ipilimumab 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
human origin 4958 477202-00-9

Description:

MoleculeDescription

Synonyms:

  • ipilimumab
  • yervoy
  • MDX-010
  • MDX-CTLA-4
  • ipilimumab (genetical recombination)
An anti-CTLA-4 ANTIGEN monoclonal antibody initially indicated for the treatment of certain types of metastatic MELANOMA. Its mode of actions may include blocking of CTLA-4 mediated inhibition of CYTOTOXIC T LYMPHOCYTES, allowing for more efficient destruction of target tumor cells.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
10 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
July 3, 2015 PMDA BRISTOL-MYERS SQUIBB K.K
March 25, 2011 FDA BRISTOL MYERS SQUIBB
July 13, 2011 EMA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Malignant neoplasm progression 2361.17 22.18 984 28333 105886 90493244
Immune-mediated enterocolitis 1525.88 22.18 345 28972 4412 90594718
Hypophysitis 1380.53 22.18 284 29033 2236 90596894
Colitis 1178.09 22.18 533 28784 69409 90529721
Immune-mediated hepatitis 744.08 22.18 176 29141 2768 90596362
Death 645.86 22.18 764 28553 455787 90143343
Immune-mediated hepatic disorder 552.92 22.18 126 29191 1666 90597464
Adrenal insufficiency 547.60 22.18 242 29075 29679 90569451
Hypopituitarism 470.22 22.18 110 29207 1643 90597487
Hypothyroidism 459.07 22.18 258 29059 52869 90546261
Pneumonitis 452.25 22.18 240 29077 43930 90555200
Hyperthyroidism 430.75 22.18 177 29140 18133 90580997
Autoimmune colitis 420.94 22.18 87 29230 700 90598430
Immune-mediated lung disease 416.14 22.18 101 29216 1779 90597351
Thyroiditis 345.60 22.18 100 29217 3537 90595593
Immune-mediated dermatitis 333.70 22.18 74 29243 857 90598273
Autoimmune hepatitis 331.08 22.18 125 29192 10226 90588904
Fulminant type 1 diabetes mellitus 326.92 22.18 72 29245 806 90598324
Type 1 diabetes mellitus 326.34 22.18 102 29215 4710 90594420
Myocarditis 316.35 22.18 131 29186 13675 90585455
Immune-mediated hypophysitis 315.63 22.18 64 29253 463 90598667
Intentional product use issue 285.62 22.18 351 28966 216541 90382589
Immune-mediated thyroiditis 264.94 22.18 55 29262 453 90598677
Immune-mediated hypothyroidism 256.32 22.18 66 29251 1492 90597638
Immune-mediated myocarditis 251.89 22.18 63 29254 1262 90597868
Secondary adrenocortical insufficiency 248.38 22.18 70 29247 2248 90596882
Lymphocytic hypophysitis 243.88 22.18 47 29270 252 90598878
Enterocolitis 231.77 22.18 97 29220 10393 90588737
Diabetic ketoacidosis 222.87 22.18 123 29194 24284 90574846
Hepatic function abnormal 222.57 22.18 155 29162 46133 90552997
Diarrhoea 216.01 22.18 729 28588 938461 89660669
Adrenocorticotropic hormone deficiency 210.22 22.18 49 29268 719 90598411
Hepatitis 182.22 22.18 164 29153 70575 90528555
Immune-mediated encephalitis 177.77 22.18 40 29277 497 90598633
Immune-mediated uveitis 171.67 22.18 31 29286 108 90599022
Cytokine release syndrome 171.49 22.18 109 29208 27864 90571266
Pyrexia 165.06 22.18 528 28789 659957 89939173
Immune-mediated nephritis 160.84 22.18 36 29281 436 90598694
Metastatic malignant melanoma 160.29 22.18 46 29271 1578 90597552
Immune-mediated adrenal insuficiency 154.68 22.18 41 29276 1041 90598089
Metastases to central nervous system 140.11 22.18 81 29236 17461 90581669
Vitiligo 131.73 22.18 42 29275 2068 90597062
Rash maculo-papular 119.62 22.18 102 29215 40831 90558299
Drug hypersensitivity 115.99 22.18 9 29308 463600 90135530
Meningitis aseptic 114.91 22.18 52 29265 6721 90592409
Joint swelling 112.42 22.18 15 29302 503285 90095845
Tumour pseudoprogression 111.12 22.18 29 29288 692 90598438
Drug intolerance 111.10 22.18 9 29308 447582 90151548
Hypothalamo-pituitary disorder 109.08 22.18 37 29280 2215 90596915
Adrenocortical insufficiency acute 107.66 22.18 38 29279 2563 90596567
Pain 103.78 22.18 102 29215 996239 89602891
Off label use 102.67 22.18 657 28660 1101595 89497535
Myositis 102.59 22.18 75 29242 24053 90575077
Sepsis 101.81 22.18 197 29120 179617 90419513
Arthropathy 101.15 22.18 4 29313 366238 90232892
Thyroid disorder 98.41 22.18 65 29252 17720 90581410
Myasthenia gravis 95.93 22.18 46 29271 6779 90592351
Immune-mediated pancreatitis 92.37 22.18 22 29295 356 90598774
Pemphigus 92.23 22.18 3 29314 326861 90272269
Immune-mediated adverse reaction 92.18 22.18 26 29291 837 90598293
Intestinal perforation 89.85 22.18 56 29261 13825 90585305
Synovitis 89.72 22.18 4 29313 329748 90269382
Liver disorder 87.95 22.18 148 29169 121121 90478009
Immune-mediated cholangitis 87.41 22.18 20 29297 269 90598861
Autoimmune thyroiditis 86.74 22.18 41 29276 5852 90593278
Encephalitis 85.17 22.18 50 29267 11084 90588046
Non-small cell lung cancer 85.14 22.18 37 29280 4344 90594786
Wound 84.71 22.18 3 29314 302977 90296153
Nasopharyngitis 84.34 22.18 15 29302 407089 90192041
Immune-mediated arthritis 82.20 22.18 19 29298 268 90598862
Swelling 81.45 22.18 18 29299 419040 90180090
Hyponatraemia 80.12 22.18 150 29167 133388 90465742
Blood corticotrophin decreased 79.68 22.18 21 29296 521 90598609
Haemophagocytic lymphohistiocytosis 79.53 22.18 54 29263 15405 90583725
Pleural effusion 78.98 22.18 135 29182 111856 90487274
Abdominal discomfort 78.88 22.18 28 29289 477300 90121830
Drug ineffective 78.24 22.18 212 29105 1384086 89215044
Autoimmune dermatitis 75.60 22.18 16 29301 146 90598984
Alopecia 75.30 22.18 33 29284 495038 90104092
Vogt-Koyanagi-Harada disease 75.28 22.18 19 29298 395 90598735
Maternal exposure during pregnancy 75.15 22.18 13 29304 360050 90239080
Lipase increased 74.89 22.18 46 29271 11065 90588065
Uveitis 73.48 22.18 52 29265 15851 90583279
Peripheral swelling 72.16 22.18 22 29295 413084 90186046
Immune-mediated hyperthyroidism 72.08 22.18 18 29299 358 90598772
Leukoderma 71.30 22.18 14 29303 84 90599046
Aspartate aminotransferase increased 71.16 22.18 123 29194 102814 90496316
Treatment failure 70.39 22.18 8 29309 303920 90295210
Autoimmune nephritis 70.01 22.18 18 29299 404 90598726
Product dose omission issue 69.28 22.18 7 29310 291680 90307450
Nephritis 68.74 22.18 29 29288 3166 90595964
Serous retinal detachment 67.26 22.18 19 29298 615 90598515
Sinusitis 66.12 22.18 15 29302 343073 90256057
Condition aggravated 65.34 22.18 58 29259 595487 90003643
Enteritis 65.19 22.18 41 29276 10280 90588850
Acute kidney injury 64.65 22.18 239 29078 320148 90278982
Dehydration 63.12 22.18 171 29146 194276 90404854
Exposure via body fluid 63.04 22.18 18 29299 606 90598524
Mobility decreased 62.28 22.18 5 29312 250729 90348401
Psoriatic arthropathy 61.34 22.18 3 29314 228332 90370798
Impaired healing 60.08 22.18 4 29313 234195 90364935
Amylase increased 60.07 22.18 34 29283 7038 90592092
Glucocorticoid deficiency 59.95 22.18 17 29300 558 90598572
Adrenalitis 59.92 22.18 11 29306 43 90599087
Guillain-Barre syndrome 58.56 22.18 29 29288 4583 90594547
Exposure during pregnancy 58.53 22.18 5 29312 238405 90360725
Duodenitis 57.08 22.18 28 29289 4335 90594795
Asthma 57.01 22.18 6 29311 242154 90356976
Hypersensitivity 56.51 22.18 39 29278 454638 90144492
Immune-mediated gastritis 56.01 22.18 13 29304 187 90598943
Wheezing 55.79 22.18 6 29311 238074 90361056
Autoimmune arthritis 55.20 22.18 11 29306 72 90599058
Discomfort 54.88 22.18 11 29306 274324 90324806
Rash 54.88 22.18 442 28875 795658 89803472
Thyrotoxic crisis 54.84 22.18 19 29298 1212 90597918
Decreased appetite 54.77 22.18 254 29063 376286 90222844
Blister 53.64 22.18 9 29308 254989 90344141
Musculoskeletal stiffness 53.20 22.18 15 29302 296517 90302613
Iridocyclitis 52.44 22.18 25 29292 3636 90595494
Tubulointerstitial nephritis 52.29 22.18 52 29265 25291 90573839
Immune-mediated myositis 52.17 22.18 22 29295 2399 90596731
Encephalitis autoimmune 52.15 22.18 21 29296 2037 90597093
Drug interaction 51.46 22.18 13 29304 276440 90322690
Alanine aminotransferase increased 50.99 22.18 116 29201 118222 90480908
Diabetes mellitus 50.80 22.18 82 29235 64793 90534337
Weight increased 50.41 22.18 37 29280 417890 90181240
Cholangitis 49.08 22.18 30 29287 7152 90591978
Pericarditis 47.84 22.18 14 29303 270137 90328993
Autoimmune haemolytic anaemia 47.57 22.18 27 29290 5618 90593512
Myasthenic syndrome 47.32 22.18 13 29304 379 90598751
Osteoarthritis 45.68 22.18 5 29312 195725 90403405
Large intestine perforation 45.43 22.18 32 29285 9680 90589450
Hepatic failure 45.34 22.18 60 29257 39668 90559462
Erythema multiforme 45.23 22.18 35 29282 12211 90586919
Dizziness 44.96 22.18 76 29241 589208 90009922
Hyperglycaemia 44.88 22.18 68 29249 50902 90548228
Interstitial lung disease 44.77 22.18 85 29232 76320 90522810
Cortisol decreased 44.75 22.18 18 29299 1741 90597389
Hepatotoxicity 44.46 22.18 64 29253 45778 90553352
Transaminases increased 43.73 22.18 57 29260 37135 90561995
Skin toxicity 42.99 22.18 27 29290 6752 90592378
Drug eruption 42.78 22.18 55 29262 35352 90563778
Respiratory failure 42.33 22.18 108 29209 118310 90480820
Migraine 41.67 22.18 6 29311 190386 90408744
Prescribed overdose 41.28 22.18 95 29222 97530 90501600
Neurofibrosarcoma 40.47 22.18 10 29307 190 90598940
Radiation necrosis 40.39 22.18 13 29304 660 90598470
Gastritis 40.06 22.18 58 29259 41695 90557435
Adrenal disorder 39.80 22.18 17 29300 1913 90597217
Immune-mediated renal disorder 39.26 22.18 10 29307 216 90598914
Memory impairment 39.25 22.18 8 29309 197236 90401894
Pregnancy on contraceptive 39.10 22.18 15 29302 1280 90597850
Metastases to lung 39.03 22.18 36 29281 15955 90583175
Hypoaesthesia 38.95 22.18 27 29290 314183 90284947
Autoimmune pancreatitis 38.94 22.18 11 29306 356 90598774
Disseminated intravascular coagulation 38.65 22.18 41 29276 21497 90577633
Urticaria 38.59 22.18 27 29290 312707 90286423
Therapeutic product effect incomplete 38.30 22.18 8 29309 193888 90405242
Immune-mediated oesophagitis 38.00 22.18 7 29310 28 90599102
Pain in extremity 37.28 22.18 55 29262 450474 90148656
Cholestasis 37.15 22.18 52 29265 36247 90562883
Anaemia 36.75 22.18 217 29100 352585 90246545
Brain oedema 36.47 22.18 36 29281 17349 90581781
Pemphigoid 35.99 22.18 27 29290 8999 90590131
Blood pressure increased 35.32 22.18 10 29307 197207 90401923
Meningitis 35.22 22.18 26 29291 8455 90590675
Product use issue 35.08 22.18 33 29284 329886 90269244
Embolism 34.81 22.18 27 29290 9454 90589676
Gastrooesophageal reflux disease 34.69 22.18 6 29311 166331 90432799
Overdose 34.44 22.18 5 29312 157704 90441426
Tumour pain 33.64 22.18 15 29302 1872 90597258
Gait inability 33.52 22.18 4 29313 146452 90452678
Fall 33.28 22.18 66 29251 481744 90117386
Lower respiratory tract infection 33.15 22.18 20 29297 250639 90348491
Immune-mediated encephalopathy 32.99 22.18 6 29311 22 90599108
Autoimmune myocarditis 32.87 22.18 9 29308 259 90598871
Feeling abnormal 32.82 22.18 7 29310 167228 90431902
Septic shock 32.43 22.18 79 29238 84081 90515049
Autoimmune hypothyroidism 32.29 22.18 9 29308 277 90598853
Arthralgia 32.28 22.18 136 29181 778386 89820744
Sleep disorder 32.01 22.18 12 29305 198018 90401112
Silent thyroiditis 31.94 22.18 8 29309 161 90598969
Pancreatitis 31.80 22.18 70 29247 69756 90529374
Capillary leak syndrome 31.03 22.18 16 29301 2751 90596379
Drug reaction with eosinophilia and systemic symptoms 30.72 22.18 52 29265 42706 90556424
Multiple organ dysfunction syndrome 30.55 22.18 68 29249 68268 90530862
Pancreatic failure 30.30 22.18 13 29304 1479 90597651
Glomerulonephritis minimal lesion 29.95 22.18 9 29308 363 90598767
Infusion related reaction 29.73 22.18 56 29261 416724 90182406
Muscle spasms 29.45 22.18 23 29294 251860 90347270
Blood thyroid stimulating hormone decreased 29.40 22.18 20 29297 5720 90593410
Systemic inflammatory response syndrome 29.39 22.18 21 29296 6495 90592635
Dermatitis 29.20 22.18 36 29281 22184 90576946
Bursitis 29.15 22.18 4 29313 131650 90467480
Demyelinating polyneuropathy 28.76 22.18 11 29306 931 90598199
Type 2 diabetes mellitus 28.62 22.18 15 29302 203229 90395901
Endocrine disorder 28.55 22.18 11 29306 949 90598181
Meningoradiculitis 28.48 22.18 7 29310 130 90599000
Contusion 28.05 22.18 24 29293 251192 90347938
Rheumatoid arthritis 27.40 22.18 47 29270 362567 90236563
Hypokalaemia 27.39 22.18 99 29218 131017 90468113
Dyspepsia 27.36 22.18 15 29302 198145 90400985
Adverse drug reaction 27.18 22.18 3 29314 116698 90482432
Propionibacterium infection 26.95 22.18 5 29312 21 90599109
Pericardial effusion 26.73 22.18 45 29272 36788 90562342
Chronic gastritis 26.52 22.18 16 29301 3725 90595405
Chorioretinitis 26.41 22.18 10 29307 823 90598307
Adenocarcinoma 26.16 22.18 15 29302 3181 90595949
Tumour haemorrhage 26.09 22.18 13 29304 2081 90597049
Oesophagitis 26.05 22.18 30 29287 17219 90581911
Drug-induced liver injury 25.91 22.18 76 29241 90242 90508888
Neoplasm progression 25.45 22.18 49 29268 44437 90554693
Facial paralysis 25.13 22.18 28 29289 15506 90583624
Immune thrombocytopenia 25.04 22.18 26 29291 13300 90585830
Cholecystitis 24.67 22.18 29 29288 17011 90582119
Hypertension 24.22 22.18 72 29245 457460 90141670
Pulmonary embolism 24.19 22.18 95 29222 130725 90468405
Loss of personal independence in daily activities 24.18 22.18 7 29310 136098 90463032
Hepatic cytolysis 24.09 22.18 39 29278 30877 90568253
Optic neuritis 24.03 22.18 22 29295 9656 90589474
Aplasia pure red cell 24.03 22.18 17 29300 5177 90593953
Immune-mediated endocrinopathy 23.67 22.18 6 29311 127 90599003
Depression 23.60 22.18 38 29279 300563 90298567
Metastases to liver 23.35 22.18 37 29280 28770 90570360
Immune-mediated cystitis 23.30 22.18 5 29312 49 90599081
Sciatica 22.64 22.18 3 29314 101379 90497751
Pituitary enlargement 22.61 22.18 5 29312 57 90599073
Inflammation 22.58 22.18 15 29302 178577 90420553
Hypercalcaemia 22.45 22.18 40 29277 34200 90564930
Primary hypothyroidism 22.35 22.18 6 29311 160 90598970

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Malignant neoplasm progression 2764.29 17.05 1688 50383 106712 42462552
Immune-mediated enterocolitis 1856.30 17.05 548 51523 5129 42564135
Hypophysitis 1752.38 17.05 457 51614 2554 42566710
Colitis 1687.79 17.05 914 51157 45658 42523606
Adrenal insufficiency 1010.16 17.05 483 51588 18441 42550823
Hypopituitarism 810.53 17.05 246 51825 2545 42566719
Immune-mediated hepatitis 769.48 17.05 254 51817 3520 42565744
Immune-mediated lung disease 653.33 17.05 220 51851 3253 42566011
Immune-mediated hepatic disorder 647.05 17.05 202 51869 2312 42566952
Immune-mediated dermatitis 617.34 17.05 167 51904 1094 42568170
Pneumonitis 613.45 17.05 464 51607 41254 42528010
Hypothyroidism 604.82 17.05 415 51656 31669 42537595
Hyperthyroidism 533.70 17.05 287 51784 14054 42555210
Autoimmune colitis 520.78 17.05 143 51928 998 42568266
Thyroiditis 515.38 17.05 181 51890 3055 42566209
Immune-mediated myocarditis 497.44 17.05 159 51912 1975 42567289
Autoimmune hepatitis 470.62 17.05 197 51874 5448 42563816
Intentional product use issue 469.93 17.05 506 51565 71327 42497937
Type 1 diabetes mellitus 429.16 17.05 183 51888 5304 42563960
Secondary adrenocortical insufficiency 410.76 17.05 137 51934 1962 42567302
Fulminant type 1 diabetes mellitus 407.01 17.05 123 51948 1251 42568013
Myocarditis 387.84 17.05 258 51813 18680 42550584
Adrenocorticotropic hormone deficiency 381.71 17.05 117 51954 1253 42568011
Death 380.45 17.05 1348 50723 469837 42099427
Immune-mediated hypothyroidism 372.88 17.05 113 51958 1161 42568103
Hepatitis 358.24 17.05 284 51787 27016 42542248
Immune-mediated hypophysitis 356.06 17.05 86 51985 329 42568935
Prescribed overdose 352.13 17.05 211 51860 12716 42556548
Lymphocytic hypophysitis 336.37 17.05 81 51990 305 42568959
Diarrhoea 330.98 17.05 1270 50801 459579 42109685
Immune-mediated adrenal insuficiency 319.38 17.05 89 51982 660 42568604
Enterocolitis 309.83 17.05 177 51894 9752 42559512
Diabetic ketoacidosis 274.95 17.05 224 51847 22143 42547121
Liver disorder 267.30 17.05 284 51787 39360 42529904
Myositis 260.50 17.05 184 51887 14682 42554582
Vitiligo 246.67 17.05 82 51989 1161 42568103
Hepatic function abnormal 242.77 17.05 307 51764 51260 42518004
Drug interaction 232.78 17.05 27 52044 266972 42302292
Immune-mediated thyroiditis 216.00 17.05 60 52011 439 42568825
Pyrexia 206.98 17.05 989 51082 393053 42176211
Hypothalamo-pituitary disorder 204.15 17.05 69 52002 1031 42568233
Drug ineffective 201.97 17.05 287 51784 629910 41939354
Non-small cell lung cancer 200.37 17.05 105 51966 4869 42564395
Rash 198.36 17.05 764 51307 276190 42293074
Cytokine release syndrome 193.74 17.05 255 51816 44272 42524992
Interstitial lung disease 181.84 17.05 336 51735 78126 42491138
Immune-mediated myositis 181.68 17.05 90 51981 3703 42565561
Metastases to central nervous system 181.01 17.05 128 51943 10227 42559037
Immune-mediated uveitis 180.42 17.05 40 52031 93 42569171
Immune-mediated nephritis 168.14 17.05 54 52017 681 42568583
Uveitis 160.80 17.05 114 51957 9144 42560120
Immune-mediated encephalitis 145.82 17.05 47 52024 600 42568664
Toxicity to various agents 142.60 17.05 51 52020 229085 42340179
Immune-mediated hyperthyroidism 138.84 17.05 36 52035 195 42569069
Immune-mediated adverse reaction 137.42 17.05 50 52021 938 42568326
Adverse event 136.16 17.05 156 51915 23484 42545780
Product dose omission issue 126.26 17.05 19 52052 154346 42414918
Lipase increased 125.98 17.05 104 51967 10462 42558802
Thyroid disorder 124.77 17.05 71 52000 3879 42565385
Autoimmune thyroiditis 124.46 17.05 53 52018 1529 42567735
Nephritis 122.09 17.05 69 52002 3720 42565544
Blood thyroid stimulating hormone decreased 113.87 17.05 56 52015 2267 42566997
Pulmonary toxicity 111.23 17.05 89 51982 8566 42560698
Encephalitis 110.98 17.05 91 51980 9067 42560197
Immune-mediated pancreatitis 108.39 17.05 32 52039 298 42568966
Myasthenia gravis 105.85 17.05 114 51957 16023 42553241
Immune-mediated cholangitis 101.40 17.05 34 52037 495 42568769
Decreased appetite 99.55 17.05 483 51588 192654 42376610
Pemphigoid 99.01 17.05 94 51977 11373 42557891
Tumour pseudoprogression 98.89 17.05 40 52031 1010 42568254
Leukoderma 98.77 17.05 23 52048 72 42569192
Haemophagocytic lymphohistiocytosis 97.83 17.05 116 51955 18106 42551158
Completed suicide 97.18 17.05 5 52066 96460 42472804
Overdose 95.80 17.05 9 52062 105255 42464009
Immune-mediated renal disorder 93.04 17.05 31 52040 442 42568822
Autoimmune nephritis 91.65 17.05 28 52043 296 42568968
Cortisol decreased 88.42 17.05 40 52031 1338 42567926
Prescribed underdose 88.23 17.05 84 51987 10198 42559066
Immune-mediated arthritis 87.99 17.05 27 52044 290 42568974
Adrenocortical insufficiency acute 87.05 17.05 46 52025 2169 42567095
Rash maculo-papular 84.77 17.05 159 51912 37344 42531920
Meningitis aseptic 84.39 17.05 58 52013 4424 42564840
Adrenal disorder 83.78 17.05 37 52034 1168 42568096
Radiation pneumonitis 82.77 17.05 49 52022 2884 42566380
Intestinal perforation 82.41 17.05 83 51988 10791 42558473
Guillain-Barre syndrome 81.43 17.05 69 52002 7194 42562070
Skin disorder 79.84 17.05 101 51970 16843 42552421
Large intestine perforation 78.22 17.05 76 51995 9460 42559804
Immune-mediated endocrinopathy 77.38 17.05 18 52053 56 42569208
Erythema multiforme 75.32 17.05 76 51995 9901 42559363
Dermatitis 74.58 17.05 82 51989 11793 42557471
Condition aggravated 74.21 17.05 128 51943 260626 42308638
Facial paralysis 72.48 17.05 83 51988 12480 42556784
Tubulointerstitial nephritis 71.60 17.05 134 51937 31414 42537850
Hyperglycaemia 69.36 17.05 165 51906 45694 42523570
Drug hypersensitivity 69.17 17.05 18 52053 99371 42469893
Autoimmune pancreatitis 68.86 17.05 24 52047 395 42568869
Autoimmune disorder 68.74 17.05 41 52030 2446 42566818
Blood corticotrophin decreased 67.89 17.05 22 52049 286 42568978
Endocrine disorder 67.59 17.05 23 52048 351 42568913
Amylase increased 67.51 17.05 60 52011 6669 42562595
Blood pressure increased 66.25 17.05 21 52050 101907 42467357
Hepatotoxicity 64.89 17.05 113 51958 25054 42544210
Hypercalcaemia 64.36 17.05 94 51977 17964 42551300
Hyponatraemia 64.35 17.05 270 51801 101192 42468072
Autoimmune haemolytic anaemia 63.83 17.05 54 52017 5617 42563647
Immune-mediated cystitis 63.28 17.05 16 52055 77 42569187
Agitation 62.72 17.05 4 52067 64310 42504954
Fall 62.35 17.05 120 51951 234400 42334864
Anxiety 61.69 17.05 34 52037 118526 42450738
Haemoglobin decreased 60.67 17.05 44 52027 132427 42436837
Immune-mediated gastritis 59.50 17.05 16 52055 102 42569162
Somnolence 59.42 17.05 51 52020 141054 42428210
Radiation necrosis 58.63 17.05 19 52052 247 42569017
Feeling abnormal 58.39 17.05 8 52063 69778 42499486
Enteritis 58.29 17.05 69 52002 10747 42558517
Pain 56.19 17.05 136 51935 244712 42324552
Dizziness 55.21 17.05 141 51930 249113 42320151
Inappropriate schedule of product administration 55.20 17.05 24 52047 95878 42473386
Intracranial tumour haemorrhage 54.53 17.05 20 52051 384 42568880
Aspartate aminotransferase increased 54.21 17.05 212 51859 76951 42492313
Myasthenic syndrome 53.21 17.05 24 52047 797 42568467
Serous retinal detachment 53.07 17.05 25 52046 919 42568345
Vogt-Koyanagi-Harada disease 51.16 17.05 16 52055 184 42569080
Pain in extremity 50.46 17.05 66 52005 150538 42418726
Silent thyroiditis 47.93 17.05 13 52058 86 42569178
Off label use 46.89 17.05 1063 51008 637272 41931992
Encephalitis autoimmune 46.87 17.05 26 52045 1351 42567913
Alanine aminotransferase increased 46.80 17.05 223 51848 88183 42481081
Enterocolitis haemorrhagic 46.72 17.05 24 52047 1067 42568197
Joint swelling 46.03 17.05 13 52058 68009 42501255
Iridocyclitis 44.93 17.05 30 52041 2181 42567083
Suicide attempt 44.55 17.05 3 52068 46097 42523167
Sialoadenitis 44.03 17.05 21 52050 794 42568470
Immune thrombocytopenia 43.81 17.05 61 52010 11155 42558109
Bradycardia 43.76 17.05 25 52046 85459 42483805
Autoimmune neuropathy 43.16 17.05 11 52060 55 42569209
Tri-iodothyronine free decreased 42.83 17.05 11 52060 57 42569207
Coma 42.82 17.05 7 52064 53547 42515717
Hallucination 42.80 17.05 9 52062 57498 42511766
Peripheral swelling 42.61 17.05 29 52042 90241 42479023
Immune-mediated encephalopathy 42.06 17.05 11 52060 62 42569202
Pituitary enlargement 41.85 17.05 9 52062 17 42569247
Therapeutic product effect incomplete 40.42 17.05 18 52053 70921 42498343
Drug eruption 40.40 17.05 88 51983 22987 42546277
Depression 40.25 17.05 46 52025 111317 42457947
Asthma 40.19 17.05 13 52058 62301 42506963
Autoimmune dermatitis 40.10 17.05 10 52061 45 42569219
Incorrect dose administered 40.03 17.05 8 52063 52966 42516298
Cardiac failure congestive 39.74 17.05 28 52043 85574 42483690
Weight increased 39.69 17.05 44 52027 107939 42461325
Tremor 39.62 17.05 36 52035 96893 42472371
Autoimmune arthritis 39.61 17.05 12 52059 123 42569141
Treatment failure 38.77 17.05 14 52057 62610 42506654
Hypertension 38.22 17.05 93 51978 167111 42402153
Meningitis 38.02 17.05 41 52030 5768 42563496
Wheezing 37.95 17.05 10 52061 54771 42514493
Aggression 37.08 17.05 5 52066 44158 42525106
General physical health deterioration 36.90 17.05 313 51758 150933 42418331
Disseminated intravascular coagulation 36.17 17.05 88 51983 24706 42544558
Myocardial infarction 36.01 17.05 60 52011 123949 42445315
Blood glucose increased 35.69 17.05 23 52048 73676 42495588
Glucocorticoid deficiency 35.45 17.05 16 52055 532 42568732
Immune-mediated neuropathy 35.32 17.05 10 52061 79 42569185
Chest discomfort 34.92 17.05 17 52054 63599 42505665
Loss of personal independence in daily activities 34.68 17.05 9 52062 49807 42519457
Polymyalgia rheumatica 34.43 17.05 26 52045 2297 42566967
Drug-induced liver injury 34.40 17.05 114 51957 38159 42531105
White blood cell count decreased 34.34 17.05 51 52020 110345 42458919
Pruritus 34.30 17.05 367 51704 188404 42380860
Skin toxicity 34.01 17.05 41 52030 6508 42562756
Giant cell arteritis 33.76 17.05 20 52051 1178 42568086
Orbital myositis 33.73 17.05 11 52060 146 42569118
Pancreatic enzymes increased 33.71 17.05 18 52053 867 42568397
Cytomegalovirus enterocolitis 33.61 17.05 21 52050 1362 42567902
Prostate cancer 33.19 17.05 7 52064 44636 42524628
Chest pain 33.16 17.05 76 51995 139454 42429810
Wrong technique in product usage process 33.14 17.05 6 52065 42629 42526635
Duodenitis 32.54 17.05 37 52034 5519 42563745
Pleural effusion 32.10 17.05 216 51855 96950 42472314
Hyperhidrosis 32.04 17.05 38 52033 90474 42478790
Melanoma recurrent 32.02 17.05 11 52060 173 42569091
Insomnia 31.82 17.05 60 52011 118193 42451071
Arthritis 31.52 17.05 118 51953 41947 42527317
Lichenoid keratosis 31.49 17.05 31 52040 3919 42565345
Autoimmune lung disease 30.96 17.05 9 52062 79 42569185
Angioedema 30.89 17.05 7 52064 42470 42526794
Epistaxis 30.83 17.05 22 52049 66804 42502460
Muscle spasms 30.59 17.05 36 52035 86008 42483256
Pancreatic toxicity 30.16 17.05 8 52063 48 42569216
Intestinal intraepithelial lymphocytes increased 30.15 17.05 11 52060 208 42569056
Coronary artery disease 30.03 17.05 14 52057 53706 42515558
Nasopharyngitis 30.01 17.05 35 52036 83961 42485303
Thyroxine free decreased 29.85 17.05 12 52059 298 42568966
Cholangitis sclerosing 29.78 17.05 22 52049 1880 42567384
Pericardial effusion 29.78 17.05 91 51980 29184 42540080
Abdominal discomfort 29.52 17.05 29 52042 75226 42494038
Musculoskeletal stiffness 29.40 17.05 17 52054 57748 42511516
Prerenal failure 29.11 17.05 24 52047 2409 42566855
Dehydration 28.78 17.05 282 51789 141485 42427779
Heart rate decreased 28.70 17.05 5 52066 36527 42532737
Tumour associated fever 28.57 17.05 14 52057 562 42568702
Immune-mediated cytopenia 27.92 17.05 10 52061 179 42569085
Hepatic cytolysis 27.83 17.05 84 51987 26760 42542504
Thrombophlebitis migrans 27.80 17.05 12 52059 358 42568906
Autoimmune myocarditis 27.71 17.05 11 52060 264 42569000
Iris adhesions 27.56 17.05 11 52060 268 42568996
Adrenalitis 27.46 17.05 7 52064 35 42569229
Hypertransaminasaemia 27.20 17.05 44 52027 9183 42560081
Drug intolerance 27.17 17.05 35 52036 80389 42488875
Cryptitis 27.11 17.05 11 52060 280 42568984
Chronic gastritis 26.97 17.05 22 52049 2175 42567089
Haematocrit decreased 26.94 17.05 5 52066 34903 42534361
Nephrolithiasis 26.92 17.05 6 52065 36824 42532440
Swelling 26.75 17.05 17 52054 54868 42514396
Sedation 26.69 17.05 3 52068 30472 42538792
Heart rate increased 26.64 17.05 16 52055 53239 42516025
Polymyositis 26.63 17.05 20 52051 1753 42567511
International normalised ratio increased 26.24 17.05 13 52058 48155 42521109
Full blood count abnormal 26.02 17.05 3 52068 29873 42539391
Cortisol increased 25.92 17.05 10 52061 222 42569042
Metastases to skin 25.79 17.05 13 52058 555 42568709
Palpitations 25.78 17.05 15 52056 50782 42518482
Metastases to lymph nodes 25.51 17.05 34 52037 5964 42563300
Microvillous inclusion disease 25.47 17.05 10 52061 233 42569031
Metastases to lung 25.26 17.05 48 52023 11376 42557888
Pleurocutaneous fistula 25.22 17.05 7 52064 51 42569213
Lichen planus 25.17 17.05 17 52054 1260 42568004
Polyarthritis 24.96 17.05 31 52040 5073 42564191
Meningoradiculitis 24.87 17.05 7 52064 54 42569210
White blood cell count increased 24.81 17.05 12 52059 45075 42524189
Sarcoid-like reaction 24.76 17.05 8 52063 103 42569161
Electrocardiogram QT prolonged 24.56 17.05 14 52057 47931 42521333
Accidental overdose 24.28 17.05 3 52068 28327 42540937
Achromotrichia acquired 24.06 17.05 6 52065 27 42569237
Tachycardia 24.06 17.05 55 52016 101032 42468232
Adverse drug reaction 23.80 17.05 8 52063 37426 42531838
Rheumatic disorder 23.75 17.05 13 52058 658 42568606
Thyroid function test abnormal 23.30 17.05 13 52058 683 42568581
Optic neuritis 23.27 17.05 27 52044 4115 42565149
Unresponsive to stimuli 23.19 17.05 5 52066 31398 42537866
Haemorrhage 22.99 17.05 24 52047 60539 42508725
Primary adrenal insufficiency 22.93 17.05 10 52061 306 42568958
Drug dependence 22.82 17.05 4 52067 29090 42540174
Metastases to meninges 22.74 17.05 19 52052 1942 42567322
Tumour haemorrhage 22.63 17.05 25 52046 3613 42565651
Lower respiratory tract infection 22.63 17.05 11 52060 41195 42528069
Gait disturbance 21.98 17.05 55 52016 97945 42471319
Transient ischaemic attack 21.82 17.05 7 52064 33732 42535532
Probiotic therapy 21.75 17.05 8 52063 155 42569109
Bile duct stenosis 21.61 17.05 16 52055 1372 42567892
Blood corticotrophin increased 21.60 17.05 8 52063 158 42569106
Gastrointestinal perforation 21.54 17.05 27 52044 4459 42564805
Loss of consciousness 21.37 17.05 51 52020 92303 42476961
Cholangitis 21.21 17.05 43 52028 10684 42558580
Thyrotoxic crisis 21.12 17.05 13 52058 821 42568443
Pneumonia bacterial 21.10 17.05 54 52017 15638 42553626
Influenza 21.06 17.05 27 52044 62148 42507116
Disease progression 21.05 17.05 97 51974 143559 42425705
Blood thyroid stimulating hormone increased 21.00 17.05 29 52042 5263 42564001
Blood urea increased 20.86 17.05 7 52064 32786 42536478
Red blood cell count decreased 20.78 17.05 7 52064 32708 42536556
Sleep disorder 20.69 17.05 17 52054 48078 42521186
Cerebrovascular accident 20.67 17.05 56 52015 97104 42472160
Neutropenia 20.49 17.05 151 51920 199280 42369984
Autoimmune hypothyroidism 20.35 17.05 8 52063 187 42569077
Metabolic acidosis 20.31 17.05 20 52051 51838 42517426
Tumour pain 20.20 17.05 15 52056 1292 42567972
Oxygen saturation decreased 19.99 17.05 30 52041 64657 42504607
Muscular weakness 19.91 17.05 172 51899 83326 42485938
Spermatogenesis abnormal 19.76 17.05 6 52065 62 42569202
Fluid retention 19.68 17.05 7 52064 31612 42537652
Apoptosis 19.65 17.05 11 52060 582 42568682
Metastatic malignant melanoma 19.62 17.05 19 52052 2354 42566910
Diabetes mellitus 19.49 17.05 133 51938 59954 42509310
Arthropathy 19.39 17.05 6 52065 29591 42539673
Nasal congestion 19.29 17.05 6 52065 29495 42539769
Gastrooesophageal reflux disease 19.26 17.05 16 52055 45007 42524257
Pulmonary sepsis 19.24 17.05 22 52049 3302 42565962
Blood corticotrophin abnormal 19.14 17.05 5 52066 28 42569236
Contusion 19.13 17.05 14 52057 41971 42527293
Thrombosis 19.09 17.05 34 52037 68477 42500787
Pulmonary sarcoidosis 19.07 17.05 12 52059 788 42568476
Psychotic disorder 19.00 17.05 6 52065 29202 42540062
Serous retinopathy 18.87 17.05 8 52063 228 42569036
Parvovirus infection 18.72 17.05 10 52061 482 42568782
Hepatic failure 18.64 17.05 94 51977 38006 42531258
Gastritis 18.62 17.05 68 52003 23879 42545385
Mobility decreased 18.53 17.05 10 52061 35296 42533968
Erectile dysfunction 18.33 17.05 4 52067 24909 42544355
Myelitis 18.15 17.05 13 52058 1059 42568205
Confusional state 18.13 17.05 125 51946 167472 42401792
Transient acantholytic dermatosis 17.98 17.05 8 52063 257 42569007
Cancer pain 17.98 17.05 22 52049 3545 42565719
Balance disorder 17.95 17.05 19 52052 47626 42521638
Disturbance in attention 17.94 17.05 7 52064 29859 42539405
Cardiac disorder 17.90 17.05 20 52051 48912 42520352
Autoimmune thyroid disorder 17.84 17.05 4 52067 10 42569254
Product prescribing error 17.64 17.05 5 52066 26107 42543157
Acute myeloid leukaemia 17.58 17.05 3 52068 22253 42547011
Physical deconditioning 17.57 17.05 18 52053 2387 42566877
Therapeutic response decreased 17.31 17.05 12 52059 37000 42532264
Product use issue 17.27 17.05 43 52028 76708 42492556
Opsoclonus myoclonus 17.26 17.05 6 52065 98 42569166
Primary hypothyroidism 17.26 17.05 6 52065 98 42569166

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Malignant neoplasm progression 4954.93 17.36 2405 73765 172162 110340967
Immune-mediated enterocolitis 3090.82 17.36 819 75351 9366 110503763
Hypophysitis 2945.05 17.36 695 75475 4720 110508409
Colitis 2479.27 17.36 1269 74901 101054 110412075
Adrenal insufficiency 1521.12 17.36 689 75481 41701 110471428
Immune-mediated hepatitis 1452.64 17.36 414 75756 6297 110506832
Hypopituitarism 1293.08 17.36 345 75825 4045 110509084
Immune-mediated hepatic disorder 1241.31 17.36 335 75835 4115 110509014
Immune-mediated lung disease 1079.92 17.36 312 75858 4991 110508138
Hypothyroidism 1067.07 17.36 650 75520 72249 110440880
Pneumonitis 1032.91 17.36 648 75522 75883 110437246
Immune-mediated dermatitis 1003.24 17.36 247 75923 2043 110511086
Hyperthyroidism 956.57 17.36 446 75724 28815 110484314
Death 898.17 17.36 1670 74500 697199 109815930
Thyroiditis 867.57 17.36 277 75893 6296 110506833
Autoimmune colitis 858.95 17.36 212 75958 1773 110511356
Type 1 diabetes mellitus 795.99 17.36 281 75889 8766 110504363
Immune-mediated myocarditis 766.84 17.36 218 75952 3280 110509849
Fulminant type 1 diabetes mellitus 740.13 17.36 195 75975 2168 110510961
Autoimmune hepatitis 711.76 17.36 296 75874 14508 110498621
Myocarditis 706.81 17.36 366 75804 29689 110483440
Immune-mediated hypophysitis 661.22 17.36 150 76020 831 110512298
Secondary adrenocortical insufficiency 648.06 17.36 202 75968 4232 110508897
Immune-mediated hypothyroidism 642.98 17.36 182 75988 2693 110510436
Adrenocorticotropic hormone deficiency 597.87 17.36 162 76008 2020 110511109
Lymphocytic hypophysitis 527.27 17.36 117 76053 576 110512553
Enterocolitis 516.39 17.36 255 75915 18694 110494435
Diabetic ketoacidosis 514.64 17.36 335 75835 41723 110471406
Hepatic function abnormal 490.20 17.36 441 75729 88854 110424275
Immune-mediated adrenal insuficiency 482.30 17.36 131 76039 1649 110511480
Diarrhoea 472.38 17.36 1784 74386 1137721 109375408
Immune-mediated thyroiditis 463.84 17.36 115 76055 981 110512148
Cytokine release syndrome 437.63 17.36 373 75797 69933 110443196
Hepatitis 402.75 17.36 397 75773 89657 110423472
Pyrexia 393.70 17.36 1433 74737 896832 109616297
Intentional product use issue 384.47 17.36 645 75525 247261 110265868
Myositis 371.24 17.36 244 75926 30872 110482257
Vitiligo 364.85 17.36 119 76051 2898 110510231
Immune-mediated uveitis 347.73 17.36 71 76099 213 110512916
Immune-mediated nephritis 340.02 17.36 92 76078 1140 110511989
Immune-mediated encephalitis 324.38 17.36 88 76082 1102 110512027
Non-small cell lung cancer 309.93 17.36 137 76033 7798 110505331
Interstitial lung disease 301.13 17.36 423 75747 138911 110374218
Liver disorder 288.54 17.36 419 75751 141824 110371305
Hypothalamo-pituitary disorder 287.39 17.36 98 76072 2748 110510381
Metastases to central nervous system 277.23 17.36 181 75989 22636 110490493
Immune-mediated myositis 242.23 17.36 107 76063 6079 110507050
Uveitis 224.89 17.36 156 76014 21554 110491575
Drug hypersensitivity 222.63 17.36 26 76144 454064 110059065
Joint swelling 220.52 17.36 24 76146 442821 110070308
Myasthenia gravis 214.50 17.36 151 76019 21360 110491769
Drug interaction 212.63 17.36 43 76127 500140 110012989
Lipase increased 212.01 17.36 142 76028 18530 110494599
Pain 209.31 17.36 210 75960 954745 109558384
Tumour pseudoprogression 208.68 17.36 67 76103 1549 110511580
Immune-mediated hyperthyroidism 207.11 17.36 54 76116 574 110512555
Immune-mediated adverse reaction 205.34 17.36 67 76103 1633 110511496
Rash maculo-papular 202.98 17.36 253 75917 73969 110439160
Drug ineffective 199.71 17.36 474 75696 1520066 108993063
Immune-mediated pancreatitis 194.82 17.36 53 76117 671 110512458
Meningitis aseptic 194.78 17.36 107 76063 9763 110503366
Encephalitis 189.60 17.36 133 76037 18706 110494423
Immune-mediated cholangitis 188.83 17.36 54 76116 830 110512299
Autoimmune thyroiditis 185.48 17.36 90 76080 6344 110506785
Haemophagocytic lymphohistiocytosis 181.25 17.36 160 76010 31399 110481730
Leukoderma 181.14 17.36 39 76131 162 110512967
Adrenocortical insufficiency acute 177.73 17.36 78 76092 4362 110508767
Drug intolerance 174.70 17.36 34 76136 406478 110106651
Toxicity to various agents 169.01 17.36 60 76110 480495 110032634
Immune-mediated arthritis 165.96 17.36 46 76124 627 110512502
Nephritis 165.56 17.36 82 76088 6044 110507085
Rash 161.29 17.36 1041 75129 819923 109693206
Synovitis 158.94 17.36 7 76163 274085 110239044
Arthropathy 158.41 17.36 10 76160 287512 110225617
Decreased appetite 158.33 17.36 698 75472 475148 110037981
Prescribed overdose 157.53 17.36 244 75926 87337 110425792
Peripheral swelling 157.23 17.36 42 76128 403992 110109137
Systemic lupus erythematosus 156.25 17.36 4 76166 254334 110258795
Swelling 155.90 17.36 27 76143 351014 110162115
Therapeutic product effect decreased 153.38 17.36 3 76167 244313 110268816
Immune-mediated renal disorder 152.27 17.36 44 76126 703 110512426
Nasopharyngitis 147.87 17.36 44 76126 394317 110118812
Hyponatraemia 147.85 17.36 405 75765 217248 110295881
Condition aggravated 146.00 17.36 175 75995 734661 109778468
Completed suicide 144.58 17.36 5 76165 242376 110270753
Intestinal perforation 144.50 17.36 118 76052 20826 110492303
Pemphigoid 142.24 17.36 114 76056 19593 110493536
Pulmonary toxicity 141.78 17.36 109 76061 17637 110495492
Guillain-Barre syndrome 139.80 17.36 89 76081 10655 110502474
Tubulointerstitial nephritis 138.84 17.36 179 75991 54105 110459024
Abdominal discomfort 138.75 17.36 49 76121 393809 110119320
Aspartate aminotransferase increased 138.17 17.36 326 75844 159610 110353519
Maternal exposure during pregnancy 137.08 17.36 10 76160 254873 110258256
Off label use 135.94 17.36 1602 74568 1498583 109014546
Blood corticotrophin decreased 133.80 17.36 41 76129 809 110512320
Hyperglycaemia 133.78 17.36 223 75947 84867 110428262
Wound 132.66 17.36 7 76163 234430 110278699
Autoimmune nephritis 131.76 17.36 40 76130 764 110512365
Pleural effusion 129.05 17.36 339 75831 177370 110335759
Large intestine perforation 128.19 17.36 100 76070 16529 110496600
Blood thyroid stimulating hormone decreased 127.94 17.36 73 76097 7166 110505963
Alopecia 127.41 17.36 46 76124 364707 110148422
Erythema multiforme 127.25 17.36 110 76060 20987 110492142
Radiation pneumonitis 126.40 17.36 62 76108 4474 110508655
Overdose 126.22 17.36 9 76161 233785 110279344
Treatment failure 126.02 17.36 20 76150 277214 110235915
Weight increased 125.89 17.36 66 76104 419578 110093551
Amylase increased 125.08 17.36 88 76082 12431 110500698
Product dose omission issue 124.13 17.36 34 76136 321748 110191381
Cortisol decreased 123.91 17.36 53 76117 2783 110510346
Thyroid disorder 122.13 17.36 98 76072 16871 110496258
Enteritis 121.91 17.36 103 76067 19053 110494076
Wheezing 121.61 17.36 16 76154 255214 110257915
Adrenal disorder 118.11 17.36 49 76121 2383 110510746
Mobility decreased 117.76 17.36 13 76157 237409 110275720
Pemphigus 116.59 17.36 8 76162 214562 110298567
Alanine aminotransferase increased 114.03 17.36 331 75839 183442 110329687
Autoimmune haemolytic anaemia 111.95 17.36 77 76093 10490 110502639
Asthma 111.65 17.36 19 76151 250272 110262857
Metastatic malignant melanoma 111.44 17.36 52 76118 3357 110509772
Vogt-Koyanagi-Harada disease 111.11 17.36 33 76137 583 110512546
Musculoskeletal stiffness 110.90 17.36 28 76142 279794 110233335
Serous retinal detachment 110.22 17.36 42 76128 1630 110511499
Sinusitis 109.56 17.36 34 76136 296654 110216475
Dizziness 105.07 17.36 201 75969 697992 109815137
Autoimmune pancreatitis 104.85 17.36 34 76136 812 110512317
Blood pressure increased 104.05 17.36 25 76145 258348 110254781
Impaired healing 102.19 17.36 9 76161 196708 110316421
Hepatotoxicity 102.13 17.36 168 76002 63232 110449897
Immune-mediated gastritis 101.58 17.36 27 76143 311 110512818
Facial paralysis 101.25 17.36 103 76067 24111 110489018
Dehydration 100.49 17.36 420 75750 279091 110234038
Hypersensitivity 100.05 17.36 79 76091 403919 110109210
Skin disorder 96.66 17.36 133 76037 42780 110470349
Pain in extremity 95.57 17.36 117 76053 487001 110026128
Exposure during pregnancy 94.71 17.36 5 76165 167419 110345710
Blister 93.54 17.36 21 76149 227355 110285774
Osteoarthritis 93.14 17.36 9 76161 182614 110330515
Radiation necrosis 92.50 17.36 31 76139 823 110512306
Product use issue 92.01 17.36 50 76120 311645 110201484
Folliculitis 91.81 17.36 6 76164 167647 110345482
Disseminated intravascular coagulation 91.56 17.36 127 76043 41159 110471970
Immune-mediated endocrinopathy 91.28 17.36 21 76149 125 110513004
Myasthenic syndrome 91.17 17.36 34 76136 1242 110511887
Dermatitis 91.07 17.36 104 76066 27733 110485396
Sepsis 90.28 17.36 455 75715 326891 110186238
Discomfort 90.00 17.36 19 76151 214688 110298441
Lower respiratory tract infection 89.49 17.36 28 76142 243078 110270051
Therapeutic product effect incomplete 89.43 17.36 22 76148 223783 110289346
Acute kidney injury 89.05 17.36 744 75426 634686 109878443
Iridocyclitis 88.82 17.36 52 76118 5356 110507773
Encephalitis autoimmune 88.79 17.36 45 76125 3483 110509646
Glucocorticoid deficiency 86.31 17.36 32 76138 1150 110511979
Autoimmune dermatitis 86.23 17.36 22 76148 213 110512916
Migraine 86.13 17.36 9 76161 171643 110341486
Duodenitis 85.79 17.36 62 76108 9134 110503995
Hypercalcaemia 85.29 17.36 131 76039 46526 110466603
Immune-mediated cystitis 85.03 17.36 20 76150 133 110512996
Feeling abnormal 84.48 17.36 12 76158 180699 110332430
Fall 83.71 17.36 182 75988 603300 109909829
Psoriatic arthropathy 83.32 17.36 17 76153 196744 110316385
Autoimmune arthritis 81.79 17.36 22 76148 266 110512863
Drug eruption 80.84 17.36 138 76032 53521 110459608
Diabetes mellitus 78.75 17.36 196 75974 99185 110413944
Cholangitis 78.56 17.36 75 76095 16260 110496869
Anxiety 77.51 17.36 74 76096 345004 110168125
Contusion 77.19 17.36 32 76138 233329 110279800
Endocrine disorder 76.85 17.36 29 76141 1095 110512034
C-reactive protein abnormal 76.20 17.36 3 76167 129692 110383437
Silent thyroiditis 75.24 17.36 21 76149 294 110512835
Immune thrombocytopenia 75.22 17.36 85 76085 22409 110490720
Meningitis 74.62 17.36 63 76107 11639 110501490
Hypertension 73.08 17.36 151 76019 509933 110003196
Adrenalitis 72.74 17.36 16 76154 75 110513054
Muscle spasms 70.60 17.36 53 76117 278104 110235025
Hepatic failure 70.39 17.36 150 76020 68589 110444540
Skin toxicity 70.18 17.36 61 76109 11722 110501407
Intracranial tumour haemorrhage 68.26 17.36 23 76147 621 110512508
Pericarditis 67.84 17.36 33 76137 219081 110294048
Bursitis 67.32 17.36 6 76164 129912 110383217
Hypoaesthesia 66.43 17.36 71 76099 314152 110198977
Immune-mediated encephalopathy 65.82 17.36 15 76155 85 110513044
Depression 65.65 17.36 73 76097 317262 110195867
Insomnia 65.16 17.36 92 76078 360498 110152631
Joint range of motion decreased 64.85 17.36 5 76165 121827 110391302
Sleep disorder 64.48 17.36 28 76142 198616 110314513
Gastrooesophageal reflux disease 63.99 17.36 22 76148 179954 110333175
Memory impairment 63.54 17.36 28 76142 196916 110316213
Pericardial effusion 63.43 17.36 129 76041 57088 110456041
Metastases to lung 62.03 17.36 78 76092 22985 110490144
Adverse drug reaction 60.17 17.36 3 76167 105556 110407573
Stress 60.03 17.36 3 76167 105345 110407784
Enterocolitis haemorrhagic 59.14 17.36 31 76139 2573 110510556
Hepatic cytolysis 58.53 17.36 122 76048 54931 110458198
Gastritis 58.27 17.36 120 76050 53579 110459550
Urticaria 57.95 17.36 81 76089 318776 110194353
Loss of personal independence in daily activities 57.53 17.36 16 76154 150004 110363125
Prescribed underdose 57.49 17.36 134 76036 65040 110448089
Thyrotoxic crisis 57.19 17.36 28 76142 2012 110511117
Medication error 57.01 17.36 4 76166 105362 110407767
Inappropriate schedule of product administration 56.75 17.36 35 76135 203602 110309527
Obesity 56.71 17.36 6 76164 113345 110399784
Autoimmune myocarditis 56.41 17.36 20 76150 631 110512498
Suicide attempt 55.73 17.36 4 76166 103390 110409739
Cytomegalovirus enterocolitis 54.23 17.36 28 76142 2253 110510876
Meningoradiculitis 53.81 17.36 15 76155 209 110512920
Road traffic accident 52.93 17.36 6 76164 107392 110405737
Autoimmune neuropathy 52.84 17.36 13 76157 107 110513022
Injection site erythema 52.67 17.36 3 76167 94173 110418956
Immune-mediated oesophagitis 52.08 17.36 12 76158 72 110513057
Agitation 51.69 17.36 8 76162 113043 110400086
Transaminases increased 51.24 17.36 126 76044 63264 110449865
Abdominal pain upper 51.11 17.36 102 76068 349009 110164120
Tri-iodothyronine free decreased 51.06 17.36 17 76153 442 110512687
Lichenoid keratosis 50.98 17.36 39 76131 6263 110506866
Paraesthesia 50.49 17.36 70 76100 276451 110236678
Polymyalgia rheumatica 50.21 17.36 39 76131 6403 110506726
Pituitary enlargement 50.05 17.36 13 76157 136 110512993
Tumour pain 49.97 17.36 29 76141 2938 110510191
Suicidal ideation 49.59 17.36 4 76166 93933 110419196
Injection site reaction 49.32 17.36 3 76167 89067 110424062
Chest pain 48.49 17.36 118 76052 376257 110136872
Haemoglobin decreased 48.45 17.36 60 76110 248667 110264462
Brain oedema 48.19 17.36 81 76089 31017 110482112
Tumour haemorrhage 48.10 17.36 35 76135 5210 110507919
Gait inability 47.91 17.36 17 76153 136359 110376770
Hypercholesterolaemia 47.59 17.36 4 76166 90833 110422296
Cholangitis sclerosing 47.42 17.36 30 76140 3552 110509577
Chronic gastritis 47.13 17.36 35 76135 5376 110507753
Gastrointestinal disorder 46.46 17.36 59 76111 241893 110271236
Pulmonary embolism 46.25 17.36 279 75891 214195 110298934
Rheumatoid arthritis 46.07 17.36 85 76085 299528 110213601
Pancreatitis 45.56 17.36 155 76015 93378 110419751
Autoimmune hypothyroidism 45.42 17.36 16 76154 495 110512634
Wrong technique in product usage process 45.34 17.36 4 76166 87344 110425785
Immune-mediated neuropathy 44.97 17.36 13 76157 208 110512921
Angioedema 44.97 17.36 7 76163 98493 110414636
Fluid retention 44.69 17.36 6 76164 94301 110418828
Pancreatic toxicity 44.14 17.36 11 76159 96 110513033
Incorrect dose administered 43.77 17.36 9 76161 103632 110409497
Embolism 43.67 17.36 55 76115 16234 110496895
Sciatica 43.49 17.36 6 76164 92393 110420736
Palpitations 43.48 17.36 28 76142 159184 110353945
Orbital myositis 43.44 17.36 13 76157 236 110512893
Product use in unapproved indication 43.42 17.36 160 76010 447217 110065912
Pancreatic enzymes increased 43.35 17.36 22 76148 1707 110511422
Pulmonary fibrosis 42.81 17.36 9 76161 102033 110411096
Gait disturbance 42.70 17.36 79 76091 278129 110235000
Heart rate increased 42.52 17.36 23 76147 143811 110369318
Primary adrenal insufficiency 42.30 17.36 16 76154 608 110512521
Pancreatic failure 42.30 17.36 24 76146 2330 110510799
Type 2 diabetes mellitus 42.16 17.36 36 76134 177196 110335933
Arthralgia 41.85 17.36 340 75830 779292 109733837
Bradycardia 41.59 17.36 28 76142 155489 110357640
Prerenal failure 41.45 17.36 30 76140 4429 110508700
Confusional state 41.42 17.36 174 75996 468506 110044623
Giant cell arteritis 41.33 17.36 28 76142 3721 110509408
Drug-induced liver injury 41.21 17.36 178 75992 119889 110393240
Thyroxine free decreased 41.09 17.36 19 76151 1201 110511928
Peripheral venous disease 40.71 17.36 5 76165 84112 110429017
Chest discomfort 40.52 17.36 36 76134 173812 110339317
Dyspepsia 40.51 17.36 43 76127 190922 110322207
Optic neuritis 40.51 17.36 44 76126 11103 110502026
Lower limb fracture 40.36 17.36 3 76167 75345 110437784
Autoimmune lung disease 40.24 17.36 12 76158 215 110512914
Achromotrichia acquired 39.96 17.36 8 76162 21 110513108
Metastases to meninges 39.87 17.36 31 76139 5097 110508032
Sialoadenitis 39.47 17.36 24 76146 2649 110510480
Tremor 39.15 17.36 49 76121 202183 110310946
Exposure via body fluid 39.12 17.36 13 76157 336 110512793
Thrombophlebitis migrans 38.96 17.36 16 76154 758 110512371
Nasal congestion 38.59 17.36 10 76160 98272 110414857
Coma 37.63 17.36 17 76153 117852 110395277
Nephrotic syndrome 37.55 17.36 47 76123 13784 110499345
Heart rate decreased 37.51 17.36 6 76164 82750 110430379
Hypertransaminasaemia 37.34 17.36 63 76107 24192 110488937
Eyelid ptosis 37.33 17.36 46 76124 13281 110499848
Gastrointestinal perforation 37.31 17.36 35 76135 7421 110505708
Capillary leak syndrome 36.71 17.36 29 76141 4879 110508250
Sedation 36.69 17.36 3 76167 69680 110443449
Polyneuropathy 36.46 17.36 73 76097 31939 110481190
Liver injury 36.46 17.36 30 76140 150383 110362746
Immune-mediated cytopenia 36.15 17.36 12 76158 309 110512820
Metastases to liver 35.97 17.36 77 76093 35309 110477820
Musculoskeletal pain 35.79 17.36 44 76126 182979 110330150
Cholecystitis 35.65 17.36 64 76106 25818 110487311
Respiratory failure 35.48 17.36 262 75908 215070 110298059
Demyelinating polyneuropathy 35.30 17.36 21 76149 2228 110510901
Intestinal intraepithelial lymphocytes increased 35.21 17.36 11 76159 232 110512897
Cholestasis 35.08 17.36 111 76059 64407 110448722
Peripheral sensory neuropathy 35.03 17.36 50 76120 16630 110496499
Polymyositis 34.59 17.36 25 76145 3683 110509446
General physical health deterioration 34.58 17.36 446 75724 424849 110088280
Neoplasm malignant 34.55 17.36 78 76092 37065 110476064
Stevens-Johnson syndrome 34.54 17.36 90 76080 46811 110466318
Pulmonary sarcoidosis 34.38 17.36 19 76151 1753 110511376
Amnesia 33.97 17.36 15 76155 105393 110407736
Somnolence 33.95 17.36 99 76071 297350 110215779
Oxygen saturation decreased 33.68 17.36 35 76135 156947 110356182
Primary hypothyroidism 33.56 17.36 11 76159 272 110512857
Oesophagitis 33.33 17.36 66 76104 28649 110484480
Cardiac tamponade 33.25 17.36 40 76130 11267 110501862
Metastases to lymph nodes 32.96 17.36 46 76124 14986 110498143
Influenza 32.70 17.36 41 76129 169060 110344069
Blood corticotrophin increased 32.54 17.36 11 76159 300 110512829
Blood corticotrophin abnormal 32.50 17.36 8 76162 66 110513063
Hypogonadism 32.29 17.36 19 76151 1975 110511154
Osteoporosis 32.12 17.36 10 76160 87142 110425987
Cardiac failure congestive 32.02 17.36 34 76136 150966 110362163
Melanoma recurrent 31.87 17.36 11 76159 320 110512809
Blood pressure systolic increased 31.54 17.36 9 76161 82982 110430147
Blood glucose increased 31.40 17.36 27 76143 132469 110380660
Pneumonia bacterial 31.25 17.36 61 76109 26200 110486929
Rhinorrhoea 30.96 17.36 16 76154 102650 110410479
Spermatogenesis abnormal 30.78 17.36 6 76164 13 110513116
Swollen tongue 30.70 17.36 3 76167 60359 110452770
Therapeutic response decreased 30.68 17.36 14 76156 96485 110416644
Sudden death 30.67 17.36 58 76112 24337 110488792
Cancer pain 30.51 17.36 30 76140 6742 110506387
Hallucination 30.30 17.36 16 76154 101416 110411713
Underdose 30.21 17.36 4 76166 63550 110449579
Joint stiffness 30.20 17.36 5 76165 67238 110445891
Neurofibrosarcoma 30.11 17.36 10 76160 258 110512871
Cryptitis 30.02 17.36 11 76159 382 110512747
Apoptosis 29.86 17.36 13 76157 713 110512416
Hyperhidrosis 29.80 17.36 52 76118 187246 110325883
Tumour associated fever 29.78 17.36 15 76155 1146 110511983
Microvillous inclusion disease 29.71 17.36 10 76160 269 110512860
Acquired tracheo-oesophageal fistula 29.59 17.36 9 76161 173 110512956
Infusion related reaction 29.22 17.36 149 76021 381013 110132116
Pleurocutaneous fistula 29.20 17.36 7 76163 51 110513078
Hepatic enzyme increased 29.04 17.36 118 76052 320774 110192355
Tumour lysis syndrome 29.01 17.36 65 76105 30736 110482393
Pulmonary sepsis 28.79 17.36 26 76144 5252 110507877
Pregnancy on contraceptive 28.75 17.36 14 76156 994 110512135
Performance status decreased 28.73 17.36 30 76140 7236 110505893
Balance disorder 28.55 17.36 23 76147 116537 110396592
Myelitis 28.47 17.36 21 76149 3192 110509937
Autoimmune uveitis 28.46 17.36 6 76164 22 110513107
Hypokalaemia 28.37 17.36 219 75951 182229 110330900
Sarcoid-like reaction 28.19 17.36 10 76160 316 110512813
Unresponsive to stimuli 28.08 17.36 5 76165 63785 110449344
Septic shock 27.87 17.36 195 75975 157333 110355796
Glomerulonephritis minimal lesion 27.70 17.36 14 76156 1077 110512052
Electrocardiogram QT prolonged 27.32 17.36 21 76149 108939 110404190
Burning sensation 27.25 17.36 7 76163 69205 110443924
Headache 26.15 17.36 439 75731 881938 109631191
Loss of consciousness 25.69 17.36 61 76109 196245 110316884
Atrioventricular block complete 25.56 17.36 48 76122 20034 110493095
Probiotic therapy 25.51 17.36 8 76162 171 110512958
Autoimmune retinopathy 25.49 17.36 6 76164 40 110513089
Night sweats 25.37 17.36 33 76137 133950 110379179
Accidental overdose 25.28 17.36 3 76167 51831 110461298
Lichen planus 25.19 17.36 20 76150 3390 110509739
Aplasia pure red cell 25.13 17.36 32 76138 9546 110503583
Polyarthritis 24.98 17.36 46 76124 18917 110494212
White blood cell count decreased 24.98 17.36 78 76092 229312 110283817
Wound infection 24.95 17.36 18 76152 96447 110416682
Cortisol increased 24.93 17.36 11 76159 623 110512506
Bile duct stenosis 24.87 17.36 18 76152 2658 110510471
Blood creatine phosphokinase increased 24.81 17.36 108 76062 72969 110440160
Diarrhoea haemorrhagic 24.58 17.36 41 76129 15598 110497531
Physical deconditioning 24.54 17.36 20 76150 3517 110509612
Inflammation 24.54 17.36 61 76109 193177 110319952
Lactic acidosis 24.42 17.36 17 76153 92794 110420335
Multiple sclerosis relapse 24.27 17.36 3 76167 50237 110462892
Gastrointestinal toxicity 24.27 17.36 34 76136 11114 110502015
Myelitis transverse 24.27 17.36 17 76153 2384 110510745
Peripheral motor neuropathy 24.02 17.36 21 76149 4065 110509064
Metastases to bone 23.93 17.36 61 76109 31311 110481818
Nephrolithiasis 23.69 17.36 8 76162 66204 110446925
Plasma cell myeloma 23.59 17.36 7 76163 62929 110450200
Blood bilirubin increased 23.34 17.36 109 76061 75863 110437266
Aggression 23.29 17.36 6 76164 59204 110453925
Encephalopathy 23.24 17.36 114 76056 80941 110432188
Autoimmune cholangitis 23.16 17.36 6 76164 62 110513067
Anaemia 22.83 17.36 515 75655 546571 109966558
Cutaneous sarcoidosis 22.82 17.36 10 76160 557 110512572
Infection 22.72 17.36 151 76019 362049 110151080
Eosinophilic fasciitis 22.72 17.36 9 76161 388 110512741
Altered state of consciousness 22.58 17.36 89 76081 57537 110455592
Retinopathy 22.57 17.36 21 76149 4408 110508721
General physical condition abnormal 22.56 17.36 27 76143 7563 110505566
Troponin I increased 22.44 17.36 23 76147 5429 110507700
Feeling hot 22.29 17.36 18 76152 91088 110422041
Serous retinopathy 22.14 17.36 8 76162 267 110512862
Throat irritation 21.90 17.36 5 76165 53547 110459582
Tumour embolism 21.86 17.36 8 76162 277 110512852
Myocardial infarction 21.86 17.36 64 76106 192019 110321110
Melanosis 21.84 17.36 6 76164 79 110513050
Blood thyroid stimulating hormone increased 21.72 17.36 34 76136 12267 110500862
Secondary hypogonadism 21.69 17.36 11 76159 852 110512277
Lymphangiosis carcinomatosa 21.49 17.36 16 76154 2466 110510663
VIth nerve paralysis 21.42 17.36 14 76156 1753 110511376
Bronchitis 21.19 17.36 48 76122 156984 110356145
Toxic epidermal necrolysis 20.94 17.36 86 76084 56641 110456488
Respiratory arrest 20.93 17.36 7 76163 58292 110454837
Renal disorder 20.68 17.36 78 76092 49401 110463728
Haematocrit decreased 20.39 17.36 10 76160 66107 110447022
Multiple organ dysfunction syndrome 20.29 17.36 176 75994 151534 110361595
Red blood cell count decreased 20.28 17.36 10 76160 65913 110447216
Metastases to adrenals 20.16 17.36 13 76157 1590 110511539
Pancreatic atrophy 20.01 17.36 10 76160 751 110512378
Cortisol abnormal 19.84 17.36 6 76164 113 110513016
Drug dependence 19.81 17.36 5 76165 50015 110463114
Sarcoidosis 19.80 17.36 33 76137 12546 110500583
Localised infection 19.78 17.36 3 76167 43045 110470084
Tumour necrosis 19.54 17.36 15 76155 2421 110510708
Tachycardia 19.47 17.36 85 76085 226560 110286569
Limbic encephalitis 19.44 17.36 10 76160 798 110512331
Cytomegalovirus colitis 19.18 17.36 24 76146 7037 110506092
Jejunal ulcer 19.03 17.36 7 76163 246 110512883
Rash pruritic 18.89 17.36 124 76046 97945 110415184
Retinal melanoma 18.84 17.36 3 76167 0 110513129
Hypoalbuminaemia 18.73 17.36 53 76117 28921 110484208
Product prescribing error 18.72 17.36 6 76164 51325 110461804
Immune-mediated cholestasis 18.70 17.36 5 76165 59 110513070
Surgery 18.69 17.36 3 76167 41280 110471849
Chylothorax 18.68 17.36 11 76159 1145 110511984
Upper respiratory tract infection 18.66 17.36 39 76131 131289 110381840
Blood lactate dehydrogenase increased 18.62 17.36 70 76100 44264 110468865
Haemolytic anaemia 18.43 17.36 43 76127 20877 110492252
Autoimmune thyroid disorder 18.26 17.36 5 76165 65 110513064
Swelling face 18.25 17.36 22 76148 92299 110420830
Rheumatic disorder 18.25 17.36 17 76153 3574 110509555
Extraocular muscle disorder 18.22 17.36 8 76162 448 110512681
Granulomatous lymphadenitis 18.20 17.36 8 76162 449 110512680
Therapy non-responder 18.20 17.36 52 76118 157255 110355874
White blood cell count increased 18.18 17.36 24 76146 96818 110416311
Inappropriate antidiuretic hormone secretion 18.18 17.36 58 76112 33793 110479336
Erosive duodenitis 18.14 17.36 14 76156 2277 110510852
Thyroiditis subacute 18.13 17.36 8 76162 453 110512676
Metastases to skin 18.10 17.36 14 76156 2285 110510844
Diabetic ketosis 18.06 17.36 10 76160 926 110512203
Acute motor axonal neuropathy 18.06 17.36 6 76164 155 110512974
Illness 17.99 17.36 18 76152 82153 110430976
Propionibacterium infection 17.96 17.36 7 76163 289 110512840
Parvovirus infection 17.91 17.36 10 76160 941 110512188
Stomatitis 17.79 17.36 111 76059 270131 110242998
Flushing 17.65 17.36 28 76142 104708 110408421
Head injury 17.62 17.36 4 76166 43013 110470116
Radiation skin injury 17.54 17.36 12 76158 1620 110511509
Epistaxis 17.47 17.36 40 76130 130332 110382797
Toxic skin eruption 17.47 17.36 50 76120 27465 110485664
Abdominal distension 17.37 17.36 62 76108 175041 110338088

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01FX04 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
Other monoclonal antibodies and antibody drug conjugates
MeSH PA D000074322 Antineoplastic Agents, Immunological
MeSH PA D000082082 Immune Checkpoint Inhibitors
MeSH PA D000970 Antineoplastic Agents
FDA PE N0000182157 Increased T Lymphocyte Activation
FDA MoA N0000182634 CTLA-4-directed Antibody Interactions
FDA EPC N0000182635 CTLA-4-directed Blocking Antibody
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:64946 anti-HIV agent

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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Unresectable advanced or recurrent malignant pleural mesothelioma indication 254645002 DOID:7474
Unresectable advanced or recurrent esophageal cancer indication 363402007
Metastatic nonsmall cell lung cancer with no sensitising EGFR mutation or ALK translocation indication 427038005
Metastatic malignant melanoma indication 443493003
Renal cell carcinoma indication 702391001 DOID:4450
Microsatellite instability-high colorectal cancer indication 737058005
High grade squamous intraepithelial neoplasia of esophagus indication 1197288009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cytotoxic T-lymphocyte protein 4 Surface antigen Kd 8.07 IUPHAR DRUG LABEL

External reference:

IDSource
D04603 KEGG_DRUG
4030653 VUID
N0000182641 NUI
4030653 VANDF
CHEBI:231679 CHEBI
CHEMBL1789844 ChEMBL_ID
6888 IUPHAR_LIGAND_ID
DB06186 DRUGBANK_ID
1094833 RXNORM
180596 MMSL
27014 MMSL
d07565 MMSL
013688 NDDF
697995005 SNOMEDCT_US
704649006 SNOMEDCT_US
C1367202 UMLSCUI
D000074324 MESH_DESCRIPTOR_UI
8568 INN_ID
6T8C155666 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
YERVOY HUMAN PRESCRIPTION DRUG LABEL 1 0003-2327 INJECTION 5 mg INTRAVENOUS BLA 26 sections
YERVOY HUMAN PRESCRIPTION DRUG LABEL 1 0003-2328 INJECTION 5 mg INTRAVENOUS BLA 26 sections