pentoxyverine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| spasmolytics with a papaverine-like action | 494 | 77-23-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | O |
| 0.10 | g | R |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R05DB05 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Other cough suppressants |
| MeSH PA | D000996 | Antitussive Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D019141 | Respiratory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
| Cough | indication | 49727002 | |
| Allergic rhinitis | indication | 61582004 | |
| Nasal discharge | indication | 64531003 | |
| Nasal congestion | indication | 68235000 | |
| Rhinitis | indication | 70076002 | DOID:4483 |
| Common cold | indication | 82272006 | DOID:10459 |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
| Hyperkalemia | contraindication | 14140009 | |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Ventricular tachycardia | contraindication | 25569003 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Acute hepatitis | contraindication | 37871000 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Chronic heart failure | contraindication | 48447003 | |
| Bradycardia | contraindication | 48867003 | |
| Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
| Acidosis | contraindication | 51387008 | |
| Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
| Acute nephropathy | contraindication | 58574008 | |
| Metabolic acidosis | contraindication | 59455009 | |
| Arterial thrombosis | contraindication | 65198009 | |
| Psychotic disorder | contraindication | 69322001 | |
| Arteriosclerotic vascular disease | contraindication | 72092001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Partial atrioventricular block | contraindication | 195039008 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Hyporeninemic hypoaldosteronism | contraindication | 236464008 | |
| Bladder outflow obstruction | contraindication | 236645006 | |
| Rhabdomyolysis | contraindication | 240131006 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Retention of urine | contraindication | 267064002 | |
| Primary adrenocortical insufficiency | contraindication | 373662000 | |
| Hypoxia | contraindication | 389086002 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
| Disorder of coronary artery | contraindication | 414024009 | |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Traumatic injury | contraindication | 417746004 | |
| Hypertensive urgency | contraindication | 443482000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.15 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 7.71 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.12 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.78 | CHEMBL | |||||
| Lysosomal Pro-X carboxypeptidase | Enzyme | IC50 | 7.49 | CHEMBL | |||||
| Solute carrier family 22 member 1 | Transporter | IC50 | 5.81 | CHEMBL | |||||
| Transmembrane protein 97 | Enzyme | Ki | 5.71 | CHEMBL | |||||
| Sodium-dependent dopamine transporter | Transporter | Ki | 5.51 | CHEMBL | |||||
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 7.96 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019655 | VUID |
| N0000179067 | NUI |
| D01260 | KEGG_DRUG |
| 23142-01-0 | SECONDARY_CAS_RN |
| 20217 | RXNORM |
| CHEBI:94484 | CHEBI |
| CHEMBL1256696 | ChEMBL_ID |
| CHEMBL73234 | ChEMBL_ID |
| C018861 | MESH_SUPPLEMENTAL_RECORD_UI |
| 474 | INN_ID |
| DB11186 | DRUGBANK_ID |
| 32C726X12W | UNII |
| 14872 | MMSL |
| 4353 | MMSL |
| d03573 | MMSL |
| 37957009 | SNOMEDCT_US |
| 412344009 | SNOMEDCT_US |
| 703555004 | SNOMEDCT_US |
| C0054668 | UMLSCUI |
| 4018918 | VANDF |
| 4019655 | VANDF |
| 2562 | PUBCHEM_CID |
| 001656 | NDDF |
| 004671 | NDDF |
| 006192 | NDDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| PANCOLD A | HUMAN OTC DRUG LABEL | 6 | 51352-189 | LIQUID | 15 mg | ORAL | OTC monograph final | 14 sections |