vaniprevir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| Hepatitis Virus C (HVC) protease inhibitors | 4939 | 923590-37-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
inhibits hepatitis C virus NS3/4a protease
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 26, 2014 | PMDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:36044 | antiviral drugs |
| CHEBI has role | CHEBI:64924 | hepatitis C protease inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Chronic hepatitis C | indication | 128302006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.6 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cathepsin S | Enzyme | IC50 | 4.11 | CHEMBL | |||||
| Genome polyprotein | Polyprotein | INHIBITOR | Ki | 10.30 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Genome polyprotein | Polyprotein | INHIBITOR | Ki | 9.05 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Nonstructural protein NS3-4A | Unclassified | Ki | 10.30 | CHEMBL | |||||
| Genome polyprotein | Unclassified | Ki | 7.66 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D09987 | KEGG_DRUG |
| CHEBI:136047 | CHEBI |
| SU3 | PDB_CHEM_ID |
| CHEMBL4525964 | ChEMBL_ID |
| C540393 | MESH_SUPPLEMENTAL_RECORD_UI |
| 11570 | IUPHAR_LIGAND_ID |
| DB11929 | DRUGBANK_ID |
| C2931927 | UMLSCUI |
| 9219 | INN_ID |
| 24765256 | PUBCHEM_CID |
| CV3X74AO1H | UNII |
Pharmaceutical products:
None