Diabetes mellitus	49.15	10.40	149	59177	78241	79606821
Therapeutic product effect decreased	48.53	10.40	31	59295	163832	79521230
Hypoglycaemic encephalopathy	47.30	10.40	18	59308	643	79684419
Multi-organ disorder	46.23	10.40	27	59299	2561	79682501
Sinusitis	45.43	10.40	47	59279	195454	79489608
Fatigue	44.92	10.40	459	58867	929268	78755794
Pulmonary interstitial emphysema syndrome	43.86	10.40	16	59310	507	79684555
Therapeutic product effect incomplete	43.05	10.40	26	59300	141619	79543443
Diabetic nephropathy	42.99	10.40	27	59299	2920	79682142
Arthralgia	42.77	10.40	250	59076	571553	79113509
Alveolar lung disease	42.32	10.40	16	59310	561	79684501
Cardiac failure	42.28	10.40	227	59099	154615	79530447
Blood creatinine increased	41.45	10.40	226	59100	154831	79530231
Cerebrovascular accident	41.28	10.40	226	59100	155066	79529996
Toxic epidermal necrolysis	40.30	10.40	97	59229	44484	79640578
Hypersensitivity	39.58	10.40	85	59241	262154	79422908
Hypoglycaemia unawareness	38.77	10.40	12	59314	226	79684836
Intentional product use issue	38.33	10.40	34	59292	152078	79532984
Discomfort	38.25	10.40	23	59303	125594	79559468
Oedema peripheral	38.03	10.40	319	59007	251969	79433093
Arrhythmia	37.98	10.40	116	59210	61156	79623906
Product use issue	37.86	10.40	61	59265	209761	79475301
General physical health deterioration	37.84	10.40	341	58985	274897	79410165
Product use in unapproved indication	36.26	10.40	83	59243	250276	79434786
Hepatic function abnormal	35.99	10.40	128	59198	72979	79612083
Platelet distribution width increased	35.40	10.40	10	59316	135	79684927
Helicobacter infection	35.18	10.40	5	59321	69699	79615363
Dehydration	34.89	10.40	309	59017	247878	79437184
Toe amputation	33.86	10.40	26	59300	3885	79681177
Clear cell renal cell carcinoma	33.61	10.40	22	59304	2554	79682508
Chronic kidney disease	32.71	10.40	116	59210	66038	79619024
Peripheral arterial occlusive disease	32.05	10.40	35	59291	8223	79676839
Hepatic enzyme increased	30.28	10.40	56	59270	182554	79502508
Central nervous system injury	29.89	10.40	9	59317	154	79684908
Gangrene	29.70	10.40	35	59291	8929	79676133
Medication error	29.46	10.40	115	59211	68527	79616535
Expired product administered	29.33	10.40	31	59295	7020	79678042
Blood urea increased	28.96	10.40	91	59235	48699	79636363
Neutropenia	28.95	10.40	113	59213	287597	79397465
Cardiac arrest	28.85	10.40	223	59103	171873	79513189
Nasopharyngitis	28.67	10.40	95	59231	253786	79431276
Paraesthesia	28.42	10.40	55	59271	176268	79508794
Peripheral swelling	28.35	10.40	104	59222	269513	79415549
Contraindicated product administered	28.22	10.40	46	59280	157492	79527570
Rash	28.05	10.40	285	59041	578073	79106989
Type 1 diabetes mellitus	28.03	10.40	30	59296	6889	79678173
Gait inability	28.01	10.40	102	59224	58815	79626247
Diabetic coma	27.63	10.40	15	59311	1236	79683826
Hepatic encephalopathy	26.76	10.40	57	59269	24109	79660953
Gastrointestinal disorder	26.59	10.40	31	59295	122174	79562888
Disseminated intravascular coagulation	26.20	10.40	72	59254	35770	79649292
Hyperlipidaemia	26.01	10.40	59	59267	26034	79659028
Angina pectoris	25.82	10.40	91	59235	51641	79633421
Polyhydramnios	25.70	10.40	16	59310	1704	79683358
Muscle injury	25.67	10.40	3	59323	48558	79636504
Retinopathy	25.52	10.40	22	59304	3869	79681193
Product monitoring error	25.02	10.40	32	59294	8874	79676188
Multiple organ dysfunction syndrome	24.91	10.40	164	59162	120082	79564980
Lactic acidosis	24.81	10.40	111	59215	70248	79614814
Fibromyalgia	23.84	10.40	9	59317	64331	79620731
Blindness	23.79	10.40	60	59266	28323	79656739
Diabetic gangrene	23.39	10.40	8	59318	209	79684853
Product administration error	23.31	10.40	64	59262	31782	79653280
Urosepsis	23.25	10.40	57	59269	26438	79658624
Diffuse alveolar damage	22.87	10.40	20	59306	3584	79681478
Psoriatic arthropathy	22.75	10.40	15	59311	77984	79607078
Irritable bowel syndrome	22.57	10.40	9	59317	62232	79622830
Hypoaldosteronism	22.29	10.40	9	59317	377	79684685
Diabetic complication	21.94	10.40	13	59313	1266	79683796
Pulmonary oedema	21.82	10.40	126	59200	88128	79596934
Urine output decreased	21.70	10.40	44	59282	17978	79667084
Splenic injury	21.62	10.40	8	59318	264	79684798
Mobility decreased	21.58	10.40	36	59290	122139	79562923
Swelling	21.23	10.40	86	59240	216625	79468437
Acidosis	21.18	10.40	46	59280	19716	79665346
Stomatitis	20.95	10.40	49	59277	146708	79538354
Diabetic hyperglycaemic coma	20.85	10.40	6	59320	87	79684975
Cerebral infarction	20.81	10.40	78	59248	45598	79639464
Diabetic foot	20.76	10.40	19	59307	3613	79681449
Malnutrition	20.38	10.40	49	59277	22453	79662609
Loss of personal independence in daily activities	20.26	10.40	28	59298	102552	79582510
Glycosylated haemoglobin decreased	20.05	10.40	10	59316	692	79684370
Hyperglycaemic hyperosmolar nonketotic syndrome	19.26	10.40	15	59311	2288	79682774
Migraine	19.24	10.40	22	59304	87471	79597591
Exposure during pregnancy	19.19	10.40	135	59191	100997	79584065
Wheezing	19.13	10.40	36	59290	116628	79568434
Bronchopneumopathy	18.89	10.40	10	59316	783	79684279
Treatment noncompliance	18.84	10.40	83	59243	52185	79632877
Platelet count decreased	18.57	10.40	224	59102	194440	79490622
Folliculitis	18.52	10.40	9	59317	55371	79629691
Shock hypoglycaemic	18.39	10.40	7	59319	250	79684812
Cold sweat	18.33	10.40	42	59284	18657	79666405
Ketosis	18.16	10.40	11	59315	1115	79683947
Pneumonia aspiration	18.14	10.40	98	59228	66869	79618193
Intestinal ischaemia	17.92	10.40	34	59292	13236	79671826
Red blood cell sedimentation rate increased	17.75	10.40	6	59320	45936	79639126
Mucosal inflammation	17.74	10.40	18	59308	75562	79609500
Renal injury	17.69	10.40	39	59287	16888	79668174
Urethral cancer	17.60	10.40	5	59321	69	79684993
Ischaemic cardiomyopathy	17.58	10.40	25	59301	7670	79677392
Drug resistance	17.22	10.40	5	59321	42208	79642854
Hypochromasia	17.22	10.40	9	59317	687	79684375
Hip arthroplasty	17.06	10.40	3	59323	35753	79649309
Renal disorder	16.83	10.40	69	59257	42036	79643026
Incorrect dose administered	16.77	10.40	106	59220	76524	79608538
Neck pain	16.55	10.40	19	59307	75398	79609664
Syncope	16.47	10.40	205	59121	179244	79505818
Eosinophilic pneumonia	16.39	10.40	20	59306	5290	79679772
Necrosis	16.27	10.40	27	59299	9466	79675596
Ill-defined disorder	16.26	10.40	15	59311	65860	79619202
Rabbit syndrome	16.06	10.40	7	59319	356	79684706
Renal cell carcinoma	15.96	10.40	22	59304	6556	79678506
Cellulitis	15.93	10.40	137	59189	108923	79576139
Systemic infection	15.74	10.40	27	59299	9725	79675337
Pericardial effusion	15.59	10.40	72	59254	46165	79638897
Serotonin syndrome	15.55	10.40	7	59319	45020	79640042
Leishmaniasis	15.51	10.40	7	59319	387	79684675
Euglycaemic diabetic ketoacidosis	15.29	10.40	22	59304	6822	79678240
Thirst	15.23	10.40	39	59287	18580	79666482
Peripheral ischaemia	15.02	10.40	26	59300	9431	79675631
Hypochromic anaemia	14.97	10.40	14	59312	2737	79682325
Haematuria	14.93	10.40	95	59231	68741	79616321
Multiple sclerosis relapse	14.91	10.40	8	59318	46525	79638537
Agitated depression	14.90	10.40	7	59319	424	79684638
Insulin autoimmune syndrome	14.89	10.40	7	59319	425	79684637
Ischaemic limb pain	14.83	10.40	4	59322	45	79685017
Blood creatine phosphokinase increased	14.83	10.40	92	59234	65998	79619064
Somogyi phenomenon	14.72	10.40	3	59323	8	79685054
Flushing	14.68	10.40	27	59299	88241	79596821
Anti-GAD antibody positive	14.67	10.40	4	59322	47	79685015
Cutaneous amyloidosis	14.67	10.40	4	59322	47	79685015
Osteonecrosis of jaw	14.49	10.40	7	59319	43219	79641843
Full blood count abnormal	14.44	10.40	6	59320	40468	79644594
Sleep disorder	14.44	10.40	26	59300	85651	79599411
Dyspnoea	14.40	10.40	777	58549	856248	78828814
Product dispensing error	14.36	10.40	31	59295	13232	79671830
Influenza	14.27	10.40	49	59277	129557	79555505
Sprue-like enteropathy	14.20	10.40	10	59316	1308	79683754
Peripheral vascular disorder	13.98	10.40	23	59303	8007	79677055
Anaemia	13.84	10.40	431	58895	444584	79240478
Stasis dermatitis	13.71	10.40	10	59316	1383	79683679
Hydrocholecystis	13.49	10.40	7	59319	526	79684536
Acute respiratory failure	13.43	10.40	83	59243	59458	79625604
Hypervolaemia	13.32	10.40	65	59261	42625	79642437
Drug interaction	13.29	10.40	223	59103	414960	79270102
Hyperchloraemia	13.24	10.40	9	59317	1112	79683950
Stevens-Johnson syndrome	13.22	10.40	61	59265	39105	79645957
Headache	13.19	10.40	378	58948	653394	79031668
Infusion site induration	13.14	10.40	9	59317	1126	79683936
Thyroid disorder	13.12	10.40	31	59295	14048	79671014
Injection site induration	13.07	10.40	25	59301	9794	79675268
Insulin C-peptide decreased	13.04	10.40	4	59322	73	79684989
Localised infection	13.03	10.40	59	59267	37516	79647546
Decubitus ulcer	12.98	10.40	33	59293	15654	79669408
Septic shock	12.91	10.40	144	59182	122657	79562405
Dry mouth	12.87	10.40	29	59297	87990	79597072
Neuropathic arthropathy	12.84	10.40	6	59320	359	79684703
Cardiac failure acute	12.83	10.40	37	59289	18892	79666170
Hyperlactacidaemia	12.52	10.40	18	59308	5577	79679485
Ear infection	12.45	10.40	5	59321	34427	79650635
Overdose	12.45	10.40	83	59243	184123	79500939
Internal haemorrhage	12.39	10.40	23	59303	8810	79676252
Urinary tract infection	12.32	10.40	279	59047	274233	79410829
Intra-abdominal haemorrhage	12.27	10.40	16	59310	4524	79680538
Drug ineffective for unapproved indication	12.26	10.40	12	59314	51226	79633836
Generalised oedema	12.08	10.40	42	59284	23667	79661395
Fall	12.08	10.40	460	58866	487169	79197893
Diabetic ketoacidotic hyperglycaemic coma	12.07	10.40	5	59321	224	79684838
Waist circumference increased	12.00	10.40	10	59316	1679	79683383
Epidermolysis	11.98	10.40	8	59318	960	79684102
Shock	11.98	10.40	64	59262	43484	79641578
Pneumonia	11.96	10.40	603	58723	659643	79025419
Altered state of consciousness	11.78	10.40	64	59262	43758	79641304
Insomnia	11.77	10.40	121	59205	245049	79440013
Blood potassium increased	11.72	10.40	48	59278	29227	79655835
Bladder cyst	11.71	10.40	4	59322	104	79684958
Bladder transitional cell carcinoma	11.65	10.40	12	59314	2638	79682424
Hypertensive nephropathy	11.65	10.40	8	59318	1006	79684056
Anisocytosis	11.47	10.40	8	59318	1031	79684031
Atrial enlargement	11.44	10.40	8	59318	1035	79684027
Lymphangitis	11.41	10.40	9	59317	1399	79683663
COVID-19 treatment	11.41	10.40	6	59320	464	79684598
Glomerular filtration rate decreased	11.38	10.40	40	59286	22662	79662400
Corneal dystrophy	11.29	10.40	5	59321	264	79684798
Product administered to patient of inappropriate age	11.18	10.40	17	59309	5536	79679526
Streptococcal infection	11.16	10.40	22	59304	8808	79676254
Lymphoproliferative disorder	11.04	10.40	17	59309	5598	79679464
Influenza like illness	11.00	10.40	23	59303	71684	79613378
Illness	11	10.40	11	59315	46500	79638562
Diabetic foot infection	10.79	10.40	7	59319	800	79684262
Product dose omission issue	10.75	10.40	125	59201	247412	79437650
Blood ketone body	10.59	10.40	4	59322	140	79684922
Dialysis	10.56	10.40	34	59292	18428	79666634
Hypoproteinaemia	10.53	10.40	14	59312	4032	79681030

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A10AB01	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, fast-acting
ATC	A10AC01	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, intermediate-acting
ATC	A10AD01	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
ATC	A10AE01	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for injection, long-acting
ATC	A10AF01	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES INSULINS AND ANALOGUES Insulins and analogues for inhalation
FDA CS	M0011417	Insulin
MeSH PA	D007004	Hypoglycemic Agents
CHEBI has role	CHEBI:35526	antidiabetic
FDA EPC	N0000175944	Insulin

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Diabetes mellitus type 2	indication	44054006	DOID:9352
Diabetes mellitus type 1	indication	46635009	DOID:9744
Overdose of beta-adrenergic blocking drug	off-label use	296335002
Overdose of calcium-channel blockers	off-label use	296355001

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Diabetes mellitus	Indication
Dogs	Diabetes mellitus	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
ProZinc	Boehringer lngelheim Animal Health USA Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Insulin receptor	Kinase	P06213	INSR_HUMAN	AGONIST			DRUG LABEL	DRUG LABEL
Tyrosine-protein kinase Lck	Kinase	P06239	LCK_HUMAN		IC50	4.74	CHEMBL
Insulin receptor	Kinase		INSR_RAT		IC50	8.71	CHEMBL

External reference:

ID	Source
D03230	KEGG_DRUG
4020217	VUID
N0000179707	NUI
4017559	VANDF
4017569	VANDF
4019786	VANDF
4021631	VANDF
CHEBI:5931	CHEBI
CHEMBL1201631	ChEMBL_ID
CHEMBL1201539	ChEMBL_ID
CHEMBL1201540	ChEMBL_ID
CHEMBL1201627	ChEMBL_ID
CHEMBL1201641	ChEMBL_ID
CHEMBL1201644	ChEMBL_ID
CHEMBL1201543	ChEMBL_ID
5012	IUPHAR_LIGAND_ID
DB00030	DRUGBANK_ID
1372744	RXNORM
4885	MMSL
4886	MMSL
d00262	MMSL
d04369	MMSL
000869	NDDF
000870	NDDF
006518	NDDF
126210001	SNOMEDCT_US
39487003	SNOMEDCT_US
412222002	SNOMEDCT_US
412223007	SNOMEDCT_US
417423002	SNOMEDCT_US
420609005	SNOMEDCT_US
67866001	SNOMEDCT_US
96367001	SNOMEDCT_US
D007328	MESH_DESCRIPTOR_UI
C0795635	UMLSCUI
5186	INN_ID
118984375	PUBCHEM_CID
1Y17CTI5SR	UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Humulin R	HUMAN OTC DRUG LABEL	1	0002-8215	INJECTION, SOLUTION	100 [iU]	PARENTERAL	BLA	30 sections
Humulin R	HUMAN OTC DRUG LABEL	1	0002-8215	INJECTION, SOLUTION	100 [iU]	PARENTERAL	BLA	30 sections
Humulin R	HUMAN OTC DRUG LABEL	1	0002-8215	INJECTION, SOLUTION	100 [iU]	PARENTERAL	BLA	30 sections
Humulin N	HUMAN OTC DRUG LABEL	1	0002-8315	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin N	HUMAN OTC DRUG LABEL	1	0002-8315	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin N	HUMAN OTC DRUG LABEL	1	0002-8315	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
HumulinR U-500	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8501	INJECTION, SOLUTION	500 [iU]	SUBCUTANEOUS	BLA	31 sections
HumulinR U-500	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8501	INJECTION, SOLUTION	500 [iU]	SUBCUTANEOUS	BLA	31 sections
Humulin 70/30	HUMAN OTC DRUG LABEL	1	0002-8715	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin 70/30	HUMAN OTC DRUG LABEL	1	0002-8715	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin 70/30	HUMAN OTC DRUG LABEL	1	0002-8715	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin 70/30 KwikPen	HUMAN OTC DRUG LABEL	1	0002-8803	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin 70/30 KwikPen	HUMAN OTC DRUG LABEL	1	0002-8803	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin 70/30 KwikPen	HUMAN OTC DRUG LABEL	1	0002-8803	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin N	HUMAN OTC DRUG LABEL	1	0002-8805	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin N	HUMAN OTC DRUG LABEL	1	0002-8805	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
Humulin N	HUMAN OTC DRUG LABEL	1	0002-8805	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	30 sections
HumulinR U-500 KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8824	INJECTION, SOLUTION	500 [iU]	SUBCUTANEOUS	BLA	31 sections
HumulinR U-500 KwikPen	HUMAN PRESCRIPTION DRUG LABEL	1	0002-8824	INJECTION, SOLUTION	500 [iU]	SUBCUTANEOUS	BLA	31 sections
NovolinR	HUMAN OTC DRUG LABEL	1	0169-1833	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
NovolinR	HUMAN OTC DRUG LABEL	1	0169-1833	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
NovolinN	HUMAN OTC DRUG LABEL	1	0169-1834	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	24 sections
NovolinN	HUMAN OTC DRUG LABEL	1	0169-1834	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	24 sections
Novolin70/30	HUMAN OTC DRUG LABEL	1	0169-1837	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	25 sections
Novolin70/30	HUMAN OTC DRUG LABEL	1	0169-1837	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	25 sections
Novolin70/30	HUMAN OTC DRUG LABEL	1	0169-1837	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	25 sections
NovolinR	HUMAN OTC DRUG LABEL	1	0169-3003	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
NovolinR	HUMAN OTC DRUG LABEL	1	0169-3003	INJECTION, SOLUTION	100 [iU]	SUBCUTANEOUS	BLA	26 sections
NovolinN	HUMAN OTC DRUG LABEL	1	0169-3004	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	24 sections
NovolinN	HUMAN OTC DRUG LABEL	1	0169-3004	INJECTION, SUSPENSION	100 [iU]	SUBCUTANEOUS	BLA	24 sections