| Stem definition | Drug id | CAS RN |
|---|---|---|
| humanized origin | 4979 | 180288-69-1 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
The HER2 (or c-erbB2) proto-oncogene encodes a transmembrane receptor protein of 185 kDa, which is structurally related to the epidermal growth factor receptor. Trastuzumab products have been shown, in both in vitro assays and in animals, to inhibit the proliferation of human tumor cells that overexpress HER2. Trastuzumab products are mediators of antibody-dependent cellular cytotoxicity (ADCC). In vitro, trastuzumab product-mediated ADCC has been shown to be preferentially exerted on HER2 overexpressing cancer cells compared with cancer cells that do not overexpress HER2.
|
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| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 28, 2000 | EMA | ROCHE REGISTRATION GMBH | |
| Sept. 25, 1998 | FDA | GENENTECH | |
| April 4, 2001 | PMDA | ROCHE JAPAN |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Ejection fraction decreased | 2866.37 | 13.99 | 1197 | 117599 | 21135 | 63349091 |
| Myelosuppression | 2561.85 | 13.99 | 1125 | 117671 | 22578 | 63347648 |
| Disease progression | 1737.40 | 13.99 | 1597 | 117199 | 121161 | 63249065 |
| Metastases to central nervous system | 1506.51 | 13.99 | 650 | 118146 | 12455 | 63357771 |
| Palmar-plantar erythrodysaesthesia syndrome | 1271.67 | 13.99 | 691 | 118105 | 22324 | 63347902 |
| Diarrhoea | 1265.09 | 13.99 | 3543 | 115253 | 711823 | 62658403 |
| Cardiotoxicity | 1227.17 | 13.99 | 495 | 118301 | 7943 | 63362283 |
| Neuropathy peripheral | 931.86 | 13.99 | 1105 | 117691 | 112562 | 63257664 |
| Febrile neutropenia | 743.06 | 13.99 | 1008 | 117788 | 117441 | 63252785 |
| Drug ineffective | 727.40 | 13.99 | 541 | 118255 | 1044224 | 62326002 |
| Neutropenia | 677.42 | 13.99 | 1191 | 117605 | 173814 | 63196412 |
| Bone marrow failure | 550.81 | 13.99 | 449 | 118347 | 28841 | 63341385 |
| Metastases to bone | 546.88 | 13.99 | 391 | 118405 | 20628 | 63349598 |
| Mucosal inflammation | 525.90 | 13.99 | 538 | 118258 | 46390 | 63323836 |
| Metastases to liver | 497.12 | 13.99 | 387 | 118409 | 23252 | 63346974 |
| Metastases to lung | 481.16 | 13.99 | 299 | 118497 | 12451 | 63357775 |
| Chills | 454.32 | 13.99 | 784 | 118012 | 112594 | 63257632 |
| Polyneuropathy | 441.91 | 13.99 | 298 | 118498 | 14291 | 63355935 |
| Cardiac dysfunction | 440.04 | 13.99 | 165 | 118631 | 2150 | 63368076 |
| Rheumatoid arthritis | 386.21 | 13.99 | 22 | 118774 | 253797 | 63116429 |
| Left ventricular dysfunction | 385.09 | 13.99 | 254 | 118542 | 11734 | 63358492 |
| Malignant neoplasm progression | 355.55 | 13.99 | 588 | 118208 | 81533 | 63288693 |
| Breast cancer recurrent | 355.23 | 13.99 | 170 | 118626 | 4171 | 63366055 |
| Joint swelling | 351.58 | 13.99 | 90 | 118706 | 327576 | 63042650 |
| Interstitial lung disease | 349.14 | 13.99 | 501 | 118295 | 61407 | 63308819 |
| Drug hypersensitivity | 343.73 | 13.99 | 80 | 118716 | 310607 | 63059619 |
| Cardiac failure | 336.97 | 13.99 | 601 | 118195 | 88541 | 63281685 |
| Synovitis | 328.37 | 13.99 | 4 | 118792 | 186914 | 63183312 |
| Metastases to lymph nodes | 327.39 | 13.99 | 199 | 118597 | 7959 | 63362267 |
| Systemic lupus erythematosus | 318.09 | 13.99 | 18 | 118778 | 208900 | 63161326 |
| Condition aggravated | 305.17 | 13.99 | 188 | 118608 | 402029 | 62968197 |
| Arthropathy | 292.45 | 13.99 | 45 | 118751 | 234747 | 63135479 |
| Cardiomyopathy | 290.08 | 13.99 | 250 | 118546 | 17334 | 63352892 |
| Therapeutic product effect decreased | 284.08 | 13.99 | 20 | 118776 | 193167 | 63177059 |
| Abdominal discomfort | 266.37 | 13.99 | 134 | 118662 | 320751 | 63049475 |
| Peripheral sensory neuropathy | 259.24 | 13.99 | 166 | 118630 | 7285 | 63362941 |
| Completed suicide | 256.35 | 13.99 | 3 | 118793 | 145670 | 63224556 |
| Metastasis | 253.91 | 13.99 | 144 | 118652 | 5053 | 63365173 |
| Fall | 250.12 | 13.99 | 220 | 118576 | 392114 | 62978112 |
| Death | 249.32 | 13.99 | 1367 | 117429 | 373014 | 62997212 |
| Breast cancer metastatic | 248.82 | 13.99 | 195 | 118601 | 11823 | 63358403 |
| Metastases to skin | 232.93 | 13.99 | 95 | 118701 | 1568 | 63368658 |
| Pleural effusion | 225.17 | 13.99 | 522 | 118274 | 92688 | 63277538 |
| Neoplasm progression | 218.92 | 13.99 | 304 | 118492 | 36124 | 63334102 |
| Neutropenic sepsis | 214.75 | 13.99 | 205 | 118591 | 16233 | 63353993 |
| Treatment failure | 208.87 | 13.99 | 57 | 118739 | 198986 | 63171240 |
| Epistaxis | 206.98 | 13.99 | 435 | 118361 | 72290 | 63297936 |
| Sinusitis | 206.20 | 13.99 | 83 | 118713 | 226570 | 63143656 |
| Skin toxicity | 204.74 | 13.99 | 121 | 118675 | 4593 | 63365633 |
| Pneumonitis | 204.32 | 13.99 | 289 | 118507 | 34933 | 63335293 |
| Lymphoedema | 198.48 | 13.99 | 169 | 118627 | 11523 | 63358703 |
| Glossodynia | 191.90 | 13.99 | 49 | 118747 | 178827 | 63191399 |
| Neurotoxicity | 186.98 | 13.99 | 193 | 118603 | 16797 | 63353429 |
| Drug interaction | 172.27 | 13.99 | 108 | 118688 | 229023 | 63141203 |
| Computerised tomogram thorax abnormal | 168.89 | 13.99 | 77 | 118719 | 1686 | 63368540 |
| Pyrexia | 168.63 | 13.99 | 1476 | 117320 | 469002 | 62901224 |
| Nail disorder | 167.52 | 13.99 | 161 | 118635 | 12854 | 63357372 |
| Swelling | 167.51 | 13.99 | 161 | 118635 | 275217 | 63095009 |
| Product dose omission issue | 165.99 | 13.99 | 118 | 118678 | 234195 | 63136031 |
| Osteonecrosis of jaw | 163.45 | 13.99 | 260 | 118536 | 34863 | 63335363 |
| Onychoclasis | 162.37 | 13.99 | 116 | 118680 | 6106 | 63364120 |
| Onycholysis | 161.61 | 13.99 | 73 | 118723 | 1563 | 63368663 |
| Drug intolerance | 158.73 | 13.99 | 207 | 118589 | 308454 | 63061772 |
| Pain | 156.18 | 13.99 | 785 | 118011 | 739843 | 62630383 |
| Hypokalaemia | 156.17 | 13.99 | 488 | 118308 | 103316 | 63266910 |
| Weight increased | 152.26 | 13.99 | 158 | 118638 | 260634 | 63109592 |
| Wound | 144.86 | 13.99 | 62 | 118734 | 163201 | 63207025 |
| Neutrophil count decreased | 141.80 | 13.99 | 321 | 118475 | 56085 | 63314141 |
| Nausea | 141.77 | 13.99 | 2312 | 116484 | 852159 | 62518067 |
| Product use issue | 139.89 | 13.99 | 124 | 118672 | 220396 | 63149830 |
| Maternal exposure during pregnancy | 139.29 | 13.99 | 124 | 118672 | 219938 | 63150288 |
| Bone pain | 135.18 | 13.99 | 309 | 118487 | 54332 | 63315894 |
| Thrombocytopenia | 132.99 | 13.99 | 598 | 118198 | 150559 | 63219667 |
| Confusional state | 130.46 | 13.99 | 150 | 118646 | 236230 | 63133996 |
| Recall phenomenon | 129.65 | 13.99 | 48 | 118748 | 602 | 63369624 |
| Fibromyalgia | 128.54 | 13.99 | 5 | 118791 | 80415 | 63289811 |
| Decreased appetite | 127.44 | 13.99 | 855 | 117941 | 250197 | 63120029 |
| Anaemia | 126.73 | 13.99 | 961 | 117835 | 292469 | 63077757 |
| Vomiting | 125.48 | 13.99 | 1597 | 117199 | 558020 | 62812206 |
| Loss of personal independence in daily activities | 124.85 | 13.99 | 17 | 118779 | 97273 | 63272953 |
| Duodenal ulcer perforation | 122.61 | 13.99 | 11 | 118785 | 87198 | 63283028 |
| Lacrimation increased | 122.18 | 13.99 | 171 | 118625 | 20460 | 63349766 |
| Psoriasis | 122.17 | 13.99 | 11 | 118785 | 86946 | 63283280 |
| Ventricular hypokinesia | 122.15 | 13.99 | 87 | 118709 | 4557 | 63365669 |
| Therapeutic product effect incomplete | 121.74 | 13.99 | 41 | 118755 | 125015 | 63245211 |
| Drug abuse | 121.33 | 13.99 | 3 | 118793 | 72515 | 63297711 |
| Hepatic function abnormal | 120.91 | 13.99 | 235 | 118561 | 36907 | 63333319 |
| Haematotoxicity | 120.70 | 13.99 | 116 | 118680 | 9260 | 63360966 |
| Vascular device infection | 120.66 | 13.99 | 104 | 118692 | 7208 | 63363018 |
| Hyperpyrexia | 119.17 | 13.99 | 78 | 118718 | 3554 | 63366672 |
| Asthenia | 118.84 | 13.99 | 1167 | 117629 | 382437 | 62987789 |
| Pericardial effusion | 117.77 | 13.99 | 206 | 118590 | 29852 | 63340374 |
| Nail toxicity | 117.08 | 13.99 | 38 | 118758 | 311 | 63369915 |
| Toxicity to various agents | 116.89 | 13.99 | 176 | 118620 | 247074 | 63123152 |
| Musculoskeletal stiffness | 115.65 | 13.99 | 105 | 118691 | 184513 | 63185713 |
| Nail discolouration | 115.28 | 13.99 | 69 | 118727 | 2681 | 63367545 |
| Metastatic neoplasm | 114.21 | 13.99 | 81 | 118715 | 4214 | 63366012 |
| Mitral valve incompetence | 113.95 | 13.99 | 161 | 118635 | 19433 | 63350793 |
| Somnolence | 112.67 | 13.99 | 101 | 118695 | 178584 | 63191642 |
| Stomatitis | 111.82 | 13.99 | 535 | 118261 | 138190 | 63232036 |
| Exposure during pregnancy | 110.53 | 13.99 | 78 | 118718 | 155469 | 63214757 |
| Lymphangiosis carcinomatosa | 110.41 | 13.99 | 54 | 118742 | 1391 | 63368835 |
| Discomfort | 109.92 | 13.99 | 91 | 118705 | 167283 | 63202943 |
| Alveolitis | 109.04 | 13.99 | 68 | 118728 | 2847 | 63367379 |
| Acute myeloid leukaemia | 108.88 | 13.99 | 147 | 118649 | 17000 | 63353226 |
| Hospitalisation | 108.85 | 13.99 | 15 | 118781 | 85066 | 63285160 |
| Overdose | 108.12 | 13.99 | 40 | 118756 | 115038 | 63255188 |
| Hepatic enzyme increased | 107.76 | 13.99 | 132 | 118664 | 202196 | 63168030 |
| Dermatitis acneiform | 107.62 | 13.99 | 83 | 118713 | 4913 | 63365313 |
| Mobility decreased | 107.47 | 13.99 | 46 | 118750 | 121113 | 63249113 |
| Metastases to spine | 107.15 | 13.99 | 70 | 118726 | 3179 | 63367047 |
| Leukopenia | 102.37 | 13.99 | 348 | 118448 | 76942 | 63293284 |
| Paronychia | 101.81 | 13.99 | 84 | 118712 | 5481 | 63364745 |
| Inappropriate schedule of product administration | 101.34 | 13.99 | 34 | 118762 | 103931 | 63266295 |
| Hyperbilirubinaemia | 99.14 | 13.99 | 114 | 118682 | 11200 | 63359026 |
| Biopsy lung abnormal | 99.03 | 13.99 | 28 | 118768 | 134 | 63370092 |
| Dyspnoea | 97.19 | 13.99 | 1756 | 117040 | 659557 | 62710669 |
| Blood cholesterol increased | 96.58 | 13.99 | 28 | 118768 | 94004 | 63276222 |
| Nail dystrophy | 95.04 | 13.99 | 44 | 118752 | 999 | 63369227 |
| Injection site pain | 95.00 | 13.99 | 63 | 118733 | 129737 | 63240489 |
| Gastrointestinal toxicity | 94.45 | 13.99 | 93 | 118703 | 7648 | 63362578 |
| Product use in unapproved indication | 93.08 | 13.99 | 119 | 118677 | 178961 | 63191265 |
| Arthritis | 92.19 | 13.99 | 51 | 118745 | 115870 | 63254356 |
| Contusion | 90.82 | 13.99 | 88 | 118708 | 149956 | 63220270 |
| Cellulitis | 89.86 | 13.99 | 347 | 118449 | 81611 | 63288615 |
| Irritable bowel syndrome | 89.44 | 13.99 | 22 | 118774 | 82390 | 63287836 |
| Asthma | 89.26 | 13.99 | 65 | 118731 | 127496 | 63242730 |
| Erysipelas | 89.15 | 13.99 | 91 | 118705 | 7814 | 63362412 |
| Colitis | 89.08 | 13.99 | 245 | 118551 | 48283 | 63321943 |
| Dysgeusia | 88.92 | 13.99 | 239 | 118557 | 46471 | 63323755 |
| Radiation necrosis | 88.62 | 13.99 | 32 | 118764 | 372 | 63369854 |
| Onychomadesis | 88.22 | 13.99 | 79 | 118717 | 5761 | 63364465 |
| Breast pain | 88.01 | 13.99 | 95 | 118701 | 8703 | 63361523 |
| Pericarditis | 87.04 | 13.99 | 71 | 118725 | 131508 | 63238718 |
| Neutropenic infection | 86.60 | 13.99 | 45 | 118751 | 1322 | 63368904 |
| Dry skin | 85.10 | 13.99 | 267 | 118529 | 56620 | 63313606 |
| Osteoarthritis | 84.87 | 13.99 | 36 | 118760 | 95307 | 63274919 |
| White blood cell count decreased | 83.05 | 13.99 | 494 | 118302 | 138610 | 63231616 |
| Organising pneumonia | 81.12 | 13.99 | 75 | 118721 | 5701 | 63364525 |
| Suicide attempt | 79.70 | 13.99 | 10 | 118786 | 60908 | 63309318 |
| Platelet count decreased | 79.63 | 13.99 | 428 | 118368 | 115694 | 63254532 |
| Hot flush | 79.19 | 13.99 | 243 | 118553 | 50916 | 63319310 |
| Disease recurrence | 78.92 | 13.99 | 167 | 118629 | 27863 | 63342363 |
| Recurrent cancer | 78.51 | 13.99 | 48 | 118748 | 1939 | 63368287 |
| Radiation skin injury | 77.36 | 13.99 | 37 | 118759 | 906 | 63369320 |
| Injury | 76.72 | 13.99 | 21 | 118775 | 73226 | 63297000 |
| Hypertransaminasaemia | 76.20 | 13.99 | 77 | 118719 | 6532 | 63363694 |
| Osteonecrosis | 75.96 | 13.99 | 152 | 118644 | 24378 | 63345848 |
| Lung infiltration | 75.60 | 13.99 | 113 | 118683 | 14350 | 63355876 |
| Myalgia | 74.81 | 13.99 | 500 | 118296 | 146029 | 63224197 |
| Computerised tomogram thorax | 74.55 | 13.99 | 29 | 118767 | 420 | 63369806 |
| Migraine | 74.49 | 13.99 | 51 | 118745 | 103295 | 63266931 |
| Cough | 73.41 | 13.99 | 854 | 117942 | 291889 | 63078337 |
| Granulocyte count decreased | 73.38 | 13.99 | 39 | 118757 | 1201 | 63369025 |
| Oligohydramnios | 73.09 | 13.99 | 74 | 118722 | 6292 | 63363934 |
| Alanine aminotransferase increased | 70.82 | 13.99 | 382 | 118414 | 103388 | 63266838 |
| Injection site erythema | 69.97 | 13.99 | 34 | 118762 | 83140 | 63287086 |
| Aortitis | 69.49 | 13.99 | 36 | 118760 | 1051 | 63369175 |
| Device related infection | 68.93 | 13.99 | 142 | 118654 | 23250 | 63346976 |
| Dehydration | 68.22 | 13.99 | 556 | 118240 | 172798 | 63197428 |
| Madarosis | 68.15 | 13.99 | 52 | 118744 | 3029 | 63367197 |
| Breast neoplasm | 68.13 | 13.99 | 39 | 118757 | 1393 | 63368833 |
| Fatigue | 66.91 | 13.99 | 2151 | 116645 | 885877 | 62484349 |
| Constipation | 66.90 | 13.99 | 679 | 118117 | 224264 | 63145962 |
| Injection site swelling | 66.86 | 13.99 | 6 | 118790 | 47566 | 63322660 |
| Atelectasis | 66.37 | 13.99 | 133 | 118663 | 21350 | 63348876 |
| Mastitis | 66.23 | 13.99 | 48 | 118748 | 2584 | 63367642 |
| Multifocal micronodular pneumocyte hyperplasia | 66.07 | 13.99 | 18 | 118778 | 73 | 63370153 |
| Bronchial polyp | 66.07 | 13.99 | 18 | 118778 | 73 | 63370153 |
| Injection site bruising | 65.65 | 13.99 | 3 | 118793 | 41907 | 63328319 |
| Blister | 64.64 | 13.99 | 89 | 118707 | 129725 | 63240501 |
| Onychalgia | 64.50 | 13.99 | 33 | 118763 | 938 | 63369288 |
| Arthralgia | 64.36 | 13.99 | 719 | 118077 | 568991 | 62801235 |
| Systolic dysfunction | 64.14 | 13.99 | 39 | 118757 | 1560 | 63368666 |
| Mastectomy | 63.38 | 13.99 | 39 | 118757 | 1594 | 63368632 |
| Injection site pruritus | 62.58 | 13.99 | 6 | 118790 | 45110 | 63325116 |
| Metastases to meninges | 62.18 | 13.99 | 46 | 118750 | 2556 | 63367670 |
| Blood lactate dehydrogenase increased | 61.95 | 13.99 | 135 | 118661 | 22981 | 63347245 |
| Chest discomfort | 60.23 | 13.99 | 382 | 118414 | 109587 | 63260639 |
| Acute interstitial pneumonitis | 58.91 | 13.99 | 28 | 118768 | 676 | 63369550 |
| Impaired healing | 58.78 | 13.99 | 63 | 118733 | 102479 | 63267747 |
| Carcinoembryonic antigen increased | 58.14 | 13.99 | 38 | 118758 | 1727 | 63368499 |
| Tumour marker increased | 58.02 | 13.99 | 58 | 118738 | 4857 | 63365369 |
| Feeling abnormal | 57.94 | 13.99 | 119 | 118677 | 148273 | 63221953 |
| Adverse event | 57.77 | 13.99 | 27 | 118769 | 67532 | 63302694 |
| Urticaria | 57.38 | 13.99 | 142 | 118654 | 165660 | 63204566 |
| Hepatitis B reactivation | 56.65 | 13.99 | 47 | 118749 | 3090 | 63367136 |
| Second primary malignancy | 56.41 | 13.99 | 72 | 118724 | 7881 | 63362345 |
| Injection site reaction | 55.54 | 13.99 | 20 | 118776 | 58504 | 63311722 |
| Peripheral swelling | 55.09 | 13.99 | 283 | 118513 | 265659 | 63104567 |
| Alopecia areata | 54.83 | 13.99 | 36 | 118760 | 1649 | 63368577 |
| Aspartate aminotransferase increased | 54.75 | 13.99 | 322 | 118474 | 89955 | 63280271 |
| Radiation pneumonitis | 54.40 | 13.99 | 35 | 118761 | 1548 | 63368678 |
| Sedation | 54.26 | 13.99 | 5 | 118791 | 38804 | 63331422 |
| Hepatotoxicity | 53.69 | 13.99 | 172 | 118624 | 36869 | 63333357 |
| Agranulocytosis | 53.37 | 13.99 | 134 | 118662 | 25000 | 63345226 |
| Erythema | 52.94 | 13.99 | 532 | 118264 | 175219 | 63195007 |
| Incorrect dose administered | 52.79 | 13.99 | 23 | 118773 | 59945 | 63310281 |
| Blood bilirubin increased | 52.51 | 13.99 | 171 | 118625 | 36969 | 63333257 |
| Ventricular dysfunction | 52.39 | 13.99 | 43 | 118753 | 2785 | 63367441 |
| Nasal congestion | 52.03 | 13.99 | 29 | 118767 | 65631 | 63304595 |
| Drug reaction with eosinophilia and systemic symptoms | 51.18 | 13.99 | 3 | 118793 | 33833 | 63336393 |
| Invasive ductal breast carcinoma | 50.95 | 13.99 | 64 | 118732 | 6894 | 63363332 |
| Ejection fraction abnormal | 50.57 | 13.99 | 35 | 118761 | 1750 | 63368476 |
| Congestive cardiomyopathy | 50.35 | 13.99 | 60 | 118736 | 6122 | 63364104 |
| Nail infection | 50.20 | 13.99 | 40 | 118756 | 2483 | 63367743 |
| Wheezing | 50.19 | 13.99 | 63 | 118733 | 95532 | 63274694 |
| Axillary pain | 49.52 | 13.99 | 36 | 118760 | 1947 | 63368279 |
| Hyperfibrinogenaemia | 49.00 | 13.99 | 12 | 118784 | 28 | 63370198 |
| Hyperkalaemia | 48.98 | 13.99 | 20 | 118776 | 54183 | 63316043 |
| Transaminases increased | 48.54 | 13.99 | 149 | 118647 | 31218 | 63339008 |
| Lactic acidosis | 48.38 | 13.99 | 7 | 118789 | 38280 | 63331946 |
| Ear infection | 48.25 | 13.99 | 7 | 118789 | 38206 | 63332020 |
| Pulmonary embolism | 47.92 | 13.99 | 378 | 118418 | 116306 | 63253920 |
| Folliculitis | 47.67 | 13.99 | 37 | 118759 | 70280 | 63299946 |
| Gait disturbance | 47.58 | 13.99 | 179 | 118617 | 182999 | 63187227 |
| Bronchitis | 47.25 | 13.99 | 102 | 118694 | 124833 | 63245393 |
| Blood uric acid decreased | 46.86 | 13.99 | 25 | 118771 | 776 | 63369450 |
| Neoplasm recurrence | 46.55 | 13.99 | 39 | 118757 | 2599 | 63367627 |
| Skin fissures | 45.84 | 13.99 | 79 | 118717 | 11309 | 63358917 |
| Adverse drug reaction | 45.65 | 13.99 | 49 | 118747 | 79665 | 63290561 |
| Gait inability | 45.54 | 13.99 | 21 | 118775 | 52938 | 63317288 |
| Depression | 45.40 | 13.99 | 201 | 118595 | 196291 | 63173935 |
| Ascites | 45.08 | 13.99 | 173 | 118623 | 40555 | 63329671 |
| Suicidal ideation | 44.71 | 13.99 | 31 | 118765 | 62390 | 63307836 |
| Hair colour changes | 44.68 | 13.99 | 41 | 118755 | 3086 | 63367140 |
| Osteoporosis | 44.46 | 13.99 | 26 | 118770 | 57312 | 63312914 |
| Hallucination | 43.74 | 13.99 | 24 | 118772 | 54793 | 63315433 |
| Dermatitis | 43.14 | 13.99 | 97 | 118699 | 16861 | 63353365 |
| Type 2 diabetes mellitus | 42.80 | 13.99 | 34 | 118762 | 63834 | 63306392 |
| Metastases to pleura | 42.39 | 13.99 | 30 | 118766 | 1555 | 63368671 |
| Meibomian gland dysfunction | 42.04 | 13.99 | 15 | 118781 | 168 | 63370058 |
| Anxiety | 41.44 | 13.99 | 238 | 118558 | 217303 | 63152923 |
| Tachycardia | 41.20 | 13.99 | 369 | 118427 | 117787 | 63252439 |
| Pseudocirrhosis | 41.17 | 13.99 | 22 | 118774 | 685 | 63369541 |
| Dyspnoea exertional | 41.13 | 13.99 | 222 | 118574 | 60080 | 63310146 |
| Tonsillar disorder | 40.88 | 13.99 | 26 | 118770 | 1127 | 63369099 |
| Therapy interrupted | 40.85 | 13.99 | 6 | 118790 | 32449 | 63337777 |
| Peripheral motor neuropathy | 40.81 | 13.99 | 30 | 118766 | 1651 | 63368575 |
| Hydrothorax | 40.70 | 13.99 | 24 | 118772 | 907 | 63369319 |
| Foot deformity | 40.56 | 13.99 | 3 | 118793 | 27850 | 63342376 |
| Intentional product misuse | 40.11 | 13.99 | 33 | 118763 | 60884 | 63309342 |
| Plasma cell myeloma | 40.11 | 13.99 | 9 | 118787 | 35896 | 63334330 |
| Dermatomyositis | 40.03 | 13.99 | 37 | 118759 | 2811 | 63367415 |
| Therapy cessation | 39.83 | 13.99 | 5 | 118791 | 30452 | 63339774 |
| Toxic cardiomyopathy | 39.79 | 13.99 | 14 | 118782 | 150 | 63370076 |
| Breast disorder | 39.76 | 13.99 | 35 | 118761 | 2495 | 63367731 |
| Mouth ulceration | 39.75 | 13.99 | 144 | 118652 | 32840 | 63337386 |
| Hypoxia | 39.35 | 13.99 | 218 | 118578 | 59574 | 63310652 |
| Troponin I increased | 39.32 | 13.99 | 33 | 118763 | 2205 | 63368021 |
| Enterocolitis | 39.09 | 13.99 | 60 | 118736 | 7798 | 63362428 |
| Delirium | 39.07 | 13.99 | 23 | 118773 | 50518 | 63319708 |
| Lymphadenopathy | 39.05 | 13.99 | 159 | 118637 | 38299 | 63331927 |
| Cystitis noninfective | 39.04 | 13.99 | 24 | 118772 | 979 | 63369247 |
| Enterocolitis infectious | 38.92 | 13.99 | 29 | 118767 | 1629 | 63368597 |
| Acute respiratory distress syndrome | 38.49 | 13.99 | 114 | 118682 | 23420 | 63346806 |
| Blood alkaline phosphatase increased | 38.48 | 13.99 | 171 | 118625 | 42796 | 63327430 |
| Cardiac failure congestive | 38.25 | 13.99 | 300 | 118496 | 92133 | 63278093 |
| Bursitis | 38.08 | 13.99 | 11 | 118785 | 37030 | 63333196 |
| Sensory disturbance | 37.95 | 13.99 | 81 | 118715 | 13591 | 63356635 |
| Keratitis | 37.87 | 13.99 | 39 | 118757 | 3383 | 63366843 |
| Sleep apnoea syndrome | 37.58 | 13.99 | 5 | 118791 | 29128 | 63341098 |
| Blood creatinine decreased | 37.45 | 13.99 | 49 | 118747 | 5496 | 63364730 |
| Influenza | 36.91 | 13.99 | 94 | 118702 | 108628 | 63261598 |
| Neoplasm | 36.42 | 13.99 | 56 | 118740 | 7289 | 63362937 |
| Metastases to chest wall | 36.08 | 13.99 | 19 | 118777 | 574 | 63369652 |
| International normalised ratio increased | 36.07 | 13.99 | 21 | 118775 | 46404 | 63323822 |
| Wrong technique in product usage process | 36.05 | 13.99 | 38 | 118758 | 62302 | 63307924 |
| Aortic valve incompetence | 36.00 | 13.99 | 50 | 118746 | 5938 | 63364288 |
| Electrocardiogram QT prolonged | 35.89 | 13.99 | 35 | 118761 | 59495 | 63310731 |
| Capillary leak syndrome | 35.71 | 13.99 | 31 | 118765 | 2169 | 63368057 |
| Tumour pain | 35.69 | 13.99 | 26 | 118770 | 1411 | 63368815 |
| Paraesthesia | 35.38 | 13.99 | 449 | 118347 | 156517 | 63213709 |
| Product prescribing error | 35.16 | 13.99 | 4 | 118792 | 26285 | 63343941 |
| Jaw operation | 34.74 | 13.99 | 21 | 118775 | 831 | 63369395 |
| HER2 positive breast cancer | 34.69 | 13.99 | 16 | 118780 | 360 | 63369866 |
| Metastases to breast | 34.47 | 13.99 | 15 | 118781 | 293 | 63369933 |
| Hair texture abnormal | 34.26 | 13.99 | 41 | 118755 | 4202 | 63366024 |
| Central nervous system lesion | 34.25 | 13.99 | 67 | 118729 | 10568 | 63359658 |
| Dyskinesia | 33.84 | 13.99 | 9 | 118787 | 31993 | 63338233 |
| Performance status decreased | 33.82 | 13.99 | 38 | 118758 | 3640 | 63366586 |
| Sense of oppression | 33.77 | 13.99 | 22 | 118774 | 994 | 63369232 |
| Excessive eye blinking | 33.71 | 13.99 | 24 | 118772 | 1256 | 63368970 |
| Breast cancer | 33.59 | 13.99 | 179 | 118617 | 48204 | 63322022 |
| Eosinophil percentage increased | 33.52 | 13.99 | 22 | 118774 | 1007 | 63369219 |
| Breast mass | 33.26 | 13.99 | 56 | 118740 | 7866 | 63362360 |
| Chronic kidney disease | 33.24 | 13.99 | 22 | 118774 | 45376 | 63324850 |
| Left ventricular dilatation | 33.20 | 13.99 | 17 | 118779 | 484 | 63369742 |
| Therapy partial responder | 32.94 | 13.99 | 66 | 118730 | 10592 | 63359634 |
| Aggression | 32.92 | 13.99 | 3 | 118793 | 23495 | 63346731 |
| Pulmonary mass | 32.81 | 13.99 | 105 | 118691 | 22491 | 63347735 |
| Hepatic failure | 32.76 | 13.99 | 143 | 118653 | 35513 | 63334713 |
| Accidental overdose | 32.59 | 13.99 | 3 | 118793 | 23306 | 63346920 |
| Chronic obstructive pulmonary disease | 32.18 | 13.99 | 42 | 118754 | 62644 | 63307582 |
| Acute pulmonary oedema | 32.06 | 13.99 | 56 | 118740 | 8102 | 63362124 |
| Prescribed underdose | 32.06 | 13.99 | 8 | 118788 | 29681 | 63340545 |
| Intracranial pressure increased | 31.95 | 13.99 | 44 | 118752 | 5183 | 63365043 |
| Joint injury | 31.87 | 13.99 | 8 | 118788 | 29564 | 63340662 |
| Treatment noncompliance | 31.78 | 13.99 | 15 | 118781 | 37310 | 63332916 |
| Cataract | 31.64 | 13.99 | 36 | 118760 | 57017 | 63313209 |
| Hepatic lesion | 31.60 | 13.99 | 42 | 118754 | 4783 | 63365443 |
| Odynophagia | 31.54 | 13.99 | 53 | 118743 | 7433 | 63362793 |
| Ejection fraction | 31.41 | 13.99 | 30 | 118766 | 2376 | 63367850 |
| Unresponsive to stimuli | 31.33 | 13.99 | 12 | 118784 | 33804 | 63336422 |
| Basal cell carcinoma | 31.30 | 13.99 | 7 | 118789 | 27984 | 63342242 |
| Coma | 31.16 | 13.99 | 45 | 118751 | 64319 | 63305907 |
| Device issue | 30.87 | 13.99 | 4 | 118792 | 23777 | 63346449 |
| Breast inflammation | 30.77 | 13.99 | 12 | 118784 | 175 | 63370051 |
| Catheter site bruise | 30.64 | 13.99 | 16 | 118780 | 475 | 63369751 |
| Illness | 30.57 | 13.99 | 28 | 118768 | 49031 | 63321195 |
| Gastric disorder | 30.34 | 13.99 | 16 | 118780 | 37353 | 63332873 |
| Foetal exposure during pregnancy | 30.19 | 13.99 | 11 | 118785 | 31951 | 63338275 |
| Medication error | 30.09 | 13.99 | 32 | 118764 | 52252 | 63317974 |
| Hypoglycaemia | 30.07 | 13.99 | 41 | 118755 | 60024 | 63310202 |
| Cardiac disorder | 29.99 | 13.99 | 180 | 118616 | 50636 | 63319590 |
| Eastern Cooperative Oncology Group performance status worsened | 29.59 | 13.99 | 22 | 118774 | 1232 | 63368994 |
| Bone lesion | 29.39 | 13.99 | 45 | 118751 | 5836 | 63364390 |
| Malignant pleural effusion | 29.38 | 13.99 | 30 | 118766 | 2576 | 63367650 |
| Blood pressure fluctuation | 29.38 | 13.99 | 26 | 118770 | 46291 | 63323935 |
| Diabetes mellitus | 29.06 | 13.99 | 37 | 118759 | 55773 | 63314453 |
| Skin exfoliation | 28.93 | 13.99 | 158 | 118638 | 42944 | 63327282 |
| Seroma | 28.63 | 13.99 | 27 | 118769 | 2104 | 63368122 |
| Orthostatic hypotension | 28.60 | 13.99 | 16 | 118780 | 36144 | 63334082 |
| Nephrolithiasis | 28.57 | 13.99 | 22 | 118774 | 41962 | 63328264 |
| Pulmonary toxicity | 28.57 | 13.99 | 58 | 118738 | 9397 | 63360829 |
| Depressed level of consciousness | 28.51 | 13.99 | 45 | 118751 | 62033 | 63308193 |
| Perforation | 28.46 | 13.99 | 21 | 118775 | 1162 | 63369064 |
| Tumour marker abnormal | 28.19 | 13.99 | 14 | 118782 | 373 | 63369853 |
| Biliary sepsis | 28.14 | 13.99 | 19 | 118777 | 912 | 63369314 |
| Pneumonitis chemical | 28.07 | 13.99 | 12 | 118784 | 224 | 63370002 |
| Intercepted product preparation error | 27.96 | 13.99 | 17 | 118779 | 680 | 63369546 |
| Gamma-glutamyltransferase increased | 27.92 | 13.99 | 132 | 118664 | 33899 | 63336327 |
| Bladder irritation | 27.54 | 13.99 | 12 | 118784 | 235 | 63369991 |
| Retinal detachment | 27.50 | 13.99 | 44 | 118752 | 5925 | 63364301 |
| Vulvovaginal inflammation | 27.48 | 13.99 | 18 | 118778 | 821 | 63369405 |
| Rash pustular | 27.35 | 13.99 | 49 | 118747 | 7233 | 63362993 |
| Blood glucose increased | 27.22 | 13.99 | 74 | 118722 | 83682 | 63286544 |
| Cardio-respiratory arrest | 27.03 | 13.99 | 44 | 118752 | 59915 | 63310311 |
| Breast cellulitis | 27.00 | 13.99 | 16 | 118780 | 610 | 63369616 |
| Tumour lysis syndrome | 26.99 | 13.99 | 55 | 118741 | 8935 | 63361291 |
| Axillary vein thrombosis | 26.68 | 13.99 | 13 | 118783 | 332 | 63369894 |
| Swollen tongue | 26.67 | 13.99 | 16 | 118780 | 34784 | 63335442 |
| Hip arthroplasty | 26.49 | 13.99 | 30 | 118766 | 47616 | 63322610 |
| Flushing | 26.42 | 13.99 | 235 | 118561 | 74852 | 63295374 |
| Rhabdomyolysis | 26.31 | 13.99 | 26 | 118770 | 43925 | 63326301 |
| Breast oedema | 26.24 | 13.99 | 8 | 118788 | 52 | 63370174 |
| Vocal cord paralysis | 26.03 | 13.99 | 26 | 118770 | 2175 | 63368051 |
| Inflammation | 25.76 | 13.99 | 74 | 118722 | 82199 | 63288027 |
| Hiccups | 25.73 | 13.99 | 26 | 118770 | 2205 | 63368021 |
| Bone marrow infiltration | 25.69 | 13.99 | 16 | 118780 | 668 | 63369558 |
| Nasopharyngitis | 25.49 | 13.99 | 329 | 118467 | 253928 | 63116298 |
| Therapy non-responder | 25.47 | 13.99 | 66 | 118730 | 75835 | 63294391 |
| Red cell distribution width increased | 25.44 | 13.99 | 59 | 118737 | 10465 | 63359761 |
| Product quality issue | 25.43 | 13.99 | 18 | 118778 | 35847 | 63334379 |
| Frequent bowel movements | 25.26 | 13.99 | 6 | 118790 | 23016 | 63347210 |
| Osteolysis | 25.25 | 13.99 | 29 | 118767 | 2845 | 63367381 |
| Bile duct stenosis | 25.18 | 13.99 | 20 | 118776 | 1236 | 63368990 |
| Myocarditis | 25.09 | 13.99 | 58 | 118738 | 10267 | 63359959 |
| Secondary cerebellar degeneration | 25.03 | 13.99 | 8 | 118788 | 62 | 63370164 |
| Palmar erythema | 24.92 | 13.99 | 23 | 118773 | 1744 | 63368482 |
| Diastolic dysfunction | 24.89 | 13.99 | 44 | 118752 | 6427 | 63363799 |
| Hypervolaemia | 24.84 | 13.99 | 11 | 118785 | 28402 | 63341824 |
| Eosinophilia | 24.83 | 13.99 | 6 | 118790 | 22750 | 63347476 |
| Pruritus | 24.82 | 13.99 | 502 | 118294 | 360951 | 63009275 |
| Gastrointestinal haemorrhage | 24.70 | 13.99 | 74 | 118722 | 81102 | 63289124 |
| Infection | 24.69 | 13.99 | 292 | 118504 | 228881 | 63141345 |
| Calcium ionised increased | 24.44 | 13.99 | 9 | 118787 | 111 | 63370115 |
| Nail bed bleeding | 24.33 | 13.99 | 12 | 118784 | 315 | 63369911 |
| Hyperchlorhydria | 24.08 | 13.99 | 23 | 118773 | 1821 | 63368405 |
| Blood creatine increased | 24.06 | 13.99 | 40 | 118756 | 5561 | 63364665 |
| Full blood count abnormal | 23.73 | 13.99 | 15 | 118781 | 31702 | 63338524 |
| Nasal disorder | 23.66 | 13.99 | 28 | 118768 | 2836 | 63367390 |
| Respiratory arrest | 23.66 | 13.99 | 16 | 118780 | 32629 | 63337597 |
| Injection site haemorrhage | 23.60 | 13.99 | 8 | 118788 | 24306 | 63345920 |
| COVID-19 | 23.58 | 13.99 | 120 | 118676 | 112983 | 63257243 |
| Dysuria | 23.54 | 13.99 | 125 | 118671 | 33613 | 63336613 |
| Vessel puncture site bruise | 23.42 | 13.99 | 13 | 118783 | 437 | 63369789 |
| Dysaesthesia | 23.42 | 13.99 | 35 | 118761 | 4443 | 63365783 |
| Vulvovaginal dryness | 23.37 | 13.99 | 28 | 118768 | 2873 | 63367353 |
| Hypersensitivity | 23.36 | 13.99 | 396 | 118400 | 292289 | 63077937 |
| Cardiac tamponade | 23.11 | 13.99 | 36 | 118760 | 4739 | 63365487 |
| Brachial plexopathy | 22.97 | 13.99 | 9 | 118787 | 133 | 63370093 |
| Asthenopia | 22.96 | 13.99 | 25 | 118771 | 2312 | 63367914 |
| Bone erosion | 22.95 | 13.99 | 3 | 118793 | 17714 | 63352512 |
| Disorientation | 22.86 | 13.99 | 24 | 118772 | 39428 | 63330798 |
| Vascular fragility | 22.79 | 13.99 | 9 | 118787 | 136 | 63370090 |
| Road traffic accident | 22.71 | 13.99 | 21 | 118775 | 36611 | 63333615 |
| Abnormal behaviour | 22.70 | 13.99 | 6 | 118790 | 21420 | 63348806 |
| Viral infection | 22.64 | 13.99 | 20 | 118776 | 35643 | 63334583 |
| Acute leukaemia | 22.61 | 13.99 | 18 | 118778 | 1116 | 63369110 |
| Acoustic stimulation tests abnormal | 22.55 | 13.99 | 8 | 118788 | 88 | 63370138 |
| Multicentric reticulohistiocytosis | 22.48 | 13.99 | 5 | 118791 | 6 | 63370220 |
| Metastases to the mediastinum | 22.44 | 13.99 | 13 | 118783 | 475 | 63369751 |
| Rhinorrhoea | 22.44 | 13.99 | 204 | 118592 | 65373 | 63304853 |
| Headache | 22.21 | 13.99 | 964 | 117832 | 632277 | 62737949 |
| Hyperaesthesia | 22.12 | 13.99 | 52 | 118744 | 9306 | 63360920 |
| Distichiasis | 22.09 | 13.99 | 6 | 118790 | 24 | 63370202 |
| Plantar erythema | 22.06 | 13.99 | 10 | 118786 | 216 | 63370010 |
| Sopor | 22.02 | 13.99 | 7 | 118789 | 22157 | 63348069 |
| Nodular regenerative hyperplasia | 22.00 | 13.99 | 13 | 118783 | 493 | 63369733 |
| Cytomegalovirus infection | 21.95 | 13.99 | 6 | 118790 | 20946 | 63349280 |
| Mental status changes | 21.94 | 13.99 | 25 | 118771 | 39574 | 63330652 |
| Mean platelet volume decreased | 21.89 | 13.99 | 26 | 118770 | 2643 | 63367583 |
| Kidney infection | 21.85 | 13.99 | 8 | 118788 | 23168 | 63347058 |
| Folate deficiency | 21.79 | 13.99 | 25 | 118771 | 2450 | 63367776 |
| Nail ridging | 21.74 | 13.99 | 12 | 118784 | 399 | 63369827 |
| Lymphangitis | 21.60 | 13.99 | 16 | 118780 | 891 | 63369335 |
| Sinus congestion | 21.36 | 13.99 | 4 | 118792 | 18119 | 63352107 |
| Tricuspid valve incompetence | 21.28 | 13.99 | 68 | 118728 | 14553 | 63355673 |
| Osteosclerosis | 21.21 | 13.99 | 31 | 118765 | 3857 | 63366369 |
| Physical capacity evaluation | 21.13 | 13.99 | 4 | 118792 | 0 | 63370226 |
| Embolism | 20.98 | 13.99 | 46 | 118750 | 7860 | 63362366 |
| Cardiac failure chronic | 20.95 | 13.99 | 33 | 118763 | 4385 | 63365841 |
| Lipoprotein increased | 20.94 | 13.99 | 5 | 118791 | 10 | 63370216 |
| Breast induration | 20.84 | 13.99 | 6 | 118790 | 31 | 63370195 |
| Osteitis condensans | 20.84 | 13.99 | 6 | 118790 | 31 | 63370195 |
| Joint range of motion decreased | 20.81 | 13.99 | 18 | 118778 | 32410 | 63337816 |
| Left ventricular enlargement | 20.79 | 13.99 | 7 | 118789 | 65 | 63370161 |
| Blood phosphorus decreased | 20.76 | 13.99 | 33 | 118763 | 4420 | 63365806 |
| Rectal haemorrhage | 20.75 | 13.99 | 160 | 118636 | 48870 | 63321356 |
| Upper respiratory tract infection | 20.75 | 13.99 | 81 | 118715 | 81966 | 63288260 |
| Hypercholesterolaemia | 20.74 | 13.99 | 7 | 118789 | 21327 | 63348899 |
| Fluid retention | 20.72 | 13.99 | 51 | 118745 | 59635 | 63310591 |
| Brain oedema | 20.64 | 13.99 | 66 | 118730 | 14129 | 63356097 |
| Sequestrectomy | 20.64 | 13.99 | 15 | 118781 | 811 | 63369415 |
| Dizziness | 20.58 | 13.99 | 630 | 118166 | 429295 | 62940931 |
| Superior vena cava syndrome | 20.50 | 13.99 | 14 | 118782 | 685 | 63369541 |
| Gallbladder disorder | 20.49 | 13.99 | 5 | 118791 | 18837 | 63351389 |
| Injection site rash | 20.44 | 13.99 | 5 | 118791 | 18804 | 63351422 |
| Multiple sclerosis | 20.44 | 13.99 | 10 | 118786 | 24362 | 63345864 |
| Bone sequestrum | 20.43 | 13.99 | 19 | 118777 | 1455 | 63368771 |
| Joint dislocation | 20.43 | 13.99 | 5 | 118791 | 18795 | 63351431 |
| Inflammatory carcinoma of the breast | 20.33 | 13.99 | 7 | 118789 | 70 | 63370156 |
| Toxic optic neuropathy | 20.21 | 13.99 | 9 | 118787 | 186 | 63370040 |
| Breast haemorrhage | 20.13 | 13.99 | 9 | 118787 | 188 | 63370038 |
| Cardiovascular disorder | 20.07 | 13.99 | 58 | 118738 | 11754 | 63358472 |
| Tooth extraction | 20.01 | 13.99 | 53 | 118743 | 10211 | 63360015 |
| Pustule | 19.96 | 13.99 | 20 | 118776 | 1679 | 63368547 |
| Dyschezia | 19.90 | 13.99 | 23 | 118773 | 2271 | 63367955 |
| Disability | 19.70 | 13.99 | 5 | 118791 | 18342 | 63351884 |
| Pneumocystis jirovecii pneumonia | 19.67 | 13.99 | 73 | 118723 | 16841 | 63353385 |
| Dysarthria | 19.57 | 13.99 | 31 | 118765 | 42680 | 63327546 |
| Hypothalamo-pituitary disorder | 19.56 | 13.99 | 14 | 118782 | 739 | 63369487 |
| Back pain | 19.47 | 13.99 | 639 | 118157 | 263506 | 63106720 |
| Cystoid macular oedema | 19.36 | 13.99 | 19 | 118777 | 1556 | 63368670 |
| Infusion site pain | 19.30 | 13.99 | 4 | 118792 | 16865 | 63353361 |
| Lipidosis | 19.30 | 13.99 | 6 | 118790 | 42 | 63370184 |
| Chromosomal mutation | 19.27 | 13.99 | 5 | 118791 | 16 | 63370210 |
| Peripheral venous disease | 19.16 | 13.99 | 3 | 118793 | 15474 | 63354752 |
| Hypoalbuminaemia | 19.13 | 13.99 | 57 | 118739 | 11748 | 63358478 |
| Transaminases | 19.11 | 13.99 | 7 | 118789 | 85 | 63370141 |
| Xerophthalmia | 19.00 | 13.99 | 12 | 118784 | 514 | 63369712 |
| Respiratory tract congestion | 18.88 | 13.99 | 5 | 118791 | 17827 | 63352399 |
| Corneal disorder | 18.87 | 13.99 | 20 | 118776 | 1794 | 63368432 |
| Blood magnesium decreased | 18.86 | 13.99 | 61 | 118735 | 13137 | 63357089 |
| Atrial thrombosis | 18.83 | 13.99 | 20 | 118776 | 1798 | 63368428 |
| Jaundice | 18.81 | 13.99 | 106 | 118690 | 29145 | 63341081 |
| Gingival bleeding | 18.74 | 13.99 | 59 | 118737 | 12528 | 63357698 |
| Myeloproliferative neoplasm | 18.69 | 13.99 | 12 | 118784 | 529 | 63369697 |
| Post-traumatic pain | 18.57 | 13.99 | 11 | 118785 | 419 | 63369807 |
| Protein total decreased | 18.46 | 13.99 | 37 | 118759 | 5940 | 63364286 |
| Coronary artery disease | 18.42 | 13.99 | 20 | 118776 | 32357 | 63337869 |
| Creatinine renal clearance decreased | 18.39 | 13.99 | 4 | 118792 | 16304 | 63353922 |
| Breast sarcoma | 18.37 | 13.99 | 4 | 118792 | 4 | 63370222 |
| Intentional product use issue | 18.35 | 13.99 | 152 | 118644 | 127740 | 63242486 |
| Myositis | 18.22 | 13.99 | 48 | 118748 | 9218 | 63361008 |
| Pleomorphic adenoma | 18.21 | 13.99 | 5 | 118791 | 21 | 63370205 |
| Congenital syphilitic osteochondritis | 18.21 | 13.99 | 5 | 118791 | 21 | 63370205 |
| Telangiectasia | 18.17 | 13.99 | 15 | 118781 | 979 | 63369247 |
| Mucosal dryness | 18.15 | 13.99 | 24 | 118772 | 2720 | 63367506 |
| Autonomic neuropathy | 18.15 | 13.99 | 16 | 118780 | 1143 | 63369083 |
| Hand dermatitis | 18.12 | 13.99 | 9 | 118787 | 240 | 63369986 |
| Device dislocation | 18.10 | 13.99 | 13 | 118783 | 25692 | 63344534 |
| Pericardial effusion malignant | 18.08 | 13.99 | 7 | 118789 | 100 | 63370126 |
| Bradycardia | 18.07 | 13.99 | 73 | 118723 | 73154 | 63297072 |
| Metastases to bone marrow | 17.84 | 13.99 | 11 | 118785 | 451 | 63369775 |
| Gingival pain | 17.84 | 13.99 | 44 | 118752 | 8118 | 63362108 |
| Leukaemia cutis | 17.83 | 13.99 | 7 | 118789 | 104 | 63370122 |
| Tremor | 17.82 | 13.99 | 347 | 118449 | 131892 | 63238334 |
| Hydrocephalus | 17.81 | 13.99 | 34 | 118762 | 5266 | 63364960 |
| Paralysis recurrent laryngeal nerve | 17.79 | 13.99 | 6 | 118790 | 56 | 63370170 |
| Sepsis | 17.76 | 13.99 | 393 | 118403 | 152730 | 63217496 |
| Sarcoid-like reaction | 17.67 | 13.99 | 5 | 118791 | 24 | 63370202 |
| Blood pressure systolic increased | 17.66 | 13.99 | 39 | 118757 | 47358 | 63322868 |
| Joint effusion | 17.66 | 13.99 | 5 | 118791 | 17055 | 63353171 |
| Sciatica | 17.61 | 13.99 | 23 | 118773 | 34301 | 63335925 |
| Emotional distress | 17.55 | 13.99 | 21 | 118775 | 32528 | 63337698 |
| Noninfective conjunctivitis | 17.48 | 13.99 | 4 | 118792 | 6 | 63370220 |
| Neutropenic colitis | 17.36 | 13.99 | 25 | 118771 | 3070 | 63367156 |
| Barotrauma | 17.35 | 13.99 | 8 | 118788 | 180 | 63370046 |
| Botryomycosis | 17.34 | 13.99 | 5 | 118791 | 26 | 63370200 |
| Spinal pain | 17.24 | 13.99 | 59 | 118737 | 13080 | 63357146 |
| Alopecia totalis | 17.22 | 13.99 | 10 | 118786 | 367 | 63369859 |
| Overflow diarrhoea | 17.19 | 13.99 | 7 | 118789 | 115 | 63370111 |
| Temperature intolerance | 17.19 | 13.99 | 46 | 118750 | 8918 | 63361308 |
| Breast ulceration | 17.16 | 13.99 | 6 | 118790 | 63 | 63370163 |
| Dilatation ventricular | 17.13 | 13.99 | 22 | 118774 | 2423 | 63367803 |
| Retracted nipple | 17.10 | 13.99 | 4 | 118792 | 7 | 63370219 |
| Chest wall abscess | 17.08 | 13.99 | 6 | 118790 | 64 | 63370162 |
| Gastritis | 17.07 | 13.99 | 124 | 118672 | 37179 | 63333047 |
| Gait apraxia | 17.03 | 13.99 | 5 | 118791 | 28 | 63370198 |
| Herpangina | 17.03 | 13.99 | 5 | 118791 | 28 | 63370198 |
| Gingival swelling | 16.94 | 13.99 | 30 | 118766 | 4388 | 63365838 |
| Therapeutic response unexpected | 16.82 | 13.99 | 7 | 118789 | 18752 | 63351474 |
| Hepatic cancer metastatic | 16.81 | 13.99 | 10 | 118786 | 384 | 63369842 |
| Cholangiectasis acquired | 16.75 | 13.99 | 4 | 118792 | 8 | 63370218 |
| Pleural disorder | 16.74 | 13.99 | 12 | 118784 | 635 | 63369591 |
| Underdose | 16.71 | 13.99 | 16 | 118780 | 27440 | 63342786 |
| Pituitary tumour | 16.70 | 13.99 | 14 | 118782 | 934 | 63369292 |
| Status epilepticus | 16.65 | 13.99 | 4 | 118792 | 15229 | 63354997 |
| Hypocalcaemia | 16.63 | 13.99 | 109 | 118687 | 31604 | 63338622 |
| Central nervous system neoplasm | 16.60 | 13.99 | 5 | 118791 | 31 | 63370195 |
| Thyroid disorder | 16.54 | 13.99 | 4 | 118792 | 15158 | 63355068 |
| Impaired work ability | 16.53 | 13.99 | 6 | 118790 | 17469 | 63352757 |
| Limb injury | 16.52 | 13.99 | 14 | 118782 | 25463 | 63344763 |
| Subclavian vein thrombosis | 16.48 | 13.99 | 19 | 118777 | 1871 | 63368355 |
| Hiatus hernia | 16.45 | 13.99 | 10 | 118786 | 21584 | 63348642 |
| Lymph node fibrosis | 16.44 | 13.99 | 4 | 118792 | 9 | 63370217 |
| Peripheral sensorimotor neuropathy | 16.40 | 13.99 | 17 | 118779 | 1486 | 63368740 |
| Macular degeneration | 16.30 | 13.99 | 13 | 118783 | 24363 | 63345863 |
| Bone disorder | 16.26 | 13.99 | 81 | 118715 | 21245 | 63348981 |
| Respiratory depression | 16.23 | 13.99 | 3 | 118793 | 13712 | 63356514 |
| Entropion | 16.22 | 13.99 | 6 | 118790 | 75 | 63370151 |
| Neuromyopathy | 16.22 | 13.99 | 12 | 118784 | 667 | 63369559 |
| Hepatic neoplasm | 16.11 | 13.99 | 19 | 118777 | 1917 | 63368309 |
| Nasal crusting | 16.10 | 13.99 | 9 | 118787 | 307 | 63369919 |
| Toxic neuropathy | 16.05 | 13.99 | 10 | 118786 | 418 | 63369808 |
| Immunodeficiency | 15.96 | 13.99 | 9 | 118787 | 20245 | 63349981 |
| Pneumonia aspiration | 15.89 | 13.99 | 25 | 118771 | 34515 | 63335711 |
| Rotator cuff syndrome | 15.87 | 13.99 | 3 | 118793 | 13499 | 63356727 |
| Simple mastectomy | 15.85 | 13.99 | 3 | 118793 | 0 | 63370226 |
| Globulinuria | 15.85 | 13.99 | 3 | 118793 | 0 | 63370226 |
| Multiple gated acquisition scan abnormal | 15.85 | 13.99 | 3 | 118793 | 0 | 63370226 |
| Left atrial volume increased | 15.85 | 13.99 | 3 | 118793 | 0 | 63370226 |
| Metastases to the respiratory system | 15.85 | 13.99 | 3 | 118793 | 0 | 63370226 |
| Inflammatory carcinoma of breast stage IV | 15.85 | 13.99 | 3 | 118793 | 0 | 63370226 |
| Colitis ischaemic | 15.76 | 13.99 | 50 | 118746 | 10658 | 63359568 |
| Apical granuloma | 15.73 | 13.99 | 5 | 118791 | 38 | 63370188 |
| Acute hepatic failure | 15.70 | 13.99 | 72 | 118724 | 18255 | 63351971 |
| Lymphopenia | 15.70 | 13.99 | 72 | 118724 | 18255 | 63351971 |
| Eye swelling | 15.69 | 13.99 | 13 | 118783 | 23905 | 63346321 |
| Catheter site inflammation | 15.65 | 13.99 | 13 | 118783 | 856 | 63369370 |
| Nervousness | 15.65 | 13.99 | 21 | 118775 | 30958 | 63339268 |
| Bronchospasm | 15.64 | 13.99 | 69 | 118727 | 17211 | 63353015 |
| Fear | 15.63 | 13.99 | 5 | 118791 | 15761 | 63354465 |
| Arachnoid cyst | 15.62 | 13.99 | 8 | 118788 | 228 | 63369998 |
| Pneumothorax | 15.54 | 13.99 | 66 | 118730 | 16195 | 63354031 |
| Scintillating scotoma | 15.53 | 13.99 | 7 | 118789 | 149 | 63370077 |
| Gamma-glutamyltransferase abnormal | 15.51 | 13.99 | 9 | 118787 | 330 | 63369896 |
| Irritability | 15.49 | 13.99 | 22 | 118774 | 31672 | 63338554 |
| Glaucoma | 15.49 | 13.99 | 8 | 118788 | 18897 | 63351329 |
| Cardiac failure acute | 15.45 | 13.99 | 46 | 118750 | 9477 | 63360749 |
| Mouth swelling | 15.43 | 13.99 | 30 | 118766 | 4710 | 63365516 |
| Intervertebral disc protrusion | 15.41 | 13.99 | 13 | 118783 | 23696 | 63346530 |
| Acral peeling skin syndrome | 15.37 | 13.99 | 4 | 118792 | 13 | 63370213 |
| Skin laceration | 15.32 | 13.99 | 12 | 118784 | 22696 | 63347530 |
| Stress | 15.32 | 13.99 | 69 | 118727 | 67098 | 63303128 |
| Metabolic acidosis | 15.26 | 13.99 | 39 | 118757 | 45030 | 63325196 |
| Vaginal prolapse | 15.23 | 13.99 | 10 | 118786 | 458 | 63369768 |
| Gram stain positive | 15.19 | 13.99 | 5 | 118791 | 43 | 63370183 |
| Rash follicular | 15.19 | 13.99 | 5 | 118791 | 43 | 63370183 |
| Lip dry | 15.17 | 13.99 | 5 | 118791 | 15465 | 63354761 |
| Oral pain | 15.14 | 13.99 | 98 | 118698 | 28296 | 63341930 |
| Dacryostenosis acquired | 15.08 | 13.99 | 11 | 118785 | 598 | 63369628 |
| Spider naevus | 15.08 | 13.99 | 7 | 118789 | 160 | 63370066 |
| Essential thrombocythaemia | 15.08 | 13.99 | 7 | 118789 | 160 | 63370066 |
| Duodenal ulcer | 15.07 | 13.99 | 40 | 118756 | 7716 | 63362510 |
| SAPHO syndrome | 15.05 | 13.99 | 6 | 118790 | 93 | 63370133 |
| Nasal ulcer | 15.00 | 13.99 | 20 | 118776 | 2284 | 63367942 |
| Bone cancer metastatic | 15.00 | 13.99 | 7 | 118789 | 162 | 63370064 |
| Product administration error | 14.91 | 13.99 | 12 | 118784 | 22385 | 63347841 |
| Laboratory test abnormal | 14.90 | 13.99 | 17 | 118779 | 26895 | 63343331 |
| Oropharyngeal candidiasis | 14.78 | 13.99 | 14 | 118782 | 1097 | 63369129 |
| Hallucination, auditory | 14.76 | 13.99 | 3 | 118793 | 12821 | 63357405 |
| Dyspnoea at rest | 14.75 | 13.99 | 27 | 118769 | 4052 | 63366174 |
| Blood lactate dehydrogenase abnormal | 14.67 | 13.99 | 9 | 118787 | 366 | 63369860 |
| Amnesia | 14.62 | 13.99 | 54 | 118742 | 55531 | 63314695 |
| Skin disorder | 14.62 | 13.99 | 100 | 118696 | 29407 | 63340819 |
| Dandy-Walker syndrome | 14.60 | 13.99 | 6 | 118790 | 101 | 63370125 |
| Extravasation | 14.55 | 13.99 | 20 | 118776 | 2352 | 63367874 |
| Foot fracture | 14.48 | 13.99 | 14 | 118782 | 23900 | 63346326 |
| Autoimmune disorder | 14.47 | 13.99 | 7 | 118789 | 17170 | 63353056 |
| Blood bilirubin decreased | 14.41 | 13.99 | 12 | 118784 | 793 | 63369433 |
| Dystonia | 14.39 | 13.99 | 4 | 118792 | 13815 | 63356411 |
| Hernia | 14.35 | 13.99 | 3 | 118793 | 12571 | 63357655 |
| Corneal bleeding | 14.35 | 13.99 | 4 | 118792 | 18 | 63370208 |
| Cerebrovascular accident | 14.33 | 13.99 | 131 | 118665 | 107893 | 63262333 |
| Merycism | 14.30 | 13.99 | 8 | 118788 | 273 | 63369953 |
| Vena cava thrombosis | 14.27 | 13.99 | 19 | 118777 | 2168 | 63368058 |
| Lethargy | 14.26 | 13.99 | 164 | 118632 | 55843 | 63314383 |
| Catheter site pain | 14.25 | 13.99 | 29 | 118767 | 4706 | 63365520 |
| Flatulence | 14.25 | 13.99 | 27 | 118769 | 34675 | 63335551 |
| Poisoning | 14.21 | 13.99 | 4 | 118792 | 13696 | 63356530 |
| Ocular vasculitis | 14.18 | 13.99 | 5 | 118791 | 54 | 63370172 |
| Therapeutic response decreased | 14.15 | 13.99 | 63 | 118733 | 61462 | 63308764 |
| Adenocarcinoma gastric | 14.10 | 13.99 | 10 | 118786 | 520 | 63369706 |
| Vulvovaginal candidiasis | 14.08 | 13.99 | 23 | 118773 | 3152 | 63367074 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Disease progression | 259.64 | 23.82 | 193 | 6548 | 107884 | 34842306 |
| Myelosuppression | 210.79 | 23.82 | 93 | 6648 | 19172 | 34931018 |
| Off label use | 143.98 | 23.82 | 274 | 6467 | 419250 | 34530940 |
| Palmar-plantar erythrodysaesthesia syndrome | 112.81 | 23.82 | 58 | 6683 | 16737 | 34933453 |
| Delusion of grandeur | 107.51 | 23.82 | 28 | 6713 | 1132 | 34949058 |
| Oligohydramnios | 104.31 | 23.82 | 22 | 6719 | 346 | 34949844 |
| Rhinalgia | 90.78 | 23.82 | 24 | 6717 | 1029 | 34949161 |
| Death | 76.40 | 23.82 | 207 | 6534 | 397842 | 34552348 |
| Affective disorder | 71.05 | 23.82 | 28 | 6713 | 4332 | 34945858 |
| Pulmonary hypoplasia | 66.00 | 23.82 | 16 | 6725 | 481 | 34949709 |
| Lymphocyte count abnormal | 60.66 | 23.82 | 18 | 6723 | 1180 | 34949010 |
| Bone marrow failure | 58.41 | 23.82 | 47 | 6694 | 29206 | 34920984 |
| Metastases to central nervous system | 56.98 | 23.82 | 29 | 6712 | 8176 | 34942014 |
| Neuropathy peripheral | 56.92 | 23.82 | 75 | 6666 | 83188 | 34867002 |
| Therapy partial responder | 55.42 | 23.82 | 30 | 6711 | 9586 | 34940604 |
| Anastomotic complication | 53.58 | 23.82 | 13 | 6728 | 392 | 34949798 |
| Schizophrenia | 52.65 | 23.82 | 28 | 6713 | 8638 | 34941552 |
| Alopecia | 52.63 | 23.82 | 41 | 6700 | 24314 | 34925876 |
| Carbohydrate antigen 15-3 increased | 48.57 | 23.82 | 9 | 6732 | 69 | 34950121 |
| Intentional product use issue | 47.37 | 23.82 | 58 | 6683 | 59758 | 34890432 |
| Tidal volume decreased | 46.99 | 23.82 | 8 | 6733 | 35 | 34950155 |
| Ejection fraction decreased | 45.23 | 23.82 | 34 | 6707 | 19120 | 34931070 |
| Hallucination, auditory | 44.35 | 23.82 | 28 | 6713 | 11889 | 34938301 |
| SARS-CoV-2 test positive | 44.22 | 23.82 | 22 | 6719 | 5911 | 34944279 |
| Diarrhoea | 43.72 | 23.82 | 169 | 6572 | 389743 | 34560447 |
| Extrapyramidal disorder | 42.36 | 23.82 | 28 | 6713 | 12852 | 34937338 |
| Neutrophil count increased | 41.75 | 23.82 | 31 | 6710 | 17115 | 34933075 |
| Mucosal inflammation | 38.19 | 23.82 | 42 | 6699 | 38580 | 34911610 |
| Metastases to lung | 37.46 | 23.82 | 23 | 6718 | 9297 | 34940893 |
| Gastric perforation | 36.95 | 23.82 | 15 | 6726 | 2505 | 34947685 |
| Onycholysis | 36.49 | 23.82 | 11 | 6730 | 761 | 34949429 |
| Metastases to liver | 36.20 | 23.82 | 26 | 6715 | 13637 | 34936553 |
| Lymphocyte count decreased | 36.19 | 23.82 | 32 | 6709 | 22590 | 34927600 |
| Nasal discomfort | 35.73 | 23.82 | 13 | 6728 | 1615 | 34948575 |
| Foetal growth abnormality | 35.10 | 23.82 | 6 | 6735 | 27 | 34950163 |
| Incorrect dose administered | 33.21 | 23.82 | 40 | 6701 | 40475 | 34909715 |
| Leukopenia | 33.08 | 23.82 | 50 | 6691 | 62806 | 34887384 |
| Drug interaction | 32.67 | 23.82 | 3 | 6738 | 225943 | 34724247 |
| Metastases to bone | 32.22 | 23.82 | 23 | 6718 | 11947 | 34938243 |
| Paranasal sinus discomfort | 31.40 | 23.82 | 10 | 6731 | 830 | 34949360 |
| Neutropenia | 31.26 | 23.82 | 83 | 6658 | 156695 | 34793495 |
| Anastomotic leak | 29.86 | 23.82 | 9 | 6732 | 622 | 34949568 |
| Metastases to meninges | 29.65 | 23.82 | 11 | 6730 | 1443 | 34948747 |
| Obstruction gastric | 29.56 | 23.82 | 10 | 6731 | 1003 | 34949187 |
| Rectal polyp | 28.70 | 23.82 | 9 | 6732 | 710 | 34949480 |
| Renal hypoplasia | 28.46 | 23.82 | 6 | 6735 | 94 | 34950096 |
| Lymphoedema | 27.36 | 23.82 | 14 | 6727 | 3989 | 34946201 |
| Psychotic disorder | 26.64 | 23.82 | 28 | 6713 | 24424 | 34925766 |
| Platelet count decreased | 26.55 | 23.82 | 66 | 6675 | 119651 | 34830539 |
| Hepatic lesion | 25.42 | 23.82 | 13 | 6728 | 3699 | 34946491 |
| Breast cancer metastatic | 24.52 | 23.82 | 5 | 6736 | 66 | 34950124 |
| Foetal growth restriction | 24.15 | 23.82 | 13 | 6728 | 4104 | 34946086 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myelosuppression | 2403.91 | 13.91 | 1104 | 94566 | 39192 | 79609526 |
| Ejection fraction decreased | 1874.74 | 13.91 | 887 | 94783 | 33690 | 79615028 |
| Diarrhoea | 998.02 | 13.91 | 2796 | 92874 | 877693 | 78771025 |
| Disease progression | 968.22 | 13.91 | 1148 | 94522 | 183214 | 79465504 |
| Palmar-plantar erythrodysaesthesia syndrome | 904.66 | 13.91 | 538 | 95132 | 32596 | 79616122 |
| Metastases to central nervous system | 895.91 | 13.91 | 423 | 95247 | 15952 | 79632766 |
| Cardiotoxicity | 724.78 | 13.91 | 334 | 95336 | 11905 | 79636813 |
| Neuropathy peripheral | 720.06 | 13.91 | 867 | 94803 | 140438 | 79508280 |
| Bone marrow failure | 497.12 | 13.91 | 444 | 95226 | 50663 | 79598055 |
| Drug ineffective | 449.85 | 13.91 | 384 | 95286 | 1080529 | 78568189 |
| Metastases to bone | 420.52 | 13.91 | 297 | 95373 | 24130 | 79624588 |
| Metastases to liver | 390.03 | 13.91 | 301 | 95369 | 28013 | 79620705 |
| Febrile neutropenia | 384.87 | 13.91 | 853 | 94817 | 230146 | 79418572 |
| Polyneuropathy | 384.45 | 13.91 | 280 | 95390 | 23871 | 79624847 |
| Mucosal inflammation | 363.85 | 13.91 | 451 | 95219 | 75129 | 79573589 |
| Metastases to lung | 362.65 | 13.91 | 242 | 95428 | 17921 | 79630797 |
| Chills | 351.23 | 13.91 | 663 | 95007 | 159571 | 79489147 |
| Neutropenia | 345.75 | 13.91 | 937 | 94733 | 286773 | 79361945 |
| Cardiac dysfunction | 343.09 | 13.91 | 143 | 95527 | 3981 | 79644737 |
| Breast cancer recurrent | 287.91 | 13.91 | 115 | 95555 | 2862 | 79645856 |
| Left ventricular dysfunction | 262.65 | 13.91 | 204 | 95466 | 19157 | 79629561 |
| Metastases to lymph nodes | 255.75 | 13.91 | 158 | 95512 | 10239 | 79638479 |
| Breast cancer metastatic | 232.86 | 13.91 | 139 | 95531 | 8463 | 79640255 |
| Drug interaction | 230.44 | 13.91 | 105 | 95565 | 415078 | 79233640 |
| Rheumatoid arthritis | 211.49 | 13.91 | 9 | 95661 | 208461 | 79440257 |
| Condition aggravated | 209.95 | 13.91 | 176 | 95494 | 500948 | 79147770 |
| Cardiomyopathy | 203.85 | 13.91 | 210 | 95460 | 28564 | 79620154 |
| Fall | 203.36 | 13.91 | 172 | 95498 | 487457 | 79161261 |
| Lymphoedema | 202.27 | 13.91 | 146 | 95524 | 12267 | 79636451 |
| Neutropenic sepsis | 199.87 | 13.91 | 202 | 95468 | 26862 | 79621856 |
| Interstitial lung disease | 197.65 | 13.91 | 425 | 95245 | 112175 | 79536543 |
| Nausea | 194.43 | 13.91 | 1873 | 93797 | 955323 | 78693395 |
| Malignant neoplasm progression | 188.82 | 13.91 | 468 | 95202 | 135522 | 79513196 |
| Drug hypersensitivity | 181.35 | 13.91 | 66 | 95604 | 298850 | 79349868 |
| Neoplasm progression | 180.69 | 13.91 | 264 | 95406 | 51418 | 79597300 |
| Drug abuse | 179.85 | 13.91 | 3 | 95667 | 162688 | 79486030 |
| Computerised tomogram thorax abnormal | 178.37 | 13.91 | 77 | 95593 | 2342 | 79646376 |
| Peripheral sensory neuropathy | 178.24 | 13.91 | 138 | 95532 | 12895 | 79635823 |
| Metastases to skin | 178.03 | 13.91 | 70 | 95600 | 1669 | 79647049 |
| Toxicity to various agents | 175.31 | 13.91 | 149 | 95521 | 421391 | 79227327 |
| Joint swelling | 168.01 | 13.91 | 68 | 95602 | 288578 | 79360140 |
| Synovitis | 165.71 | 13.91 | 3 | 95667 | 150731 | 79497987 |
| Contraindicated product administered | 162.48 | 13.91 | 6 | 95664 | 157532 | 79491186 |
| Onycholysis | 155.87 | 13.91 | 67 | 95603 | 2016 | 79646702 |
| Stomatitis | 155.38 | 13.91 | 457 | 95213 | 146300 | 79502418 |
| Cardiac failure | 153.40 | 13.91 | 471 | 95199 | 154371 | 79494347 |
| Osteonecrosis of jaw | 152.83 | 13.91 | 222 | 95448 | 43004 | 79605714 |
| Epistaxis | 146.63 | 13.91 | 376 | 95294 | 111139 | 79537579 |
| Therapeutic product effect decreased | 135.72 | 13.91 | 18 | 95652 | 163845 | 79484873 |
| Product dose omission issue | 135.03 | 13.91 | 64 | 95606 | 247473 | 79401245 |
| Hyperpyrexia | 133.36 | 13.91 | 86 | 95584 | 6006 | 79642712 |
| Hypokalaemia | 133.32 | 13.91 | 428 | 95242 | 143612 | 79505106 |
| Confusional state | 130.18 | 13.91 | 114 | 95556 | 317883 | 79330835 |
| Metastasis | 128.55 | 13.91 | 88 | 95582 | 6792 | 79641926 |
| Pleural effusion | 124.92 | 13.91 | 421 | 95249 | 144841 | 79503877 |
| Arthropathy | 121.98 | 13.91 | 31 | 95639 | 177080 | 79471638 |
| Vomiting | 117.42 | 13.91 | 1267 | 94403 | 664561 | 78984157 |
| Vascular device infection | 115.46 | 13.91 | 97 | 95573 | 10179 | 79638539 |
| Pneumonitis | 115.20 | 13.91 | 237 | 95433 | 60623 | 79588095 |
| Nail toxicity | 114.60 | 13.91 | 34 | 95636 | 329 | 79648389 |
| Recall phenomenon | 113.70 | 13.91 | 45 | 95625 | 1092 | 79647626 |
| Bone pain | 111.37 | 13.91 | 222 | 95448 | 55520 | 79593198 |
| Biopsy lung abnormal | 110.36 | 13.91 | 28 | 95642 | 140 | 79648578 |
| Nail disorder | 109.32 | 13.91 | 100 | 95570 | 11752 | 79636966 |
| Nail dystrophy | 108.02 | 13.91 | 42 | 95628 | 971 | 79647747 |
| Skin toxicity | 107.13 | 13.91 | 85 | 95585 | 8229 | 79640489 |
| Abdominal discomfort | 106.11 | 13.91 | 87 | 95583 | 250640 | 79398078 |
| Systemic lupus erythematosus | 106.05 | 13.91 | 11 | 95659 | 121138 | 79527580 |
| Lacrimation increased | 104.67 | 13.91 | 132 | 95538 | 22345 | 79626373 |
| Alveolitis | 104.01 | 13.91 | 64 | 95606 | 4116 | 79644602 |
| Decreased appetite | 99.31 | 13.91 | 727 | 94943 | 341691 | 79307027 |
| Fatigue | 99.09 | 13.91 | 1614 | 94056 | 928113 | 78720605 |
| Lymphangiosis carcinomatosa | 97.77 | 13.91 | 49 | 95621 | 2105 | 79646613 |
| Paronychia | 96.71 | 13.91 | 78 | 95592 | 7730 | 79640988 |
| Cellulitis | 96.32 | 13.91 | 319 | 95351 | 108741 | 79539977 |
| Nail discolouration | 92.65 | 13.91 | 53 | 95617 | 2978 | 79645740 |
| Neurotoxicity | 92.44 | 13.91 | 151 | 95519 | 32367 | 79616351 |
| Gastrointestinal toxicity | 92.05 | 13.91 | 77 | 95593 | 8032 | 79640686 |
| Treatment failure | 91.53 | 13.91 | 45 | 95625 | 170441 | 79478277 |
| Pyrexia | 90.88 | 13.91 | 1226 | 94444 | 677483 | 78971235 |
| Overdose | 89.64 | 13.91 | 55 | 95615 | 184151 | 79464567 |
| Alopecia | 89.43 | 13.91 | 528 | 95142 | 230827 | 79417891 |
| Oligohydramnios | 89.41 | 13.91 | 54 | 95616 | 3358 | 79645360 |
| Metastases to meninges | 89.26 | 13.91 | 55 | 95615 | 3546 | 79645172 |
| Somnolence | 89.20 | 13.91 | 93 | 95577 | 238888 | 79409830 |
| Sinusitis | 88.88 | 13.91 | 63 | 95607 | 195438 | 79453280 |
| Computerised tomogram thorax | 87.07 | 13.91 | 29 | 95641 | 421 | 79648297 |
| Madarosis | 85.66 | 13.91 | 49 | 95621 | 2753 | 79645965 |
| Dyspnoea | 85.42 | 13.91 | 1472 | 94198 | 855553 | 78793165 |
| Dysgeusia | 84.86 | 13.91 | 202 | 95468 | 56975 | 79591743 |
| Psoriasis | 84.22 | 13.91 | 6 | 95664 | 89581 | 79559137 |
| Neutrophil count decreased | 84.01 | 13.91 | 276 | 95394 | 93683 | 79555035 |
| Weight increased | 82.70 | 13.91 | 128 | 95542 | 277258 | 79371460 |
| Loss of personal independence in daily activities | 80.91 | 13.91 | 13 | 95657 | 102567 | 79546151 |
| Onychoclasis | 80.52 | 13.91 | 61 | 95609 | 5517 | 79643201 |
| Erysipelas | 80.13 | 13.91 | 81 | 95589 | 10769 | 79637949 |
| Inappropriate schedule of product administration | 80.13 | 13.91 | 30 | 95640 | 133598 | 79515120 |
| Metastases to spine | 80.06 | 13.91 | 55 | 95615 | 4269 | 79644449 |
| Metastatic neoplasm | 79.18 | 13.91 | 58 | 95612 | 4984 | 79643734 |
| Pericardial effusion | 78.18 | 13.91 | 172 | 95498 | 46065 | 79602653 |
| Mastitis | 77.03 | 13.91 | 42 | 95628 | 2149 | 79646569 |
| Hyperkalaemia | 76.89 | 13.91 | 21 | 95649 | 114377 | 79534341 |
| Mitral valve incompetence | 76.31 | 13.91 | 129 | 95541 | 28436 | 79620282 |
| White blood cell count decreased | 76.17 | 13.91 | 435 | 95235 | 187853 | 79460865 |
| Ventricular hypokinesia | 75.44 | 13.91 | 73 | 95597 | 9206 | 79639512 |
| Product use in unapproved indication | 74.18 | 13.91 | 116 | 95554 | 250243 | 79398475 |
| Multifocal micronodular pneumocyte hyperplasia | 74.00 | 13.91 | 18 | 95652 | 73 | 79648645 |
| Bronchial polyp | 73.62 | 13.91 | 18 | 95652 | 75 | 79648643 |
| Invasive ductal breast carcinoma | 73.27 | 13.91 | 59 | 95611 | 5833 | 79642885 |
| Aortitis | 70.52 | 13.91 | 35 | 95635 | 1472 | 79647246 |
| Hypertransaminasaemia | 70.32 | 13.91 | 79 | 95591 | 11845 | 79636873 |
| Anaemia | 69.25 | 13.91 | 827 | 94843 | 444188 | 79204530 |
| Rhabdomyolysis | 69.19 | 13.91 | 19 | 95651 | 103112 | 79545606 |
| Pain | 69.00 | 13.91 | 528 | 95142 | 703274 | 78945444 |
| Suicide attempt | 68.91 | 13.91 | 9 | 95661 | 82923 | 79565795 |
| Hot flush | 67.96 | 13.91 | 181 | 95489 | 54696 | 79594022 |
| Acute myeloid leukaemia | 67.78 | 13.91 | 128 | 95542 | 30757 | 79617961 |
| Granulocyte count decreased | 67.31 | 13.91 | 36 | 95634 | 1772 | 79646946 |
| Dermatitis acneiform | 67.30 | 13.91 | 71 | 95599 | 9922 | 79638796 |
| Tumour marker increased | 66.76 | 13.91 | 49 | 95621 | 4223 | 79644495 |
| Alopecia areata | 66.66 | 13.91 | 36 | 95634 | 1807 | 79646911 |
| Therapy partial responder | 65.37 | 13.91 | 92 | 95578 | 17305 | 79631413 |
| Fibromyalgia | 64.48 | 13.91 | 3 | 95667 | 64337 | 79584381 |
| Drug reaction with eosinophilia and systemic symptoms | 64.36 | 13.91 | 3 | 95667 | 64241 | 79584477 |
| Product use issue | 64.28 | 13.91 | 95 | 95575 | 209727 | 79438991 |
| Haematotoxicity | 64.24 | 13.91 | 86 | 95584 | 15433 | 79633285 |
| Cough | 63.95 | 13.91 | 697 | 94973 | 366092 | 79282626 |
| Hospitalisation | 63.90 | 13.91 | 17 | 95653 | 94219 | 79554499 |
| Leukopenia | 63.75 | 13.91 | 293 | 95377 | 116220 | 79532498 |
| Colitis | 63.44 | 13.91 | 213 | 95457 | 73094 | 79575624 |
| Breast pain | 63.42 | 13.91 | 63 | 95607 | 8202 | 79640516 |
| Hyperbilirubinaemia | 63.22 | 13.91 | 109 | 95561 | 24409 | 79624309 |
| Therapeutic product effect incomplete | 62.61 | 13.91 | 47 | 95623 | 141598 | 79507120 |
| Device related infection | 60.75 | 13.91 | 130 | 95540 | 34164 | 79614554 |
| Atelectasis | 60.30 | 13.91 | 125 | 95545 | 32132 | 79616586 |
| Lactic acidosis | 60.01 | 13.91 | 7 | 95663 | 70352 | 79578366 |
| Platelet count decreased | 59.63 | 13.91 | 419 | 95251 | 194245 | 79454473 |
| Hepatic function abnormal | 58.54 | 13.91 | 207 | 95463 | 72900 | 79575818 |
| Mastectomy | 57.63 | 13.91 | 28 | 95642 | 1124 | 79647594 |
| Radiation skin injury | 57.48 | 13.91 | 30 | 95640 | 1404 | 79647314 |
| Disease recurrence | 57.18 | 13.91 | 148 | 95522 | 43961 | 79604757 |
| Onychalgia | 56.40 | 13.91 | 26 | 95644 | 926 | 79647792 |
| Arthritis | 56.29 | 13.91 | 34 | 95636 | 114846 | 79533872 |
| Hair texture abnormal | 56.28 | 13.91 | 41 | 95629 | 3493 | 79645225 |
| Acute interstitial pneumonitis | 56.04 | 13.91 | 28 | 95642 | 1195 | 79647523 |
| Mobility decreased | 56 | 13.91 | 39 | 95631 | 122136 | 79526582 |
| Organising pneumonia | 55.37 | 13.91 | 67 | 95603 | 10872 | 79637846 |
| Chest discomfort | 55.20 | 13.91 | 318 | 95352 | 137726 | 79510992 |
| Neutropenic infection | 54.95 | 13.91 | 35 | 95635 | 2392 | 79646326 |
| Drug intolerance | 53.35 | 13.91 | 152 | 95518 | 263967 | 79384751 |
| Myalgia | 53.06 | 13.91 | 393 | 95277 | 185248 | 79463470 |
| Myocardial infarction | 52.93 | 13.91 | 87 | 95583 | 184042 | 79464676 |
| Cardio-respiratory arrest | 51.94 | 13.91 | 33 | 95637 | 108477 | 79540241 |
| Delusion of grandeur | 51.87 | 13.91 | 28 | 95642 | 1404 | 79647314 |
| Asthenia | 51.53 | 13.91 | 881 | 94789 | 510808 | 79137910 |
| Hepatic enzyme increased | 50.90 | 13.91 | 88 | 95582 | 182522 | 79466196 |
| Duodenal ulcer perforation | 50.86 | 13.91 | 9 | 95661 | 66202 | 79582516 |
| International normalised ratio increased | 50.81 | 13.91 | 19 | 95651 | 84702 | 79564016 |
| Acute kidney injury | 50.66 | 13.91 | 390 | 95280 | 519014 | 79129704 |
| Carcinoembryonic antigen increased | 50.37 | 13.91 | 32 | 95638 | 2177 | 79646541 |
| Asthma | 49.90 | 13.91 | 53 | 95617 | 135042 | 79513676 |
| Hair colour changes | 49.73 | 13.91 | 41 | 95629 | 4191 | 79644527 |
| Tonsillar disorder | 49.37 | 13.91 | 26 | 95644 | 1240 | 79647478 |
| Gastrointestinal haemorrhage | 49.13 | 13.91 | 63 | 95607 | 147656 | 79501062 |
| Paraesthesia | 49.10 | 13.91 | 371 | 95299 | 175952 | 79472766 |
| Musculoskeletal stiffness | 49.09 | 13.91 | 84 | 95586 | 174924 | 79473794 |
| Delirium | 49.07 | 13.91 | 20 | 95650 | 84607 | 79564111 |
| Injury | 48.85 | 13.91 | 16 | 95654 | 77480 | 79571238 |
| Axillary pain | 48.68 | 13.91 | 31 | 95639 | 2118 | 79646600 |
| Swelling | 48.09 | 13.91 | 119 | 95551 | 216592 | 79432126 |
| Infusion related reaction | 47.98 | 13.91 | 454 | 95216 | 229783 | 79418935 |
| Osteonecrosis | 47.37 | 13.91 | 111 | 95559 | 30984 | 79617734 |
| Contusion | 45.90 | 13.91 | 67 | 95603 | 148709 | 79500009 |
| Meibomian gland dysfunction | 45.80 | 13.91 | 15 | 95655 | 206 | 79648512 |
| Hallucination | 45.45 | 13.91 | 23 | 95647 | 85722 | 79562996 |
| Pseudocirrhosis | 44.80 | 13.91 | 20 | 95650 | 660 | 79648058 |
| Breast neoplasm | 44.67 | 13.91 | 22 | 95648 | 910 | 79647808 |
| Sedation | 44.67 | 13.91 | 5 | 95665 | 51890 | 79596828 |
| Recurrent cancer | 44.61 | 13.91 | 32 | 95638 | 2661 | 79646057 |
| Feeling abnormal | 44.11 | 13.91 | 77 | 95593 | 159122 | 79489596 |
| Plasma cell myeloma | 43.72 | 13.91 | 6 | 95664 | 53253 | 79595465 |
| Blood uric acid decreased | 43.38 | 13.91 | 24 | 95646 | 1264 | 79647454 |
| Dry skin | 43.30 | 13.91 | 179 | 95491 | 67816 | 79580902 |
| Bradycardia | 42.86 | 13.91 | 60 | 95610 | 135497 | 79513221 |
| Carbohydrate antigen 15-3 increased | 42.56 | 13.91 | 23 | 95647 | 1156 | 79647562 |
| Wound | 42.43 | 13.91 | 46 | 95624 | 116133 | 79532585 |
| Discomfort | 42.37 | 13.91 | 53 | 95617 | 125564 | 79523154 |
| Orthostatic hypotension | 42.35 | 13.91 | 8 | 95662 | 56156 | 79592562 |
| Metastases to chest wall | 42.33 | 13.91 | 18 | 95652 | 527 | 79648191 |
| Product prescribing error | 42.12 | 13.91 | 3 | 95667 | 44810 | 79603908 |
| Hyperfibrinogenaemia | 42.04 | 13.91 | 12 | 95658 | 100 | 79648618 |
| Hypoglycaemia | 42.02 | 13.91 | 36 | 95634 | 101558 | 79547160 |
| Drug ineffective for unapproved indication | 41.53 | 13.91 | 6 | 95664 | 51232 | 79597486 |
| Nasal congestion | 41.38 | 13.91 | 20 | 95650 | 76532 | 79572186 |
| Arthralgia | 41.23 | 13.91 | 463 | 95207 | 571340 | 79077378 |
| Injection site reaction | 40.90 | 13.91 | 8 | 95662 | 54777 | 79593941 |
| Injection site pain | 40.52 | 13.91 | 58 | 95612 | 129780 | 79518938 |
| Hydrothorax | 40.45 | 13.91 | 24 | 95646 | 1444 | 79647274 |
| Breast mass | 40.26 | 13.91 | 45 | 95625 | 6709 | 79642009 |
| Intentional product misuse | 40.25 | 13.91 | 33 | 95637 | 95132 | 79553586 |
| Erythema | 40.10 | 13.91 | 427 | 95243 | 222863 | 79425855 |
| Second primary malignancy | 39.92 | 13.91 | 66 | 95604 | 14284 | 79634434 |
| Electrocardiogram QT prolonged | 39.92 | 13.91 | 30 | 95640 | 90356 | 79558362 |
| Hepatotoxicity | 39.90 | 13.91 | 144 | 95526 | 51208 | 79597510 |
| Unresponsive to stimuli | 39.89 | 13.91 | 9 | 95661 | 55779 | 79592939 |
| Blood creatinine decreased | 39.72 | 13.91 | 48 | 95622 | 7777 | 79640941 |
| Cytomegalovirus infection | 39.66 | 13.91 | 3 | 95667 | 42641 | 79606077 |
| Constipation | 39.64 | 13.91 | 516 | 95154 | 282534 | 79366184 |
| Wheezing | 39.58 | 13.91 | 49 | 95621 | 116615 | 79532103 |
| Blood cholesterol increased | 39.33 | 13.91 | 26 | 95644 | 83694 | 79565024 |
| Central nervous system lesion | 39.25 | 13.91 | 63 | 95607 | 13305 | 79635413 |
| Agranulocytosis | 39.09 | 13.91 | 131 | 95539 | 44899 | 79603819 |
| Keratitis | 38.95 | 13.91 | 36 | 95634 | 4286 | 79644432 |
| Glossodynia | 38.76 | 13.91 | 40 | 95630 | 103297 | 79545421 |
| Nail infection | 38.58 | 13.91 | 28 | 95642 | 2371 | 79646347 |
| Medication error | 38.55 | 13.91 | 17 | 95653 | 68625 | 79580093 |
| Chronic obstructive pulmonary disease | 38.18 | 13.91 | 28 | 95642 | 85391 | 79563327 |
| Blood lactate dehydrogenase increased | 37.66 | 13.91 | 118 | 95552 | 39052 | 79609666 |
| Depression | 37.30 | 13.91 | 134 | 95536 | 216656 | 79432062 |
| Osteoarthritis | 37.27 | 13.91 | 30 | 95640 | 87279 | 79561439 |
| Injection site erythema | 37.12 | 13.91 | 24 | 95646 | 78173 | 79570545 |
| Dyskinesia | 36.86 | 13.91 | 5 | 95665 | 44768 | 79603950 |
| Enterocolitis | 36.74 | 13.91 | 64 | 95606 | 14448 | 79634270 |
| Metastases to pleura | 36.66 | 13.91 | 23 | 95647 | 1531 | 79647187 |
| Injection site pruritus | 36.58 | 13.91 | 4 | 95666 | 42279 | 79606439 |
| Sensory disturbance | 36.24 | 13.91 | 65 | 95605 | 15012 | 79633706 |
| Accidental overdose | 36.21 | 13.91 | 3 | 95667 | 39578 | 79609140 |
| HER2 positive breast cancer | 35.99 | 13.91 | 14 | 95656 | 324 | 79648394 |
| Temperature intolerance | 35.98 | 13.91 | 51 | 95619 | 9654 | 79639064 |
| Vulvovaginal dryness | 35.87 | 13.91 | 26 | 95644 | 2198 | 79646520 |
| Hepatic lesion | 35.84 | 13.91 | 43 | 95627 | 6916 | 79641802 |
| Radiation necrosis | 35.57 | 13.91 | 15 | 95655 | 430 | 79648288 |
| Coronary artery disease | 35.55 | 13.91 | 17 | 95653 | 65457 | 79583261 |
| Odynophagia | 35.49 | 13.91 | 55 | 95615 | 11272 | 79637446 |
| Mental status changes | 35.43 | 13.91 | 18 | 95652 | 66941 | 79581777 |
| Ejection fraction | 35.40 | 13.91 | 26 | 95644 | 2243 | 79646475 |
| Adverse event | 35.28 | 13.91 | 14 | 95656 | 60200 | 79588518 |
| Bladder irritation | 35.23 | 13.91 | 13 | 95657 | 259 | 79648459 |
| Eosinophilia | 35.19 | 13.91 | 6 | 95664 | 45339 | 79603379 |
| Flushing | 35.05 | 13.91 | 203 | 95467 | 88065 | 79560653 |
| Onychomadesis | 34.86 | 13.91 | 37 | 95633 | 5205 | 79643513 |
| Acoustic stimulation tests abnormal | 34.75 | 13.91 | 8 | 95662 | 24 | 79648694 |
| Cystitis noninfective | 34.58 | 13.91 | 21 | 95649 | 1319 | 79647399 |
| Dermatitis | 34.56 | 13.91 | 78 | 95592 | 21243 | 79627475 |
| Anxiety | 34.44 | 13.91 | 167 | 95503 | 248345 | 79400373 |
| Coma | 34.43 | 13.91 | 42 | 95628 | 100607 | 79548111 |
| Respiratory arrest | 34.35 | 13.91 | 13 | 95657 | 57537 | 79591181 |
| Blood pressure fluctuation | 34.13 | 13.91 | 19 | 95651 | 67126 | 79581592 |
| Blister | 33.81 | 13.91 | 57 | 95613 | 119419 | 79529299 |
| Skin fissures | 33.55 | 13.91 | 58 | 95612 | 13015 | 79635703 |
| Suicidal ideation | 32.87 | 13.91 | 26 | 95644 | 76314 | 79572404 |
| Breast disorder | 32.81 | 13.91 | 24 | 95646 | 2057 | 79646661 |
| Irritable bowel syndrome | 32.53 | 13.91 | 17 | 95653 | 62224 | 79586494 |
| Dehydration | 32.48 | 13.91 | 447 | 95223 | 247740 | 79400978 |
| Gait inability | 32.45 | 13.91 | 15 | 95655 | 58902 | 79589816 |
| Jaw operation | 32.25 | 13.91 | 17 | 95653 | 812 | 79647906 |
| Rhinalgia | 32.22 | 13.91 | 25 | 95645 | 2342 | 79646376 |
| Pulmonary mass | 32.20 | 13.91 | 92 | 95578 | 28942 | 79619776 |
| Eosinophil percentage increased | 32.17 | 13.91 | 21 | 95649 | 1497 | 79647221 |
| Diabetes mellitus | 32.14 | 13.91 | 28 | 95642 | 78362 | 79570356 |
| Pericarditis | 32.09 | 13.91 | 47 | 95623 | 104189 | 79544529 |
| Catheter site bruise | 31.88 | 13.91 | 14 | 95656 | 444 | 79648274 |
| Chronic kidney disease | 31.82 | 13.91 | 20 | 95650 | 66134 | 79582584 |
| Sense of oppression | 31.57 | 13.91 | 21 | 95649 | 1545 | 79647173 |
| Depressed level of consciousness | 31.33 | 13.91 | 42 | 95628 | 96610 | 79552108 |
| Thrombocytopenia | 31.24 | 13.91 | 469 | 95201 | 264790 | 79383928 |
| Congestive cardiomyopathy | 31.20 | 13.91 | 53 | 95617 | 11727 | 79636991 |
| Vascular fragility | 31.18 | 13.91 | 10 | 95660 | 128 | 79648590 |
| Perforation | 30.89 | 13.91 | 20 | 95650 | 1406 | 79647312 |
| Gait disturbance | 30.79 | 13.91 | 136 | 95534 | 207370 | 79441348 |
| Troponin I increased | 30.73 | 13.91 | 33 | 95637 | 4705 | 79644013 |
| Tumour pain | 30.69 | 13.91 | 24 | 95646 | 2275 | 79646443 |
| Cardiac arrest | 30.52 | 13.91 | 105 | 95565 | 171991 | 79476727 |
| Migraine | 30.47 | 13.91 | 36 | 95634 | 87457 | 79561261 |
| Dysarthria | 30.44 | 13.91 | 22 | 95648 | 67600 | 79581118 |
| Neoplasm recurrence | 30.28 | 13.91 | 31 | 95639 | 4183 | 79644535 |
| Disorientation | 30.16 | 13.91 | 19 | 95651 | 62757 | 79585961 |
| Enterocolitis infectious | 30.02 | 13.91 | 26 | 95644 | 2843 | 79645875 |
| Excessive eye blinking | 30.00 | 13.91 | 21 | 95649 | 1680 | 79647038 |
| Exposure during pregnancy | 29.79 | 13.91 | 47 | 95623 | 101085 | 79547633 |
| Wrong technique in product usage process | 29.56 | 13.91 | 27 | 95643 | 73848 | 79574870 |
| Asthenopia | 29.54 | 13.91 | 24 | 95646 | 2403 | 79646315 |
| Mouth ulceration | 29.27 | 13.91 | 107 | 95563 | 38287 | 79610431 |
| Treatment noncompliance | 29.26 | 13.91 | 13 | 95657 | 52255 | 79596463 |
| Systolic dysfunction | 29.25 | 13.91 | 29 | 95641 | 3766 | 79644952 |
| Therapy cessation | 29.08 | 13.91 | 5 | 95665 | 37557 | 79611161 |
| Death | 28.79 | 13.91 | 886 | 94784 | 565628 | 79083090 |
| Mean platelet volume decreased | 28.62 | 13.91 | 25 | 95645 | 2765 | 79645953 |
| Corneal disorder | 28.61 | 13.91 | 23 | 95647 | 2268 | 79646450 |
| Capillary leak syndrome | 28.43 | 13.91 | 29 | 95641 | 3896 | 79644822 |
| Hyperchlorhydria | 28.39 | 13.91 | 22 | 95648 | 2057 | 79646661 |
| Anastomotic complication | 28.36 | 13.91 | 13 | 95657 | 457 | 79648261 |
| Urticaria | 28.32 | 13.91 | 120 | 95550 | 185081 | 79463637 |
| Tachycardia | 28.28 | 13.91 | 332 | 95338 | 177436 | 79471282 |
| Blood glucose increased | 28.02 | 13.91 | 60 | 95610 | 114915 | 79533803 |
| Ear infection | 27.98 | 13.91 | 4 | 95666 | 34428 | 79614290 |
| Abnormal behaviour | 27.86 | 13.91 | 5 | 95665 | 36416 | 79612302 |
| Lung infiltration | 27.78 | 13.91 | 75 | 95595 | 22837 | 79625881 |
| Impaired healing | 27.50 | 13.91 | 39 | 95631 | 87616 | 79561102 |
| Off label use | 27.40 | 13.91 | 1340 | 94330 | 905875 | 78742843 |
| Vessel puncture site bruise | 27.30 | 13.91 | 13 | 95657 | 499 | 79648219 |
| Red cell distribution width increased | 27.24 | 13.91 | 58 | 95612 | 15184 | 79633534 |
| Tumour marker abnormal | 27.19 | 13.91 | 11 | 95659 | 283 | 79648435 |
| Back pain | 27.10 | 13.91 | 514 | 95156 | 303666 | 79345052 |
| Nasal discomfort | 26.80 | 13.91 | 33 | 95637 | 5450 | 79643268 |
| Aortic valve incompetence | 26.74 | 13.91 | 44 | 95626 | 9486 | 79639232 |
| Dyspepsia | 26.57 | 13.91 | 222 | 95448 | 108465 | 79540253 |
| Osteoporosis | 26.52 | 13.91 | 16 | 95654 | 54096 | 79594622 |
| Breast cancer | 26.47 | 13.91 | 95 | 95575 | 33686 | 79615032 |
| Osteosclerosis | 26.36 | 13.91 | 28 | 95642 | 3943 | 79644775 |
| Blood alkaline phosphatase increased | 26.31 | 13.91 | 148 | 95522 | 63516 | 79585202 |
| Biliary sepsis | 26.30 | 13.91 | 19 | 95651 | 1598 | 79647120 |
| Dizziness | 26.23 | 13.91 | 459 | 95211 | 525982 | 79122736 |
| Nephrolithiasis | 25.78 | 13.91 | 16 | 95654 | 53275 | 79595443 |
| Nasal disorder | 25.77 | 13.91 | 27 | 95643 | 3742 | 79644976 |
| Metabolic acidosis | 25.61 | 13.91 | 37 | 95633 | 82492 | 79566226 |
| Lymphocyte count abnormal | 25.22 | 13.91 | 18 | 95652 | 1485 | 79647233 |
| Maternal exposure during pregnancy | 25.10 | 13.91 | 82 | 95588 | 136456 | 79512262 |
| Renal failure | 25.06 | 13.91 | 140 | 95530 | 200828 | 79447890 |
| Papilloedema | 24.97 | 13.91 | 34 | 95636 | 6199 | 79642519 |
| Breast inflammation | 24.93 | 13.91 | 9 | 95661 | 168 | 79648550 |
| Lymphadenopathy | 24.86 | 13.91 | 128 | 95542 | 53119 | 79595599 |
| Basal cell carcinoma | 24.85 | 13.91 | 7 | 95663 | 37368 | 79611350 |
| Bone lesion | 24.80 | 13.91 | 33 | 95637 | 5886 | 79642832 |
| Swollen tongue | 24.77 | 13.91 | 10 | 95660 | 42560 | 79606158 |
| Subdural haematoma | 24.74 | 13.91 | 4 | 95666 | 31430 | 79617288 |
| Vulvovaginal candidiasis | 24.73 | 13.91 | 22 | 95648 | 2492 | 79646226 |
| Multicentric reticulohistiocytosis | 24.70 | 13.91 | 5 | 95665 | 6 | 79648712 |
| Therapy interrupted | 24.64 | 13.91 | 4 | 95666 | 31337 | 79617381 |
| Peripheral motor neuropathy | 24.61 | 13.91 | 25 | 95645 | 3342 | 79645376 |
| Adverse drug reaction | 24.56 | 13.91 | 26 | 95644 | 66366 | 79582352 |
| Lymphocyte count decreased | 24.44 | 13.91 | 117 | 95553 | 47172 | 79601546 |
| Renal impairment | 24.26 | 13.91 | 102 | 95568 | 157681 | 79491037 |
| Sopor | 24.26 | 13.91 | 5 | 95665 | 33005 | 79615713 |
| Eastern Cooperative Oncology Group performance status worsened | 24.25 | 13.91 | 20 | 95650 | 2045 | 79646673 |
| Road traffic accident | 24.23 | 13.91 | 11 | 95659 | 43653 | 79605065 |
| Cerebrovascular accident | 24.12 | 13.91 | 100 | 95570 | 155192 | 79493526 |
| Breast cellulitis | 24.09 | 13.91 | 11 | 95659 | 383 | 79648335 |
| Performance status decreased | 23.97 | 13.91 | 33 | 95637 | 6080 | 79642638 |
| Emotional distress | 23.90 | 13.91 | 9 | 95661 | 39960 | 79608758 |
| Infection | 23.74 | 13.91 | 181 | 95489 | 241531 | 79407187 |
| Pulmonary embolism | 23.61 | 13.91 | 312 | 95358 | 171342 | 79477376 |
| Vulvovaginal inflammation | 23.55 | 13.91 | 12 | 95658 | 534 | 79648184 |
| Osteitis condensans | 23.48 | 13.91 | 6 | 95664 | 31 | 79648687 |
| Blood creatine phosphokinase increased | 23.22 | 13.91 | 27 | 95643 | 66063 | 79582655 |
| Palmar erythema | 23.16 | 13.91 | 19 | 95651 | 1928 | 79646790 |
| Lipoprotein increased | 23.15 | 13.91 | 5 | 95665 | 10 | 79648708 |
| Dermatomyositis | 23.09 | 13.91 | 25 | 95645 | 3598 | 79645120 |
| Influenza | 23.03 | 13.91 | 79 | 95591 | 129527 | 79519191 |
| Gastrointestinal disorder | 23.00 | 13.91 | 236 | 95434 | 121969 | 79526749 |
| Calcium ionised increased | 22.95 | 13.91 | 9 | 95661 | 213 | 79648505 |
| Respiratory depression | 22.95 | 13.91 | 3 | 95667 | 27627 | 79621091 |
| Cystoid macular oedema | 22.88 | 13.91 | 19 | 95651 | 1961 | 79646757 |
| Folate deficiency | 22.85 | 13.91 | 24 | 95646 | 3336 | 79645382 |
| Pneumonia aspiration | 22.84 | 13.91 | 28 | 95642 | 66939 | 79581779 |
| Frequent bowel movements | 22.72 | 13.91 | 4 | 95666 | 29535 | 79619183 |
| Neutrophil count increased | 22.47 | 13.91 | 82 | 95588 | 29314 | 79619404 |
| Illness | 22.45 | 13.91 | 14 | 95656 | 46497 | 79602221 |
| Post-traumatic pain | 22.45 | 13.91 | 11 | 95659 | 450 | 79648268 |
| Pneumonitis chemical | 22.20 | 13.91 | 11 | 95659 | 461 | 79648257 |
| Lipidosis | 22.19 | 13.91 | 6 | 95664 | 40 | 79648678 |
| Dysaesthesia | 22.08 | 13.91 | 31 | 95639 | 5817 | 79642901 |
| Acute pulmonary oedema | 21.89 | 13.91 | 51 | 95619 | 14179 | 79634539 |
| Lymphangitis | 21.66 | 13.91 | 16 | 95654 | 1392 | 79647326 |
| Bursitis | 21.55 | 13.91 | 8 | 95662 | 35836 | 79612882 |
| Rash pustular | 21.33 | 13.91 | 44 | 95626 | 11267 | 79637451 |
| Folliculitis | 21.26 | 13.91 | 21 | 95649 | 55359 | 79593359 |
| Alopecia totalis | 21.07 | 13.91 | 10 | 95660 | 381 | 79648337 |
| Xerophthalmia | 21.06 | 13.91 | 12 | 95658 | 669 | 79648049 |
| Blood lactate dehydrogenase abnormal | 21.05 | 13.91 | 9 | 95661 | 267 | 79648451 |
| Nail bed bleeding | 20.98 | 13.91 | 12 | 95658 | 674 | 79648044 |
| Pulmonary hypoplasia | 20.71 | 13.91 | 6 | 95664 | 53 | 79648665 |
| Hypoxia | 20.69 | 13.91 | 202 | 95468 | 103041 | 79545677 |
| Metastases to breast | 20.66 | 13.91 | 9 | 95661 | 280 | 79648438 |
| Limb injury | 20.64 | 13.91 | 5 | 95665 | 29523 | 79619195 |
| Pustule | 20.48 | 13.91 | 18 | 95652 | 2007 | 79646711 |
| Distichiasis | 20.42 | 13.91 | 5 | 95665 | 21 | 79648697 |
| Hypervolaemia | 20.40 | 13.91 | 13 | 95657 | 42677 | 79606041 |
| Poisoning | 20.38 | 13.91 | 3 | 95667 | 25269 | 79623449 |
| Left ventricular dilatation | 20.37 | 13.91 | 14 | 95656 | 1087 | 79647631 |
| Sinus bradycardia | 20.36 | 13.91 | 3 | 95667 | 25244 | 79623474 |
| Hypotension | 20.32 | 13.91 | 389 | 95281 | 439928 | 79208790 |
| Barotrauma | 20.30 | 13.91 | 8 | 95662 | 192 | 79648526 |
| Hypoaesthesia | 20.28 | 13.91 | 315 | 95355 | 179037 | 79469681 |
| Vaginal prolapse | 20.16 | 13.91 | 9 | 95661 | 297 | 79648421 |
| Encephalopathy | 20.15 | 13.91 | 31 | 95639 | 67366 | 79581352 |
| Breast sarcoma | 20.14 | 13.91 | 4 | 95666 | 4 | 79648714 |
| Urinary retention | 20.04 | 13.91 | 23 | 95647 | 56607 | 79592111 |
| Mouth swelling | 19.83 | 13.91 | 30 | 95640 | 6021 | 79642697 |
| Radiation pneumonitis | 19.76 | 13.91 | 24 | 95646 | 3909 | 79644809 |
| Bronchitis | 19.75 | 13.91 | 85 | 95585 | 130559 | 79518159 |
| Metastases to the mediastinum | 19.54 | 13.91 | 11 | 95659 | 599 | 79648119 |
| Subclavian vein thrombosis | 19.35 | 13.91 | 19 | 95651 | 2438 | 79646280 |
| Viral infection | 19.35 | 13.91 | 14 | 95656 | 43002 | 79605716 |
| Hypothalamo-pituitary disorder | 19.35 | 13.91 | 14 | 95656 | 1180 | 79647538 |
| Ulcerative keratitis | 19.33 | 13.91 | 23 | 95647 | 3666 | 79645052 |
| Tidal volume decreased | 19.29 | 13.91 | 6 | 95664 | 69 | 79648649 |
| Pancreatitis | 19.14 | 13.91 | 33 | 95637 | 68542 | 79580176 |
| Angioedema | 19.10 | 13.91 | 39 | 95631 | 75996 | 79572722 |
| Foot deformity | 19.09 | 13.91 | 3 | 95667 | 24071 | 79624647 |
| Herpangina | 19.09 | 13.91 | 5 | 95665 | 29 | 79648689 |
| Blood magnesium decreased | 18.97 | 13.91 | 53 | 95617 | 16459 | 79632259 |
| Metastases to bone marrow | 18.97 | 13.91 | 12 | 95658 | 810 | 79647908 |
| Intracranial pressure increased | 18.89 | 13.91 | 35 | 95635 | 8287 | 79640431 |
| Joint injury | 18.83 | 13.91 | 7 | 95663 | 31328 | 79617390 |
| Osteolysis | 18.73 | 13.91 | 25 | 95645 | 4473 | 79644245 |
| Transaminases | 18.69 | 13.91 | 6 | 95664 | 77 | 79648641 |
| Gait apraxia | 18.67 | 13.91 | 5 | 95665 | 32 | 79648686 |
| Inflammatory carcinoma of the breast | 18.67 | 13.91 | 5 | 95665 | 32 | 79648686 |
| Retinal detachment | 18.67 | 13.91 | 37 | 95633 | 9210 | 79639508 |
| Acute respiratory distress syndrome | 18.58 | 13.91 | 103 | 95567 | 43964 | 79604754 |
| Ventricular dysfunction | 18.53 | 13.91 | 29 | 95641 | 5994 | 79642724 |
| Ovarian failure | 18.49 | 13.91 | 11 | 95659 | 665 | 79648053 |
| Gastric disorder | 18.44 | 13.91 | 11 | 95659 | 37422 | 79611296 |
| Full blood count abnormal | 18.43 | 13.91 | 13 | 95657 | 40461 | 79608257 |
| Movement disorder | 18.32 | 13.91 | 5 | 95665 | 27254 | 79621464 |
| Spinal pain | 18.28 | 13.91 | 50 | 95620 | 15342 | 79633376 |
| Lymph node fibrosis | 18.20 | 13.91 | 4 | 95666 | 9 | 79648709 |
| Hand dermatitis | 18.19 | 13.91 | 9 | 95661 | 376 | 79648342 |
| Device issue | 18.16 | 13.91 | 5 | 95665 | 27103 | 79621615 |
| Gingival pain | 18.16 | 13.91 | 36 | 95634 | 8962 | 79639756 |
| Merycism | 18.15 | 13.91 | 8 | 95662 | 256 | 79648462 |
| Haemorrhoids | 18.00 | 13.91 | 76 | 95594 | 29052 | 79619666 |
| Therapy non-responder | 17.97 | 13.91 | 54 | 95616 | 92251 | 79556467 |
| Overflow diarrhoea | 17.88 | 13.91 | 7 | 95663 | 165 | 79648553 |
| Autoimmune hypothyroidism | 17.73 | 13.91 | 8 | 95662 | 271 | 79648447 |
| Gout | 17.68 | 13.91 | 4 | 95666 | 24745 | 79623973 |
| Aphasia | 17.62 | 13.91 | 18 | 95652 | 46714 | 79602004 |
| Malignant pleural effusion | 17.59 | 13.91 | 21 | 95649 | 3359 | 79645359 |
| Nail bed tenderness | 17.57 | 13.91 | 9 | 95661 | 405 | 79648313 |
| Toxic cardiomyopathy | 17.53 | 13.91 | 9 | 95661 | 407 | 79648311 |
| Gastritis | 17.52 | 13.91 | 108 | 95562 | 47885 | 79600833 |
| Type 2 diabetes mellitus | 17.34 | 13.91 | 26 | 95644 | 57096 | 79591622 |
| Cataract | 17.24 | 13.91 | 30 | 95640 | 62090 | 79586628 |
| Left atrial volume increased | 17.18 | 13.91 | 3 | 95667 | 0 | 79648718 |
| Metastases to the respiratory system | 17.18 | 13.91 | 3 | 95667 | 0 | 79648718 |
| Simple mastectomy | 17.18 | 13.91 | 3 | 95667 | 0 | 79648718 |
| Globulinuria | 17.18 | 13.91 | 3 | 95667 | 0 | 79648718 |
| Cytokine release syndrome | 17.15 | 13.91 | 11 | 95659 | 35987 | 79612731 |
| Toxic neuropathy | 17.05 | 13.91 | 12 | 95658 | 968 | 79647750 |
| Blood creatine increased | 16.92 | 13.91 | 36 | 95634 | 9419 | 79639299 |
| Dandy-Walker syndrome | 16.89 | 13.91 | 5 | 95665 | 48 | 79648670 |
| Pituitary tumour | 16.84 | 13.91 | 13 | 95657 | 1209 | 79647509 |
| Hypertensive crisis | 16.78 | 13.91 | 59 | 95611 | 20711 | 79628007 |
| Inflammation | 16.75 | 13.91 | 57 | 95613 | 93696 | 79555022 |
| Vocal cord paralysis | 16.75 | 13.91 | 18 | 95652 | 2569 | 79646149 |
| Leukaemia cutis | 16.72 | 13.91 | 7 | 95663 | 197 | 79648521 |
| Protein total decreased | 16.72 | 13.91 | 35 | 95635 | 9057 | 79639661 |
| Corneal toxicity | 16.69 | 13.91 | 4 | 95666 | 15 | 79648703 |
| Product quality issue | 16.68 | 13.91 | 10 | 95660 | 33930 | 79614788 |
| Flatulence | 16.64 | 13.91 | 16 | 95654 | 42708 | 79606010 |
| Fluid retention | 16.54 | 13.91 | 37 | 95633 | 69772 | 79578946 |
| Axillary vein thrombosis | 16.51 | 13.91 | 10 | 95660 | 625 | 79648093 |
| Tooth extraction | 16.47 | 13.91 | 39 | 95631 | 10956 | 79637762 |
| Toothache | 16.37 | 13.91 | 57 | 95613 | 19913 | 79628805 |
| Blood phosphorus decreased | 16.35 | 13.91 | 29 | 95641 | 6639 | 79642079 |
| Agitation | 16.25 | 13.91 | 63 | 95607 | 99652 | 79549066 |
| Stress cardiomyopathy | 16.08 | 13.91 | 39 | 95631 | 11127 | 79637591 |
| Secondary cerebellar degeneration | 16.04 | 13.91 | 5 | 95665 | 58 | 79648660 |
| Naevus haemorrhage | 16.01 | 13.91 | 6 | 95664 | 125 | 79648593 |
| Botryomycosis | 15.96 | 13.91 | 5 | 95665 | 59 | 79648659 |
| Loss of consciousness | 15.90 | 13.91 | 127 | 95543 | 167816 | 79480902 |
| Dysuria | 15.77 | 13.91 | 110 | 95560 | 50841 | 79597877 |
| Skin infection | 15.76 | 13.91 | 53 | 95617 | 18192 | 79630526 |
| Paralysis recurrent laryngeal nerve | 15.75 | 13.91 | 6 | 95664 | 131 | 79648587 |
| Pleural neoplasm | 15.62 | 13.91 | 8 | 95662 | 360 | 79648358 |
| Urogenital prolapse | 15.60 | 13.91 | 4 | 95666 | 21 | 79648697 |
| Clostridial infection | 15.52 | 13.91 | 26 | 95644 | 5688 | 79643030 |
| Metastases to nervous system | 15.52 | 13.91 | 5 | 95665 | 65 | 79648653 |
| Prescribed underdose | 15.51 | 13.91 | 8 | 95662 | 29506 | 79619212 |
| Injection site haemorrhage | 15.49 | 13.91 | 7 | 95663 | 27863 | 79620855 |
| Dental fistula | 15.46 | 13.91 | 9 | 95661 | 523 | 79648195 |
| Breast ulceration | 15.45 | 13.91 | 5 | 95665 | 66 | 79648652 |
| Peripheral swelling | 15.42 | 13.91 | 229 | 95441 | 269388 | 79379330 |
| Tongue coated | 15.37 | 13.91 | 13 | 95657 | 1376 | 79647342 |
| Rhinorrhoea | 15.32 | 13.91 | 149 | 95521 | 75925 | 79572793 |
| Gingival swelling | 15.32 | 13.91 | 23 | 95647 | 4586 | 79644132 |
| Myoclonus | 15.29 | 13.91 | 7 | 95663 | 27653 | 79621065 |
| Catheter site pain | 15.25 | 13.91 | 25 | 95645 | 5371 | 79643347 |
| Delusion | 15.20 | 13.91 | 3 | 95667 | 20420 | 79628298 |
| Entropion | 15.11 | 13.91 | 5 | 95665 | 71 | 79648647 |
| Human epidermal growth factor receptor increased | 15.11 | 13.91 | 3 | 95667 | 3 | 79648715 |
| Acute myocardial infarction | 15.05 | 13.91 | 45 | 95625 | 76991 | 79571727 |
| Bone marrow infiltration | 15.03 | 13.91 | 10 | 95660 | 736 | 79647982 |
| Spider naevus | 14.92 | 13.91 | 6 | 95664 | 152 | 79648566 |
| Pleural disorder | 14.84 | 13.91 | 11 | 95659 | 962 | 79647756 |
| Fear | 14.84 | 13.91 | 4 | 95666 | 21982 | 79626736 |
| Product administration error | 14.81 | 13.91 | 10 | 95660 | 31836 | 79616882 |
| Myeloproliferative neoplasm | 14.68 | 13.91 | 11 | 95659 | 978 | 79647740 |
| Gastric perforation | 14.65 | 13.91 | 21 | 95649 | 4016 | 79644702 |
| Amenorrhoea | 14.60 | 13.91 | 30 | 95640 | 7662 | 79641056 |
| Head injury | 14.54 | 13.91 | 14 | 95656 | 37355 | 79611363 |
| Peripheral sensorimotor neuropathy | 14.53 | 13.91 | 18 | 95652 | 2992 | 79645726 |
| Gamma-glutamyltransferase abnormal | 14.37 | 13.91 | 9 | 95661 | 597 | 79648121 |
| Urinary tract disorder | 14.37 | 13.91 | 20 | 95650 | 3722 | 79644996 |
| Bone disorder | 14.34 | 13.91 | 53 | 95617 | 19060 | 79629658 |
| Generalised tonic-clonic seizure | 14.31 | 13.91 | 19 | 95651 | 43891 | 79604827 |
| Irritability | 14.25 | 13.91 | 17 | 95653 | 41127 | 79607591 |
| Tumour haemorrhage | 14.23 | 13.91 | 21 | 95649 | 4123 | 79644595 |
| Diabetic ketoacidosis | 14.22 | 13.91 | 12 | 95658 | 34110 | 79614608 |
| Eye swelling | 14.17 | 13.91 | 7 | 95663 | 26461 | 79622257 |
| Corneal bleeding | 14.16 | 13.91 | 4 | 95666 | 32 | 79648686 |
| Hypercholesterolaemia | 14.15 | 13.91 | 5 | 95665 | 23090 | 79625628 |
| Hyperhidrosis | 14.14 | 13.91 | 115 | 95555 | 151377 | 79497341 |
| Transient ischaemic attack | 14.13 | 13.91 | 26 | 95644 | 52669 | 79596049 |
| COVID-19 | 14.12 | 13.91 | 121 | 95549 | 157553 | 79491165 |
| Ejection fraction abnormal | 14.10 | 13.91 | 16 | 95654 | 2424 | 79646294 |
| Cardiac failure chronic | 14.06 | 13.91 | 37 | 95633 | 11098 | 79637620 |
| Nasal ulcer | 14.05 | 13.91 | 15 | 95655 | 2125 | 79646593 |
| Aspartate aminotransferase increased | 13.99 | 13.91 | 239 | 95431 | 138402 | 79510316 |
| Hyponatraemia | 13.98 | 13.91 | 141 | 95529 | 177707 | 79471011 |
| Chromosomal mutation | 13.94 | 13.91 | 4 | 95666 | 34 | 79648684 |
| Haemorrhage intracranial | 13.92 | 13.91 | 7 | 95663 | 26186 | 79622532 |
None
| Source | Code | Description |
|---|---|---|
| ATC | L01FD01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors |
| ATC | L01XY02 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Combinations of antineoplastic agents |
| FDA MoA | N0000020008 | HER2/Neu/cerbB2 Antagonists |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D000074322 | Antineoplastic Agents, Immunological |
| FDA EPC | N0000175661 | HER2/neu Receptor Antagonist |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Secondary malignant neoplasm of female breast | indication | 94297009 | |
| Secondary malignant neoplasm of stomach | indication | 94606003 | |
| Human epidermal growth factor 2 positive gastric cancer | indication | 102453009 | |
| HER2-positive salivary gland tumors | indication | 255072001 | |
| HER2-positive rectal cancer | indication | 363351006 | DOID:1993 |
| HER2-positive colon cancer | indication | 363406005 | DOID:219 |
| HER2-positive carcinoma of breast | indication | 427685000 |
None
None
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Receptor tyrosine-protein kinase erbB-2 | Kinase | ANTIBODY BINDING | DRUG LABEL | DRUG LABEL |
| ID | Source |
|---|---|
| P188ANX8CK | UNII |
| D03257 | KEGG_DRUG |
| 4021140 | VUID |
| N0000148593 | NUI |
| 4021140 | VANDF |
| 4038908 | VANDF |
| C0728747 | UMLSCUI |
| CHEMBL1201585 | ChEMBL_ID |
| DB00072 | DRUGBANK_ID |
| D000068878 | MESH_DESCRIPTOR_UI |
| 7637 | INN_ID |
| C000630669 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5082 | IUPHAR_LIGAND_ID |
| 101306 | RXNORM |
| 11893 | MMSL |
| 266775 | MMSL |
| 33398 | MMSL |
| 7554 | MMSL |
| d04357 | MMSL |
| 007663 | NDDF |
| 017423 | NDDF |
| 327397006 | SNOMEDCT_US |
| 387003001 | SNOMEDCT_US |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ontruzant | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0006-5033 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 28 sections |
| Trazimera | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0308 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 29 sections |
| Herceptin Hylecta | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50242-077 | INJECTION, SOLUTION | 600 mg | SUBCUTANEOUS | BLA | 28 sections |
| Herceptin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50242-132 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 25 sections |
| Phesgo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 50242-245 | INJECTION, SOLUTION | 600 mg | SUBCUTANEOUS | BLA | 30 sections |
| Phesgo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 50242-245 | INJECTION, SOLUTION | 600 mg | SUBCUTANEOUS | BLA | 30 sections |
| Phesgo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 50242-260 | INJECTION, SOLUTION | 600 mg | SUBCUTANEOUS | BLA | 30 sections |
| Phesgo | HUMAN PRESCRIPTION DRUG LABEL | 3 | 50242-260 | INJECTION, SOLUTION | 600 mg | SUBCUTANEOUS | BLA | 30 sections |
| Kanjinti | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-132 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 420 mg | INTRAVENOUS | BLA | 28 sections |
| Kanjinti | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-132 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 420 mg | INTRAVENOUS | BLA | 28 sections |
| Kanjinti | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-132 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 420 mg | INTRAVENOUS | BLA | 28 sections |
| Kanjinti | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-141 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 28 sections |
| Kanjinti | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-141 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 28 sections |
| Kanjinti | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55513-141 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 28 sections |
| HERZUMA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63459-303 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 29 sections |
| HERZUMA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63459-303 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 29 sections |
| HERZUMA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63459-303 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 29 sections |
| OGIVRI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67457-845 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 420 mg | INTRAVENOUS | BLA | 29 sections |
| OGIVRI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67457-991 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 29 sections |
| Ontruzant | HUMAN PRESCRIPTION DRUG LABEL | 1 | 78206-147 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 28 sections |
| Ontruzant | HUMAN PRESCRIPTION DRUG LABEL | 1 | 78206-147 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 28 sections |
| OGIVRI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 83257-001 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 150 mg | INTRAVENOUS | BLA | 29 sections |
| OGIVRI | HUMAN PRESCRIPTION DRUG LABEL | 1 | 83257-003 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 420 mg | INTRAVENOUS | BLA | 29 sections |