DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
vaniprevir 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
Hepatitis Virus C (HVC) protease inhibitors
4939
923590-37-8
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
vaniprevir
vanihep
MK-7009
inhibits hepatitis C virus NS3/4a protease
Molecular weight: 757.94
Formula: C38H55N5O9S
CLOGP: 7.78
LIPINSKI: 3
HAC: 14
HDO: 3
TPSA: 180.52
ALOGS: -4.72
ROTB: 6
Drug dosage:
None
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
Sept. 26, 2014
PMDA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
CHEBI has role
CHEBI:36044
antiviral drugs
CHEBI has role
CHEBI:64924
hepatitis C protease inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Chronic hepatitis C
indication
128302006
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
4.6
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Cathepsin S
Enzyme
P25774
CATS_HUMAN
IC50
4.11
CHEMBL
Genome polyprotein
Polyprotein
POLG_HCVBK
INHIBITOR
Ki
10.30
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
Genome polyprotein
Polyprotein
POLG_HCVJF
INHIBITOR
Ki
9.05
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
Nonstructural protein NS3-4A
Unclassified
A0A0K1CY61_9HEPC
Ki
10.30
CHEMBL
Genome polyprotein
Unclassified
K7XJL6_9HEPC
Ki
7.66
CHEMBL
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External reference:
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ID
Source
SU3
PDB_CHEM_ID
11570
IUPHAR_LIGAND_ID
24765256
PUBCHEM_CID
9219
INN_ID
C2931927
UMLSCUI
C540393
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:136047
CHEBI
CHEMBL4525964
ChEMBL_ID
CV3X74AO1H
UNII
D09987
KEGG_DRUG
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Pharmaceutical products:
None
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vaniprevir